http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1
연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.
상완골 근위부 골절 치료에서 잠김 압박 금속판의 유용성
김동휘,이준영,조승환,양훈,하상호 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.34 No.1
Purpose: To prove the efficacy of locking compression plate (LCP) in proximal humerus fracture. Materials and Methods: Forty four out of 48 patients who had proximal humerus fracture operation with LCP from November, 2004 to June, 2008 and available for follow up for more than 6 months were evaluated. Eighteen cases were male and 26 cases were female with mean age of 56 years (range 29-85 years). Cause of injury was traffic accident in 17 cases, slip down in 20 cases and fall down in 7 cases. Mean interval from injury to operation was 6.8 days (range 2-30 days) and mean operation time was 80. 5 minutes(range 40-130 minutes). Open reduction and internal fixation with LCP using deltopectoral approach was used in all cases. Postoperative clinical evaluation was done using Constant-Murley assessment and bone union and neck-shaft angle was checked using radiographic exam. Results: Bone union was achieved in 41 out of 44 cases at mean interval of 11.2 weeks(range 6-16 weeks). Mean neck-shaft angle was 129.7 degree (range 101-146) with more than 20 degree of angular deformation in 2 cases. For the complication, 2 cases of temporary axillary nerve injury, 1 case of nonunion, 2 case of delayed unions with angulation, 2 case of ankylosis was observed. Conclusion: LCP can prevent reduction loss and minimize soft tissue injury which result in firm fixation and early immobilization. It seem to be very efficient in treating proximal humerus fracture in elderly.
광선각화증, 각화극세포종과 Bowen's병에서 p53과 p21의 표출 양상
조명구,조현득,양승하,김의한 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2
Background The function of the p53 protein was known to regulate cell proliferation by inhibiting cells entering Sphase. So DNA damaged cell proliferation was inhibited by apoptosis. P21 is a cyclin dependent kinase inhibitor induced by wild type p53, not mutant p53. Thus p21 is thought go mediate the signal of p53 induced by DNA damaged agents to arrest the cell cycle in G1 phase. p53 and p21 were expressed in many malignant tumors, and its role in oncogenesis, tumor progression and prognosis were important. The authors analyzed immunohistochemical expression of mutant p53 and p21 protein in some skin tumors. Method Thirteen cases of actinic keratosis, 7 cases of keratoacanthoma and 8 cases of Bowen's disease were immunohistochemically stained with p53 and p21 monoclonal antibodies. Results; 1. In cases of positive p53 protein and negative p21 protein, the expressed p53 protein was suggested as mutant form. 2. Positive expression of p53 protein and p21 protein in prickle cell layer of actinic keratosis and Bowen's disease was suggesded that the composing cells of prickle cell layer were transformed into the proliferated cell. The p21 protein expression was suggested to be induced by the p53 independent pathway. 3. Negative expression of p53 protein and p21 protein in prickle cell layer of keratoacanthoma was suggested that the composing cells of prickle cell layer were completely mature cells, so the keratoacanthoma had good prognosis.
DIF와 시토키닌의 상호작용이 포도의 기내생장에 끼치는 영향
김선규,김승희,조현정 충북대학교 첨단원예기술개발연구센터 1999 연구보고서 Vol.4 No.-
주야간 온도 변화(DIF)와 시토키닌의 상호작용이 포도의 기내생장에 끼치는 영향을 구명하여 포도의 기내 대량증식체계를 확립하기 위하여 유럽종 양조용 품종 'Cabernet Sauvignon'과 생식용 구미잡종 'Campbell Early' 포도를 공시하여 metal halide lamp와 형광등으로 210μmolㆍm-2ㆍs-1의 광량자속밀도, 상대습도 70±5%, 16시간 광주기로 조절된 생육상에서 일련의 시험을 수행하였다. 주야간 온도는 25/25, 25/18, 18/25℃로 설정하였고, 시토키닌은 zeatin, kinetin, 2ip, BA및 TDZ를 단용 처리하였다. 모든 시험은 3반복으로 실시하였으며, 4주 후 생장과 분지, 그리고 생체중을 조사하였다. Cabernet Sauvignon 에서는 DIF처리와 상관없이 대조구가 신초의 생장이 가장 좋았는데 -7DIF에서 생장이 전반적으로 나빴다. 그리고 BA와 TDZ처리는 DIF에 영향을 크게 받지 않은 것으로 나타났다. 0DIF는 시토키닌의 농도가 높을수록 생장이 다소 좋은 경향을 나타냈고, kinetin 10mM은 87mm로 대조구를 제외한 시토키닌 처리구 가운데에서 가장 높았다. Campbell Early 에서 -7DIF에서는 Zeatin 5mM처리가 162mm로 대조구의 112mm 보다 생장이 좋았으며 +7DIF에서 kinetin 5mM처리가 110mm로 가장 좋았다. 0DIF에서는 Zeatin 5mM 처리가 162mm로 대조구보다 약 2배 정도 높은 생장을 보였다. Cabernet Sauvignon에서 분지수는 DIF처리와 관계없이 대조구는 1개가 분지 되었으며 모든 DIF처리에서 신초의 생장이 적었던 BA와 TDZ처리에서 분지가 많았다. 0, +7DIF에서는 BA 10mM처리가 약 4개로 나타났으며 -7DIF처리는 TDZ 5mM처리에서 가장 많았다. Zeatin, 2ip와 kinetin 처리는 분지가 되지 않은 것으로 나타났다. Campbell Early 에서도 같은 결과였다. 총절편체수는 Cabernet Sauvignon에서는 모든 DIF처리에서 BA 10mM 처리가 가장 많았다. 신초생장이 좋았던 CT와 Zeatin, 2ip, kinetin 보다 생장은 적었지만 분지수가 많았던 BA와 TDZ처리에서 총절편체수가 많은 것으로 나타났다. Campbell Early 역시 Cabernet Sauvignon과 비슷한 경향을 나타냈으며, 0DIF처리가 -, +7DIF처리보다는 절편체수가 많은 것으로 나타났다. Cabernet Sauvignon에서는 -7DIF처리에서 대체로 200mg 이하로 적었으며 시토키닌의 종류에 차이도 크지 않았다. 0DIF처리는 2ip 10mM 처리가 가장 높았으며, +7DIF에서는 TDZ 5mM이 대조구와 비슷하게 380mg을 나타냈다. Campbell Early는 +7DIF처리에서 BA 5mM을 제외한 나머지 모든 처리구에서 대조구보다 높게 나타났고 2ip 10mM이 410mg으로 가장 높았다. 0DIF처리는 Zeatin 5와 2ip 10mM처리가 900, 840mg으로 대조구의 약 8배에 달했으며, kinetin 10mM처리가 가장 낮게 나타났다. -7DIF처리에서 모든 처리구가 대조구보다 높았으나 다른 DIF처리보다는 낮았다. Shoot growth, number of shoots and fresh weight of Vitis vinifera L.'Cabernet Sauvignon' and Vitis labruscana B. 'Campbell Early' explants under three DIF levels, -7, 0 and +7, 210μmolㆍm-2ㆍs-1 provided by metal halide and fluorescent lamps, under 16hㆍd-1 photoperiod were studied. Basal MS media were supplemented with 5 and 10 mM BA, TDZ, Zeatin, 2ip, kinetin, respectively. In all media, 2.1gㆍL-1 gelite and 3% sucrose were used and cultured for 4 weeks. Shoot growth was significantly increased by control regardless of DIF in Cabernet Sauvignon and was suppressed by -7DIF. Effects of BA and TDZ were not affected by DIF. 0DIF enhanced the growth with increasing cytokinin level. Kinetin at 10 mM was most effective for shoot growth with 87mm among cytokinins used except for control. Zeatin and kinetin each at 5 mM significantly increased shoot growth to respective 162 and 110mm. In 0DIF, double increase of 162 mm was obtained by 5 mM zeatin. In control, no further shoot proliferation was observed in Cabernet Sauvignon regardless of DIF. In 0 and +7DIF, 4 shoots were observed with 10 mM BA. Zeatin, 2ip, and kinetin resulted in poor shoot proliferation. BA at 10 mM resulted in profuse branching in all DIFs.
최적설계 기법을 적용한 1톤 운반차용 P.T.O축 및 트랜스미션 개발에 관한 기초연구
김재열,심재기,최승현,정효희,김훈조,오현중,박경섭 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-
Now, power tillers and cultivators which are spread among fruit tree households have usage, low application, and high accident risk. Therefore, the development of multi-purpose work vehicles is needed as an alternative for these problems. Especially, easy usage and the ability to easily change gears when driving and the development of the P.T.O for various tasks such as pruning, water lifting, pest control, application and, mowing are needed. In this research, we will develop a transmission with design on P.T.Oaxle for agricultural work vehicles including multi-purpose vehicles. We aim to develop a 4-wheel drive transmission of synchronous contact type for practical use in fruit tree households which is required to be a large-sized agricultural vehicle. Therefore, we have per performed as follows that are composed of load capacity from 500kg to 1,000kg, safety securing for passengers, and drive securing under bad conditions of the topography slope and swampy land and the rest. For this purpose, we have developed a prototype vehicle through strength analysis of transmission design. we have selected optimal design conditions (Optimal RPM and torque according to some works) on the power transmission with multi-purpose vehicle for various jobs: spraying, manure spreading, mowing, brush wood chopping. If development of the P.T.O containing variable RPM and torque is successful, the following tasks can be possible. Air pruning, air maintenance, water lift, pest control, application, mowing, spraying, and brush wood chopping are possible with this developed P.T.O. Methods and contents for research are followed. Therefore, we have achieved performance-tests through the prototype of the multi-purpose work vehicle and have improved on troubles by the analysis of results of R&D. Also, we provided solutions to problems in mass production in the future.
조팝나무 揷木時期 및 揷床土의 種類가 發根에 미치는 影響
趙鎭泰,尹汰,金泰重,洪承敏,白基燁 한국화훼연구회 1995 화훼연구 Vol.4 No.1
Cutting experiment was conducted to develop a mass propagation method for Spiraea prunifolia var. simpliciflora Nakai. The optimum season for hardwood cutting was between December and early April, but cutting could be done year-round by using rhizome. NAA treatment (100 ppm) was the most effective as rooting promoter. IBA and IAA were also found to be effective. The effect of sand, red clay, loam, silty loam and vermiculite had little differences in rooting especially when cuttings were done earlier than April 5.
김도경,조용철,김승현 경희대학교 디자인연구원 2004 예술· 디자인학연구 Vol.7 No.1
This paper is master plan for pet memorial space lacking of social-understanding and legislation. Therefore instances of domestic and foreign country and investigation of laws are studied, also memorial space of human is studied for pet-memorial space is not to be planned as a cremation ground and crypt. Also, research on pet related business has a connection with this plan. As problem of reasonableness of business, this paper is planned pet memorial space with other pet business. But according to domestic social-condition is advanced, pet memorial park of large scale will be constructed.
초등교사의 과학과 환경 교육에 대한 수업실태 분석 및 인식도
조태호,서승조,백남권,김성규,박강은,박원석 한국환경과학회 2002 한국환경과학회지 Vol.11 No.7
The purpose of this study was to analyze the elementary school teachers' perception toward the environment-related subjects in science education and to investigate their instructional methods in delivering the subjects in the classroom. The participants of this study were 300 elementary school teachers sampled from elementary schools in Kyung Nam Province. The findings of this study were as follows; First, more than half of the teachers surveyed showed that the environment-related units and contents in the science textbook were insufficient to the existing issues. Second, the large portion of teachers responded that the teaching materials in the textbook were insufficient to deliver the contents. Third, the largest portion of respondents replied that their preferred instructional method was a teacher-directed instruction followed by a case study approach. Fourth, in terms of the effectiveness of environmental education, both male and female teachers showed negative responses. Furthermore, male teachers were more negative than female teachers. Fifth, total means of their preference of the environment-related units was 3.13. The unit for sixth graders titled 'Environmental Pollution and Protecting Nature' showed the highest preference, whereas the unit for fifth graders titled 'Structure and Functions of Plants' showed the lowest preference. Sixth, there was no statistically significance in gender and their working areas. Seventh, there was statistically significant differences between male and female teachers in terms of teaching experience. In detail, the teachers with 5 to 9 teaching experience showed the lowest scores, while the teacher with more than 15 years teaching experience showed the highest scores in their perception of the units. Eighth, there was a significant difference between two groups in terms of their educational background. For example, two-year college graduates showed higher preference than four-year college graduates.