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신재호,Sung-Jin Park,Hyun-Jin Cho,Geumhee Gwak,Byung-Noe Bae,Ki Whan Kim,Hong-Yong Kim2,Kyeongmee Park,Sehwan Han 한국유방암학회 2009 Journal of breast cancer Vol.12 No.1
Purpose: Human epidermal growth factor receptor-2 (HER-2)/neu amplification affects the cell proliferation through the modulation of multiple G1 cell cycle regulators in breast tumor cells. We performed this study to investigate whether retinoblastoma protein (pRB) and p27Kip1 were differently expressed according to the HER2 amplification status in human breast cancer. Methods: HER2 amplification was assayed by fluorescence in situ hybridization and the expression of cell cycle regulators were assayed by immunohistochemistry on 153 consecutive invasive breast cancers. The proliferative activity of breast cancer was analyzed according to the HER2 amplification and cell cycle protein expression status. Results: HER2 amplification was observed in 39 (25.5%) of 153 breast cancers. In the HER2 amplified breast cancers, the pRB expression was significantly increased (p=0.011) whereas there was no significant relationship between HER2 amplification and p27Kip1 expression. There was an inverse correlation between pRB expression and Ki-67 labeling index in the HER2 amplified breast cancers (p=0.036). In contrast, Ki67 labeling index was significantly decreased as p27Kip1 expression increased in HER2 non-amplified breast cancers (p=0.028). In HER2 non-amplified breast cancers, we could not observe any association between the pRB expression and Ki67 labeling index. Conclusion: The proliferation of the breast cancers was associated with pRB expression in HER2 amplified tumors whereas it was associated with p27Kip1 expression in HER2 non-amplified tumors. The results of the current study indicate that the cell proliferative activity of the breast cancer is under different growth signal pathways according to HER2 amplification status.
Electrochromic Diffraction from Nanopatterned Poly(3-hexylthiophene)
Kim, Yuna,Kim, Yoonjung,Kim, Sehwan,Kim, Eunkyoung American Chemical Society 2010 ACS NANO Vol.4 No.9
<P>Poly(3-hexylthiophene) (P3HT) films were patterned by a soft lithography technique using a nanopatterned polydimethylsiloxane (PDMS) mold to generate one-dimensional (1D) grating and two-dimensional (2D) crossed line pillar patterns. The redox currents (<I>i</I><SUB>p</SUB>) were significantly increased due to the facilitated diffusion of ClO<SUB>4</SUB><SUP>−</SUP> counterions associated with redox processes at the P3HT electrode as analyzing cyclic voltammetry (CV) was performed at different scan rates (ν). It was found that the diffusion coefficient (<I>D</I><SUB>f</SUB>, cm<SUP>2</SUP> s<SUP>−1</SUP>) for ion diffusion in the patterned electrode was much larger than that of the pristine P3HT electrode. Furthermore, the value of <I>D</I><SUB>f</SUB> in the 2D electrode was three times higher than that in a pristine film. As a result of such facilitated charge transport, the electrochromic (EC) properties of the patterned P3HT electrode were greatly enhanced and dependent on the dimension of the pattern. Thus, the electrochromic efficiency (<I>E</I><SUB>e</SUB>), including the coloration (<I>E</I><SUB>c</SUB>) and bleaching efficiencies (<I>E</I><SUB>b</SUB>), was higher as the dimension of the pattern was increased; <I>E</I><SUB>e</SUB> was maximized in the 2D patterned P3HT film. In a patterned cell, electrochromic diffraction was reversibly observed with a switching efficiency (<I>R</I><SUB>DE</SUB>) of 2 and 2.5 for the 1D and 2D patterned cells, respectively.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2010/ancac3.2010.4.issue-9/nn1016378/production/images/medium/nn-2010-016378_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn1016378'>ACS Electronic Supporting Info</A></P>
Interrelation of Cyclin D1, Cyclin E, and p27Kip1 Expression on Tissue Arrays of Breast Cancer
Sehwan Han,Young-Duck Kim,Hong-Yong Kim,Hong-Joo Kim,Kyeongmee Park,Byung-Noe Bae,Suk Yong Ryu,Ki Hwan Kim 대한암학회 2002 Cancer Research and Treatment Vol.34 No.5
Purpose: To evaluate the clinical impact of the alteredexpression of cell cycle regulators in stage I and II breastcancers.Materials and Methods: The interaction between cyclinD1/E and p27Kip1 expressions were analyzed usingtissue microarray (TMA) technology in 133 breast cancers.Data from the immunohistochemical assays of 3molecules were merged, and analyzed, with a Ki67labeling index of the same tumors.Results: Cyclin D1 was expressed in 72 breast carcinomas(54.1%) and cyclin E in 60 (45.1%) out of the 133breast carcinomas. Expressions of cyclin D1 and cyclinE were inversely related to each other, and significantlyassociated with the estrogen receptor (ER) expressionand differentiation of the breast carcinoma. The expressionof cyclin E was significantly decreased in tumorsexpressing cyclin D1 (p=0.022). There was a trend forcyclin D1 expression to increase in tumors expressingp27Kip1 (p=0.053), but the expression of cyclin E didnot correlate with p27Kip1 expression. The Ki67 labelingindex was markedly increased in tumors expressing cyclinE, whereas it was significantly decreased in the cyclin D1or p27Kip1 expressing-tumors. From survival analysis,cyclin E expression was the only significant variable forthe prediction of poor survival.Conclusion: The abnormal expressions of cell cycleregulatory molecules are prevalent, and interrelated witheach other in breast cancer. Integration of TMA technologyallowed a high-throughput analysis for correlating molecularthe in situ findings, with the clinico-pathologicinformation. Among the three molecules studied, thecyclin E had a prognostic implication for stage I and IIbreast cancer. (Cancer Res Treat. 2002;34:388-393)
Inverted organic photovoltaic cells using three-dimensionally interconnected TiO2 nanotube arrays.
Kim, Sehwan,Koh, Joo Hwan,Kim, Jong Hak,Kim, Eunkyoung American Scientific Publishers 2013 Journal of Nanoscience and Nanotechnology Vol.13 No.4
<P>Here we describe a simple sol-gel method to fabricate inverted organic photovoltaics (OPV) using interconnected TiO2 nanotubes (inter-TiO2 NT) as an efficient electron transport layer. Three-dimensionally inter-TiO2 NT arrays were prepared by spin-coating a TiO2 precursor solution on the ZnO nanorod (NR) template grown via the liquid phase deposition method. Upon etching of ZnO NRs, inter-TiO2 NT arrays were generated, as confirmed by X-ray diffraction (XRD), energy-filtering transmission electron microscopy (EF-TEM) and field-emission scanning electron microscopy (FE-SEM). A blend of poly(3-hexylthiophene) (P3HT) and phenyl-C61-butyric acid methyl ester (PCBM) deeply infiltrated into the pores of inter-TiO2 NT, as revealed by FE-SEM and atomic force microscopy (AFM) images. The power conversion efficiency (PCE) of inter-TiO2 NT-based inverted OPV reached 3.0% at an air mass of 1.5 (100 mW/cm2), which is a 25% performance improvement compared to flat TiO2 films derived from the sol-gel process or commercial paste. The efficiency improvement arises from facilitated charge separation and collection due to the increased TiO2 interface arera and efficient transport pathway.</P>
An Enhanced Finite-Settling-Step Direct Torque and Flux Control (FSS-DTFC) for IPMSM Drives
Sehwan Kim,Jul-Ki Seok 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.4
This paper presents a discrete-time version of voltage and current limited operation using an enhanced direct torque and flux control method for interior permanent magnet synchronous motor (IPMSM) drives. A command voltage vector for airgap torque and stator flux regulation can be uniquely determined by the finite-settling-step direct torque and flux control (FSS-DTFC) algorithm under physical constraints. The proposed command voltage vector trajectories can be developed to achieve the maximum inverter voltage utilization for the discrete-time current limit (DTCL)-based FSS-DTFC. The algorithm can produce adequate results over a number of the potential secondary upsets found in the steady-state current limit (SSCL)-based DTFC. The fast changes in the torque and stator flux linkage improve the dynamic responses significantly over a wide constant-power operating region. The control strategy was evaluated on a 900W IPMSM in both simulations and experiments.
Remote structural health monitoring systems for next generation SCADA
Kim, Sehwan,Torbol, Marco,Chou, Pai H. Techno-Press 2013 Smart Structures and Systems, An International Jou Vol.11 No.5
Recent advances in low-cost remote monitoring systems have made it possible and practical to perform structural health monitoring (SHM) on a large scale. However, it is difficult for a single remote monitoring system to cover a wide range of SHM applications due to the amount of specialization required. For the remote monitoring system to be flexible, sustainable, and robust, this article introduces a new cost-effective, advanced remote monitoring and inspection system named DuraMote that can serve as a next generation supervisory control and data acquisition (SCADA) system for civil infrastructure systems. To evaluate the performance of DuraMote, we conduct experiments at two representative counterpart sites: a bridge and water pipelines. The objectives of this article are to improve upon the existing SCADA by integrating the remote monitoring system (i.e., DuraMote), to describe a prototype SCADA for civil engineering structures, and to validate its effectiveness with long-term field deployment results.