GR-tree: 무선 센서 네트워크에서 에너지 효율적인 분산 공간색인기법

김민수,장인성,Kim, Min-Soo,Jang, In-Sung 대한공간정보학회 2011 한국공간정보학회지 Vol.19 No.5

Recently, there has been much interest in the spatial query which energy-efficiently acquires sensor readings from sensor nodes inside specified geographical area of interests. The centralized approach which performs the spatial query at a server after acquiring all sensor readings, though simple, it incurs high wireless transmission cost in accessing all sensor nodes. In order to remove the high wireless transmission cost, various in-network spatial indexing schemes have been proposed. They have focused on reducing the transmission cost by performing distributed spatial filtering on sensor nodes. However, these in-network spatial indexing schemes have a problem which cannot optimize both the spatial filtering and the wireless routing among sensor nodes, because these schemes have been developed by simply applying the existing spatial indexing schemes into the in-network environment. Therefore, we propose a new distributed spatial indexing scheme of the GR-tree. The GR-tree which form s a MBR-based tree structure, can reduce the wireless transmission cost by optimizing both the efficient spatial filtering and the wireless routing. Finally, we compare the existing spatial indexing scheme through extensive experiments and clarify our approach's distinguished features.

Genetic Variations of the Apolipoprotein B Gene in Korean People and Its Association with Hypercholesterolemia

( Sung Han Kim ),( Un Kyung Kim ),( Jae Jin Chae ),( Jeong In Baek ),( Soo Young Choi ),( Jae Woong Bae ),( Sang Hyun Kim ),( Hyo Soo Kim ) 한국유전학회 2008 Genes & Genomics Vol.30 No.5

Genetic polymorphisms at the apolipoprotein B have been associated with elevated plasma concentrations of LDL, atherosclerosis and increased risk of coronary artery disease. 106 individuals composed of 46 hypercholesterolemic patients and 60 controls were analyzed with Ins/Del length polymorphism, four RFLPs (HincII, PvuII, AluI, EcoRI) and 3`-VNTR to clarify the characteristics of the apolipoprotein B gene and to determine their influence on the lipid profile of hypercholesterolemic patients and controls in Korea. A total of 212 apolipoprotein B alleles from six markers were identified in this study. Heterozygosityranges from zero to 0.32, and the genotyope frequencies in the case of 3`-VNTR are significantly different between two groups. Analysis of linkage disequilibrium revealed paired nonrandom associations between four pairs of polymorphic sites of the apolipoprotein B gene (p<0.05). Moreover, addition of all 4 polymorphic sites provided the highest PIC value. This study also investigated the association of these polymorphisms with the patients and with variation in lipid levels. A significant association between 3`-VNTR genotypes and Lp(a) was observed in hypercholesterolemic patients (p<0.05). The results suggest that genotypes of six polymorphic markers were not significantly associated with TC, TG or LDL-chol level between the patients and controls in the Koreans.

<i>In vitro</i> and <i>in vivo</i> evaluation of a novel polymer-free everolimus-eluting stent by nitrogen-doped titanium dioxide film deposition

Park, Dae Sung,Bae, In-Ho,Jeong, Myung Ho,Lim, Kyung Seob,Sim, Doo Sun,Hong, Young Joon,Lee, So-Youn,Jang, Eun Jae,Shim, Jae-Won,Park, Jun-Kyu,Lim, Han Chul,Kim, Han Byul Elsevier 2018 Materials Science and Engineering C Vol.91 No.-

<P><B>Abstract</B></P> <P>Inflammation and thrombosis are linked to the use of polymer-based drug-eluting stents (DES). The aim of this study was to develop a polymer-free everolimus (EVL)-eluting stent using nitrogen-doped titanium dioxide (N-TiO<SUB>2</SUB>) and verify its efficacy by <I>in vitro</I> and <I>in vivo</I> assessment in a porcine coronary model. Various analytical approaches such as scanning electron microscopy and atomic force microscopy, electron spectroscopy, Fourier transform infrared spectrometry and contact angle measurement were employed for the characterization. As a part of biocompatibility assessment, platelet adhesion and smooth muscle cell (SMC) proliferation were examined. Bare metal stent (BMS), N-TiO<SUB>2</SUB> stent, everolimus-eluting N-TiO<SUB>2</SUB> (N-TiO<SUB>2</SUB>-EVL) stent, and commercialized EVL-eluting stent (EES) were randomly placed in forty coronary arteries in twenty pigs. After four weeks of implantation, the stents were subjected to histological and quantitative analysis. The N-TiO<SUB>2</SUB> film used in this study was well coated without any cracks or peeling. Surface hydrophilicity (88.8% of angle decrement) could be associated with the decrease in surface roughness post N-TiO<SUB>2</SUB> deposition (37.0%). The platelet adhesion on the N-TiO<SUB>2</SUB> surfaces was less than that on the BMS surface. The proliferation of SMC was suppressed in the N-TiO<SUB>2</SUB>-EVL group (30.2%) but not in the BMS group. In the animal study, the percent area restenosis was significantly decreased in the N-TiO<SUB>2</SUB>-EVL group compared to that in the BMS group. The results (BMS; 47.0 ± 11.00%, N-TiO<SUB>2</SUB>-EVL; 31.7 ± 10.50%, and EES; 29.1 ± 11.21%, <I>n</I> = 10, <I>p</I> < 0.05) were almost at par with those of the commercialized EVL-eluting stent. The introduction of N-TiO<SUB>2</SUB> deposition during fabrication of polymer-free DES may be an efficient accessorial process for preventing in-stent restenosis and thrombosis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> N-TiO<SUB>2</SUB> surfaces can help to reduce the platelet adhesion. </LI> <LI> In porcine model, N-TiO<SUB>2</SUB> everolimus decreased in-stent restenosis and fibrin deposition. </LI> </UL> </P>

In-hospital mortality in patients with STEMI admitted during off hours

( Sung-Soo Kim ),( Myung Ho Jeong ),( Jeong Gwan Cho ),( Young Keun Ahn ),( Jong Hyun Kim ),( Shung Chull Chae ),( Young Jo Kim ),( Seung Ho Hur ),( In Whan Seong ),( Taek Jong Hong ),( Dong-hoon Choi 대한내과학회 2013 대한내과학회 추계학술발표논문집 Vol.2013 No.1

Conflicting results exist on the outcome of off hours PCI in ST elevation myocardial infarction (STEMI). However, there were only a few studies that have focused on the clinical characteristics and outcomes of off hours PCI in STEMI. So, we studied the clinical characteristics and hospital mortality in STEMI patients treated with primary PCI during regular hours (weekdays 9:00 AM to 6:00 PM) versus off hours Weekdays 6:01 PM to 8:59 AM, weekends, and holidays) in Korea Acute Myocardial Infarction Registry. We analyzed in hospital and one year mortality among 5,665 consecutive ST segment elevation myocardial infarction patients treated with primary PCI between November 2005 to January 2008. Total 2,848 (50.2%) patients were treated during off hours. Baseline finding were similar, although regular hours patients were older. Median symptom to balloon time (304 min, IQR 175 to 750 vs. 270 min, IQR 145 to 551, p=0.001) were longer for regular hours primary PCI. Median door to balloon time (71min, IQR: 48 to 132 vs. 59 min, IQR 39 to 110 min, p=0.001) were longer for off hours pPCI. Also, Cardiac enzyme such as Max CK-MB (212.1±299.3 vs 194.7±303.4, p=0.031) and max TnI (72.6±239.5 vs. 58.9±94.4, p=0.013) were increased in off hours pPCI. However, unadjusted in hospital (6.0% off hours vs. 6.0% regular hours, p=0.946) and one year cardiac mortality (11.3% off hours vs. 11.7% regular hours, p=0.661) were comparable. In multivariate analysis, off hours primary PCI did not predict an adverse outcome. In conclusion, when primary PCI was performed within an appropriate reperfusion strategy, the clinical effectiveness of either off hours or regular hours pPCI is comparable.

Recurrent thrombosis after endovascular treatment for malignant superior vena cava syndrome

( Sang Ho Lee ),( Sun Young Kim ),( Heung Tae Kim ),( Chang Woo Shim ),( Ho Seok Chi ),( Hye In Lee ),( Do Il Choi ),( Hyun Bum Kim ),( In Jun Lee ) 대한내과학회 2015 대한내과학회 추계학술발표논문집 Vol.2015 No.1

Endovascular treatment (EVT) including angioplasty and stenting is an effective treatment for superior vena cava (SVC) syndrome. Recurrence of SVC syndrome is mainly caused by tumor progression and occurs in around 20% after EVT, but sometimes venous thrombosis within stent accounts for recurrence of SVC syndrome. Anticoagulation after EVT is still a controversial issue. In our case, a 73 year-old man with SVC syndrome caused by mediastinal lymph node metastasis from non-small cell lung cancer underwent EVT followed by anticoagulation with low molecular weight heparin (LMWH), but symptomatic progression due to in-stent thrombosis necessitated the second procedure after two weeks. A total of 4 sessions of EVT and anticoagulation with LMWH, warfarin and rivaroxaban did not induce durable resolution of in-stent thrombosis. The 4th EVT was done with stent -graft, but computed tomography after the last procedure revealed remained thrombus in SVC and newly developed pulmonary thromboembolism during warfarinization. Our case suggests refractory in-stent thrombosis could develop despite of anticoagulation after EVT for SVC syndrome.

In-situ fabrication of TiC-Fe₃Al cermet

Kim, Yong-In,Seok An, Gye,Lee, Wonsik,Man Jang, Jin,Park, Bong-Geun,Jung, Yeon-Gil,Choi, Sung-Churl,Ko, Se-Hyun Elsevier 2017 CERAMICS INTERNATIONAL Vol.43 No.8

<P><B>Abstract</B></P> <P>Titanium carbide has high hardness, resistance to oxidation and abrasion while iron aluminide has proper ductility as well as good strength and excellent oxidation resistance up to high temperatures. Therefore, it can be expected TiC-iron aluminide cermet to have excellent mechanical properties as a cutting tool and a wear-resistance material. In this study, mechanical milling and hot press sintering processes were used to manufacture in-situ TiC-Fe<SUB>3</SUB>Al cermet, whose microstructure and mechanical properties were examined according to the changes in volume fraction of TiC and milling time. After 48h of milling each mechanically alloyed powder crystallized in a TiC and Fe<SUB>3</SUB>Al biphasic material. The milled powder was hot-pressed at 1250℃ and 50MPa for 30min to obtain sintered bodies also consisting of only TiC and Fe<SUB>3</SUB>Al phases. The hard phase, TiC, had a size of 100–300nm with overall uniform distribution decreasing as the volume fraction of TiC increased. The hardness of each sintered body showed a linearly increasing tendency according to the increase in TiC content, the hardness for 90vol% TiC cermet being as high as 1813Hv. On the other hand, the bending strength was 1800MPa and 1780MPa when TiC volume fraction was 50% and 70%, respectively, while it showed an abrupt decrease up to 580MPa at 90% TiC volume fraction. Fe<SUB>3</SUB>Al phase is effective to toughening of TiC-Fe<SUB>3</SUB>Al cermet and the volume fraction of Fe<SUB>3</SUB>Al phase significantly influences the bending strength of the cermet.</P>

X-ray 실시간 관찰에 의한 알루미늄 합금의 응고 결함 관찰

조인성 ( In Sung Cho ),김정인 ( Jung In Kim ),임채호 ( Chae Ho Lim ) 한국주조공학회 2010 한국주조공학회지 Vol.30 No.5

In the present study, in-situ real-time observation with an X-ray radioscopic facility was carried out on pure aluminum and aluminum alloy solidification. The three kinds of aluminum alloys, such as pure aluminum, Al-8.5%Si alloy, commercial A356(AC4C) alloys, were used in the present study. The formations of the shrinkage defects in the castings were visualized and different formation phenomena for different aluminum alloys were investigated.

Skin Safety of the UV Absorbers by Measurement Cytotoxicity High Functional Product with Water-In-Silicone System

( Kim In-young ),( Kim Min-ho ),( Nam Sang-in ),( Chun Kil Whan ) 대한화장품학회 1997 대한화장품학회지 Vol.23 No.3

Consumers have recently preferred to purchase extensive UV intercepting products, which are waterproof and free from side effects on skin. Testing Cytotoxicity (in-vitro) in SK method, cell survival ratio of UV-B interceptors decreased above 0.08W/V%, and so did that of UV-A interceptors above 0.06W/V%. Also, Patch-test of inorganic UV interceptors resulted in no skin irritation ever below 10.0 and 11.25. UV interceptors in the sunlight showed yellowish discoloration in 5 to 14 days. In absorption curves, UV-B was most suitable for Octyl methoxycinnamate (OMC) and UV-A for Butyl methoxy dibenzoylmethane (BMDM). For this reason, Nylonpoly UVA/UVB the material of OMC and BMDM coated with Nylon & polyethylene, was used as the organic UV interceptor. And zinc oxide (ZnO) and titanium dioxide (TiO,) was used as inorganic UV interceptors. The appropriate mixture ratio of ZnO and TiO, was 6 to 4. 6% of ZnO, 4% of TiO, and 5% of Nylonpoly UVA/UVB were all combined with our sunscreen cream. The SPF value of in-vivo applied to a guinea pig was 34.9 and that of in-vivo was 38.5. Cyclomerhicone and dimethicone were used in water-in-Silicone system. Ceryl dimethi-cone and sorbitan sesquiolente were used as emulsifiers and MgSO, · 7 H₂O, Mg-stearate/Mg-Al-stearate copolymer as emulsification stabilizers. In practical application, each SPF duration of O/’W type and W/S type containing sunscreen cream of the same content showed that W/S type of sunscreen cream was 5 times as durable as the other. This product is fit for using in swimming, climbing or skiing. This research is to minimize skin trouble caused by UV interceptors and to make one with proper softness, skin safety and UV intercepting efficiency.

Effects of Phenytoin and Diazepam on the Seizure Activity in the Cortical Dysplasia Animal Models

Kim, Si-Hyung,Choi, In-Sun,Cho, Jin-Hwa,Park, Eun-Ju,Jang, Il-Sung,Choi, Byung-Ju,Kim, Hyun-Jung,Kim, Young-Jin,Nam, Soon-Hyeun The Korean Academy of Oral Biology 2006 International Journal of Oral Biology Vol.31 No.2

Dysplasia-associated seizure disorders are markedly resistant to pharmacological intervention. Relatively little research has been conducted studying the effects of antiepileptic drugs(AEDs) on seizure activity in a rat model of dysplasia. We have used rats exposed to methylazoxymethanol acetate(MAM) in utero, an animal model featuring nodular heterotopia, to investigate the effects of AEDs in the dysplastic brain. Pilocarpine was used to induce acute seizure in MAM-exposed and age-matched vehicle-injucted control animals. Field potential recordings were used to monitor amplitude and numbers population spikes, and paired pulse inhibition in response to stimulation of commissural pathway. Two commonly used AEDs were tested: diazepam 5, 2.5mg/kg;phenytoin 40, 60mg/kg. Diazepam(DZP) and phenytoin(PHT) reduced the amplitude of population spike in control and MAM-exposed rats. However, the amplitude of population spike was nearly eliminated in control rats as compared to the MAM-exposed rats. Pharmaco-resistance was tested by measuring seizure latencies in awake rats after pilocarpine administration(320mg/kg, i.p.) with and without pretreatment with AEDs. Pre-treatment with PHT 60 mg prolonged seizure latency in control rats, but not in MAM-exposed animals. The main findings of this study are that acute seizures initiated in MAM-exposed rats are relatively resistant to standard AEDs assessed in vivo. These data suggest that animal model with cortical dysplasia can be used to screen the effects of potential AEDs.

Tuberculosis risk is associated with genetic polymorphisms in the LRP2, CUBN, and VDR genes

Sung‑Soo Kim,Sang In Lee,Hyun‑Seok Jin,Sangjung Park 한국유전학회 2020 Genes & Genomics Vol.42 No.10

Background Vitamin D (Vit. D) is used extensively during tuberculosis treatment. Low levels of serum Vit. D increase the risk of active tuberculosis development. Altered expression of the proteins involved in Vit. D metabolism impairs cathelicidin production, thereby increasing the host susceptibility to tuberculosis. Objective We are trying to investigate whether single nucleotide polymorphisms (SNPs) in LRP2, CUBN, and VDR genes could afect tuberculosis development. Methods We included participants of the Korean Association Resource (KARE), part of the Korean Genome and Epidemiology Study (KoGES), and used their recorded data. A total of 8840 people (4182 men and 4658 women) were eligible subjects. The 5-kb regions from the ends of transcripts of GC, LRP2, CUBN, and VDR genes were amplifed to select 13, 47, 70, and 15 SNPs, respectively. For association analysis and statistical analysis, PLINK version 1.07 and PASW Statistics version 18.0 were used. Results Signifcant correlation was observed in 11, 2, and 1 SNPs in LRP2, CUBN, and VDR genes. The efect of rs6747692 of LRP2 on transcription factor binding was confrmed using RegulomeDB. We confrmed that rs2239182 of VDR is located in the genomic eQTL region and can afect transcription factor binding and gene expression. Conclusions Genetic polymorphisms in genes encoding proteins involved in Vit. D metabolism infuence immune system components. Therefore, such polymorphisms may infuence the susceptibility to Mycobacterium tuberculosis invasion and alter the defense mechanisms against Mycobacterium tuberculosis infection. The correlation between genetic variation and tuberculosis development can provide new guidelines for the management of tuberculosis.