2003년 국내 중증급성호흡기증후군 진료 현황 및 문제점 분석

이진수,김은실,정문현,백제중,정선화,안주희,최영화,이선희,고철우,김성범,김민자,박승철,기현균,송재훈,최상호,김양수,이상오,조용균,박영훈,정숙인,김연숙,이흥범,손창희,장성희,정희진,김우주 대한감염학회 2004 감염과 화학요법 Vol.36 No.3

목적 : 2002년 말 중국에서 SARS가 발생한 이후 국내에서도 2003년 10월까지 총 3명의 추정환자, 17명의 의심환자가 보고되었다. 향후 추가적인 SARS의 유행이 우려되는 상황에서, 그간의 SARS 환자 진료에 있어서의 실질적인 준비사항, 진료 현황 등에 대한 조사를 통해 문제점을 파악하여, 향후 더 나은 대비가 될 수 있도록 개선점을 제시하고자 하였다. 재료 및 방법 : SARS로 의심되는 환자를 진료 경험이 있는 병원의료진을 대상으로 2003년 10월에 설문조사를 실시하였다. 설문에는 SARS 환자 진료 시의 실질적인 조치, 진료 현황, 병실, 응급실 및 외래에서의 격리 시설과 준비사항, 보건당국의 관리와 지원에 관한 사항을 포함하였다. 결과 : 대상이 되는 22개 병원 중 17개(17/22, 77.2%) 병원이 설문에 응하였다. SARS 환자를 위한 격리실은 응급실, 외래, 일반병실 및 중환자실에서 각각 9개(9/17, 52.9%), 5개(5/17, 29.4%), 15개(15/16, 93.7%), 4개(4/16, 25%) 병원에서 음압처리가 되어있지 않은 일인실 혹은 다인실이 사용되었고, 1개(1/16, 6.3%) 병원에서만 일반병실에서 음압격리실이 운영되었다. 입원환자의 진찰 시 개인보호구의 착용은 거의 모든 의료기관에서 이루어졌다. 보건당국에서 SARS지정병원의 시설 등을 사전에 확인한 곳은 1곳(1/12, 8.3%)이였고, 14개 병원(14/15, 93.3%)에서는 보건당국에 의뢰한 검사결과를 통하 받지 못하였다. 결론 : 의료기관에서 SARS 환자용 격리실뿐만 아니라 기존의 격리실 설비 등이 미흡하였으며, 특히 중환자실 및 외래의 준비가 더욱 부족하였다. 보건당국의 의료기관에 대한 종합적인 지원이 부족하였고, 병원과의 원활한 연계가 잘 이루어지지 않았다. SARS 만이 아닌 격리를 필요로 하는 질환의 적절한 진료를 위해 향후 병원 시설의 정비와 정부차원에서의 보다 구체적이고 실질적인 대책마련이 필요하다. Background : There was an worldwide outbreak of the Severe Acute Respiratory Syndrome (SARS) originated from China in late 2002. During that period three cases of suspected SARS and 17 cases of probable SARS were reported in Korea. With the concerns about the reemergence of SARS-coV transmission, it is important to be prepared for any possibility. So, this study is aimed to analysis the past measures in managing SARS and propose the amendatory plans to improve the preparedness. Materials & Methods : Questionnaires were collected among clinicians with any experience in managing the probable or suspected SARS cases in Oct. 2003. 17 out of 22 hospitals responded to the questionnaire. The contents in the questionnaire were practical activities, personal equipments, response plans, isolation facilities in emergency centers, outpatient clinics, general wards and intensive care units, and relationship with the public health department. Results : The dedicated isolation rooms in emergency centers, outpatient clinics, general wards, and intensive care units were prepared in 9 (9/17, 52.9%), 5 (5/17, 29.4%), 15 (15/16, 93.7%), and 4 (4/16, 25.0%) hospitals, respectively. Except for one hospital that newly made negative pressure room for SARS, single or multi-bed rooms without airborne infection control were used in all the other hospitals. The personal precaution principles were kept quite well in general wards. Before the designation of SARS hospital by the public health department prior evalution to see if the hospital was suitable for managing SARS was conducted in only 1 (1/12, 8.3%) hospital. The results of laboratory diagnosis were reported back in 1 (1/15, 6.6%) hospital. Conclusions : The isolation facilities which can control airborne infection were almost deficient not only for SARS but also for other respiratory transmissible diseases. For the infection control of transmissible diseases including SARS, more investment is needed on medical facilities and comprehensive support from the public health department required.

간호실무에서 신봉이론(Espoused theories)에 대한 탐색적 연구

서문자,김혜숙,이은희,박영숙,조경숙,강현숙,임난영,김주현,이소우,조복희,이명하,지성애,하양숙,손영희,권성복,김희진,추진아 성인간호학회 2001 성인간호학회지 Vol.13 No.1

As a nursing practice involves nurses' actions in a specific context of health care, this study has focused on exploring the espoused theories in nursing practice within the action science perspectives, Espoused theories are the belief, principles, and rationale expressed by the practitioner as guiding her/his actions in a situation of practice. The data were analysed qualitatively and 25 elements of espoused theories of nursing action were identified and clustered into 6 categories. The 25 elements of espoused theories are as follows: The clinical nurse worked in wholistic and individual nursing, focussed on the patient's needed, comfort and supportive nursing (5 theories of nursing goal) ; excellent skills, knowledge based, assessment and data collection, explaining, educating or a scientific basis(6 theories of nursing intervention): advocacy, value oriented, treatment, account- ability and commitment(4 theories of nursing ethics) ; human respect. partnership, trust(3 theories of patient-nurse relationship) : knowledgable, accumulated clinical experiences and personally lived experiences. positive perspectives(4 theories of nurse), role of intervention. rewarding peer relationship(3 theories of situations) The above mentioned espoused theories are similar to that of nursing textbooks which students learned through basic nursing education and almost the same as the Acts ofa Nurse in Korean. However, we are doubtful whether nurses actually do as they think. Therefore. it is recommended to review the theories-in-use in order to and any discrepancies between the espoused theories and the reality of nursing actions

어린이집 교사의 생애사 연구: 김교사 이야기

김희연 ( Hee Yeon Kim ),김은숙 ( Eun Sook Kim ) 한국교육인류학회 2013 교육인류학연구 Vol.16 No.1

본 연구는 다양한 유형의 어린이집(민간, 국공립, 직장)에서 10년 동안 보육교사로살았던 한 교사의 이야기이다. 보육교사 초임에서 경력교사로 발전하는 과정을 거쳐 육아휴직으로 교사로서의 생을 마감한 30대 여성의 10년간의 삶을 시간을 축으로 한 변화와 연속성을 중심으로 서술하였다. 일기, 수첩, 계획안, 메모, 편지, 통화상담 기록표, 교사와의 인터뷰 전사본, 연구자간 대화 전사본과 회상을 바탕으로 자서전 텍스트를 구성하였고, 의미 있는 주제를 도출하고 핵심사건을 추출하고 주제 간의 유기적인 관계가 드러날 수 있도록 텍스트 재구성을 반복하였다. 그 결과 근무했던 각 기관에서의 생활 경험은 ``원장님이 시키는 대로 해내는 여성``, ``학습공장의 직공``, ``잘 가르쳐 보려는 교수자``, ``부모-위탁체-회사라는 갑의 계약직을``, ``부담스러운 기혼 고경력 교사``로 표현되었고, 각 기관에서의 삶은 기관의 속성에 따라 운영 기제와 관련된 주요 경험내용 주제와 개인적 직무 인식과 관련된 주요 경험내용 주제로 조직되어 서술되었다. 유아교육 재개념화의 관점에서 보육교사의 직업 생애가 함의하는 시사점에 대해 논의하였다. This study is about the life history of a nursery school teacher, Ms. Kim, who has worked at private, national/public, and workplace day care centers for 10 years. It was described in time-frames focusing on the change and continuity of experiences as a nursery teacher. Life history text was primarily constructed based on her diaries, her notebooks and memos, her schedulers, the letters she received, the transcription of teacher interviews, the transcription of dialogues with the co-authors, and memory. And then the texts were repetitively reconstructed in order to draw meaningful themes, extract key life-events, and represent interwoven relationship among the themes. As a result, Ms. Kim`s life history was depicted, in accordance with each of the five day care centers she worked in, as ``a woman who complies with director`s orders, ``a factory-hand in learning factories``, ``an instructor who tries to teach well``, ``a temporary contract employee of parent/commissioned-company/company employer``, and ``a burdensome being who is married and on high pay-step``. Under each theme, Ms. Kim`s career life experiences were categorized in two phases; the characteristics of the operating mechanism and the ways that her caring/teaching functions. Lastly, it was discussed about the implications of the life history of a nursery teacher as a typical job symbolizing a female was discussed, enduring strong physical and emotional labor holding low positions in a small-group organization, and grew as an early education teacher with praxis-based identity, but had to be short-lived due to the early education system in Korea.

Journal of Korean Academy of Psychiatric and Mental Health Nursing Accepted for Inclusion in SCOPUS

( Kim¸ Hee Sook ),( Kim¸ Young Joo ) 한국정신간호학회 2021 정신간호학회지 Vol.30 No.3

Bupivacaine과 ropivacaine이 Xenopus oocyte에 발현된 HERG 전류에 미치는 영향

김국성,이규승,김효신,손숙진,이상도,김광진,전병화,김윤희,박진봉 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

Bupivacaine is an amide-type local anesthetic widely used for regional anesthesia. Ropivacaine is developed as a less cardiotoxic alternatives to bupivacaine. In the present study, we have analyzed the effects of bupivacaine and ropivacaine on HERG currents expressed in Xenopus oocytes. Bupivacaine and ropivacaine(3∼1,000μM) blocked HERG currents in a concentration dependent manner. EC_(50) was 26.1±3.1μM(n_(R) 0.65±0.04) and 43.5±7.9μM(n_(H) 0.99±0.13) in bupivacaine and ropivacaine, respectively. Bupivacaine and ropivacaine did not affect the activation and deactivation kinetics of HERG channels. However, the drugs decreased the slope conductance measured from fully activated current-voltage relationship curves. These results suggest that bupivacaine and ropivacaine have a similarinhibitory effect on HERG channels, which could be a possible cellular mechanism of LQT or ventricular arrythmia by the drugs.

Lysophosphatidic acid increases mesangial cell proliferation in models of diabetic nephropathy via Rac1/MAPK/KLF5 signaling

Kim, Donghee,Li, Hui Ying,Lee, Jong Han,Oh, Yoon Sin,Jun, Hee-Sook Nature Publishing Group UK 2019 Experimental and molecular medicine Vol.51 No.2

<▼1><P>Mesangial cell proliferation has been identified as a major factor contributing to glomerulosclerosis, which is a typical symptom of diabetic nephropathy (DN). Lysophosphatidic acid (LPA) levels are increased in the glomerulus of the kidney in diabetic mice. LPA is a critical regulator that induces mesangial cell proliferation; however, its effect and molecular mechanisms remain unknown. The proportion of α-SMA<SUP>+</SUP>/PCNA<SUP>+</SUP> cells was increased in the kidney cortex of <I>db/db</I> mice compared with control mice. Treatment with LPA concomitantly increased the proliferation of mouse mesangial cells (SV40 MES13) and the expression of cyclin D1 and CDK4. On the other hand, the expression of p27<SUP>Kip1</SUP> was decreased. The expression of Krüppel-like factor 5 (KLF5) was upregulated in the kidney cortex of <I>db/db</I> mice and LPA-treated SV40 MES13 cells. RNAi-mediated silencing of KLF5 reversed these effects and inhibited the proliferation of LPA-treated cells. Mitogen-activated protein kinases (MAPKs) were activated, and the expression of early growth response 1 (Egr1) was subsequently increased in LPA-treated SV40 MES13 cells and the kidney cortex of <I>db/db</I> mice. Moreover, LPA significantly increased the activity of the Ras-related C3 botulinum toxin substrate (Rac1) GTPase in SV40 MES13 cells, and the dominant-negative form of Rac1 partially inhibited the phosphorylation of p38 and upregulation of Egr1 and KLF5 induced by LPA. LPA-induced hyperproliferation was attenuated by the inhibition of Rac1 activity. Based on these results, the Rac1/MAPK/KLF5 signaling pathway was one of the mechanisms by which LPA induced mesangial cell proliferation in DN models.</P></▼1><▼2><P><B>Kidney disease: Mechanisms of diabetes-related damage</B></P><P>A potent molecular mediator of diabetic kidney disease induces its pathogenic effects via proteins that could be targeted with future drug therapies. Yoon Sin Oh
from Eulji University in Seongnam-si and Hee-Sook Jun from Gachon University in Incheon, both in South Korea, and colleagues treated certain cells found in the kidney’s glomerulus, the organ’s filtering unit, with a signaling molecule called lysophosphatidic acid (LPA) that is elevated in the blood of diabetic mice. They showed that LPA stimulated cellular proliferation and boosted the expression of proteins involved in regulating the cell cycle and a multipurpose signaling pathway. They then inhibited the activity of these proteins to prevent the kidney cells’ hyperproliferation, both in cell culture and in diabetic mice. The results highlight the potential of blocking mediators of LPA signaling to treat kidney-related complications of diabetes.</P></▼2>

대두단백질 가수분해물의 특성

김동수,양승택,문윤희,류병호,김희숙,염동민,김진목 慶星大學校 1998 論文集 Vol.19 No.1

The present study was conducted to elucidate some characteristics of soy protein hydrolysates. The soy protein was obtained from defatted soy power by the treatment of n-hexan. The hydrolysates of soy protein were prepared from hydrolysis by bromelian and pepsin with the two kinds of samples of precooking for 30 min in steam oven and noncooking, and fractionated through Bio-gel P-4 column chromatography. Fractions of hydrolysates separated on the Bio-gel column chromatography were carried out to SDS-PAG electrophoresis, resulting to show some different bends from 66kD to 14.2kD of molecular weight. In addition, the fractions showed different activities of superoxide dismutase. From these results, it was found that the hydrolysates could be available to use in a lot of food industrial fields as new functional food materials because the hydrolysates had different characteristics in electrophoresis and could increase the activity of superoxide dismutase.

On the Interpretive Complex Phenomena in terms of Apparent Imperfections

Kim, Sung Hun,Choe, Hee Sook 한국현대언어학회 2001 언어연구 Vol.17 No.1

Kim, Sung-Hun & Choe, Sook Hee. 2001. 의미해석 복합체에 관한 고찰: 외견상 비완벽성을 중심으로. 언어연구 17-1, 297-311. 본 논문에서는 Chomsky(1998, 1999)의 외견상 비완벽성 개념에 의하여 설명될 수 있는 문법 현상인 의미해석 복합체에 관하여 조사한다. 한국어의 격 첨사들이 초점과 같은 정보 구조에 미치는 효과들을 최소주의 이론에서 어떻게 설명하고 있는지를 논의한다. 특히, 어떤 문맥에서는 격 첨사의 초점 정보 효과들이 외견상 비 완벽성에 의하여 포착되는 의미해석 복합체 현상(Chomsky 1999)이라고 제안한다. 또한 한국어에서 어떤 장거리 뒤섞기 현상들은 외견상 비완벽성에 기인하는 정보 구조 효과를 일으키는 것으로 간주한다. 다시 말해서, 장거리 뒤섞기는 비완벽성이지만 장거리 뒤섞기의 초점 효과들은 외견상 비완벽성을 이끈다고 주장한다. (단국대학교/한국과학기술원)

대학 e-러닝의 학습자 특성 및 교수자 특성 요인에 대한 한국과 중국의 인식도 차이

김희정(Hee jung Kim),장몽로(Zhang Meng Lu),조숙진(Sook jin Cho),이석준(Seog iun Lee) 건국대학교 경제경영연구소 2013 商經硏究 Vol.38 No.2

전통적인 면대면 교수-학습 환경에 대한 대안으로 인터넷을 통해 학습자의 학습 환경을 촉진하고 지원하며, 학습자가 자기 주도적(Self-Directed)으로 학습하도록 도와주는 e-러닝이 빠르게 확산되고 있다. e-러닝이 활성화 되면서 관련 분야의 연구도 활발하게 진행되고 있다. 한국과 마찬가지로 중국에서도 e-러닝 분야가 급속하게 성장하고 있으며 특히 대학 고등교육을 e-러닝으로 실시하려고 노력하고 있다. 그러나 중국 대학이 e-러닝을 효과적으로 실행하는 비율은 한국보다 낮고 e-러닝에 대한 연구도 충분히 이루어지지 않고 있다. 이에 본 연구는 한국과 중국 간의 대학 e-러닝의 학습 성과에 영향을 미치는 학습자 특성 및 교수자 특성 요인에 대한 인식도 차이를 알아보고자 한다. 이를 통해 e-러닝을 활용하고자 하는 중국 대학이나 기업에 국가별 특성에 적합한 e-러닝을 도입, 활용, 확산 등에 관련된 유용한 시사점을 제공하고자 하였다. 본 연구는 김희정･이석준･김종인(2011)의 연구에서 제시한 e-러닝의 학습자 특성 및 교수자 특성 요인을 도출하여 한국과 중국의 인식도 차이를 분석하고자 하였다. e-러닝 학습 경험이 있는 중국 대학생을 대상으로 설문지를 이용하여 자료를 수집하였으며 총 94부를 분석하였다. 간단한 기초통계를 비롯하여 신뢰도 분석과 한국과 중국 간 차이를 분석하기 위해 독립표본 T-검정 실시하였다. 분석 결과 한국과 중국 간 e-러닝의 학습자 특성과 교수자 특성의 인식에는 모두 차이가 있는 것으로 나타났는데 총 22개의 세부 요인 중 12개의 요인에서 한국과 중국 간 인식 차이가 있는 것으로 나타났다. E-learning is spreading rapidly as an alternative for traditional face-to-face ‘teaching-learning’ environment and as a tool for helping learners to study in a self-directed way by promoting and supporting their learning environment through the Internet. As e-learning is vitalized, its relevant researches are also proceeding briskly. China, like Korea, is enjoying swift growth of the e-learning sectors and especially trying to universities educations with e-learning. However, the rate of Chinese Universities’ effective use of e-learning is lower than that of Korea, and their e-learning related researches are not being achieved enough. Hence, this study will examine the perception differences in characteristic factors of learners and teachers, which influence the universities e-learning’s learning achievements in Korea and China. This will be able to help provide Chinese universities or companies with useful implications regarding the introduction, application, and diffusion of e-learnings suitable for the country’s characteristics. This study tries to analyze the perception differences between Korea and China, by deducting the characteristic factors of e-learning learners and teachers suggested in the study by Kim Hee-jung, Lee Seog-jun, and Kim Jong-in (2011). The data was collected by questionnaires targeting Chinese universities students who were having experience in e-learning use, and a total 94 of them were analyzed. Including the reliability analysis with simple basic statistics, the study conducted independent samples t-test in order to make analysis for differences between Korea and China. The analyses results indicate that the perception differences of learners and teachers exist there in all sectors between Korea and China. Out of a total of 22 detail factors, it was revealed that 12 of them show the perception differences between Korea and China.

임신 중 발견된 대망 종괴 1례

조인숙,김태의,김정식,이해혁,이권해,김희경,남계현 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

A case of omental mass during Pregnancy Omental cyst is a rare lesion and occur primarily during childhood and young adulthood. When encountered, most of them are benign and intraabdominal masses. It shows a large mass but not palpable and often asymptomatic. The precise diagnosis is made by most commonly at surgery or during pathologic examination. So, we report this case with brief review of literatures.