알데히드탈수소효소 2(ALDH2) 및 CYP2E1 유전자 다형성에 따른 요중 뮤콘산 농도와 요중 8-hydroxydeoxyguanosine과의 관련성

김용대,강종원,엄상용,장연위,김성훈,김은영,이철호,문재동,김헌 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.2

질소산화물의 급성 노출로 인한 폐 손상 1례

김정호,김대환,손병철,이창희,김정원,문덕환,이채언,김주인 대한산업의학회 2000 대한직업환경의학회지 Vol.12 No.2

Objectives : Lung injuries due to exposure to nitrogen oxides can occur in various process in industry. We experienced a case of chemical pneumonitis induced by accidental inhalation of nitrogen oxides emitted from the bath in an acid dipping operation. Case : Dyspnea, cough and blood-tinged sputum production, cyanosis, and tachypnea occurred after exposure to oxides of nitrogen. There were bilateral diffuse ground glass opacities in simple chest radiography and high resolutional computed tomography, hypoxemia in arterial blood gas analysis, mixed ventilation defect and reduced diffusion capacity in spirometry. As an oxygen and supportive therapy, after hospitalization, was given, the patient recovered completely from the lung injury on the 8th day after admission. There was no evidence of delayed onset of bronchiolitis obliterance or pulmonary edema in a follow-up for about 6 months. Conclusions : Acid dip operation require more efficient hooding and exhausting system for the prevention of lung injuries caused by inhalation of nitrogen oxides. Also health education for worker need.

브로콜리 추출물의 향장활성 효과

김대용ㆍ조석철ㆍ권혁선ㆍ김미경(Dae Young KimㆍSeok chul ChoㆍHyuk sun KwonㆍMee Kyung Kim) 한국인체미용예술학회 2016 한국인체미용예술학회지 Vol.17 No.1

In this study, we investigated the anti-oxidative effects, antimicrobial, and anti-inflammatory activities of the extracts from broccoli to evaluate its use as a functional ingredient in cosmetics. The extracts are WE (water extract at RT), MWE (mineral water extract at RT), EE (70% ethanol extract at RT), and USEE (heat process for 12 hours at 60℃ after ultrasonification for six hours with 70% ethanol). The measurements of the total polyphenol content from broccoli extracts were highest in EE at 425.24±13.9 mg/g dry. The result of electron donating ability of EE was the highest at 10,000 ㎍/㎖ as 97.81% and increased in a concentration-dependent manner. The ferric reducing antioxidant powder (FRAP) of EE was the highest at 10,000 ㎍/㎖ as 1235.6 μM. In an antimicrobial activity test, the EE showed significant antimicrobial activity against S. epidermidis, S. aureus, E. coli, P. acnes, and P. ovale. Furthermore, broccoli extract exhibited no cytotoxicity in RAW 264.7 cells. Also anti- inflammatory activity by NO assay showed LPS-induced NO was significantly inhibited following treatment with EE of 1,000 ㎍/㎖. Therefore, the broccoli ethanol extract can be used as a resource of natural cosmetic material for functional cosmetics.

정신분열병 및 정신분열형 장애에 대한 올란자핀의 효과와 안전성

안용민,강대엽,권준수,김창윤,김철응,반건호,신영민,이기철,이동우,이중서,조현상,채정호,김용식 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 본 다기관 공동임상연구는 국내 환자를 대상으로 새로운 항정신병약물인 올라자핀의 치료 효과와 안전성을 확인하고자 시행되었다. 방 법 : 1999년 7월부터 2000년 3월까지 국내 10개 병원에 방문한 정신분열병 및 정신분열형 장애 105명을 대상으로 비대조 개방 임상연구를 시행하였다. 중등도 이상의 정신병 증상을 지니거나, 부작용으로 약물교체가 필요한 경우 또는 기분장애 증상의 치료가 필요한 환자를 대상으로 하였다. 2∼7일간의 약물 배설기간 후에 1일 10mg의 올란자핀을 투여하였고, 이후로 3∼7일 간격으로 용량을 조절하여 총 8주간 투여하였다. 치료 효과는 PANSS(Positive and Negative Syndrome Scale), BPRS(Brief Psychiatric Rating Scale), CGI(Clinical Global Impression-Severity), MADRS(Montgomery-Asberg Depression Rating Scale), HAM-A(Hamilton Rating Scale for Anxiety)로 판정하였다. 안전성 평가는 자발적인 이상반응 보고, 활력징후와 혈액 검사 및 SAS(Simpson-Angus Scale), BARS(Barnes Akathisia Rating Scale), AIMS(Abnormal Involuntary Movement Scale)척도를 이용하였다. 결 과 : 105명중에서 85.7%인 90명이 8주간의 치료를 완료하였다. 평균 최빈 용량은 일일 16.1(±4.7)mg이었고, 종료시점에서의 BPRS전체 점수가 기저 상태에 비해 40%이상 감소된 반응군은 69.5%이었다. PANSS의 양성 증후군과 일반정신병리 뿐만 아니라 음성 증후군 소척도에서도 유의한 감소를 보였으며, 이 감소들은 치료 초기부터 나타나서 8주간 지속되었다. 43.8%의 피험자가 중등도 이상의 우울증상을 같이 지니고 있었으며, 올란자핀에 의해 MADRS와 HAM-A가 유의하게 감소하였다. 치료 기간 동안에 활력징후에는 뚜렷한 변화가 없었으나 체중은 8주간 지속적으로 증가하였다. SAS와 AIMS는 감소하였으며, 정좌불능증을 제외한 나머지 추체외로 증상의 발생비율도 낮았다. 임상적인 증상이나 징후를 동반하지 않는 ALT/SGPT의 상승을 보였지만 프로락틴을 포함하는 대부분의 혈액 검사상 뚜렷한 이상 변화는 없었다. 결 론 ; 비록 본 임상연구가 비대조 개방 임상연구로서 많은 제한점을 가지고 있지만, 올란자핀이 기존 약물에 내약성을 보이거나 기분증상을 동반하는 정신병에 치료 효과가 있었다. 그리고 기존 항정신병약물 치료시에 문제가 되었던 추체외로 증상과 고프르로락틴 혈증을 포함하는 대부분의 부작용면에서 안전성을 보여 주었다. Objective : This multicenter clinical trial was carried out to investigate the efficacy and the safety of olanzpine for the treatment of Korean patients. Mothod : 105 patients with schizophrenia and schizophreniform disorder, visited at 10 mental or university hospitals, had received an open and non-comparative treatment with olanzapine for 8 weeks. Patients had psychotic or depressive symptoms with the severity above moderate degree or intolerable side effects to previous antipsychotics. After a wash-out period of 2-7 days, 10mg olanzapine was prescribed initially to all the patients, and then the dosage could be adjusted within the range of 5-20mg/day of olanzapine by 3-7 days. Results : 90(85.7%) of 105 patients completed the 8-weeks trial and the mean modal dose of olanzapine was 16.1(±4.7%)mg/day. At the end of the trial, 73 patients(69.5%) were classified as responder, which was defined as 40% or more improvement in BPRS(Brief Psychiatric Rating Scale) score comparing to baseline. There was a significant reduction in the scores of PANSS(Positive and Negative Syndrome Scale)and subscales including negative symptom scores and CGI. Also weekly analysis showed that the reductions in scores were kept on for the whole period of the trial. 43.8% of all the patients had depressive symptoms at the baseline and total scores of MADRS(Montgomery-Asberg Depression Rating Scale) and HAM-A(Hamilton Rating Scale for Anxiety) were also reduced after the trials. Vital signs revealed no clinically significant changes but continuous weight gain was observed during the treatment with olanzapine. The scores of SAS(Simpson-Angus Scale) and AIMS(Abnormal Involuntary Movement Scale) for assessing the EPS(extrapyramidal symptoms)and tardive dyskinesia respectively were significantly decreased and only a few patients reported EPS as adverse events. Although mild and clinically non-significant of ALT/SGPT was observed, most laboratory parameters including plasma prolactin level showed to significant changes during the trial. Conclusions : Although this trial had many limitations because it was a non-comparative and open study, olanzapine showed high efficacy on the positive, negative and depressive symptoms in schizophrenia and schizophreniform disorder.In addition to that, olanzapine showed a substantially favorable safety profile, such as low incidence of EPS and hyperprolactinemia.

기업물류경쟁력확보를 위한 물류용기 풀시스템 도입성과 분석

김대기,김상철,김정혁 한국로지스틱스학회 2002 로지스틱스연구 Vol.10 No.1

본 연구의 목적은 물류용기 풀시스템 도입효과에 대한 이론적이고도 계량적인 근거를 제시함으로써 기존의 물류용기 사용 관행에서 오는 낭비요인을 찾아 제거하고, 이를 통해 물류표준화 및 공동화의 필요성을 강조하고자 함에 있다. 물류용기표준화 및 공동화의 도입효과를 분석하기 위하여, 국내의 한 완성 차 업계의 실 데이터를 이용한 Box Pool System 시뮬레이션 모델을 구축하였다. 평균 상차시간, box 보유량, 평균 box 체류시간 등의 성과척도를 중심으로 BPS도입효과를 분석한 결과, 평균 상차시간은 62%, 시스템 내 box 체류시간은 38% 감소하였으며, 기존의 약 1/3수준의 box보유만으로도 시스템을 효율적으로 운영할 수 있다는 긍정적인 결론을 도출하였다. 즉, 물류용기 표준화 및 공동화 작업은 물류비용절감과 물류서비스 개선을 통한 기업물류경쟁력 확보의 가장 기초적이고도 필수적인 조건이다. The purpose of the study is to provide theoretical and qualitative grounds to the introduction of container pool system. By finding our and eliminating wastes from our everyday routine practices, we emphasize the importance of joint utilization and standardization of containers. In order to qualitatively measure the effects of joint utilization and standardization of containers, we constructed BPS : 62% reduction in average loading time, 38% reduction in system queue time, and 68% reduction in box inventories in the system. That is, standardization and joint utilization of containers is the most fundamental and requisite condition to secure business logistics competitiveness, which is realized by logistics cost reduction as well as logistics service improvement.

위선암에서 p53과 P-glycoprotein의 분포에 관한 연구

김대중,김의한,강상균,양승하,민병철 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.1

Gastric adenocarcinoma express many oncogenes, such as p53, c-erbB, k-sam, etc. The p53 especially acts as tumor suppressor in normal tissue and various mutational changes. of p53 are known as doing important role in carcinogenesis of gastric adenocarcinoma. P-glycoprotein, as a pleotrophic membrane transport protein, shows specific distribution in many normal tissues and malignant tumors. This protein, produced by MDR gene, shows multidrug resistance to anticancer drug by pumping out intracellular drug. resulting in resistance to chemotherapeutics. The expression of p53 and P-glycoprotein according to clincopathologic findings in gastric adenocarcinoma has been studied, even though their results are controversial. To observe the relationship between both antigens and clinicopathologic findings of gastric adenocarcinoma. we were analysesed 40 cases gastric adenocarcinoma then processed for immunohistochemical stain by SLAB method using p53 and JSB-1 monoclonal antibodies. The results were as followings: 1) The p53 and P-glycoprotein showed positive in 20 cases(50%) and 21 cases(52.5%) of 40 cases respectively, and 10 cases(25%) showed positive reaction to both antigens. 2) p53 revealed higher positive rate in intestinal type(54.6%), differentiated form(57.1%), advanced form(58.1%) compared to diffuse type(28.6%), poorly differentiated form(42.1%), early cancer(22.2%), but no difference according to age, sex, lymphatic metastasis and signet ring cell within tumor. 3) P-glycoprotein revealed higher positive rate in interstinal type(54.6%), differentiated form(61.9%), advanced form(58.1%), absence of signet ring cell (63.3%) compared to diffuse type (28.6%), poorly differentiated form (36.8%), early cancer(33.3%), presence of signet ring cell(20.0%), but no difference according to sex, age, lymphatic metastasis. 4) Positive rate in intestinal type, differentiated form, advanced form, and presence of signet ring cells in gastric adenocarcinoma showing both positive reaction of p53 and P-glycoprotein, are higher, but no difference according to age, sex, lymphatic metastasis. 5) In noneoplastic mucosa adjacent to cancer, p53 revealed negative reaction in all cases. P-glycoprotein showed positive reaction in all metaplastic glands 33 cases and parietal cells 17 cases, and in 16 cases(40%) of 40 cases of luminal surface and gastric glandular epthelium, and showed negative reaction in all 12 cases of chief cell. Above results revealed that positive rates of p53 and P-glycoprotein in gastric adenocarcinoma are almost same and there is no relationships between both antigens. Both antigens showed simillar high positive rate in intestinal type, differentiated form and advanced form, indicating association with these clinicopathologic findings.

前立腺炎 外治法에 대한 文獻的 考察

金大福,趙忠植,金哲中 대전대학교 한의학연구소 2002 한의학연구소 논문집 Vol.11 No.1

According to the literature on the, the results were as follows. 1. The mechanism of External therapy for prostatitis is some medicicne to come into prostate have anti-inframation and the other medicine to come into nerve system control pain. 2. For the method are uesed hip bath, enema and stiching the pacth to the umbilicus etc. 3. For the medicine are used safflower(紅花), patrinia(敗醬草), chrysanthemum flower(菊花) and Cortex Phellodenri(黃柏). nature and flavor of the medicine is almost cold, bitter in taste and hot in taste. 4. For the classification of medicine are used drug to induce diuresis to elominate stranguria(利尿通淋藥) and drug to induce diuresis to dispersing swelling (利尿通淋藥). sometines they are used to Heat-clearing and detoxifying drug(淸熱解毒藥) and blood-quickining aget(활혈거어약).

배전계통의 신뢰도에 관한 연구

金慶哲,全大根,姜倫摸 홍익대학교 산업기술연구소 2002 産業技術 Vol.12 No.-

Reliability is the probability of a device or system performing its function adequately for the period of time intended, under the operating conditions. Electric power networks are prime examples of systems where a very high degree of reliability is also absolutely essential for some industrial customers. A system consists of a set of components, interconnected in some purposeful way. The reliability of a system depends on the reliability of its components and on the configuration of the system. The basic indices used to examine and predict the performance of a distribution system at a customer load point are the average outage frequency, average outage duration and average unavailability. The case study system is a kind of radial configuration distribution system. This paper shows that a better meshed distribution configuration was selected by comparing the indices obtained from EDSA's reliability worth assessment of distribution systems program.

3-5㎜ 강판절단용 아크플라즈마 절단기 팁 개발

김대철,김곤호,박강석 漢陽大學校 工學技術硏究所 1999 工學技術論文集 Vol.8 No.1

3-5mm 강판 절단용 플라즈마 토치의 핵심 부품인 토치 팁의 개발을 위하여 기존의 전원부 및 토치 팁의 특성을 관찰하였다. 강판의 두께, 강판과 팁 사이의 간격 그리고, 유입 가스의 압력 변화에 따른 절단 속도를 측정하였다. 전산 모사를 통하여 가스 흐름에 대한 최적의 조건을 얻어 swirl number=2.5에서 최대 온도 분포를 갖음이 관찰되었다. 이 결과를 이용하여 Electrode를 가공하였으며 높은 온도를 가진 Plasma Jet의 분포를 얻을 수가 있었다. 또한 Nozzle의 모양을 V자 형태로 변화하여 Slag 형성이 최소한으로 발생하는 최적의 토치 팁을 개발하였다. In order to develop new torch tip, major component of the plasma torch for cutting steel plate with 3-5mm thickness, the characterization of power supply and torch tip was carried on the jutting speed with steel thickness, the distance between steel and tip, and inlet pressures. The optimum design condition of gas flow to provide the high temperature distribution in the torch, the swirling number 2.5, was obtained from the computer code (DC plasma torch) simulation. It was also observed that a new torch tip manufactured with the of optimum conditions, swirling number=2.5, and V-shaped nozzle formed less slag after the cutting process.

분자역학적 방법을 이용한 부산시내 대형건물 냉각탑수의 레지오넬라균의 형별 분류

김정만,정석훈,서대영,박은희,송은주,최재철,이은엽,장철훈 대한임상미샐물학회 2004 Annals of clinical microbiology Vol.7 No.1