뇌동맥류 수술시 체성감각유발전위의 모니터링

염기훈,김국기,이기택,박종태,임영진,김태성,이봉암,임언 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.4

BMB Reports : Connexin32 inhibits gastric carcinogenesis through cell cycle arrest and altered expression of p21^Cip1 and p27^Kip1

( Hyang Jee ),( Su Hyung Lee ),( Jun Won Park ),( Bo Ram Lee ),( Ki Taek Nam ),( Dae Yong Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2013 BMB Reports Vol.46 No.1

Gap junctions and their structural proteins, connexins (Cxs), have been implicated in carcinogenesis. To explore the involvement of Cx32 in gastric carcinogenesis, immunochemical analysis of Cx32 and proliferation marker Ki67 using tissue-microarrayed human gastric cancer and normal tissues was performed. In addition, after Cx32 overexpression in the human gastric cancer cell line AGS, cell proliferation, cell cycle analyses, and p21^Cip1 and p27^Kip1 expression levels were examined by bromodeoxyuridine assay, flow cytometry, real-time RT-PCR, and western blotting. Immunohistochemical study noted a strong inverse correlation between Cx32 and Ki67 expression pattern as well as their location. In vitro, overexpression of Cx32 in AGS cells inhibited cell proliferation significantly. G1 arrest, up-regulation of cell cycle-regulatory proteins p21^Cip1 and p27^Kip1 was also found at both mRNA and protein levels. Taken together, Cx32 plays some roles in gastric cancer development by inhibiting gastric cancer cell proliferation through cell cycle arrest and cell cycle regulatory proteins. [BMB Reports 2013; 46(1): 25-30]

HBsAg 양성자에 있어서의 HBe 항원 및 간기능검사에 대한 고찰

배기택,김병성,최원충 인제대학교 1990 仁濟醫學 Vol.11 No.2

건강관리과 신체 검사에서 발견된 473명의 HBsAg 양성자를 대상으로 HBeAg 및 transaminase치를 추적 조사하여 HBeAg 양성률이 45.1%, transaminase 상승률이 28.5%이고 HBsAg 보균자가 지속될 확률은 98% 이상임을 밝혀냈다. Among those who received regular health examination at health center, 473 HBsAg carriers were followed for 5 years with serial measurements of transaminase levels, hepatitis B surface antigen (HBsAg), hepatitis Be Ag(HBeAg). Male to female ratio was 4.7:1 and the average age was 32 in male, 26 in female. Persistent HBsAg positive rate was 98.7% and HBsAg was seroconverted to negative in 6.4%. The HBeAg positivity rate among HBsAg carriers was 45.1%, and seroconversion late of HBeAg was 4.3%. Transaminase levels were elevated in 28.5% of the HBsAg carriers. The proportion of abnormal transaminase levels in HBeAg positive carriers (42.9%) were significantly higher than that of HBeAg negative carriers (20.2%)(P<0.005) and the Odds ratio was 2.96. The 24 clients out of 135 carriers (17.8%) who had elevatd transaminase levels were normalized and the average duration was 7.1±7.0 months.

한랭환경하에서 면양의 Glucose 및 Insulin 분비의 Adrenalin 작동성 분비조절에 관한 연구

남기택 안성산업대학교 2006 論文集 Vol.38 No.-

In the present work, using sheep, we studied in detail the effects of α- and β-adrenergic receptor activation on the secretory response of both glucose and insulin by various doses of adrenergic blockers to obtain further information about the adrenergic modulation of insulin secretion in ruminant animals in cold environment. The plasma concentrations of glucose and insulin were determined at 15min intervals during before (2hour) and after 8(hour) intravenous infusion of adrenergic antagonist. The effects of intravenous infusion of adrenergic antagonist, Phenoxybenzamine(α-antagonist, 50nmol/kg/min), Propranolol(β-antagonist, 1 00nmol/kg/min), and Phenoxybenzamine + Propranolol, on the secretion insulin, were studied in six cross-bred castrated adult male sheep. The effects of β-receptor antagonist infusion (propranolol) was not clear, but the plasma insulin concentration was increased significantly by α-receptor antagonist infusion (phenoxybenzamine) in cold exposure. In the α- and β-receptor antagonist coinfusion, plasma insulin concentration was decreased significantly compared with saline infusion, but there was no difference in comparison with β-receptor antagonist infusion. Therefore it has been thought plasma insulin concentration was controlled by β-receptor in cold environment. Plasma glucose concentration was increased drastically by β-receptor antagonist infusion, however, there was no effect of α-receptor antagonist infusion. In both the α- and β-receptor antagonist coinfusion, plasma glucose concentration was increased. This result blood glucose was controlled through both α- and β-receptor under cold exposure. Furthermore, the action mechanism of α-receptor is prior to that of β-receptor.

수용성 Polymer-metal Complex의 형성과 중합 개시제로서의 활용성에 관한 연구(Ⅱ)

맹기석,송해영,황명천,황택성 충남대학교 공업교육연구소 1985 論文集 Vol.8 No.1

The optimum conditions for the formation of PAAm-Cu(Ⅱ) and PMA-Cu(Ⅱ) complexes have been determined through thermal analyzing and scanning electron microscope measurements. In addition, it was found that they can be used as an initiator for methylmethacrylate(MMA) and styrene vinyl type monomers and as a catalyst of alkylation. Water-soluble PMA-Cu(Ⅱ) complex had the first endothermic reaction around 380℃ and endothermic reaction around 400℃, respectively and then the secondary exothermic reaction only was observed around 450℃. As pH is increased the formation of water soluble PMA-Cu(II) complex has become more compact. It was also observed that the function as catalyst of alkylation and an initiator of the water-soluble PMA-Cu(Ⅱ) complex is very active at around pH7 and the complex can polymerize MMA and styrene monomer up to 9% and 8% conversion. These results can explain the fact that formed complex can be used as good initiator and catalyst.

5세 된 유전성 구상 적혈구증 환아에서 폐쇄성 황달을 동반한 다발성 담석증 1례

민택기,이인규,박경배,박준수 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Hereditary spherocytosis is a common cause of hemolysis and hemolytic anemia. Some children remain asymptomatic into adulthood but others may have severe anemia with pallor, jaundice and fatigue. After infancy, the spleen is usually enlarged, and pigmentary gallstones may form as early as age 4~5 year. But it increases abruptly after age 10 year. At least 50% of unsplenectomized patients ultimately form gallstones, although for the most part they remain asymptomatic. We report herewith a case of multiple gallstone with obstructive jaundice in 5 years old patient with hereditary spherocytosis.

제2형 당뇨병 남성 환자에서 유리 테스토스테론과 성호르몬 결합 글로블린 농도

남기덕,김영설,박철영,오승준,김덕윤,우정택,김성운,양인명,김진우,최영길 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.24 No.6

연구배경:인슐린저항성은 제2형 당뇨병과 심혈관질환의 주요한 위험 인자로 성호르몬과 상호 관계가 있다고 알려져 있다. 그러나 여성과는 달리 남성에서는 연령과 인슐린저항성에 따른 유리 테스토스테론과 성호르몬 결합 글로블린 농도의 변화에 대한 연구가 부족한 실정이다. 그러므로, 본 저자등은 제2형 당뇨병 남성 환자에서 정산인과 비교해서 유리 테스토스테론과 성호르몬 결합 글로블린 농도를 측정하고 연령에 따른 변화 정도를 알아보고자 하였다. 방법:대상 환자 모두에서 연령과 체질량지수, 총 콜레스테롤, 중성지방, 공복혈당과 인슐린 농도를 측정하였다. 혈중 유리 테스토스테론 농도는 방사면역측정법(radioimmunoassay)을 이용해서 측정하였고, 혈중 성호르몬 결합글로불린은 면역방사계측측정법(immunoradiometric assay)을 이용해서 측정하였다(Diagnostic System Laoratories, Wbster, TX, USA). 결과:1)제2형 당뇨병 남성 환자에서 정상 대조군 남성에 비해 성호르몬 결합글로불린은 104.1±35.0 vs 25.7±3.5 mole×10??로 의미 있게 높았으나(p<0.001), 유리 테스토스테론은 13.7±9.5 vs 13.6±6.5 ng/dL로 차이가 없었다. 2)연령과 성호르몬 결합 글로블린 사이의 상관 계수는 제2형 당뇨병 남성 환자에서 0.40로 중등고의 양의 상관 관계를 보였고(p<0.001), 정상 대조군 남성에서 0.11로 유의한 상관 관계를 보이지 않았다. 연령과 유리 테스토스테론 사이의 상관 계수는 제2형 당뇨병 남성 환자에서 0.08, 정상 대조군 남성에서-0.17로 모두에서 유의한 상관 관계를 보이지 않았다. 3)연령과 체질량지수를 보정한 후에 제2형 당뇨병 남성 환자와 정상 대조군 남성에서 혈중 인슐린 농도, 유리 테스토스테론과 성호르몬 결합 글로블린 사이에는 상관 관계가 없었다. 결론:제2형 당뇨병 남성 환자에서 정상 남성에 비해 성호르몬 결합 글로블린 농도가 증가되어 있었으며, 유리 테스토스테론은 차이가 없었다. 연령이 증가함에 따라 성호르몬 결합 글로블린이 제2형 당뇨병 남성 환자에서 정상 남성에 비해 증가 폭이 의미있게 컸으며, 유리 테스토스테론은 변화가 없었다. Background: Insulin resistance is a risk factor for cardiovascular disease and type 2 diabetes mellitus. There are many previous studies indicating that insulin lowers serum sex hormone-binding globulin levels, and there is inverse correlation between insulin resistance and serum sex hormone-binding globulin levels in women. However, in men, a limited number of studies are available to explain the effect of sex hormone on age and insulin. Therefore, the present study was undertaken to investigate the relationship among free testosterone, hormone-binding globulin and age in type 2 diabetic men and control subjects. Method: Age, body mass index, total cholesterol, triglyceride, fasting blood sugar, and insulin concentrations were examined on 89 type 2 diabetic men and 47 control subjects. The free testosterone level was measured by commercially available double-antibody system (Radioimmunoassay). The sex hormone-binding globulin level was also measured by commercially available double-antibody system(Immunoradiometric assay). Results: 1) Sex hormone-binding globulin level was significantly increased in patients with type 2 diabetes. However, there was no significantly difference in free testosterone level between the two groups. 2) Sex hormone-binding globulin was positively correlated with age (r=0.4, p <0.001) in patients with type 2 diabetes. Sex hormone-binding globulin and free testosterone were not correlated with age in control sujects. 3) Free testosterone and sex hormone-binding globulin concentrations were not significantly related to serum insulin concentration after adjusting for age and body mass index. Conclusions: We observed increased sex hormone-binding globulin concentration in diabetes man, and was a positively related to age. Further studies are needed to understand the relationships between age, insulin resistance, testosterone, and sex hormone-binding globulin concentrations(J Kor Diabetes Asso 24:699~707,2000).

흰 쥐 모델에서 지연재식 시 dexamethasone과 OP-1의 표면처리가 치주조직 재생 및 항흡수 작용에 미치는 효과

권오택,금기연,이승종 대한치과보존학회 2001 Restorative Dentistry & Endodontics Vol.26 No.4

본 연구를 종합하면 통계학적인 유의차는 없었으나 OP-1에 비해서는 DEX로 처치한 군에서 더 많은 골유합이 나타났으며 고농도의 OP-1으로 처치한 군에서는 골유합 없이 치주재생이 일어나는 부위가 많이 관찰되었다. 그러나 차후에는 DEX나 OP-1이 치주조직 내의 어느 세포에 어떠한 기전으로 작용하는지 분자생물학적인 방법을 통하여 규명하고 이를 토대로 치주인대의 손상 후 야기되는 골성 유합을 줄이는 효과적인 치료약제나 방법을 개발하는 연구가 계속적으로 이루어져야 할 것으로 사료되며 6주 이상의 재식기간 후 각 약제의 조직학적 반응을 평가하기 위한 실험도 추가되어야 할 것으로 사료된다. 태생 40일 된 Spray-Dolwey계 흰 쥐의 상악 제1대구치를 발거하고 30분간 자연건조시킨 뒤 MB치근을 Caviton으로 근관충전하고 MB 치근표면에 DEX와 OP-1을 농도를 달리하여 도포한 후 재식하고 3주후 골 및 백악질의 재형성과 치주재생 및 치근 흡수 방지효과를 관찰한 결과 고농도의 OP-1이 조직학적인 관찰에서 치근흡수, 골성 유합 및 염증 정도에서 가장 우수한 결과를 보여주었고 치주 재생능력 면에서도 가장 뛰어난 것으로 나타났으나 추후에는 6주 이상의 장기관찰 후 각 약제의 조직학적 반응도를 평가하기 위한 실험이 추가되어야 할 것으로 사료된다.

사과酒에서 分離한 産膜酵母에 關한 硏究 : Ⅱ. 産膜酵母 FY-5의 生育條件 Ⅱ. Grouwth Conditions of Film-Forming Yeast FY-5

鄭基澤,宋亨翼 COLLEGE OF AGRICULTURE KYUNGPOOK NATIONAL UNIVERSI 1984 慶北大農學誌 Vol.2 No.-

As a basic study for growth inhibition of film-forming yeasts in apple wine during storage periods, the growth conditions of Hansenula beijerinckii FY-5 which was isolated and identified in previous paper were investigated. The optimum conditions for film-formation were pH 3.0 and temperature of 30-35℃, and sugar concentration in medium had no effect on film-formation. The thermal death of strain FY-5 was observed at 70℃ for 10 minutes. This strain was able to grow in synthetic medium contained 12% or less ethanol, but in apple wine contained 8% or less ethanol. The strain belonged to true-film yeast, which did not required biotin for film-formation in synthetic medium, and had low tolerance for SO_(2) (70ppm). Also, the effect of amino acids and other vitamins on film-formation were investigated.

악안면 유형에 따른 측모 연조직 양상에 대한 연구

태기출,김상철,국윤아,권영택 대한치과교정학회 1997 대한치과교정학회지 Vol.27 No.5

본 연구의 목적은 악안면유형에 따라 측모 연조직 양상에 차이가 있는지를 알아보고자 17세 이상의 연령을 가진 다양한 수직적 양상을 보이는 Ⅱ급 및 Ⅲ급 남, 녀 79명을 선택하여 각 계측치를 계측하고 통계처리하여 다음과 같은 결과를 얻었다. 1. Nasolabial angle, interlabial angle, lower lip angle, mentolabial angle, symphyseal angle이 골격성 Ⅱ급군과 Ⅲ급군간에 유의한 차이를 보였고, nasofrontal angle, upper lip angle, mentolabial angle, symphyseal angle이 high angle군과 low angle군간에 유의한 차이를 보였다. 2. 악골의 시상적관계를 나타내는 ANB값이 연조직의 nasolabial angle, symphyseal angle, interlabial angle과 정상관 관계를 보였고, lower lip angle과는 역상관 관계를 보였다. 3. 악골의 수직적관계를 나타내는 SN-GoMe값은 연조직의 mentolabial angle, symphyseal angle, nasofrontal angle, upper lip angle과 정상관 관계를 보였다. 4. 골격성 Ⅲ급군에 비해 Ⅱ급군에서 SN-GoMe값에 따른 측모연조직 양상의 차이가 현저하였다. The purpose of this study was to investigate the variations of the soft tissue profile contour in relation to the skeletal patterns and to confirm the correlation of soft tissue angles to the sagittal or vertical skeletal elements. Lateral cephalograms of 79 cases which were older than 17 years in age, were traced and statistically analyzed The obtained results were as follows: 1. Nasolabial, interlabial, lower lip, mentolabial, and symphyseal angles showed the significant differences between skeletal ClassⅡ and skeletal. Class Ⅲ group, but nasofrontal, upper lip, mentolabial, and symphyseal angles showed the significant differences between high angle and low angle group. 2. ANB value showed the significant positive correlation to nasolabial, symphyseal, and interlabial angles and the significant negative relation to lower lip angle. 3. SN-GoMe value showed the significant positive correlation to mentolabial, symphyseal, nasofrontal, and upper lip angles. 4. Soft tissue profile contour in SK. ClassⅡ group showed greater accordance to SN-GoMe value than those in SK. class Ⅲ group.