간내 담석과 동반된 간내 담도암에서의 p53과 Ki-ras의 발현

김명환,이성구,서동완,이승규,남승우,박능화,민영일,김연석,심기남,공경엽 대한소화기학회 1997 대한소화기학회지 Vol.30 No.5

Background/Aims: Hepatolithiasis or primary intrahepatic stones may be accompanied later by intrahepatic cholangiocarcinoma. This cancerous lesion is frequently associated with atypical hyperplastic epithelium that was suspected of being precancerous. To investigate the Ki-ras or p53 mutation may play a role in carcinogenesis, and to determine whether atypical hyperplastic epithelium may be precancerous, this study was performed in intrahepatic cholangiocarcinomas associated with hepatolithiasis. Methods: We examined 12 patients with intrahepatic cholangiocarcinomas associated with hepatolithiasis. Ki-ras point mutations were assessed by direct DNA sequencing. Expressions of p53 protein were immunohistochemically assessed. The overexpression of p53 and point mutation of Ki-ras were examined in normal, hyperplastic, atypical hyperplastic, and can- cerous tissues separately. Results: The expressions of p53 protein were detected in 4 (33%) of 12 cholangiocarcinomas and Ki-ras point mutations at codon 12 were found in 2 (17%) of 12 cholangiocarcinomas. In those two carcinoma cases which contained the mutant sequence of Ki-ras, the same point mutation from wild type GGT (glycine) to GAT (aspartic acid) was. found in the associated atypical hyperplastic epithelium. However, none of the normal and hyperplastic epithelium harbored Ki-ras or p53 mutations. Conclusions: The overexpression of p53 may play a part in the carcinogenesis of some intrahepatic cholangiocarcinomas associated with hepatolithiasis, whereas the role of Ki-ras mutations in those cases is dubious. However, Ki-ras point mutation at codon 12 may be responsible for either cancer or atypical hyperplastic epithelium associated with hepatolithiasis in certain cases, suggesting atypical hyperplastic epithelium may give rise to carcinoma.

직장 카르시노이드 종양에서 Ki-67 발현의 예후적 중요성

홍수민 ( Su Min Hong ),김유선 ( You Sun Kim ),문정섭 ( Jung Seop Moon ),김진남 ( Jin Nam Kim ),오명기 ( Myoung Ki Oh ),권선옥 ( Sun Ok Kwon ),정성연 ( Seong Yeon Jeong ),홍성우 ( Seong Woo Hong ),강윤경 ( Yun Kyung Kang ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2

Background/Aims: Rectal carcinoid tumors can be resected with endoscopy, and it is important to assess their prognostic factors. We evaluated the potential of Ki-67 expression as a prognostic factor in rectal carcinoid tumors. Methods: We retrospectively reviewed the medical records of 37 patients with rectal carcinoid tumors who got endoscopic resection from January 2001 to January 2011 at Inje University Seoul Paik Hospital. We analyzed their endoscopic and histologic findings, Ki-67 expression, clinical outcome, and prognosis. Results: The mean age (±SD) of the patients was 56.3±10.7 years, and the male : female ratio was 3.6:1. The mean tumor size was 0.5±0.4 cm, 33 patients showed grade 1 tumors (89.2%) and the average Ki-67 expression was 0.7±1.2%. Thirty five patients underwent endoscopic mucosal resection, and two required endoscopic submucosal dissection. Eight patients had positive margins after resection, but no cases of lymphovascular invasion were identified. The median follow-up duration was 21.4±25.4 months, and no recurrences were observed. Conclusions: In low grade rectal carcinoid tumors which are lack of central depression on colonoscopy, the expression of a molecular marker of malignant potential, Ki-67, was low. Therefore, endoscopic resection seemed to be a safe and effective treatment for these tumors.

Globalization of Korean Electrical Installations Standards and Codes Based on Comparison of IEC 60364 with NFPA 70(NEC)

Ki,Chung-Young,Ro,Kwak-Hee,Seop,Shin-Hyo,Joo,Nam-Taik 한국화재소방학회 2002 한국화재소방학회 학술대회 논문집 Vol.2002 No.추계

Most Technological laws of Korea are almost identical to those of Japan. Electricity was not introduced to Korea until lighting ceremony in Kyong-Bok palace observed in 1887. Since Korea was annexed to Japan in 1910, Korea have applied Japanese law and regulations made by Chosun government-general. And public works were under Japan control. Korea accepted adopted the power plants of America, codes of NESC, ASME / ANSI, MEMA while Japan accepted or adopted only IEC. Our generation distribution system takes American style while our consumer side takes Japanese style. As global trade system was transferred GATT into WTO, the technological standards, certification, construction and testing are in harmony internationally. The WTO / TBT agreement came in effect after 12th, April, 1979. The sections in the agreement require the members to exchange their own standards and codes for the harmonized ones by degree. The Korean distribution system has a strong resemblance to American system so that the internal engineers are confused in application of the relevant standards. IEC60364 and NEC are technologically similar but practically unconvertible because both have their different originality, that is to say Europe and USA. This paper deals with the fundamental elements of electrical safety system on review of IEC 60364 and NEC. This paper considers how engineers should apply IEC60364 and NFPA 70(NEC) based on all-the-way review of them.

Globalization of Korean Electrical Installations Standards and Codes Based on Comparison of IEC 60364 with NFPA

Ki,Chung-Young,Ro,Kwak-Hee,Seop,Shin-Hyo,Joo,Nam-Taik 한국화재소방학회 2001 한국화재소방학회 학술대회 논문집 Vol.2001 No.추계

Most of the laws and standards relevant to technology in Korea bear a resemblance to those in Japan. Electricity was not introduced to Korea until Lighting ceremony in Kyong-Bok palace observed in 1887. Since Korea was annexed to Japan in 1910 and our public works were under Japan control we have applied Japanese laws and regulations made by Chosun government-general. Independently from Japan the power electricity accepted power plants of USA, codes of NESC, ASME / ANSI, NEMA. Our generation and distribution system takes American style while our consumer side takes Japanese style. As global trade system was transferred GATT into WTO, the harmonization of technological standards, certification construction testing in the trend of world. This paper is based on WTO / TBT agreement coming in effect after 12th, April, 1979. For Korea the distribution system has a strong resemblance to American system so that unconvertible because IEC 60364 originated from Europe while NEC originated from USA. This papers deals with the fundamental elements of electrical safety system with comparing IEC 60364 with NEC. This paper considers how engineers should apply NFPA 70(NEC) and IEC based on the comparison of NEC to IEC in relation to electrical installations.

A cephalometric study on the velopharyngeal changes after maxillary protraction

Lee, Nam-Ki,Cha, Bong-Kuen 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.2

이 연구의 목적은 훼이스마스크로 상악 전방견인치료를 받은 성장기 골격성 Ⅲ급 부정교합자 25명(남 10, 여 15, 평균나이 9.9세)에서 단기간의 정적인 구개범인두 변화를 측모두부방사선 계측사진상에서 선 계측, 각도 계측 및 비율 계측을 시행하여 평가하는 것이다. 경구개 평면각의 변화량은 maxillary depth 또는 N perp to A의 변화량과 음의 상관관계를 보였다(p <0.01). 경 연구개 각의 증가는 유의성이 있었으며, 이는 경구개 평면각의 변화보다 연구개 평면각의 변화의 영향을 더 받았다(p <0.001). 연조직 과 경조직 비인두 깊이의 증가는 유의성이 있었으며 (p <0.001), 이들의 변화량과 연구개 평면각의 변화량간에는 양의 상관관계를 보였다(p <0.05). 경구개 길이의 증가는 유의성이 있었으며 (p <0.001), 이는 연조직 비인두 깊이의 증량과 음의 상관관계를 보였다(p <0.05). Need 비율 S (C)의 증가는 유의성이 있었으나 (p <0.001), 이러한 증가는 이전 연구에서 보고된 Need 비율 S (C)의 정상범위 내에 있었다. 이 연구로 상악골의 전방견인 후에 정적인 구개범인두 부위에 변화가 있을지라도 구개범인두의 적격성이 유지됨을 알 수 있었다. The purpose of this study was to investigate cephalometrically the short term static velopharyngeal changes in 25 patients (10 boys and 15 girls, aged from 5 years 9 months to 12 years 10 months in the beginning of treatment) with skeletal Class Ⅲ malocclusions who underwent nonsurgical maxillary protraction therapy with a facemask The linear, angular and ratio measurements were made on lateral cephalograms. Only the change in hard palatal plane angle was negatively correlated with the change in maxillary depth or N-perp to A (p < 0.01). The change in velar angle showed a statistically significant increase (p < 0.001). This change was influenced more by the soft palatal plane angle than by the hard palatal plane angle (p < 0.001). The changes in soft tissue nasopharyngeal depth and hard tissue nasopharyngeal depth showed statistically significant increases (p < 0.001). Correlations between the changes in soft tissue (or hard tissue) nasopharyngeal depth and the change in soft palatal plane angle were significant (p < 0.05). The increase in hard palate length was statistically significant (p < 0.001). The change in hard palate length was negatively correlated with the change in soft tissue nasopharyngeal depth (p < 0.05). The change in need ratio S (C) showed a statistically significant increase (p < 0.001). But this difference was within the normal range reported by previous studies. These findings indicate that the velopharyngeal competence was maintained even if the anatomical condition of the static velopharyngeal area were changed after maxillary protraction.

『燕轅日錄』에 나타난 기녀의 생활과 애환

김남기(Kim Nam-ki) 돈암어문학회 2007 돈암어문학 Vol.- No.20

『燕轅日錄』은 1888년과 1889년에 冬至使行을 배종한 저자미상의 연행록으로 白話文으로 썼는데, 기녀들의 歌舞樂과 연희 등의 공연 상황, 그리고 그녀들의 일상생활의 모습과 애환을 집중적으로 기록하였다. 본고에서는 『연원일록』을 통하여 19세기 후반 서도 출신 기녀의 삶의 양태, 즉 그들의 다양한 기예의 공연 상황, 의식주와 관련된 기본적인 생활 부분, 삶의 애환과 그에 대한 인식 등을 고찰하였다. 평안도와 황해도의 기녀는 十二歌詞, 十二雜歌, 西道雜歌, 民謠, 時調 및 歌曲唱, 歌辭, 辭賦 등을 가창하였고, 〈瑤池獻蟠桃舞〉, 〈彩鳳悅親舞〉, 〈得勝奏凱舞〉, 〈項莊舞〉, 〈馳馬術[馬上劍舞]〉 등 여러 춤과 연희를 공연하였다. 19세기 후반 서도에서 공연되던 歌舞樂과 연희의 연행 양상은 물론이고 기녀들의 이력, 공연의 형태와 상황, 기예의 습득과정, 저자의 감상평, 나아가 관람자들의 반응 등을 적어 예술사 연구에 적지 않은 도움을 주리라 기대한다. 또한 저자는 기녀들의 복식과 치장, 먹는 음식, 주거의 상황 등 일상생활에 대해서도 적었다. 각종 공연에 비하여 의식주 부분은 비교적 소략하게 기술되었지만 당시 기생들의 삶의 모습을 유추할 수 있다. 특히 유하원의 아내인 退妓 난혜의 경우 馳馬術을 할 때의 차림새, 그녀가 사는 집안의 건물과 조경, 실내의 집기 등을 상세하게 적어 주목된다. 아울러 기녀들과의 대화를 통하여 그녀들이 겪는 삶의 애환, 즉 생계의 곤란함과 미래의 암담함, 만남과 헤어짐에서 오는 숙명적인 아픔 등을 절실하게 표현하여 기녀들의 생활상을 살피는데 도움이 된다. Yonwonilrok recorded the public performances and daily lives of the official dancing girls, and sorrow-joy of the official dancing girls intensively. This dissertation investigated the public performance, the food, clothing and shelter and life of the official dancing girl in Pyongan and Whanghae-do in 19century latter half. The official dancing girl various was performed the song, the dance and the play. The writer in addition wrote career of official dancing girls, Form and situation of public performance, process of accomplishments, appreciation criticism of writer, reaction of spectators etc. It gives a help to art-history research consequently. Also the writer wrote the dress and embellishment and the food, the house situation of the official dancing girls. It is paid attention specially the dress and embellishment, building and landscape architecture, Things in household of Nanhae. The writer earnestly was wrote life difficulty and Future gloominess, pain of meeting and separating. Consequently becomes the place help which observes the life of the official dancing girl.

석면에 장기간 노출된 퇴직한 수리조선업 근로자의 폐영상 : 단순흉부촬영 및 고해상전산화단층촬영 소견과 그 유병률 Lung and Pleural Diseases Prevalence on Chest Radiograph and HRCT

김기남,김정일,,이기남,정갑열,김준연 大韓産業醫學會 2006 대한직업환경의학회지 Vol.18 No.2

목적: 장기간 석면에 노출되었던 퇴직한 조선소 근로자에서 단순흉부촬영과 고해상 CT소견 및 그 유병률을 알아보고자 하였다. 대상 및 방법: 수리조선소에서 배관공 또는 영선반에서 근무한 후 퇴직한 근로자 18명을 대상으로 하여 후전면 및 측면 단순흉부촬영과 고해상 CT를 시행하였다. 이들은 모두 조선소에서 사용하는 단열재 사용 작업 중에 석면에 노출되었다. 결과: 단순흉부촬영에서 총 18례 중 12례(66.7%)에서 흉막병변이 관찰되었다. 흉막플라크의 위치는 횡경막 단독으로 비후된 경우가 5례로 가장 많았으며, 외측흉벽 흉막플라크의 두계는 a가 3례, b가 1례에서 보였고, 길이는 1이 4례, 2가 1례에서 보였다. 흉막플라크를 가진 12례 중 2례는 미만성 흉막비후를 동시에 보였다. 흉막플라크의 석회화는 횡경막에서만 4례 관찰되었다. 석면과 관련된 폐실질병변이 의심되는 소견은 관찰되지 않았다. 고해상 CT에서는 16례(88.9%)에서 흉막비후가 관찰되었으며, 위치는 척추 주위 13례, 횡경막 11례 등이었다. 동반된 석회화는 7례에서 보였다. 두께는 1 mm부터 1cm까지 이었고, 길이는 2cm부터 47cm이상까지 매우 다양하였다. 3명(16.7%)에서 흉막비후 근처의 하폐 기저부에 흉막하 곡선이 나타나는 석면폐증의 초기 소견이 보였다. 결론: 장기간 석면에 노출된 근로자의 석면 관련 흉막병변의 유병률이 매우 높아 장기적인 추적검사가 필요하다고 사료된다. Purpose: To determine imaging findings among retired workers who were long-term exposed to asbestos. Lung and pleural diseases prevalence were studied on chest radiograph and HRCT. Materials and Methods: Eighteen workers who were long-term exposedto asbestos occupationally in shipyards were examined by chest radiographs (PA and lateral view) and HRCT (high-resolution computed tomography). Results: In 12of 18 subjects (66.7%), asbestos-related pleural abnormalities were evident in diaphragmatic, lateral chest wall and costophrenic angle of the pleura on chest radiographs. The thickness of pleural plaques at the lateral chest wall varied. Diffuse pleural thickening was evident in 2 workers. Parenchymal abnormalities were not found on chest radiographs. On HRCT, pleural thickening wasobserved in 16 of 18 subjects (88.9%), in the areas of juxtavertebral, diaphragmatic, anterior, lateral, mediastinal and fissural pleura. Curvilinear subpleural lines representing early parenchymal asbestosis were found in the lower posterior lung in three of 18 subjects (16.7%). Conclusions: In long term asbestos-exposed workers, the asbestos-related pleural disease was 66.7% on chest radiographs and 88.9% on HRCT. The authors suggest that this group should be followed up periodically

명리학에서 십성(十星)의 성립과 개념 확장에 관한 연구

이남연 ( Nam-yeon Lee ),김기승 ( Ki-seung Kim ) 산업진흥원 2022 산업진흥연구 Vol.7 No.1

이 논문의 목적은 명리학(命理學)에서 사용되는 육친(六親) 혹은 육신이라 불리는 십성(十星)의 근원과 주요고전에서의 십성의 의미를 확인하고, 현대 명리학에서 사용되는 십성의 개념을 분석하는 한편, 단순한 육친관계에 그치지 않고 보다 발전적인 형태의 십성의 개념을 심도 있게 연구하는 것이었다. 실제로 명리학에서 육친의 관념을 정하고 육친이라는 용어를 처음 사용한 것은『연해자평』이다. 『연해자평』, 『삼명통회』, 『자평진전』등 주요 고전 명리학에서 설명하는 십성의 내용은 대부분 순수 육친이라는 설정에 그쳤다. 이후 1963년에 발간된 『사주정설』에서는 육친의 설정에 그친 그간의 한계를 벗어나 십성의 작용을 설명하기 시작하였는데, 특히 김기승의 『과학명리』는 십성의 개념을 단순히 육친관계와 작용을 설명하는데 그치지 않고 인간의 심리와 선천적성을 확인할 수 있는 새로운 장을 열었다는 것에 주목할 만하다. 이 연구에서는 주요 고전에서의 십성의 개념과 현대 명리학에서 김기승의 『과학명리』에서 설명하는 십성의 개념과 성향을 알아보고 그 개념이 어떻게 변화되었는지를 알아보고자 하였다. 이 연구가 십성에 대한 인식 및 활용면에서 향후 명리학(命理學)의 연구에 발전적인 도움이 될 것으로 사료된다. The purpose of this paper was to confirm the source of Shipsong called Yookchen or Yooksheen used in Myeongleehak and the meaning of Shipsong in major classics. It is to investigate the concept of Shipsong used in modern Myeongri, and to study in-depth the concept of Shipsong in a more advanced form, not just in family relationships. In reality, the concept of Yookchen was defined and the term Yookchen was first used in Yeonhaejapyeong. Most of the contents of the major classics, such as Yeonhaejapyeong, Sammyeontonghwe, and Japyeonjinjeong, were limited to setting only family concepts. Then, in 1963, Sajoojeongsul was published, which explained both family relations and the action of Shipsong. In particular, it is noteworthy that the scientific reputation written by Ki-seung Kim did not only explain the concept of Shipsong but also opened a new chapter to confirm human psychology and aptitude. In this study, I tried to find out the concept and tendency of Shipsong described in Kim Ki-seung's Science Myeongri in the major classics and how the concept changed. I hope this study will be of some help to the study of Myeongleehak in the future in terms of understanding and utilization of Shipsong.

Effects of <i>Ginkgo biloba</i> Extract on Promotion of Neurogenesis in the Hippocampal Dentate Gyrus in C57BL/6 Mice

YOO, Dae Young,NAM, YoonYi,KIM, Woosuk,YOO, Ki-Yeon,PARK, Jaeil,LEE, Choong Hyun,CHOI, Jung Hoon,YOON, Yeo Sung,KIM, Dong-Woo,WON, Moo-Ho,HWANG, In Koo Japanese Society of Veterinary Science 2011 The Journal of veterinary medical science Vol.73 No.1

<P><I>Ginkgo biloba </I>leaf extract (Gb) has been known to improve blood flow and preclude the tissue from free radical damage. Effects of Gb were examined by using Ki67, a specific proliferative marker for cellular proliferation, and doublecortin (DCX), a marker for immature neurons, indicating degree of neuroblast differentiation in the hippocampal dentate gyrus (DG) of adult C57BL/6 mice. The mice were fed with Gb at 40 and 100 mg/kg once daily for 28 days. The increase of Ki67- and DCX-immunoreactive cells in the DG was increased in a dose-dependent manner. Especially, the group having 100 mg/kg Gb showed a significant increase of DCX-immunoreactive neuroblasts with well-developed tertiary dendrites. Expression of DCX protein in the Gb groups was also significantly increased upon compared with the vehicle group. The results suggested that repeated intake of Gb would enhance cell proliferation and neuroblast differentiation in the mouse DG.</P>

기대빈도를 활용한 새로운 상대집중지수의 제안

남기성,오민홍,홍현균,Nam, Ki-Seong,Oh, Min-Hong,Hong, Hyun-Guyn 한국통계학회 2008 응용통계연구 Vol.21 No.4

본 연구는 기존의 순위만 고려하는 집중도를 보완하여 기대빈도를 이용한 새로운 상대집중지수 NOHI(Nam-Oh-Hong Index)를 제안하고, 이를 지역별 직업별 종사자 수에 적용함으로써 지역별 특화 직종 분포에 활용하는데 있다. 지역 간 특화정도를 보여주기 위해 개발된 입지계수(LQ)의 경우, 해당산업의 지역 내 비중을 상대적으로 고려하지 못함에 따라 지역 내 특성화를 반영하지 못하는 한계를 내포하고 있다. 본 연구에서 제안하는 NOHI는 이러한 단점을 보완하여 산업 및 직종의 지역간 지역내 특화도를 동시에 나타낼 수 있다. 본 연구에서 제안하는 NOHI를 활용하여 분석한 결과 서울은 경영 회계 사무관련직의 특화도가 높은 것으로 나타났으며, 부산은 기계 재료관련직의 특화도가 높은 것으로 나타났다. The purpose of this study is to introduce a relative specialization index, the Nam-Oh-Hong Index(NOHI) and to investigate regional distribution of occupational specialization using the newly developed index. Compared with Location Quotient(LQ), the advantages of the index is that the NOHI enables comparison between inter-regional and intra-regional concentration of employment possible at the same time. The results of the specialization analyses show that Seoul is specialized in management, book-keeping and office related occupations, whereas Busan in machine and material related occupations.