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Khairnar, Nivedita P.,Joe, Min-Ho,Misra, H. S.,Lim, Sang-Yong,Kim, Dong-Ho American Society for Microbiology 2013 Journal of Bacteriology Vol.195 No.12
<P><I>Deinococcus radiodurans</I> R1 exposed to a lethal dose of cadmium shows differential expression of a large number of genes, including <I>frnE</I> (dr<I>frnE</I>) and some of those involved in DNA repair and oxidative stress tolerance. The dr<I>frnE</I>::<I>nptII</I> mutant of <I>D. radiodurans</I> showed growth similar to that of the wild type, but its tolerance to 10 mM cadmium and 10 mM diamide decreased by ∼15- and ∼3-fold, respectively. These cells also showed nearly 6 times less resistance to gamma radiation at 12 kGy and ∼2-fold-higher sensitivity to 40 mM hydrogen peroxide than the wild type. In <I>trans</I> expression of drFrnE increased cytotoxicity of dithiothreitol (DTT) in the <I>dsbA</I> mutant of <I>Escherichia coli</I>. Recombinant drFrnE showed disulfide isomerase activity and could maintain insulin in its reduced form in the presence of DTT. While an equimolar ratio of wild-type protein could protect malate dehydrogenase completely from thermal denaturation at 42°C, the C22S mutant of drFrnE provided reduced protection to malate dehydrogenase from thermal inactivation. These results suggested that drFrnE is a protein disulfide isomerase <I>in vitro</I> and has a role in oxidative stress tolerance of <I>D. radiodurans</I> possibly by protecting the damaged cellular proteins from inactivation.</P>
Khairnar, Sanyukta,Bhate, Kalyani,Santhosh, Kumar S.N.,Kshirsagar, Kapil,Jagtap, Bhagyashree,Kakodkar, Pradnya The Korean Dental Society of Anesthsiology 2019 Journal of Dental Anesthesia and Pain Medicine Vol.19 No.5
Background: Pain, limitations in opening, asymmetrical jaw movements, and temporomandibular joint (TMJ) sounds are the most common findings in temporomandibular joint disorders (TMDs), which causes excruciating pain, inflammation of the surrounding muscles, posterior fibers, and synovial fluid. This study aimed to evaluate and compare the effects of ultrasound heat therapy and low-level laser therapy (LLLT) in reducing TMD-related pain. Methods: This prospective study included 42 patients (age range, 25-45 years), who were divided into two groups of 21 patients each. All patients were prescribed a non-steroidal anti-inflammatory drug (NSAID) twice a day for 5 days for temporary relief of pain prior to the commencement of treatment. Patients were kept on a soft diet and asked to restrict mouth opening during the same period. Fifteen sessions of LLLT (Group A) or ultrasound therapy (Group B) were administered to the affected side. Results: Post-therapy, the mean visual analog scale score for group A and group B was 4.81 (2.01) and 6.19 (1.20), respectively; the difference was statistically significant and favoring the LLLT group. Similarly, the mean mouth opening for group A and group B was 3.99 (0.40) and 3.65 (0.41), respectively; the difference was statistically significant and favoring the LLLT group. Conclusion: Our study recommends LLLT for treating TMD-related pain with no underlying bony pathology.
Gokul Khairnar,Jitendra Naik,Vinod Mokale 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.6
The aim of this study was to investigate thecombined influence of 3 independent variables in thepreparation of sustained release Nateglinide (NTG)microspheres by O/W solvent emulsification method. A3-factor, 3-level Box–Behnken design was used to derivesecond order polynomial equation and construct contourplots to predict responses. The independent variablesselected were polymer concentration (A), surfactant concentration(B) and speed of the stirrer (C). Percentage drugloading (Y1) and Percentage drug release (Y2) were considereddependent variables. The prepared microsphereswere evaluated for percentage of yield, drug loading, drugrelease study in 6.8 phosphate buffer, Fourier transforminfrared (FT-IR), X-ray diffraction (XRD), scanning electronmicroscopy analysis. Contour plots were constructedto show the effects of of A, B, C on Y1 and Y2. The yieldof microspheres was found to be in the range of42.29–97.22 %. The drug loading was found to be in therange of 12.18 % (F9) to 24.55 % (F14). FT-IR analysisrevealed no drug excipient interference. The morphologyof evaluated microspheres were found to be spherical andsmooth in nature. In XRD analysis crystalline pattern ofpure NTG was changed to amorphous pattern when convertedto microspheres. Out of 17 batches, formulationbatches F1, F4, F12, F14, F17 had percentage drug loading52.75, 50.78, 43.88, 47.45, 44.78 % at 10 h respectivelywhich indicated excellent sustained drug release pattern. From this study it was concluded that NTG loaded ethylcellulose sustained release microspheres were developedusing 3-factor, 3-level Box–Behnken design.
Piyush Khairnar Council on Tall Building and Urban Habitat Korea 2023 International journal of high-rise buildings Vol.12 No.2
Typical floor systems in contemporary tall buildings consist of reinforced concrete or composite metal deck over framing members and account for a majority of the structural weight of the building. The use of high-density materials, such as reinforced concrete and steel, increases the weight of floor systems, reducing the system's overall efficiency. With the introduction of high-performance materials, mainly mass timber products, and fiber-reinforced composites, in the construction industry, designers and engineers have multiple options to choose from when selecting structural materials. This paper discusses the application of mass timber and carbon fiber composites as structural materials in floor systems of tall buildings. The research focused on a comparative analysis of the structural system efficiency for five different design options for tall building floor systems. Finite Element Analysis (FEA) method was adopted to develop a simulation framework, and parametric structural models were simulated to evaluate the structural performance under specific loading conditions. Simulation results revealed the advantages of lightweight structural materials to improve system efficiency and reduce material consumption. The impact of mechanical properties of materials, loading conditions, and issues related to fire engineering and construction were briefly discussed, and future research topics were identified in conclusion.
Vilas Khairnar,Sandesh Jaybhaye,Chi-Chang Hu,Rakesh Afre,Tetsu Soga,Madhuri Sharon,Maheshwar Sharon 한국탄소학회 2008 Carbon Letters Vol.9 No.3
Porous carbon materials synthesized from various plant derived precursors i.e. seeds of [Castor (Ricinus communis), Soap nut (Sapindus sp.), Cashew-nut (Semecarpus anacardium), Jack fruit (Artocarpus heterophyllus), Safflower (Carthamus tinctorius), Ambadi (Crotolaria juncea), Neem (Azadirachta indica), Bitter Almond (Prunus amygdalus), Sesamum (Sisamum indicum), Date-palm (Phoenix dactylifera),Canola (Brassica napus), Sunflower (Helianthus annulus)] and fibrous materials from [Corn stem- (Zea mays), Rice straw (Oryza sativa), Bamboo (Bombax bambusa) and Coconut fibers (Cocos nucifera)] were screened to make supercapacitor in 5M KOH solution. Carbon material obtained from Jack fruit seeds (92.0 F/g), Rice straw (83.0 F/g), Soap nut seeds (54.0 F/g), Castor seeds (44.34 F/g) and Bamboo (40.0 F/g) gave high capacitance value as compared to others. The magnitude of capacitance value was found to be inversely proportional to the scan rate of measurement. It is suggested that carbon material should possess large surface area and small pore size to get better value of capacitor. Moreover, the structure of carbon materials should be such that majority of pores are in the plane parallel to the plane of electrode and surface is fluffy like cotton ball.