http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Kesmarky (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
In vitro hemorheological effects of parenteral agents used in peripheral arterial disease
Biro, Katalin,Sandor, Barbara,Toth, Andras,Koltai, Katalin,Papp, Judit,Rabai, Miklos,Toth, Kalman,Kesmarky, Gabor 한국유변학회 2014 Korea-Australia rheology journal Vol.26 No.2
Peripheral arterial disease (PAD) is a frequent manifestation of systemic atherosclerosis. In PAD hemorheological parameters were defined as risk factors in a number of studies and several therapeutic agents were tried in these conditions. Our study aims to investigate and compare the in vitro hemorheological effects of various drugs generally used in the parenteral treatment of intermittent claudication and critical limb ischemia. Blood samples of healthy male volunteers were incubated with iloprost, alprostadil, pentoxifylline, sulodexide or pentosan polysulfate at calculated therapeutic serum concentration. Hematocrit (Hct) was determined by microhematocrit centrifuge. Plasma and apparent whole blood viscosities (WBV) were evaluated by capillary viscometer. Red blood cell aggregation was measured by LORCA (laserassisted optical rotational cell analyzer) aggregometer, and LORCA ektacytometer was used for measuring erythrocyte deformability at $37^{\circ}C$. Iloprost, alprostadil, and pentoxifylline incubation did not have any significant effect on plasma and apparent WBV. Elongation index increased in samples incubated with alprostadil at low shear stresses 0.95 and 0.53 Pa (p < 0.05). Sulodexide significantly improved WBV and Hct/WBV ratio (p < 0.05). Incubation with pentosan polysulfate resulted in higher WBV, lower Hct/WBV ratio and deterioration in the aggregation parameters (p < 0.05). Sulodexide may have beneficial effect on a macrorheological parameter; alprostadil may improve a microrheological parameter. Hemorheological alterations could be important in PAD patients with hampered vasodilator capacity.
-
Hemorheological parameters in coronary artery disease detected by multi-slice CT
Toth, Andras,Szukits, Sandor,Varady, Edit,Sandor, Barbara,Rabai, Miklos,Papp, Judit,Juricskay, Istvan,Kesmarky, Gabor,Toth, Kalman,Sumegi, Balazs,Battyani, Istvan 한국유변학회 2014 Korea-Australia rheology journal Vol.26 No.2
Epidemiological studies have confirmed that hemorheological parameters are primary risk factors in CAD; and their alterations in CAD have been described. We aimed to investigate both macro- and microrheological properties of blood in patients with CAD. The data of 121 patients (mean age: $58.8{\pm}9.6$ years) undergoing coronary CT were analyzed. Blood samples were obtained right before CT examinations. Hematocrit (Hct), plasma (PV) and apparent whole blood viscosity (WBV), red blood cell (RBC) aggregation and RBC deformability were measured. Patients were classified into four groups according to their coronary vessel state: Negative group (n = 32, mean age: $56.8{\pm}11.1$ years) without any coronary stenosis or atherosclerotic lesion and zero calcium-score, Non-significant group (n = 27, mean age: $59.2{\pm}7.5$ years) below 40% area stenosis, Single-vessel group (n = 32, mean age: $58.8{\pm}8.5$ years) over 40% area stenosis or history of PCI or CABG on one coronary vessel, Multi-vessel group (n = 30, mean age: $62.1{\pm}8.4$ years) with over 40% area stenosis or history of PCI or CABG on multiple coronary vessels. Hct was significantly (p < 0.05) higher in all CAD (Non-significant, Single-vessel, Multi-vessel) groups compared to the Negative group. WBV was significantly (p<0.05) higher in the Multi-vessel group compared to the Negative group. No significant ($p{\geq}0.05$) differences were observed in PV. RBC aggregation was significantly (p < 0.05) increased in the Multi-vessel group compared to the Negative group. RBC deformability showed a decreasing tendency with the increasing number of atherosclerotic vessels. Our results indicate that hemorheological variables are deteriorated in patients with CAD established by coronary CT, which is more pronounced in severe coronary disease.
-
Hemorheological parameters in coronary artery disease detected by multi-slice CT
Andras Toth,Sandor Szukits,Edit Varady,Barbara Sandor,Miklos Rabai,Judit Papp,Istvan Juricskay,Gabor Kesmarky,Kalman Toth,Balazs Sumegi,Istvan Battyani 한국유변학회 2014 Korea-Australia rheology journal Vol.26 No.2
Epidemiological studies have confirmed that hemorheological parameters are primary risk factors in CAD;and their alterations in CAD have been described. We aimed to investigate both macro- and microrheologicalproperties of blood in patients with CAD. The data of 121 patients (mean age: 58.8 ± 9.6 years) undergoingcoronary CT were analyzed. Blood samples were obtained right before CT examinations. Hematocrit (Hct),plasma (PV) and apparent whole blood viscosity (WBV), red blood cell (RBC) aggregation and RBC deformabilitywere measured. Patients were classified into four groups according to their coronary vessel state: Negativegroup (n = 32, mean age: 56.8 ± 11.1 years) without any coronary stenosis or atherosclerotic lesion andzero calcium-score, Non-significant group (n = 27, mean age: 59.2 ± 7.5 years) below 40% area stenosis, Single-vessel group (n = 32, mean age: 58.8 ± 8.5 years) over 40% area stenosis or history of PCI or CABG onone coronary vessel, Multi-vessel group (n = 30, mean age: 62.1 ± 8.4 years) with over 40% area stenosis orhistory of PCI or CABG on multiple coronary vessels. Hct was significantly (p < 0.05) higher in all CAD(Non-significant, Single-vessel, Multi-vessel) groups compared to the Negative group. WBV was significantly(p<0.05) higher in the Multi-vessel group compared to the Negative group. No significant (p ≥ 0.05) differenceswere observed in PV. RBC aggregation was significantly (p < 0.05) increased in the Multi-vesselgroup compared to the Negative group. RBC deformability showed a decreasing tendency with the increasingnumber of atherosclerotic vessels. Our results indicate that hemorheological variables are deteriorated inpatients with CAD established by coronary CT, which is more pronounced in severe coronary disease.
-
In vitro hemorheological effects of parenteral agents used in peripheral arterial disease
Katalin Biro,Barbara Sandor,Andras Toth,Katalin Koltai,Judit Papp,Miklos Rabai,Kalman Toth,Gabor Kesmarky 한국유변학회 2014 Korea-Australia rheology journal Vol.26 No.2
Peripheral arterial disease (PAD) is a frequent manifestation of systemic atherosclerosis. In PAD hemorheologicalparameters were defined as risk factors in a number of studies and several therapeutic agents weretried in these conditions. Our study aims to investigate and compare the in vitro hemorheological effectsof various drugs generally used in the parenteral treatment of intermittent claudication and critical limbischemia. Blood samples of healthy male volunteers were incubated with iloprost, alprostadil, pentoxifylline,sulodexide or pentosan polysulfate at calculated therapeutic serum concentration. Hematocrit(Hct) was determined by microhematocrit centrifuge. Plasma and apparent whole blood viscosities (WBV)were evaluated by capillary viscometer. Red blood cell aggregation was measured by LORCA (laserassistedoptical rotational cell analyzer) aggregometer, and LORCA ektacytometer was used for measuringerythrocyte deformability at 37°C. Iloprost, alprostadil, and pentoxifylline incubation did not have any significanteffect on plasma and apparent WBV. Elongation index increased in samples incubated with alprostadilat low shear stresses 0.95 and 0.53 Pa (p < 0.05). Sulodexide significantly improved WBV and Hct/WBV ratio (p < 0.05). Incubation with pentosan polysulfate resulted in higher WBV, lower Hct/WBV ratioand deterioration in the aggregation parameters (p < 0.05). Sulodexide may have beneficial effect on a macrorheologicalparameter; alprostadil may improve a microrheological parameter. Hemorheological alterationscould be important in PAD patients with hampered vasodilator capacity.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
