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      • KCI등재SCOPUS

        Are patients and physicians willing to accept less-radical procedures for cervical cancer?

        Kemal,Gungorduk,Roman,Kocian,Derman,Basaran,Taner,Turan,Aykut,Ozdemir,David,Cibula 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.4

        OBJECTIVE: To evaluate the opinions of women who underwent surgery for cervical cancer (CC) and physicians who treat CC about the acceptability of increased oncological risk after less-radical surgery. METHODS: One hundred eighty-two women who underwent surgery for CC and 101 physicians participated in a structured survey in 3 tertiary cancer centers in Czech Republic and Turkey. Patients and physicians were asked whether they would accept any additional oncological risks, which would be attributable to the omission of parametrectomy (radical hysterectomy/trachelectomy vs. simple hysterectomy/trachelectomy) or pelvic lymph node dissection (systematic resection vs. sentinel lymph node sampling). RESULTS: Although 52.2% of patients reported morbidity related to their previous treatment, the majority of patients would not accept less-radical surgical treatment if it was associated with any increased risk of recurrence (50%-55%, no risk; 17%-24%, risk <0.1%). Physicians tended to accept a significantly higher risk than patients in the Czech Republic, but not in Turkey. Patients with higher education levels, more advanced-stage of disease, or adverse events related to previous cancer treatment, and patients who received adjuvant therapy were significantly more likely to accept an increased oncological risk. CONCLUSION: Patients, even if they suffered from morbidity related to previous CC treatment, do not want to choose between oncological safety and a better quality of life. Physicians tend to accept the higher oncological risk associated with less-radical surgical procedures, but attitudes differ regionally. Professionals should be aware of this tendency when counselling the patients before less-radical surgery.

      • KCI우수등재

        The use of infrared thermography to detect the stages of estrus cycle and ovulation time in anatolian shepherd dogs

        ( Kemal Tuna Olgac ), ( Ergun Akcay ), ( Beste Cil ), ( Burak Mehmet Ucar ), ( Ali Daskın ) 한국축산학회(구 한국동물자원과학회) 2017 한국축산학회지 Vol.59 No.10

        Background: The aim of the study is to evaluate the effectiveness of thermographic monitoring, using the temperature changes of perianal and perivulvar areas for the determination of estrus in Anatolian Shepherd bitches. Fifteen bitches were used in the study. Blood and vaginal smear samples were collected and thermographic monitoring of perianal and perivulvar areas were carried out starting from proestrus to early diestrus. Also, external signs of estrus were investigated. Smear samples were evaluated by light microscopy after Diff-Quik staining method and superficial and keratinized superficial cells were determined as percentage (S + KS%). Progesterone and luteinizing hormone measurements were done by radioimmunoassay. The difference in temperature between perianal and perivulvar areas was evaluated through thermographic images by FLIR ResearchIR Software. Results: According to the results obtained from the study, differences between progesterone and S + KS% were statistically significant (P < 0,05). Although temperature showed increase and decrease with progesterone and S + KS%, the differences were not important statistically (P > 0,05). Serum luteinizing hormone levels did not sign any difference (P > 0,05). Conclusions: As a result, thermographic monitoring alone is not enough for estrus detection in Anatolian Shepherd bitches. However, it can be used to assist the actual estrus detection technique in terms of providing some foreknowledge by evaluating the differences in temperature

      • KCI등재SCOPUS

        Prognostic Significance of Retroperitoneal Lymphadenectomy, Preoperative Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Primary Fallopian Tube Carcinoma: A Multicenter Study

        Kemal,Gungorduk,Ibrahim,E.,Ertas,Aykut,Ozdemir,Emrah,Akkaya,Elcin,Telli,Salih,Taskin,Mehmet,Gokcu,Ahmet,Baris,Guzel,Tufan,Oge,Levent,Akman,Tayfun,Toptas,Ulas,Solmaz,Askın,Dogan,Mustafa,Cosan,Terek,Muz 대한암학회 2015 Cancer Research and Treatment Vol.47 No.3

        Purpose The purpose of this study is to evaluate the prognostic role of preoperative neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) and the need for para-aortic lymphadectomy in patients with primary fallopian tube carcinoma (PFTC). Materials and Methods Ninety-one patients with a diagnosis of PFTC were identified through the gynecologic oncology service database of six academic centers. Clinicopathological, surgical, and complete blood count data were collected. Results In univariate analysis, advanced stage, suboptimal surgery, and NLR > 2.7 were significant prognostic factors for progression-free survival, whereas in multivariate analysis, only advanced stage and suboptimal surgery were significant. In addition, in univariate analysis, cancer antigen 125 ! 35 U/mL, ascites, advanced stage, suboptimal surgery, NLR > 2.7, PLR > 233.3, platelet count ! 400,000 cells/mm3, staging type, and histological subtype were significant prognostic factors for overall survival (OS); however, in multivariate analysis, only advanced stage, suboptimal surgery, NLR > 2.7, and staging type were significant. Inclusion of pelvic and para-aortic lymphadenectomy in surgery showed significant association with longer OS, with a mean and median OS of 42.0 months and 35.5 months (range, 22 to 78 months), respectively, vs. 33.5 months and 27.5 months (range, 14 to 76 months), respectively, for patients who underwent surgery without para-aortic lymphadenectomy (hazard ratio, 3.1; 95% confidence interval, 1.4 to 5.7; p=0.002). Conclusion NLR (in both univariate and multivariate analysis) and PLR (only in univariate analysis) were prognostic factors in PFTC. NLR and PLR are inexpensive and easy tests to perform. In addition, patients with PFTC who underwent bilateral pelvic and para-aortic lymphadenectomy had longer OS.

      • KCI등재

        Assessment of endodontically treated teeth by using different radiographic methods: an ex vivo comparison between CBCT and other radiographic techniques

        Kemal,Özgür,Demiralp,Kivanç,Kamburŏglu,Kahraman,Güngör,Selcen,Yüksel,Gokcen,Demiralp,Özlem,Üçok 대한구강악안면방사선학회 2012 Imaging Science in Dentistry Vol.42 No.3

        Purpose: To compare different radiographic methods for assessing endodontically treated teeth. Materials and Methods: Root canal treatments were applied in 120 extracted mandibular teeth, which were divided into four groups: (1) ideal root canal treatment (60 teeth), (2) insufficient lateral condensation (20 teeth), (3) root canals filled short of the apex (20 teeth), (4) overfilled root canal treatment (20 teeth). The teeth were imaged using intraoral film, panoramic film, digital intraoral systems (CCD and PSP), CCD obtained with portable X-ray source, digital panoramic, and CBCT images obtained at 0.3 mm3 and 0.2 mm3 voxel size. Images were evaluated separately by three observers, twice. Kappa coefficients were calculated. The percentage of correct readings obtained from each modality was calculated and compared using a t-test (p⁄0.05). Results: The intra-observer kappa for each observer ranged between 0.327 and 0.849. The inter-observer kappa for each observer for both readings ranged between 0.312 and 0.749. For the ideal root canal treatment group, CBCT with 0.2 mm3 voxel images revealed the best results. For insufficient lateral condensation, the best readings were found with periapical film followed by CCD and PSP. The assessment of teeth with root canals filled short of the apex showed the highest percentage of correct readings by CBCT and CCD. For the overfilled canal treatment group, PSP images and conventional periapical film radiographs had the best scores. Conclusion: CBCT was found to be successful in the assessment of teeth with ideal root canal treatment and teeth with canals filled short of the apex.

      • KCI등재SCOPUS

        The Psychological Impact of COVID-19 Disease is more Severe on Intensive Care Unit Healthcare Providers: A Cross-sectional Study

        Kemal,Tolga,Saracoglu,Tahsin,Simsek,Selime,Kahraman,Elif,Bombaci,Özlem,Sezen,Ayten,Saracoglu,Recep,Demirhan 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.4

        Objective: Fear, anxiety, depression and sleep deprivation are common mental health disorders in COVID-19 disease. We aimed to analyse the risk for healthcare providers during COVID-19 pandemic in a university hospital. Methods: Anesthesiologists, nurses and nurse anesthetists were invited to fill out the survey. The survey was consist of questions from ‘'The Fear of COVID-19 Scale'', ‘'Patient Health Questionnaire'' and ‘'Pittsburgh Sleep Quality Index'' (PSQI). Each question was worth a point. Results: The data of 208 participants were analyzed. Mean age was 29 ± 7.748 years, 72.1% were male, 67.3% were nurses, 62% were working in intensive care units, 38% were in hospital wards, 62% of all participants were living alone. Moderate depression was the most frequently detected outcome (n = 90, 43.3%). Mean The Fear of COVID-19 Scale for all participants was 18.56 ± 7.731. The mean PSQI of patients was 6.18 ± 4.356 with a 45.7% rate of poor sleep quality. PSQI was found significantly higher in nurses (7.1 ± 4.7, p = 0.000). Nurses were the group with the highest deterioration in sleep quality (53.6%, p = 0.003). The rate of moderate-to-severe depressive symptoms was significantly higher in intensive care unit nurses and physicians (p = 0.018). PSQI score was found significantly higher in intensive care unit nurses and physicians than hospital ward co-workers (7.02 ± 4.59 vs. 4.81 ± 3.57 respectively, p = 0.001). A significant positive correlation was observed between PSQI and The Fear of COVID-19 Scale total score in all patients (p < 0.005). Conclusion: Depression, anxiety, fear and sleep disorders may occur in healthcare workers during COVID-19 outbreak. Intensive care unit nurses were at highest risk.

      • KCI등재

        CARDAN POSITIONS IN THE LORENTZIAN PLANE

        ( Kemal Eren ), ( Soley Ersoy ) 호남수학회 2018 호남수학학술지 Vol.40 No.1

        In this paper, we study the instantaneous geometric properties of motion of rigid bodies in the Lorentzian plane. For this purpose we define Lorentzian form of Bottemas instantaneous invariants. In these regards, we obtain the necessary and sufficient condition of a Lorentzian plane to be at Cardan position with re-spect to these invariants.

      • KCI등재SCOPUS

        Increased Serum Hepcidin Levels in Children and Adolescents with Attention Deficit Hyperactivity Disorder

        Kemal,Utku,Yazici,Ipek,Percinel,Yazici,Bilal,Ustundag 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.1

        Objective: In this study, we aimed to evaluate the serum hepcidin levels in attention deficit hyperactivity disorder (ADHD) patients that were newly diagnosed with no history of psychotropic drugs. Methods: A total of 70 ADHD patients and 69 healthy controls were enrolled in our study. During the diagnosis, the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime version were applied. The sociodemographic data form, Turgay DSM-IV-Based Child and Adolescent Behavior Disorders Screening and Rating Scale, and Conners' Rating Scales-Revised: Long Form were used for the clinical evaluation. Serum hepcidin levels were measured and compared between the groups. Results: No significant difference between the groups in terms of age (p =0.533) and gender (p =0.397) was determined. In addition, the groups did not differ significantly for the other sociodemographic variables recorded. Serum hepcidin levels were found to be significantly higher in the patients with ADHD than healthy controls (p =0.019). Conclusion: To the best of our knowledge, this study is the first to evaluate the total serum hepcidin levels in ADHD patients. Our study findings may suggest that high levels of hepcidin may cause iron dysregulation in ADHD patients. However, further studies are required to establish a definite conclusion.

      • SCIESCOPUSKCI등재

        Taurine relaxes human radial artery through potassium channel opening action

        Kemal,Gokhan,Ulusoy,Erkan,Kaya,Kubilay,Karabacak,Melik,Seyrek,İ,brahim,Duvan,Vedat,Yildirim,Oguzhan,Yildiz 대한생리학회-대한약리학회 2017 The Korean Journal of Physiology & Pharmacology Vol.13 No.3

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        The vascular actions and mechanisms of taurine were investigated in the isolated human radial artery (RA). RA rings were suspended in isolated organ baths and tension was recorded isometrically. First, a precontraction was achieved by adding potassium chloride (KCl, 45 mM) or serotonin (5-hydroxytryptamine, 5-HT, 30 µM) to organ baths. When the precontractions were stable, taurine (20, 40, 80 mM) was added cumulatively. Antagonistic effect of taurine on calcium chloride (10 µM to 10 mM) -induced contractions was investigated. Taurine-induced relaxations were also tested in the presence of the K<sup>+</sup> channel inhibitors tetraethylammonium (1 mM), glibenclamide (10 µM) and 4-aminopyridine (1 mM). Taurine did not affect the basal tone but inhibited the contraction induced by 5-HT and KCl. Calcium chloride–induced contractions were significantly inhibited in the presence of taurine (20, 40, 80 mM) (p<0.05). The relaxation to taurine was inhibited by tetraethylammonium (p<0.05). However, glibenclamide and 4-aminopyridine did not affect taurine -induced relaxations. Present experiments show that taurine inhibits 5-HT and KCl -induced contractions in RA, and suggest that large conductance Ca<sup>2+</sup>-activated K<sup>+</sup> channels may be involved in taurine –induced relaxation of RA.

      • KCI등재SCOPUS

        Synthesis-chracteristics and sintering behavior of PZT-powder

        Kemal,Köseo,lu 한양대학교 세라믹연구소 2007 Journal of Ceramic Processing Research Vol.8 No.1

        In the Pb(Zr0,525Ti0,475)O3 system, two powders were produced by chemical co-precipitation and mechanical mixing of Pb(NO3)2, Zr(OC3H7)4 and Ti(OC3H7)4. The powders were characterized with regard to their specific surface area, particle size distribution, phases present and the pore size distribution of the pressed powder tablets. The co-precipitated powder was sintered already at 750 °C to 99% of its theoretical density. The mechanically-mixed powders reached only 62.5% of the theoretical density at 900 °C sintering temperature, although they had a higher specific surface area and finer particle size than the co-precipitated powder. The better sintering behavior of the co-precipitated powder can be explained by a narrow pore size distribution and small pore size in its pressed powder tablets. This is further proof that a determination of the pore size distribution of pressed powder tablets gives reliable indications about the sintering behavior. In the Pb(Zr0,525Ti0,475)O3 system, two powders were produced by chemical co-precipitation and mechanical mixing of Pb(NO3)2, Zr(OC3H7)4 and Ti(OC3H7)4. The powders were characterized with regard to their specific surface area, particle size distribution, phases present and the pore size distribution of the pressed powder tablets. The co-precipitated powder was sintered already at 750 °C to 99% of its theoretical density. The mechanically-mixed powders reached only 62.5% of the theoretical density at 900 °C sintering temperature, although they had a higher specific surface area and finer particle size than the co-precipitated powder. The better sintering behavior of the co-precipitated powder can be explained by a narrow pore size distribution and small pore size in its pressed powder tablets. This is further proof that a determination of the pore size distribution of pressed powder tablets gives reliable indications about the sintering behavior.

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