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- 저자 : Kazuhiro Kondo (검색결과 4 건)
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Measurement of Gamma-ray Yield from Thick Carbon Target Irradiated by 5 and 9 MeV Deuterons
Araki, Shouhei,Kondo, Kazuhiro,Kin, Tadahiro,Watanabe, Yukinobu,Shigyo, Nobuhiro,Sagara, Kenshi The Korean Association for Radiation Protection 2017 방사선방어학회지 Vol.42 No.1
Background: The design of deuteron accelerator neutron source facilities requires reliable yield estimation of gamma-rays as well as neutrons from deuteron-induced reactions. We have so foar measured systematically double-differential thick target neutron yields (DDTTNYs) for carbon, aluminum, titanium, copper, niobium, and SUS304 targets. In the neutron data analysis, the events of gamma-rays taken simultaneously were treated as backgrounds. In the present work, we have re-analyzed the experimental data for a thick carbon target with particular attention to gamma-ray events. Materials and Methods: Double-differential thick target gamma-ray yields from carbon irradiated by 5 and 9 MeV deuterons were measured using an NE213 liquid organic scintillator at the Kyushu University Tandem accelerator Laboratory. The gamma-ray energy spectra were obtained by an unfolding method using FORIST code. The response functions of the NE213 detector were calculated by EGS5 incorporated in PHITS code. Results and Discussion: The measured gamma-ray spectra show some pronounced peaks corresponding to gamma-ray transitions between discrete levels in residual nuclei, and the measured angular distributions are almost isotropic for both the incident energies. Conclusion: PHITS calculations using INCL, GEM, and EBITEM models reproduce the spectral shapes and the angular distributions generally well, although they underestimate the absolute gamma-ray yields by about 20%.
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Kensuke Hori,Shin Nishio,Kimio Ushijima,Yuka Kasamatsu,Eiji Kondo,Kazuhiro Takehara,Kimihiko Ito 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.4
Objective: To determine the safety and efficacy of dose-dense (dd) paclitaxel (PTX) and carboplatin (CBDCA) in treating advanced or recurrent endometrial cancer. Methods: Women aged 20–75 years with histologically confirmed endometrial cancer, the International Federation of Gynecology and Obstetrics (FIGO) stage III disease with some residual tumor, FIGO stage IV disease, recurrence after front-line curative treatment, or recurrence after second-line chemotherapy or radiotherapy were enrolled in this study. PTX (80 mg/m2) was administered intravenously (IV) to every participant on days 1, 8, and 15, and CBDCA (area under the curve of 5) was administered IV on day 1 once every 3 weeks until the disease progressed, unacceptable adverse events occurred, or consent was withdrawn. The primary endpoint was the response rate (RR), while the secondary endpoints were progression-free survival, overall survival, and adverse effects. Results: Forty-eight participants were enrolled, and 46 were eligible to receive treatment. The patients' median age was 61 years (range, 43–76 years). Twenty-two participants had experienced recurrence, and the remaining patients had primary advanced endometrial cancer. There were 10 cases of serous carcinoma, 3 cases of endometrioid carcinoma G3, 2 cases of carcinosarcoma, and 2 cases of clear-cell carcinoma according to histology. Twenty- nine participants (63.0%) received ≥6 cycles of chemotherapy. The RR (complete, 13 cases; partial, 20 cases) was 71.3% (95% confidence interval: 59.0%–84.5%). Conclusion: The dd PTX with CBDCA is feasible and available as a treatment option for advanced or recurrent endometrial cancer. Trial Registration: UMIN Clinical Trials Registry Identifier: UMIN000017138
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Elevated Brain-Derived Neurotrophic Factor Levels During Depressive Mixed States
Naoaki Otsuka,Yoshikazu Takaesu,Yu Zamami,Kazuki Ota,Kazuhiro Kurihara,Hotaka Shinzato,Tsuyoshi Kondo 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.11
Objective Neurotrophin-like brain-derived neurotrophic factor (BDNF) and pro-inflammatory cytokines may modulate the pathophysiology of mood disorders. Although several studies show alterations in these biomarkers during the depressive, manic, and euthymic states of mood disorders, evidence is lacking for those in a mixed state. Therefore, this study aimed to investigate the relationship between the depressive mixed state (DMX) and peripheral neurobiological factors.Methods We enrolled 136 patients with major depressive episodes. Depressive symptoms were assessed using the Quick Inventory of Depressive Symptomatology Self-Report Japanese version (QIDS-SR-J). The severity of DMX was assessed using the self-administered 12-item questionnaire (DMX-12). Categorical screening as DMX-positive (n=54) was determined by a cutoff score of 13 or more in the specific eight symptoms from the DMX-12; the remaining were DMX-negative (n=82). Serum BDNF, tumor necrosis factor-α, highsensitivity C-reactive protein, and interleukin-6 levels were measured.Results When comparing biomarkers between the DMX-positive and DMX-negative groups, higher serum BDNF concentration in the DMX-positive group than in the DMX-negative group was the only significant finding (p=0.009). A positive correlation existed between the total score of the eight specific symptoms of DMX-12 and the BDNF concentration (r=0.190, p=0.027). After adjustment for confounders, logistic regression analysis revealed that BDNF (odds ratio [OR]=1.07, 95% confidence interval [CI]=1.00–1.14, p=0.045), bipolar diagnosis (OR=3.43, 95% CI=1.36–8.66, p=0.009), and total QIDS-SR-J score (OR=1.29, 95% CI=1.15–1.43, p<0.001) were significantly associated with DMX positivity.Conclusion BDNF was positively associated with DMX severity, suggesting that higher BDNF concentrations may be involved in the pathophysiology of DMX.
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