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Design, Synthesis, and Membrane-Translocation Studies of Inositol-Based Transporters
Maiti, Kaustabh K.,Jeon, Ock-Youm,Lee, Woo Sirl,Kim, Dong-Chan,Kim, Kyong-Tai,Takeuchi, Toshihide,Futaki, Shiroh,Chung, Sung-Kee WILEY-VCH Verlag 2006 Angewandte Chemie Vol.45 No.18
<B>Graphic Abstract</B> <P>Delivery vehicles: Novel guanidine-containing “transporters” constructed on a dimeric inositol scaffold show significant translocation across the cell membrane and the blood–brain barrier, as well as unique in vitro and in vivo distributions. Doxorubicin was efficiently delivered to mouse-brain tissue by conjugating the compound with such a transporter (see the fluorescence microscopy image). <img src='wiley_img/14337851-2006-45-18-ANIE200600312-content.gif' alt='wiley_img/14337851-2006-45-18-ANIE200600312-content'> </P>
Maiti, Kaustabh ,K.,Lee, Woo ,Sirl,Takeuchi, Toshihide,Watkins, Catherine,Fretz, Marjan,Kim, Dong-Chan,Futaki, Shiroh,Jones, Arwyn,Kim, Kyong-Tai,Chung, Sung-Kee WILEY-VCH Verlag 2007 Angewandte Chemie. international edition Vol.46 No.31
<B>Graphic Abstract</B> <P>Special delivery: Transporters constructed on a sorbitol scaffold with eight guanidine residues show significant translocation across the cell membrane and the blood–brain barrier and high affinities toward mitochondria in HeLa and KG1a leukemia cells. The picture shows colocalisation of one such transporter (T) with MitoTracker red in KG1a cells (scale bars: 10 μm). <img src='wiley_img/14337851-2007-46-31-ANIE200701346-content.gif' alt='wiley_img/14337851-2007-46-31-ANIE200701346-content'> </P>
Cellular Uptake Properties of the Complex Derived from Quantum Dots and G8 Molecular Transporter
임정균,Kaustabh K. Maiti,김완일,김경태,정성기 대한화학회 2011 Bulletin of the Korean Chemical Society Vol.32 No.4
The biotin-attached G8 molecular transporter (5) was synthesized and used together with quantum dots in preparing the complexes (QD-MT). The QD-MT complexes were studied in terms of the cellular uptake and the internalization mechanism in live HeLa cells with the aid of various known endocytosis inhibitors. It has been concluded that the QD-MT complex is internalized largely by macropinocytosis. The mouse tissue distribution of the QD-MT complex by i.p. and i.v. routes showed some organ selectivity and a good ability to cross the BBB.
Ultrasensitive Near‐Infrared Raman Reporters for SERS‐Based In Vivo Cancer Detection
Samanta, Animesh,Maiti, Kaustabh Kumar,Soh, Kiat‐,Seng,Liao, Xiaojun,Vendrell, Marc,Dinish, U. S.,Yun, Seong‐,Wook,Bhuvaneswari, Ramaswamy,Kim, Hyori,Rautela, Shashi,Chung, Junho,Olivo, Ma WILEY‐VCH Verlag 2011 Angewandte Chemie Vol.123 No.27
<P><B>Zuverlässige Berichterstattung</B>: Das Screening einer 80‐teiligen Tricarbocyanin‐Bibliothek lieferte CyNAMLA‐381 als Nahinfrarot‐SERS‐Reporter mit guter Signalstabilität und höherer Empfindlichkeit als der Standard (SERS=oberflächenverstärkte Raman‐Spektroskopie). Durch Verkapselung von CyNAMLA‐381 an der Oberfläche von Gold‐Nanopartikeln und Konjugation mit Antikörpern wurden SERS‐Nanomarker mit ausgezeichneter Empfindlichkeit, Stabilität und Tumorspezifität in Xenograft‐Modellen erhalten (siehe Bild).</P>
Cellular Uptake Properties of the Complex Derived from Quantum Dots and G8 Molecular Transporter
Im, Jung-Kyun,Maiti, Kaustabh K.,Kim, Wan-Il,Kim, Kyong-Tai,Chung, Sung-Kee Korean Chemical Society 2011 Bulletin of the Korean Chemical Society Vol.32 No.4
The biotin-attached G8 molecular transporter (5) was synthesized and used together with quantum dots in preparing the complexes (QD-MT). The QD-MT complexes were studied in terms of the cellular uptake and the internalization mechanism in live HeLa cells with the aid of various known endocytosis inhibitors. It has been concluded that the QD-MT complex is internalized largely by macropinocytosis. The mouse tissue distribution of the QD-MT complex by i.p. and i.v. routes showed some organ selectivity and a good ability to cross the BBB.
Jin, Juyoun,Lee, Woo Sirl,Joo, Kyeung Min,Maiti, Kaustabh K.,Biswas, Goutam,Kim, Wanil,Kim, Kyong-Tai,Lee, Se Jeong,Kim, Kang-Ho,Nam, Do-Hyun,Chung, Sung-Kee Royal Society of Chemistry 2011 MedChemComm Vol.2 No.4
<P>The per oral administration of compound 1, prepared by covalently attaching paclitaxel to a molecular carrier, shows good anti-tumor activity in the orthotopic mouse model of glioblastoma. The anti-tumor effects may be attributable to the cytotoxicity as well as the anti-angiogenic activity of the paclitaxel conjugate or paclitaxel itself in the brain parenchyma.</P> <P>Graphic Abstract</P><P>The per oral administration of 1, prepared by covalently attaching paclitaxel to a molecular carrier, shows good anti-tumor activity in the orthotopic mouse model of glioblastoma. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0md00235f'> </P>