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Mukherjee, Kaushik,Gupta, Sanjay Techno-Press 2014 Advances in biomechanics & applications Vol.1 No.2
Peri-acetabular bone ingrowth plays a crucial role in long-term stability of press-fit acetabular cups. A poor bone ingrowth often results in increased cup migration, leading to aseptic loosening of the implant. The rate of peri-prosthetic bone formation is also affected by the polar gap that may be introduced during implantation. Applying a mechano-regulatory tissue differentiation algorithm on a two-dimensional plane strain microscale model, representing implant-bone interface, the objectives of the study are to gain an insight into the process of peri-prosthetic tissue differentiation and to investigate its relationship with implant-bone relative displacement and size of the polar gap. Implant-bone relative displacement was found to have a considerable influence on bone healing and peri-acetabular bone ingrowth. An increase in implant-bone relative displacement from $20{\mu}m$ to $100{\mu}m$ resulted in an increase in fibrous tissue formation from 22% to 60% and reduction in bone formation from 70% to 38% within the polar gap. The increase in fibrous tissue formation and subsequent decrease in bone formation leads to weakening of the implant-bone interface strength. In comparison, the effect of polar gap on bone healing and peri-acetabular bone ingrowth was less pronounced. Polar gap up to 5 mm was found to be progressively filled with bone under favourable implant-bone relative displacements of $20{\mu}m$ along tangential and $20{\mu}m$ along normal directions. However, the average Young's modulus of the newly formed tissue layer reduced from 2200 MPa to 1200 MPa with an increase in polar gap from 0.5 mm to 5 mm, suggesting the formation of a low strength tissue for increased polar gap. Based on this study, it may be concluded that a polar gap less than 0.5 mm seems favourable for an increase in strength of the implant-bone interface.
Susmita Sil,Kaushik Bhandari,Pritha Gupta,Rupsa Ghosh,Analava Mitra,Bijoy Chandra Ghosh,Tusharkanti Ghosh 경희대학교 융합한의과학연구소 2018 Oriental Pharmacy and Experimental Medicine Vol.18 No.1
India is the largest consumer of black tea in the world, which has been reported to have different protective functions in several diseases. TV 25 variety back tea has high content of polyphenols and has anti-oxidant potential. This anti-oxidant property of black tea (TV 25 variety) may prove to be effective in ameliorating the oxidative stress, neuroinflammation linked cognitive impairments and peripheral immune responses in intracerebroventricular colchicine injected rats (ICIR). However, there is no report in literature in this regard. Aim of the study: Therefore, this study has been designed to investigate the effects of black tea (BT) (TV 25 variety) on the colchicine induced cognitive impairments, acetylcholine esterase activity and peripheral immune responses along with oxidative/ nitrosative stress. The oxidative stress (OS)/ nitrosative stress (NS) and increased acetylcholine esterase level in the hippocampus of ICIR were associated with working and reference memory impairments along with changes of stress markers of serum and alteration of peripheral immune responses (higher phagocytic activity of blood WBC and splenic PMN, higher cytotoxicity and lower leukocyte adhesion inhibition index of splenic MNC). Administration of BT in ICIR resulted in recovery of colchicine induced memory impairments, acetylcholine esterase level in the hippocampus, OS and NS in hippocampus and serum along with recovery of peripheral immune responses and serum corticosterone level. Therefore, it appears that the anti-oxidant potential of BT (TV 25) is potent enough to protect the colchicine induced OS/ NS and related memory impairments in ICIR.
Indranil Saha,Uday Chand Ghosh,Kaushik Gupta,Sudipta Chakraborty,Debashis Chatterjee 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4
This study investigates the adsorption of As(III) on b-cyclodextrin modified hydrous ferric oxide (HCC). This is characterized by XRD, FESEM, AFM, XPS, BET, surface site concentration and FTIR. The modification of hydrous ferric oxide (HFO) surface by b-cyclodextrin provides ample –OH groups which in turn increase As(III) adsorption on HCC compared to HFO. The adsorption remains almost constant in pH range 3–8 which decreases at higher pH (>8) and followed monolayer and pseudo first order kinetics. It is spontaneous at 303 K with increasing entropy and decreasing enthalpy. Thus HCC is found to be more efficient adsorbent than HFO.
Singh Himani,Niharika,Lamichhane Pradeep,Gupta Ravi,Kaushik Neha,최은하,Kaushik Nagendra Kumar 한국식물생명공학회 2023 Plant biotechnology reports Vol.17 No.6
Pesticides have been an integral part of modern agriculture as their use ensures good harvests. However, excessive use of pesticides in the last few decades has caused significant environmental degradation. Moreover, excessive use of pesticides causes stress on crops and non-target plants and exhibits toxicity to other organisms including mammals, microbes, and insects. Plants employ various morphological, physiological, and biochemical mechanisms to reduce pesticides toxicity. One such mechanism is production of secondary metabolites that improves stress tolerance of plants. In addition, recent studies have also highlighted a potential role of plasma technology in mitigating various abiotic and biotic environmental stresses. Besides, plasma treatment improves seed germination, physiological processes, and seedling establishment during the early growth stages of a plant under adverse and non-adverse conditions and thus can be used an alternate to the pesticide treatment. This review article summarizes recent advancements in understanding the synthesis, accumulation, and transportation of secondary metabolites which have significant relevance to crop improvement programs. We also present an overview of the effects of plasma treatment on phytopathogenic bacterial cell suspensions and plant responses to metabolic activity. In the future, researchers need to develop innovative ideas to reduce the use of chemical pesticides in farming practices.