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        • KCI등재SCOPUS

          In vitro hemorheological effects of parenteral agents used in peripheral arterial disease

          Katalin,Biro,Barbara,Sandor,Andras,Toth,Katalin,Koltai,Judit,Papp,Miklos,Rabai,Kalman,Toth,Gabor,Kesmarky 한국유변학회 2014 Korea-Australia rheology journal Vol.26 No.2

          Peripheral arterial disease (PAD) is a frequent manifestation of systemic atherosclerosis. In PAD hemorheologicalparameters were defined as risk factors in a number of studies and several therapeutic agents weretried in these conditions. Our study aims to investigate and compare the in vitro hemorheological effectsof various drugs generally used in the parenteral treatment of intermittent claudication and critical limbischemia. Blood samples of healthy male volunteers were incubated with iloprost, alprostadil, pentoxifylline,sulodexide or pentosan polysulfate at calculated therapeutic serum concentration. Hematocrit(Hct) was determined by microhematocrit centrifuge. Plasma and apparent whole blood viscosities (WBV)were evaluated by capillary viscometer. Red blood cell aggregation was measured by LORCA (laserassistedoptical rotational cell analyzer) aggregometer, and LORCA ektacytometer was used for measuringerythrocyte deformability at 37°C. Iloprost, alprostadil, and pentoxifylline incubation did not have any significanteffect on plasma and apparent WBV. Elongation index increased in samples incubated with alprostadilat low shear stresses 0.95 and 0.53 Pa (p < 0.05). Sulodexide significantly improved WBV and Hct/WBV ratio (p < 0.05). Incubation with pentosan polysulfate resulted in higher WBV, lower Hct/WBV ratioand deterioration in the aggregation parameters (p < 0.05). Sulodexide may have beneficial effect on a macrorheologicalparameter; alprostadil may improve a microrheological parameter. Hemorheological alterationscould be important in PAD patients with hampered vasodilator capacity.

        • SCIESCOPUSKCI등재

          In vitro hemorheological effects of parenteral agents used in peripheral arterial disease

          Biro,,Katalin,Sandor,,Barbara,Toth,,Andras,Koltai,,Katalin,Papp,,Judit,Rabai,,Miklos,Toth,,Kalman,Kesmarky,,Gabor 한국유변학회 2014 Korea-Australia rheology journal Vol.26 No.2

          Peripheral arterial disease (PAD) is a frequent manifestation of systemic atherosclerosis. In PAD hemorheological parameters were defined as risk factors in a number of studies and several therapeutic agents were tried in these conditions. Our study aims to investigate and compare the in vitro hemorheological effects of various drugs generally used in the parenteral treatment of intermittent claudication and critical limb ischemia. Blood samples of healthy male volunteers were incubated with iloprost, alprostadil, pentoxifylline, sulodexide or pentosan polysulfate at calculated therapeutic serum concentration. Hematocrit (Hct) was determined by microhematocrit centrifuge. Plasma and apparent whole blood viscosities (WBV) were evaluated by capillary viscometer. Red blood cell aggregation was measured by LORCA (laserassisted optical rotational cell analyzer) aggregometer, and LORCA ektacytometer was used for measuring erythrocyte deformability at $37^{\circ}C$. Iloprost, alprostadil, and pentoxifylline incubation did not have any significant effect on plasma and apparent WBV. Elongation index increased in samples incubated with alprostadil at low shear stresses 0.95 and 0.53 Pa (p < 0.05). Sulodexide significantly improved WBV and Hct/WBV ratio (p < 0.05). Incubation with pentosan polysulfate resulted in higher WBV, lower Hct/WBV ratio and deterioration in the aggregation parameters (p < 0.05). Sulodexide may have beneficial effect on a macrorheological parameter; alprostadil may improve a microrheological parameter. Hemorheological alterations could be important in PAD patients with hampered vasodilator capacity.

        • COMPARISON OF HOTEL CLASSIFICATION IN JAPAN AND KOREA

          Katalin,Cser,Yukihiko,Oyanagi,Azuma,Ohuchi 세계문화관광학회 2007 Conference Proceedings Vol.8 No.0

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          This paper examines two Asian countries, Japan and Korea and compares their hotel classification system. Many studies have been reported about classification schemes in general, but less research has been engaged with detailed analysis. This work aims to contribute to fill in the gap by comparing structures and characteristics of the two systems and analyzing the differences. This work further investigates high-class hotels in Hokkaido and studies whether they would meet the requirements for high-category hotels in Korea as well. This paper suggests that the results of this investigation would assist Korean tourists to make easier and faster decisions for hotels in Japan and to avoid disappointments and misperceptions in advance.

        • Expectation of smart mentality and citizen participation in technology-driven cities

          Katalin,Feher 국제구조공학회 2021 Smart Structures and Systems, An International Jou Vol.27 No.3

          The purpose of the paper is to investigate the expectations of smart mentality and citizen participation in technology-driven cities. 150 mainstream trend reports, white papers, and research summaries are analyzed in one corpus as business, governmental, and university research cooperations. The changing trends of the related academic literature frame the study. Keyword statistics, word pairs, content networks, and correlation matrix reveal the expected citizen participation. The most referenced top ten cities and their strategies support the understanding of the smart mentality behind the participation. According to the findings, open data, communities, collective participation, socio-technical engagement, and empowerment are the most expected human factors. Anonymity, neighborhood-based implementations, and temporary human roles are underrepresented in the corpus, as well as the privacy concerns and ethical issues. However, the emerging AI technology and the interpretative metaphors with rainforest, team player, and public agora urge a focus also on these indicators with a contribution of citizen engagement. The paper provides governmental policymaking and the academic research of technology-driven cities with a citizen-centric and complex summary.

        • KCI등재

          Efficient and Reliable in vitro Regeneration System for Rubus Species as the Basis of Genetic Engineering

          Kalai,Katalin,Meszaros,Annamaria,Denes,Ferenc,Zatyko,Jozsef,Balazs,Ervin The Korean Society of Plant Biotechnology 2005 식물생명공학회지 Vol.7 No.4

          Factors affecting regeneration of different Rubus varieties (blackberry, raspberry and their hybrid) were examined and a reliable regeneration system was established. Media for stock plant maintenance were tested; different explants and media were investigated to find the best circumstances for the regeneration. The effect of the commonly used antibiotics was studied to determine the most suitable one for selection of the transformants. We found that both MS and LS media supplemented by $20\;gL^{-1}$ sucrose are suitable for the stock plant maintenance. The optimal hormone content for the stock plants is $0.125\;mgL^{-1}$ 6-benzylaminopurine (BAP) with $0.01\;mgL^{-1}$ indole-3- butyric acid (IBA). The highest regeneration rate was observed on medium containing MS salts with B5 vitamins complemented with glucose, sucrose, maltose, $10\;gL^{-1}$ each, supplemented with benzylaminopurine riboside (BAR) ($2\;mgL^{-1}$) and indole-3-acetic acid (IAA) ($0.1\;mgL^{-1}$). The regenerated shoots appeared directly from the cut edges, without callus phase. Hygromycin and geneticin proved to be good selection agents for the Rubus explants, but due to their severe effect on the tissues we propose to use marker-free constructions for the transformation.

        • KCI등재SCOPUS

          Apocrine Encapsulated Papillary Carcinoma of the Breast: The First Reported Case with an Infiltrative Component

          Bence,Kővári,Katalin,Ormándi,Zsolt,Simonka,András,Vörös,Gábor,Cserni 한국유방암학회 2018 Journal of breast cancer Vol.21 No.2

          Apocrine encapsulated papillary carcinoma (EPC) of the breast is a rare neoplasm, and only 10 cases have been reported in the literature to date. Although EPC by definition lacks a peripheral myoepithelial layer, all previously published apocrine EPC cases were clinically indolent and lacked a conventional invasive component. Herein, we report the 11th case of apocrine EPC, which had a conventional invasive carcinoma component and provides evidence of the malignant potential of this entity. We postulate that apocrine EPC is most likely a morphological variant of conventional EPC, with the same unpredictable malignant potential as non-apocrine cases.

        • KCI등재

          Comparative Study of Hydroxyapatite Prepared from Seashells and Eggshells as a Bone Graft Material

          이상운,Csaba,Balázsi,Katalin,Balázsi,서동현,김한성,김창현,김성곤 한국조직공학과 재생의학회 2014 조직공학과 재생의학 Vol.11 No.2

          The aims of this study were to determine the physical properties of hydroxyapatite from seashells (sHA)and from eggshells (eHA), to analyze elements within sHA and eHA, and to compare the bone regeneration ability between sHA and eHA in a rat parietal bone defect model. The sHA and eHA particles had a similar morphology in scanning electron microscope images. From the Fourier-transform infrared absorbance spectra and X-ray diffraction results, both types of hydroxyapatite (HA) had the characteristics of pure HA. Inductively coupled plasma atomic emission spectroscopy results suggested that the sHA had higher levels of sodium and strontium than the eHA,whereas the eHA had higher levels of magnesium than the sHA. In µ-CT results, the mean bone mineral density of the sHA was significantly higher than the control at 4 weeks after the operation (p=0.012). The mean bone volume of the eHA was significantly higher than the control at 8 weeks after the operation (p=0.012). In the histological images at 4 weeks after the operation, foreign body multinucleated giant cells were observed around the agglomer-ated sHA particles, while there were fewer inflammatory reactions around the agglomerated eHA particles. The eHA group showed better results in bone formation than did the sHA group in this study.

        • SCOPUSKCI등재

          Comparison of the rheological and diffusion properties of some gelling agents and blends and their effects on shoot multiplication

          Dobranszki,,Judit,Magyar-Tabori,,Katalin,Tombacz,,Etelka The Korean Society of Plant Biotechnology 2011 Plant biotechnology reports Vol.5 No.4

          The rheological and diffusion properties of blends of agar/guar gum, agar/Phytagel and Phytagel/guar gum were analysed and compared to those properties of agar or Phytagel applied alone at two different gelling concentrations. Moreover, their effects on the shoot multiplication of the apple scion Galaxy and two black locust clones (SF63, SF82) were studied, and their cost benefits over agar were calculated. Elastic hydrogel formation was demonstrated for each blend by rheological measurements, but the gel strength depended on the types and concentrations of the applied gelling agents and blends. Guar gum was able to speed the diffusion in the different blends, and diffusion was independent of gel strength. The rate of shoot multiplication increased (to 8.9 shoots per explant) and the percent of hyperhydrated shoots decreased (to 12%) when the blend of agar/guar gum was used for the shoot multiplication of apple. Similarly, the highest multiplication rates of black locust clones (between 3.9 and 4.1) were obtained on media solidified by blends containing guar gum. The best shoot performance with the lowest percent of hyperhydrated shoots (11-12% in SF63 and 2-23% in SF82) was achieved using agar alone or the agar/guar gum blend. The shoot multiplication was improved of both species and the production cost was reduced by 42% by using the agar/guar gum blend.

        • KCI등재SCOPUS

          The Frequency of and Risk Factors for the Use of Bisphosphonates in the Adjuvant Setting of Primary Breast Cancer in Germany

          Eva-Maria,Fick,Alexander,Katalinic,Annika,Waldmann 대한암학회 2015 Cancer Research and Treatment Vol.47 No.4

          Purpose The aim of this cross-sectional health care study (use of bisphosphonates in primary tumorsof the mammae, EBisMa) is to determine how often bisphosphonate medication is used inpatients with non-metastatic primary breast cancer treatment, but who do not suffer fromosteoporosis. Furthermore, we describe patients' characteristics and the most frequentlyused type of bisphosphonate in adjuvant therapy. Materials and MethodsThe study population included primary breast cancer patients of four breast centers in northernGermany. Data on bisphosphonate therapy were collected by use of patient questionnaires;clinical data were extracted from the registers. Patients with and without prescribedbisphosphonate adjuvant treatment were tested for statistically significant differencesregarding their characteristics. ResultsFour hundred seventy-four of 663 contacted patients participated in the study. Thirty-nineout of 474 patients (9.6%) were on adjuvant bisphosphonate therapy. Zoledronic acid wasthe most frequently reported bisphosphonate used for prevention of bone metastases. Comparedto patients who did not report bisphosphonate medication, women who did reportbisphosphonate therapy had a significantly higher advanced tumor stage (p < 0.001). Boththe T2-T4 stage and N+ stage remained significant predictors in multivariate-adjustedregression models. ConclusionBisphosphonates are rarely used in the adjuvant treatment of primary breast cancer. Patients with advanced tumor stage were more likely to use bisphosphonates in the adjuvanttreatment of primary breast cancer. Further research is needed to identify patientswho may benefit most from adjuvant bisphosphonate treatment.

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