In vitro Activity of Sodium Benzoate Against Clinically Relevant Enterococcus faecalis and Enterococcus faecium Isolates

Karabay Oguz,Kocoglu Esra,Ince Nevin,Sahan Tufan,Ozdemir Davut The Microbiological Society of Korea 2006 The journal of microbiology Vol.44 No.1

The antimicrobial effects of sodium benzoate against Enterococcus faecalis and Enterococcus faecium were investigated. The $MIC_{90}$ of sodium benzoate were 64 mg/ for E. faecalis and 32 mg/L for E. faecium, while the $MBC_{90}$ were 128 mg/L and 64mg/L, respectively. Although further studies are required for clinical evidence, sodium benzoate seems to be effective against Enterococcus spp.

The effect of mobile scaffolding on academic achievement and cognitive load of third grade students in mathematical problem solving

Firuzan Hilal Karabay,Can Meşe 서울대학교 교육연구소 2025 Asia Pacific Education Review Vol.26 No.1

In the study, problem-solving educational software (ProSES) was developed to reduce the challenges and mistakes experienced by primary school third-grade students in mathematical problem solving and to provide scafolding and hint support for teacher help for the students using mobile technologies. The study aimed to determine the impact of the employment of this educational software on academic achievements and cognitive load of the students. The study was conducted with the experimental design, a quantitative research method, with 130 third grade students during the 2019–2020 academic year fall semester. Based on the study aim, ProSES was employed in two experimental and one control groups. All group members were assigned with simple random sampling method. Mental efort scale, task completion speed and academic achievement test were used to collect the study data. The fndings showed that scafolding was efective in academic achievement. Thus, this study adds to the current literature by showing that mobile scafolding efective to improve students’ problem solving in mathematical problems of teacher support in primary education.

The Effects of Systemic Psoriasis Therapies on the C-Reactive Protein and the Neutrophil-Lymphocyte Ratio

( Ezgi Aktaş Karabay ),( Aslı Aksu Çerman ),( Damla Demir ),( Ilknur Kıvanç Altunay ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.6

Background: Currently, no generally accepted laboratory marker for monitorizing the disease activity and therapy response of psoriasis is known. Objective: The aim of the study is to evaluate the effects of systemic therapies on C-reactive protein (CRP) and the neutrophil-lymphocyte ratio (NLR) in psoriasis. Methods: One hundred patients with psoriasis treated with narrow band ultraviolet B, acitretin, cyclosporine, methotrexate, adalimumab, etanercept, and ustekinumab were prospectively evaluated. At baseline and at week 12, CRP, NLR, and Psoriasis Area and Severity Index (PASI) were evaluated. Results: A statistically significant decrease was observed in PASI scores, CRP, and NLR values from the baseline to the 12-week visit (p=0.001, p=0.001, p=0.001, respectively). The reduction in PASI scores and NLR values was positively correlated (r=0.460, p=0.001). The comparisons between treatment groups revealed that the median decrease in NLR values was statistically higher in the adalimumab group than in the methotrexate group (p=0.007). And the median decrease in PASI scores was significantly higher in the adalimumab group compared with the methotrexate and acitretin therapy group (p=0.007, p=0.042, respectively). Conclusion: In the present study, systemic therapy of psoriasis was demonstrated to decrease the levels of CRP and NLR, which are known to be indicators of systemic inflammation and cardiovascular comorbidities. (Ann Dermatol 31(6) 601∼610, 2019)

In vitro Activity of Sodium Benzoate Against Clinically RelevantEnterococcus faecalis and Enterococcus faecium Isolates

Esra Kocoglu,Oguz Karabay,Nevin Ince,Tufan Sahan,Davut Ozdemir 한국미생물학회 2006 The journal of microbiology Vol.44 No.1

The antimicrobial effects of sodium benzoate against Enterococcus faecalis and Enterococcus faecium were investigated. The MIC90 of sodium benzoate were 64 mg/L for E. faecalis and 32 mg/L for E. faecium, while the MBC90 were 128 mg/L and 64mg/L, respectively. Although further studies are required for clinical evidence, sodium benzoate seems to be effective against Enterococcus spp.

Letter to the Editor: The Bacterial Etiology of Otitis Media and Specimen Collection

Ertugrul Guclu,Oguz Karabay 대한의학회 2017 Journal of Korean medical science Vol.32 No.9

Our journey as intern junior editors at the Journal of Experimental Psychology: Human Perception and Performance

Ségolène M. R. Guérin,Cynthia Tarlao,Aytaç Karabay 한국과학학술지편집인협의회 2024 Science Editing Vol.11 No.2

Dynamic Finite Element Analysis on Single Impact Plastic Deformation Behavior Induced by SMAT Process in 7075-T6 Aluminum Alloy

Eser Yarar,A. Tamer Erturk,Sedat Karabay 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.8

Surface mechanical attrition treatment (SMAT) is a method that enhances the mechanical properties of metallic materialsby generating a thin nanostructured layer on the top surface. In this study, single-shot impact behavior was modeled for the7075-T6 aluminum alloy to reach maximum values of equivalent stress, plastic strain, deformation depth, residual stressdepth, and residual stress. Finite element simulations have been carried out to analyze the efect of selected parameters onstress and strains in the component. For simulating the SMAT process, a rigid sphere on a rectangular component is modeledusing ANSYS/AUTODYN explicit dynamic solver. The plastic deformation process during SMAT was analyzed accordingto shot velocity and diameter with a dynamic explicit fnite element method (FEM). The response surface methodologywas used to evaluate the parametric results for the SMAT process. In addition, deformation behavior was evaluated after asingle-shot impact according to the restitution coefcient.

An Outbreak of Oropharyngeal Tularemia with Cervical Adenopathy Predominantly in the Left Side

Irfan Sencan,Idris Sahin,Sukru Oksuz,Davut Ozdemir,Oguz Karabay 연세대학교의과대학 2009 Yonsei medical journal Vol.50 No.1

Purpose: We describe the epidemiological and clinical characteristics and the efficacy of a delayed initiation to therapy in an oropharyngeal tularemia outbreak in Duzce, Turkey. Materials and Methods: Between March and June 2000, 22 patients with tularemia were diagnosed by microagglutination tests. Results: Oropharyngeal and ulceroglandular forms of the disease were discovered. Most of the cases were oropharyngeal (19 cases). The most common symptoms were sore throat (95.4%) and fever (90.9%). Lymphadenopathy (95.4%) and pharyngeal hyperemia (81.8%) were usually observed signs. The lymphadenopathies were localized especially in the left cervical region (66.7%), a finding that has not been previously reported in the literature. The time between the onset of the symptoms and diagnosis was 40.7±22.8 (10-90) days. The patients were treated with streptomycin plus doxycycline and ciprofloxacin. The patients' recoveries took up to 120 days. Conclusion: This report describes the first outbreak of tularemia in northwest Turkey. Tularemia may occur in any region where appropriate epidemiological conditions are found and should be kept in mind for differential diagnosis in oropharyngeal symptoms. Late initiation of therapy may delay complete recovery. In this outbreak, cervical lymph nodes predominantly localized on the 1eft side were found, which had not been previously reported.

Reduced-Dose Systemic Fibrinolysis in Massive Pulmonary Embolism: A Pilot Study

Aykan Ahmet Çağrı,Gökdeniz Tayyar,Gül İlker,Kalaycıoğlu Ezgi,Karabay Can Yücel,Boyacı Faruk,Hatem Engin,Weingart Scott D.,Dursun İhsan 대한응급의학회 2023 Clinical and Experimental Emergency Medicine Vol.10 No.3

Objective: Severe pulmonary embolism (PE) has a high mortality rate, which can be lowered by thrombolytic therapy (TT). However, full-dose TT is associated with major complications, including life-threatening bleeding. The aim of this study was to explore the efficacy and safety of extended, low-dose administration of tissue plasminogen activator (tPA) on in-hospital mortality and outcomes in massive PE. Methods: This was a single-center, prospective cohort trial at a tertiary university hospital. A total of 37 consecutive patients with massive PE were included. A peripheral intravenous infusion was used to administer 25 mg of tPA over 6 hours. The primary endpoints were in-hospital mortality, major complications, pulmonary hypertension, and right ventricular dysfunction. The secondary endpoints were 6-month mortality and pulmonary hypertension and right ventricular dysfunction 6 months after the PE. Results: The mean age of the patients was 68.76±14.54 years. The mean pulmonary artery systolic pressure (PASP; 56.51±7.34 mmHg vs. 34.16±2.81 mmHg, P<0.001) and right/left ventricle

Which One is More Effective, Filgrastim or Lenograstim, During Febrile Neutropenia Attack in Hospitalized Patients with Solid Tumors?

Sonmez, Ozlem Uysal,Guclu, Ertugrul,Uyeturk, Ummugul,Esbah, Onur,Turker, Ibrahim,Bal, Oznur,Budakoglu, Burcin,Arslan, Ulku Yalcintas,Karabay, Oguz,Oksuzoglu, Berna Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.3

Background: Chemotherapy-induced febrile neutropenia (FN) with solid tumors causes mortality and morbidity at a significant rate. The purpose of this study was to compare the effects of filgastrim and lenograstim started with the first dose of antibiotics in hospitalized patients diagnosed with FN. Materials and Methods: Between February 2009 and May 2012, 151 patients diagnosed with FN were evaluated, retrospectively. In those considered appropriate for hospitalization, convenient antibiotic therapy with granulocyte colony stimulating factors was started within first 30 minutes by completing necessary examinations in accordance with FEN guide recommendations. Results: In this study, 175 febrile neutropenia attacks in 151 patients were examined. Seventy three of the patients were male and 78 were female. The average age was 53.6 and 53.6, respectively. The most common solid tumor was breast carcinoma in 38 (25%). One hundred and five FN patients (58%) were those who received granulocyte colony stimulating factors as primary prophylaxis. Conclusions: While studies comparing both drugs generally involve treatments started for prophylaxis, this study compared the treatment given during the febrile neutropenia attack. Compared to lenograstim, filgastrim shortens the duration of hospitalization during febrile neutropenia attack by facilitating faster recovery with solid tumors.