간세포암의 고주파 열치료 후 천자침 경로를 통한 전이 1례

조영완,박석주,진한영,김준영,이재익,강명주,박정하,윤정희,박성재,지삼룡,이연재,이상혁,설상영 인제대학교 2006 仁濟醫學 Vol.27 No.-

Radiofrequency ablation(RFA), as a form of minimally invasive therapy for hepatocellular carcinoma, has become an important treatment modality. Because of limitation of surgery, RFA has become standard therapy for hepatocellular carcinoma in some situations. But there are some complications of RFA such as bleeding, infection, hematoma, adjacent organ thermal damage including intestinal perforation, needle track seeding, and so on. There are few reports in the literature that systematically evaluate the incidence of needle tract seeding and its associated risk factors. And only 2 cases of needle tract seeding of hepatocellular carcinoma after RFA were reported in Korea. We report a case of needle tract seeding of hepatocellular carcinoma after RFA.

남성화를 보이는 여성에서 발견된 난소의 Steroid Cell Tumor 1예

조인호,정대훈,박영미,서영진,손영실,정철회,강영미,정수전,김영남,이경복,성문수,김기태 인제대학교 2006 仁濟醫學 Vol.27 No.-

Steroid cell tumor is a rare ovarian sex cord-stromal tumor which accounts for 0.1% of all ovarian tumors. Until now, only 4 cases have been reported in domestic literatures. Steroid cell tumor often secrets testosterone and presents virilization in adult women or precocious puberty in children. Treatment is often performed by surgical removal, adjuvant chemotherapy and radiation, but completely accepted treatment was not existed. We experienced a case of steroid cell tumor, which was manifested by typical virilization in a 43-year old patient, who was previously performed hysterectomy and unilateral oophorectomy. So, we present with a brief review of the literatures.

Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

영도에서 조망하는 부산항 경관의 시각적 특성

박문순,강영조,조승래,강헌우,차명숙,Park, Moon-Sook,Kang, Young-Jo,Cho, Seung-Rae,Kang, Hyon-Woo,Cha, Myeong-Sook 한국조경학회 2010 韓國造景學會誌 Vol.38 No.4

본 연구는 영도에서 부산항을 체험할 수 있는 조망점을 대상으로 조망점의 공간적 분포, 부산항을 체험하는 시선의 유형, 항구경관의 구도적 특성 그리고 조망점의 시각특성을 밝히고자 하였다. 선정된 조망점 27개소를 대상으로 한 연구의 결과는 다음과 같다. 첫째, 조망점의 공간적 분포 유형은 공원형, 공공시설형, 도로변형으로 구분되었다. 조망점은 도로변형에서 가장 많이 분포하는 것으로 나타났다. 둘째, 부산항을 체험하는 시선의 유형은 수제선회유형, 항만대변형, 도시관통형으로 나타났다. 영도에서 바라보는 부산항 경관에 대한 시선의 유형은 도시관통형이 가장 많이 나타났다. 이유로는 영도라는 섬이 도시화로 인해 시가지와 도로가 점점 확장되면서 부산항을 바라보는 시선이 도시를 관통하여 바다를 조망하는 시선이 많아지게 된 것으로 보인다. 셋째, 항구경관의 구도적 특성은 파노라마형, 회랑형, 지붕너머형으로 파악되었다. 그 중 지붕너머형이 가장 많이 나타났다. 이를 통해 영도에서 체험하는 부산항의 모습은 대부분 경관의 연속성이 상실되고, 주거지의 지붕이 거리감을 차단하여 일종의 차경 역할을 하는 것을 알 수 있었다. 마지막으로 조망점의 시각특성을 분석하였다 조망정의 부각은 수평경에 가까운 $-3^{\circ}{\sim}-1^{\circ}$사이에 13개소, $-6^{\circ}{\sim}-4^{\circ}$의 범위에 12개소로 가장 많은 분포를 보였다. 부감의 시축에 해당되는 조망점은 2개소로 나타났다. 이는 시가지가 확장되면서 건물에 의해 내려다보는 시선이 차단된 결과로 판단되었다. 그리고 시거리의 지리적 범위는 0.2km~6.4km에 이르는 광범위한 조망역을 이루고 있었다. 최적의 부감경을 체험할 수 있는 조망점 2개소는 지속적으로 조망을 보전하기 위한 방법을 제안하였다. 본 연구의 성과는 부산의 경우와 같은 항만도시에 있어서 조망점의 관리 및 보전 등의 경관계획에 기초자료로 활용할 수 있을 것으로 기대한다. This study will define the features of the viewpoint that best enables the view of Busan Port from Young-Do. Special focus will be on spatial distribution, the type Busan Port sights that can be experienced from Young-Do, the compositional characteristic of a port landscape and visual characteristic. The results are based on 27 selected viewpoints and are as follows. Firstly, the patterns of the spatial distribution of viewpoints are classified as park, public facility and wayside types. It was found that most viewpoints are located along a wayside. Secondly, the types of Busan Port sights that can be experienced from Young-Do are divided into three kinds: surrounding stand-line type, facing the port and the type of penetrating city. The major type was of penetrating city among the three patterns. The reason for this is that the point of view for Busan Port was changed into a prospect over the sea since city and road sections have been expanding due to the urbanization of Young-Do. Thirdly, the compositional characteristics of the port landscape are divided into three styles: panoramic, corridor, and rooftop. The most frequent type is the rooftop style among the three characteristics. This fact indicates that the picture of Busan Port seen from Young-Do loses continuity of view and that housetops inhibit the sense of distance. Lastly, the visual characteristics of the viewpoint were analyzed. The angles of the declination of the viewpoints are concentrated on the horizontally closed parts. Thirteen points lie between $-3^{\circ}$ and $-1^{\circ}$, and twelve points between $-6^{\circ}$ and $-4^{\circ}$. The visual axes of the depression are two points because sight is interrupted by buildings which are built when the city expands. Two viewpoints for experiencing the optimum landscape of depression should be prepared to ensure continuous preservation of the viewpoints. The sight creates a wide prospect, reaching from 0.2km to 6.4km. It is expected that the results of this study can be used for the landscape plans of port cities including the management and preservation of viewpoints.

거주지역의 녹지환경평가와 녹지의 종류에 관한 주민의식 : 부산시 소재 국민학교 학부형의 의식조사를 중심으로

姜榮祚 동아대학교 환경문제연구소 1989 硏究報告 Vol.12 No.2

This study was carried out to evaluation the citizen's satifaction and quantity toward the green space residential area in pusan. The purpose of this study was to development more rational and user-oriented theory of urban green space planning. The results are following as ; 1. The evaluation of green correlation with the comfortableness and beauty of residential environment. 2. Citizen's evaluation of green quantity determinant a daily green space which are mountain, garcen, building green, roadside tree. 3. Citize's evaluation of green satisfaction determinant a daily green space which mountain, garden, roadside tree, mineral spring. 4. It is important green to plan green space in residential area such a daily green as visual green and recreation space. 5. Garden and mountain is a important green space to plan green space in residential area.

해운대 달맞이 언덕에 있어서 바다조망경관의 역사적 변천에 관한 연구

강영조,신수안,조미나,이현주,박은희 동아대학교 건설기술연구소 2000 硏究報告 Vol.24 No.1

The purpose of this study is to clarify the historic transition of the prospects on Haeundae dalmaji hill. Dalmaji hill is well known for a character of configuration on the ground with the scene of the sea. We will infer that how did it change the prospects of Dalmaji hill's sea through the analyzing of the preset situation and location of building on the hill. (1) We investigated the stories of the building, the history, the business condition. (2) We collect the twenty four view points which is able to have seascape on the hill, being easily approaching to the road, and condition of changing the building. (3) We clarified the transition of seascape prospect and considered the characteristics of the six types from which were divided the condition of seascape prospect.

지형의 相貌的知覺에 의한 생활규범과 그 역할에 관한 사례연구

姜榮祚 東亞大學校 大學院 1997 大學院論文集 Vol.22 No.-

Experience of landscape consist of "space aspect" and "figure". However there has been limited discussion on space aspect and pace array on landscape design. In order to obtain the landscape desingng concept in consideration landform, I aimed to prove the role of customs based on the physiognomically perceived landform as figure by analyzing place-names extracted from 13 settlements in Kyong-Sang-Nam-Do. Findings are as follows: 1. Customs which are controlled by the aspects based on physiognomic perception of landform divided into taboo, encouragement and conscience of ills. 2. Customs based on physiognomic perception of landform affect social bond of community. 3. I clarified the fact that the space taking on physiognomic figure can be a sacred place, and there are the living activity to preserve those place by customs.

Monotone l^(p) Shift의 性質에 관한 硏究

강주호,조영수 대구대학교 부설 과학교육연구소 1991 과학교육 Vol.4 No.-

터널노선의 지형적 입지와 坑門 형태의 상관관계 : 고속도로의 터널갱문을 중심으로 From analysis of the space perception about the entrance of a tunnel

강영조,박한우 동아대학교 건설기술연구소 2002 硏究報告 Vol.26 No.1

The purpose of this study is to clarify interrelation pithead of a tunnel and location of tunnel reviewing the landscape appreciation on the basis of space perception of the reviewing the landscape appreciation on the basis of space perception of the entrance of a tunnel. It is generally believed that the simple meaning of tunnel is a mere shortcut of road in order to move into another space at a short time. However it implies more than a short cut of road for the drivers and the passengers. They could enjoy not only a short distance but also appreciate the landscape and surrounding of the entrance of tunnel. To solve the above mentioned requirements, it is suggested that following factors must be considered at the step of drawing. first, the principle of landscape and appreciation. second, the condition of the route and the topography. third, the type grouping of the subject pit head of investigation according to the condition of the topography. As mentioned above, if the pithead form is designed, the result of study will be applied as the base data.