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Kim, Tae-Hoon,Kang, Heoung-Keun,Park, Kwangsung,Jeong, Gwang-Woo by The North American Menopause Society. 2014 Menopause Vol.21 No.1
OBJECTIVE: Functional magnetic resonance spectroscopy was used to compare brain metabolite changes between nonpostmenopausal and postmenopausal women exposed to visual sexual stimulation with erotic video clips. METHODS: Twenty nonpostmenopausal women and 20 postmenopausal women were enrolled in this study. Menopause was defined as continuous amenorrhea for more than 12 months and a follicle-stimulating hormone level higher than 40 mIU/mL. Brain metabolite concentrations were measured from a localized voxel on the anterior cingulate gyrus, one of the most important areas associated with sexual arousal. Subjective sexual arousal and attention to visual stimulation were assessed using a 5-point scale. Functional magnetic resonance spectroscopy data were acquired from nonpostmenopausal and postmenopausal women during rest and activation conditions. RESULTS: Compared with nonpostmenopausal women, postmenopausal women showed significantly lower levels of both &bgr;&ggr;-glutamate/glutamine and lipid during the “rest” period but had lower levels of &bgr;&ggr;-glutamate/glutamine only during the “activation” period (P < 0.05). CONCLUSIONS: This study finds differential brain metabolite changes during visual sexual arousal in nonpostmenopausal and postmenopausal women. These findings would be helpful in understanding the neural mechanism of visual sexual arousal in connection with brain metabolite changes after menopause.
Kim, Tae-Hoon,Kang, Heoung-Keun,Jeong, Gwang-Woo Blackwell Pub 2013 JOURNAL OF SEXUAL MEDICINE Vol.10 No.4
<P>Numerous functional magnetic resonance imaging (fMRI) studies demonstrated the key brain areas associated with visual sexual arousal. However, the changes in brain metabolites involved in sexual stimuli have not been reported.</P>
Shen, Yu-Lan,Kang, Heoung-Keun,Kim, Tae-Hoon,Sundaram, Thirunavukkarasu,Kim, Hyeong-Jung,Jeong, Gwang-Woo Korean Magnetic Resonance Society 2009 Journal of the Korean Magnetic Resonance Society Vol.13 No.2
The purpose of this study was to evaluate the usefulness of in vivo 3T $^1H$ MRS with short TE for prescreening various brain diseases. Together with ten normal volunteers, 12 brain tumor patients(2 lymphomas, 5 malignant gliomas) and 5(benign meningiomas) and 10 brain ischemic disease patients(6 acute and 4 subacute infarctions) participated. Lymphomas showed increased intensities of Cho and Lac. Likewise, gliomas showed increased Cho and Lac, but with decreased NAA and ${\beta}\;{\gamma}$-Glx; in higher grade of gliomas, Lac, Cho, mI and Lip predominantly increased with decrease of NAA. Benign meningiomas showed increased Cho, Lac and ${\beta}\;{\gamma}$-Glx; with decreased of NAA. The alanine peak at 1.47 ppm is a neuronal marker for meningiomas. Infarctions showed increased Lac and Lip and decreased NAA, ${\alpha}$-Glx and ${\beta}\;{\gamma}$-Glx where Lac increased with decreased of ${\alpha}$-Glx in acute, and Cho, Lac and Lip increased with decrease of NAA in subacute. Elevated Lac and decreased NAA levels were more aggravated in subacute. Clinical application of the $^1H$ MRS with short TE at 3T is able to povide valuable spectral information for prescreening various brain diseases by monitoring the changes of disease-specific cerebral metabolite concentrations in vivo, and consequently, it can be applicable to assessment of differential diagnosis and malignancy as well.