뇌성마비 환자의 뇌자기공명영상

강용수,김봉옥,김종철,송창준 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

Brain MRI findings were analyzed in 30 patients with clinical cerebral palysy to determine clinical role in assessment of time of brain damage. The patients (1 day to 14 yrs. old) underwent MR scanning and findings were correlated with clinical history retrospectively. Among 13 prematurely born patients, 11 cases showed abnormal findings in brain MR, which were periventricular leukomalacia in 10 patients and cortical gray matter disease in 1 patient. And MR scans of 17 patients born at or around the expected date of confinement were reviewed. Fifteen cases showed abnormal findings in MR, which are, cortical gary matter disease in 10 patients, deep white matter lesion in 3 patients and neuronal migration anomaly such as schizencephaly, polymicrogyria and pachygyria in 3 patients. Abnormality in contour of ventricle in prematurely born patients were dilatation of trigone & irregular ventricular contour in 4 patients and diffuse enlargement in 3patients. Among patients born at term, dilatation of trigone & irregular ventricular contour in 3 patients and diffuse enlargement in 6 patients were observed. Corpus callosal abnormalities were thinning of posterior body in 7 patients, diffuse thinning in one patient and irregularity in 4 patients among the prematurely born and thinning of posterior body in 9 patients, diffuse thinning in 2 patients, abscent in 1 patient and irregularity in 3 patients among the patients born at term. MR imaging seemed to be very useful in determining the time of the insult which could have been the cause of the cerebral palsy.

모 축전지 회사 근로자들의 연폭로 지표에 대한 경시적 관찰

강명식,김용배,이용진,리갑수,김화성,황규윤,장봉기,이성수,안규동,이병국 순천향대학교 산업의학연구소 1998 순천향산업의학 Vol.4 No.1

Lead poisoning is still prevalent and one of important occupational disease in Korea. To prevent undue high lead burden and maintain good health condition of lead workers in lead using industries, periodic health examination and regular biological monitoring of lead workers are often required in addition to the fundamental improvement of their working condition. To evaluate the effect of comprehensive occupational health program with regular biological monitoring on the level of lead exposure of lead workers in lead using industries, 11 year database from 1983 to 1994 of one storage battery factory was reviewed. From 1983 to end of 1986 only periodic health examination was provided to the lead workers, but from 1987 comprehensive occupational health program with regular biological monitoring was provided to maintain better health condition of lead workers. Selected study variables for lead exposure were blood lead(PbB), zinc protoporphyrin in blood(ZPP), δ-aminolevulinic acid in urine(ALAU), hemoglobin(Hb), hematocrit(HCT). Information on sex, age and work duration was also reviewed. 5 years data from 1983 to 1987 and 3 years data from 1990, 1993 and 1994 were available for all lead exposure indices except ALAU which has only 5 years data from 1983 to 1997. The results of 11 years longitudinal observation of lead indices are all follows: 1. The mean value of ZPP of lead workers in 1983 was 148.7±73.1 ㎍/㎗(Male: 145.5±72.3, Female: 168.1±79.1), whereas that of ZPP of lead workers in 1994 was decreased to 64.3±32.7 ㎍/㎗(Male: 60.2±28.8, Female: 95.2±43.4). 2. The mean value of PbB of lead workers in 1983 was 56.4±18.8 ㎍/㎗(Male: 55.59±19.1, Female: 59.6±19.1), whereas that of PbB of lead workers in 1994 was dcreased to 35.4±11.9 ㎍/㎗(Male: 35.7±12.0, Female: 32.8±10.8). 3. The mean value of Hb of lead workers in 1983 was 14.1±1.4 g/㎗(Male: 14.4±1.1, Female: 11.7±0.8), whereas that of Hb of lead workers in 1994 was increased to 15.6±1.5 g/㎗(Male: 15.9±1.2, Female: 12.9±1.1). 4. Blood lead is most highly correlated with ZPP(r=0.522, male:0.54 and female:0.50) and also correlated with ALAU and work duration also. 5. The simple regression analysis of PbB and ZPP showed different coefficient of regression by the measurement year, but there was no difference of coefficient of regression between sex. The slope of equation of pooled data for 1983-1986 without comprehensive occupational health program was 2.16 and differed from that of pooled data for 1987-1994(1.25). This difference suggests that the unit effect of blood lead on ZPP was relatively smaller in later period of comprehensive occupational health program than carly period without comprehensive program. The slope change in the analysis of linear regression of PbB on ZPP in lead workers can be used to evaluate the possible effect of health intervention to prevent undue high lead absorption in lead using industries. 6. 11 years occupational health service in this storage battery factory brought out considerable improvement of health status of lead workers in terms of decrease of PbB and ZPP and increase of Hb and the improvement was more remarkable after the introduction of comprehensive occupational health program.

Modal SI 기법 적용을 위한 최적 측정위치 선택

강태우,권순정,김용현,신수봉 東亞大學校 建設技術硏究所 2001 硏究論文集 Vol.25 No.2

In applying a modal system identification with a limited number of measuring degrees of freedom, the selection of optimal sensor locations (OSL) is critical for a good identification. The current research proposes a new OSL method applicable to a modal system identification (SI) and compares it with a widely used OSL method. The proposed method utilizes the sensitivity of eigenvectors with respect to the structural parameters. A simulation study for a tower structure has been carried out to demonstrate the efficiency of the proposed method. Through the simulation study, the influence of OSL on the structural parameters estimated by a S1 method are investigated.

달팽이관내 기저막의 유한요소 모델링

강희용,양성모,김봉철,임재중,용부중 한국공작기계학회 2002 한국생산제조학회지 Vol.11 No.1

Cochlea is well known to have the ability to analyze a wide frequency and this ability seems to be caused to the Basilar Membrane(BM) configuration. However, the relationship between the Cochlea frequency-position map is not clear. In this paper, the three-dimensional BM model was made using the Finite Element Method. Then, an attempt was made to examine the influence of the BM configuration on the Cochlea frequency-position map.

아세클로페낙 연질캡슬(클란자 에스 연질캡슬)의 개발

용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1

To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.

生物膜 ?過裝置에 의한 下水處理에 관한 硏究

姜龍太,全裕燦,趙奉衍 東亞大學校 1986 東亞論叢 Vol.23 No.1

This study, through the filtration experiment by biofilm, was explained the operation for each processes in its system, and were investigated the actual(filtration experiment by biofilm) applicational propriety for the existing headloss quation and the correlation of factors. The results of the experiment are the following. 1. When the raw water quality was reached to standars of the treated water quality in about a week, the average removal rates of SS, BOD and COD were 92%, 91% and 74%, respectively. 2. In case that the experimental conditions were water quantity, 0.67㎥/day, BOD 100㎎/ℓ, oxygen absorption efficiency, 16%, air quantity was 15N㎥ and showed high BOD removal rate. 3. The backwashing water quantity was required the twice or the three times of the packed volume. 4. When thd BOD loading was less then 5 ㎏/㎥·day, the BOD removal rate showed more than 95%. 5. The headloss of this experiment was approximated to the value obtained from substiting the filtration Model Ⅰ for the Kang's headloss equation corrected for the Kozeny-Carman's.

새로운 잔류분석법을 이용한 제초제 Pyributicarb의 토양 및 볏짚, 현미중 잔류량평가

이강봉,서용택,심재한 全南大學校 農漁村開發硏究所 1992 農業科學技術硏究 Vol.27 No.-

A new method was performed to determine the residue amounts of pyributicarb. Persistence of pyributicarb in rice cultivated soil under the different soil texture was studied by spraying the herbicide pyributicarb at the rate of 160 g a.i /10a at 10 and 20 days after transplanting. The analysis for residues conducted upto 90 days after the final application. The decomposition rate was varied with soils and conditions. The half lives of pyributicarb in Kwangju and Iri field conditions for 1 times application were 15 and 38 day, respectively. In two times application fields of pyributicarb, the half lives were 20.7 and 38 day, respectively. The disappearance of pyributicarb in laboratory conditions was remarkably slow compared to those of those of field tests. The residue amounts of pyributicarb from brown rice and rice straw were <0.006 and <0.007ppm regardless of application times.

濟州地方에서 한라부추(Allium taquetii) 栽培法 確立에 關한 硏究 : Ⅰ. 赤色光과 植物生長調節劑가 種子發芽에 미치는 영향 Ⅰ. Effect of Red Light and Plant Growth Regulators on Seed Germination

朴庸奉,康勳,金基澤 제주대학교 1991 논문집 Vol.33 No.-

한라부추 種子發芽에 對한 溫度, 光質(赤色光), 低溫處里 및 몇가지 植生物長調節劑를 處里하여 發芽하는 狀態를 調査한 結果 다음과 같은 結論을 얻었다. 1. 한라부추의 發芽適溫은 20∼25℃였으며 高溫인 30℃에서는 發芽가 極히 抑制되었다. 2. 赤色光은 15∼20℃ 溫度에서는 發芽促進 效果가 있었지만 25℃以上의 溫度에서는 그 促進效果가 喪失되었다. 그리고 모든 溫度에서 暗處理와 類似한 發芽樣相을 보였다. 3. 低溫處理 한 것은 對照區와 거의 비슷한 傾向을 나타내었다. 4. NAA는 發芽抑制 效果가 나타나 對照區보다 오히려 發芽率이 떨어지는 傾向을 나타내었다. GA는 25㎎/ℓ, Ethephon은 50㎎/ℓ, BA는 10㎎/ℓ에서 發芽가 가장 促進되었으나, Ethephon과 BA의 경우 濃度가 높을 수록 發芽抑制 程度가 심하였다. In view of seed germination of Halla gynmigit (Allium taquetii) its known to grow wild (natually) at the 110m level of Mt. Halla. A study was conducted to see if several plant growth regulators, high and low temperature and red light treatment have any promotive influence on the germination of Halla gynmigit seed and its practical value, when applied at various concentrations. 1) 20~25℃ showed promotion of germination of Hallh gynmigit seeds and shortened the mean number of days necessary for germination, while deleyed germination was observed if 30℃ was applied. 2) Red light promoted the seed germination of Halla gynmigit at 15~20℃, but at the over 25℃, promotive effect was lost. 3) the low temperature treatment group was not more significantly influence than the control. 4) The NAA treatment showed the effect of germination retard, On the contrary, The germination percentage was decreased less than that of the control. However, GA 25㎎/ℓ, Ethephon 50㎎/ℓ, and BA 10㎎/ℓ promoted the germinaton percentage markedly. Especially. BA and Ethephon treatment at latively higher concentration levels resulted in less seed germination.

국가독점자본주의의 기제와 위기

尹龍熙,姜鳳求 경북대학교 1987 社會科學 Vol.6 No.-

State intervention in monopoly capitalism has two main reasons: firstly, monopoly capitalism is faced with crisis of capital accumulation because of fundamental contradiction between socialization of production and private ownership, and secondly, the domination of monopoly capital is becoming fragile, since economic confrontation has shifted to political realm owing to new antagonistic relation between classes. Social integration and capital accumulation is two essential functions of state intervention in state monopoly capitalism, but whatever policy the state in a capitalist society may choose, that is ineffective in view of legitimization and capital accumulation. In state monopoly capitalism, the politicization of economic struggles requires labor class to get into political arena, that is to say, social relation is reproducted so that class struggle may be carried out within boundary of the mode of production. The development of state monopoly capitalism is likely to accelerate political movement and resistance of anti-monopoly bodies, and bourgeois democracy faces attack of the working class masses because of its bias against labor class. Crisis of state monopoly capitalism and democratic change could depend upon whether labor class recognizes necessity of fundamental change and how antimonopoly democratic bodies unite their powers.

覆盆子類가 白鼠의 排卵과 卵巢에 미치는 影響

金捧秀,朴涌基,康秉秀 대한본초학회 2001 大韓本草學會誌 Vol.16 No.1

Rubi Fructus is a well known remedy for female infertility, especially due to lack of kidney-yang or shenyangxu(???). An attempt was made to evaluate the influences of Rubi Fructus (mature Rubus crataegifolius BUNGE, mature Rubus coreanus MIQ and immature Rubus coreanum MIQ) on the morphological changes of the ovary. The experiment was performed to investigate the effects of the seeds of mature Rubus cratagifolius BUNGE (W1), the seeds of mature Rubus coreanus MIQ (W2) and the seeds of immature Rubus coreanus MIQ (W3) on the formation of follicles in rat ovary. The results are as follows: 1. Results using three herbs of mature seed of Rubus cratagifolius BUNGE (W1), mature seed of Rubus coreanus MIQ (W2)and immature seed of Rubus coreanus MIQ (W3) clearly showed the stimulating effects on the increasing number of follicles in rat ovary. Of them, W1 increased the follicle formation by 171% compared to normal control after 4 days of treatment. In cases of W2 and W3, the formed numbers of the follicle were increased to 228% and 285%, respectively. On the other hand, the follicle formations of W1, W2, and W3 were most effective, showing 208, 258 and 266%, respectively, after 8 days of treatment. These results showed that effect of immature Rubus coreanus MIQ was similar to that of the mature Rubus coreanus MIQ without any differences. 2. The size of the follicle stimulated by W2 was about 1.0 mm, although the size of the normal control was 0.3 mm. However, those of W1 and W2 were about 0.5 mm, indicating that the treatments of the herbal extracts are also effective for the follicle size. Therefore, it was concluded that all these herbs showed the effects on average of follicles in ovary. Especially, mature Rubus coreanus MIQ showed the highest effect among them. 3. Fractions of W1-B, W2-B and W3-B, when each extract were separated by analytical HPLC(high performance liquid chromatography), showed the activities of follicle number and size of follicles in ovary. These results suggest that the effect of Rubi Fructus is related to treatment of female infertility due to ovulation difficuty. Of them, mature Rubus coreanus MIQ is the most potent effector on the ovulation in Rats.