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RISS 인기검색어
- 검색키워드
- 저자 : Kanakapura, S. (검색결과 2 건)
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Kanakapura Basavaiah,Salmara ganeshbhat Hiriyanna,Kanakapura Basavaiah Vinay,Kalsang Tharpa,Urdigere Rangachar Anil Kumar,Nagaraju Rajedraprasad 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.9
Two simple and sensitive spectrophotometric methods are described for the determination of raloxifene hydrochloride (RLX) in pure form and in tablets. The first method (method A) is based on the formation of a yellowish-brown chromogen peaking at 430 nm when RLX was reacted with permanganate in acetic acid medium. In the second method (method B), RLX was reacted with a measured excess of permanganate in H2SO4 medium followed by the spectrophotometric measurement of the unreacted KMnO4 at 550 nm. Under the optimized experimental conditions, Beer’s law is obeyed in the concentration range 0.6-6.0 and 1.5-15.0 μg mL-1 with molar absorptivity of 7.01 × 104 and 2.8 × 104 L mol-1 cm-1 for method A and method B, respectively. The limits of detection (LOD) and quantification (LOQ) have also been reported. The intra-day and inter-day RSD and RE values at three different concentrations were assessed. The proposed methods were applied to the commercially available tablets, and the results were statistically compared with those of the reference method. The accuracy and reliability of the methods were further ascertained by recovery studies.
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Torumkuney, D.,Chaiwarith, R.,Reechaipichitkul, W.,Malatham, K.,Chareonphaibul, V.,Rodrigues, C.,Chitins, D. S.,Dias, M.,Anandan, S.,Kanakapura, S.,Park, Y. J.,Lee, K.,Lee, H.,Kim, J. Y.,Lee, Y.,Lee, Oxford University Press 2016 The Journal of antimicrobial chemotherapy Vol.71 No.suppl1
<P>Objectives: To provide susceptibility data for community-acquired respiratory tract isolates of Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae and Moraxella catarrhalis collected in 2012-14 from four Asian countries. Methods: MICs were determined using Etest (R) for all antibiotics except erythromycin, which was evaluated by disc diffusion. Susceptibility was assessed using CLSI, EUCAST and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. For macrolide/clindamycin interpretation, breakpoints were adjusted for incubation in CO2 where available. Results: Susceptibility of S. pneumoniae was generally lower in South Korea than in other countries. Penicillin susceptibility assessed using CLSI oral or EUCAST breakpoints ranged from21.2% in South Korea to 63.8% in Singapore. In contrast, susceptibility using CLSI intravenous breakpointswasmuch higher, at 79% in South Korea and similar to 95% or higher elsewhere. Macrolide susceptibilitywas similar to 20% in South Korea and similar to 50%-60% elsewhere. Among S. pyogenes isolates (India only), erythromycin susceptibility (similar to 20%) was lowest of the antibiotics tested. In H. influenzae antibiotic susceptibility was high except for ampicillin, where susceptibility ranged from 16.7% in South Korea to 91.1% in India. South Korea also had a high percentage (18.1%) of beta-lactamase-negative ampicillin-resistant isolates. Amoxicillin/clavulanic acid susceptibility for each pathogen (PK/PD high dose) was between 93% and 100% in all countries except for H. influenzae in South Korea (62.5%). Conclusions: Use of EUCAST versus CLSI breakpoints had profound differences for cefaclor, cefuroxime and ofloxacin, with EUCASTshowing lower susceptibility. Therewas considerable variability in susceptibilityamong countries in the same region. Thus, continued surveillance is necessary to track future changes in antibiotic resistance.</P>
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