Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

간세포암의 고주파 열치료 후 천자침 경로를 통한 전이 1례

조영완,박석주,진한영,김준영,이재익,강명주,박정하,윤정희,박성재,지삼룡,이연재,이상혁,설상영 인제대학교 2006 仁濟醫學 Vol.27 No.-

Radiofrequency ablation(RFA), as a form of minimally invasive therapy for hepatocellular carcinoma, has become an important treatment modality. Because of limitation of surgery, RFA has become standard therapy for hepatocellular carcinoma in some situations. But there are some complications of RFA such as bleeding, infection, hematoma, adjacent organ thermal damage including intestinal perforation, needle track seeding, and so on. There are few reports in the literature that systematically evaluate the incidence of needle tract seeding and its associated risk factors. And only 2 cases of needle tract seeding of hepatocellular carcinoma after RFA were reported in Korea. We report a case of needle tract seeding of hepatocellular carcinoma after RFA.

Comparative study on long-term stability in mandibular sagittal split ramus osteotomy: hydroxyapatite/poly-ʟ-lactide mesh versus titanium miniplate

Park, Young-Wook,Kang, Hyun-Sik,Lee, Jang-Ha Korean Association of Maxillofacial Plastic and Re 2019 Maxillofacial Plastic Reconstructive Surgery Vol.41 No.-

Background: Resorbable devices have recently been adopted in the field of orthognathic surgery with controversies about their postoperative skeletal stability. Hence, we determined the long-term skeletal stability of unsintered hydroxyapatite/poly-ʟ-lactic acid (HA/PLLA) mesh for osteofixation of mandibular sagittal split ramus osteotomy (SSRO), and compared it with that of titanium miniplate. Methods: Patients were divided into resorbable mesh and titanium miniplate fixation groups. A comparative study of the change in the mandibular position was performed with preoperative, 1-day, 6-month, and 2-year postoperative lateral cephalograms. Results: At postoperative 6 months-compared with postoperative 1 day, point B (supra-mentale) was significantly displaced anteriorly in the titanium-fixation group. Moreover, at postoperative 2 years-compared with postoperative 6 months, point B was significantly displaced inferiorly in the titanium-fixation. However, the HA/PLLA mesh-fixation group did not show any significant change with respect to point B postoperatively. Conclusions: The HA/PLLA mesh-fixation group demonstrated superior long-term skeletal stability with respect to the position of mandible, when compared with the titanium-fixation group.

성인 쇄골 간부 골절에서 두 가지 수술적 치료군 간의 결과 비교: 금속판을 이용한 관혈적 정복 및 내고정술과 Steinmann Pin을 이용한 경피적 겸자 정복 및 골수강내 고정술의 결과 비교

허성식 ( Sung Sik Ha ),심재천 ( Jae Chun Sim ),홍기도 ( Ki Do Hong ),김재영 ( Jae Young Kim ),강정호 ( Jung Ho Kang ),박광희 ( Kwang Hee Park ) 대한골절학회 2007 대한골절학회지 Vol.20 No.3

Purpose: To evaluate the results between open reduction and internal fixation with the plate and percutaneous reduction by towel clip and intramedullary fixation with Steinmann pin for clavicle shaft fractures in adult. Materials and Methods: We have studied the results in 33 cases with the plate. 35 cases with the Steinmann pin among total 68 cases of clavicle shaft fracture. The patients were followed up over a period of at least 12 months. The final postoperative outcome was analyzed with the clinical outcomes using Kang`s criteria. radiological union time and operation time. Results: The clinical outcome that was good or excellent according to the Kang`s criteria showed a distribution of 88% in the group using the plate with 29 cases out of total 33 cases. 91% in the group using the Steinmann pin with 32 cases out of total 35 cases. The mean radiological union time was 8.9 weeks in the group using the plate. 9.1 weeks in the group using Steinmann pin. The mean operation time was 72 minutes in the group using the plate, whereas was 18 minutes in the group using Steinmann pin. Conclusion: In the treatment of adult clavicle shaft fracture. two groups did not show a significant statistical difference in clinical and radiological outcomes. However, the operation time and postoperative functional recovery was significantly shorter and faster in the group using Steinmann pin. Additionally economic and cosmetic aspect was more satisfactory in the group using Steinmann pin.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

최적 디지탈 서보계의 설계에 관한 연구

하영원,강정호,정주수 慶南專門大學 1995 論文集 Vol.23 No.1

식품공장폐수의 활성오니처리중 오존에 의한 산화분해효과

강경수,최영찬,하진환,송대진 濟州大學校 工科大學 産業技術硏究所 1991 産業技術硏究報告 Vol.2 No.-

For the increase of treatment efficiency when waste water which included residual chlorine was biologically treated with activated sludge, elimination efficiency of COD and change of transmittance by activated sludge method were examined after the treatment of residual chlorine with ozone of 100 volt and l0ℓ-air/min., 0.8g-0_(3)/hr. in velocity. The results were as follows. 1) When the sample which included residual chlorine was treated with ozone of 0.8g-O_(3)/hr., COD removal rate by the change of pH and ozonization time was more efficient than acidity solution of pH 3.2(20%) and alkaline solution of pH 12.0(10%). Since the COD removal rate become 35% after 50 minutes of ozonization time at neutral solution of pH 7.2. 2) After the residual chlorine included sample was treated with ozone for 50 minutes to make the F/M rate of 0.1㎏·BOD/㎏·MLSS, the sample was reacted with activated sludge for 3, 6, 9 and 15 hours. The 6 hours reaction gave 85.8% COD elimination which showed higher efficiency than 60.5% by Na_(2)S_(2)O_(3) treatment togather with shorting efficiency of reaction time. 3) When such sample as polyphenol which gives dark brown color was treated with ozone for 50 minutes after being made into acidic, neutral and alkaline solution. the transmittance increased from 30- 40% to 70% and gave better result in alkaline solution.

유방선암의 유형에 따른 c-erbB-2, p53, bcl-2, 그리고 c-myc의 발현

강영근,조현득,오미혜,김의한,양승하 순천향의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.2

Breast carcinoma is a common malignant tumor in female of the korea. Various oncogenes have been found in malignant tumor cells. There were many reports or correlation between the prognosis of patients and c-erbB-2, p53, bcl-2, and c-myc, but is controversial. We performed immunohistochemical stain for above antigenic protein for 80 cases of breast carcinoma and evaluated expression rate of each antigens, and we compared their correlation with prognosis of patients. The results were as follow; 1) The expression rates in breast carcinoma was c-erbB-2 80%, p53 56.3%, bcl-2 51.3% and c-myc 53.8%. 2) c-erbB-2 showed no significant difference according to histologic types, grade, and lymph node metastatic status of breast carcinoma. 3) p53 showed higher expression rate in metastatic cases compared to non-metastatic cases, and it showed higher expression rate according to increasing of grade without significant difference. There is no significant difference according to types. 4) The expression rate of bcl-2 in breast carcinoma be lowed according to increasing of grade. There was no significant difference according to types, side, and status of lymph node metastasis. 5) c-myc showed higher expression rate in non-metastatic cases compared to and metastatic cases, and it showed decreasing expression rate according to increasing of grade without significant difference. There is no significant difference according to types. 6) p53 and bcl-2 in breast carxinoma showed reverse corre1ation(P < 0.05), and bc1-2 and c-myc showed close correlation without statiscally significance. Above results showed that p53 may be related to poor prognosis of the patients and c-myc may be related good prognosis in breast carcinoma. There was reverse correlation between p53 and bcl-2 and bcl-2 and c-myc may be correlated closely. c-erbB-2 and bcl-2 showed no interrelation to prognosis.

食品工場廢水의 活性汚泥處理中 오존에 依한 酸化分解效果

康京壽,崔永贊,宋大鎭,河璡桓 濟州大學校工科大學附屬産業技術硏究所 1991 尖端技術硏究所論文集 Vol.2 No.-

잔류염소를 함유한 發水를 活性汚泥에 의한 處理效率을 增加시키기 위하여 전압 100Volt, 유속 10ℓ-air/min, 0.8g-O₃/hr의 오존으로 처리했을때 COD의 除去效果및 투과율의 變化를 實驗한 結果를 要約하면 다음과 같다. 1. 잔류염소를 함유한 시료를 0.8g-O₃/hr의 오존으로 處理하였을때 pH의 變化 및 反應時間에 의한 COD의 除去率은 中性溶液(pH=7.2)에서 오존處理時間 50分 후 35%의 除去效果를 나타내어 酸性溶液(pH=3.2)의 20%, 알칼리性溶液(pH=12.0)의 10%의 除去效果보다 좋았다. 2. 잔류염소를 함유한 試料를 오존으로 50分間 處理하여 F/M比 0.1㎏·BOD/㎏·MLSS로 한 후 3. 6. 9 및 15時間 活性汚泥로 反應시켰을 때 反應時間 6時間 후 85.8%의 COD의 除去效果가 있어 티오황산나트륨(Na₂S₂O₃)으로 處理한 試料의 除去率 60.5%보다 좋았으며, 反應時間의 단축효과도 있었다. 3. Polyphenol色素 等 暗褐色을 띄는 試料를 酸性, 中性, 알칼리性 溶液으로 하여 오존으로 50分間 處理하였을 때 투과율이 30~40%에서 70% 以上 상승하였으며 알칼리성溶液에서가 투과율이 더 좋았다. For the increase of treatment efficiency when waste water which included residual chlorine was biologically treated with activated sludge, elimination efficiency of COD and change of transmittance by activated sludge method were examined after the treatment of residual chlorine with ozone of 100 volt and 10ℓ-air/min., 0.8g-O₃/hr. in velocity. The results were as follows. 1) When the sample which included residual chlorine was treated with ozone of 0.8g-O₃/hr., COD removal rate by the change of pH and ozonization time was more efficient than acidity solution of pH 3.2(20%) and alkaline solution of pH 12.0(10%). Since the COD removal rate become 35% after 50 minutes of ozonization time at neutral solution of pH 7.2. 2) After the residual chlorine included sample was treated with ozone for 50 minutes to make the F/M rate of 0.1㎏·BOD/㎏·MLSS, the sample was reacted with activated sludge for 3, 6, 9 and 15 hours. The 6 hours reaction gave 85.8% COD elimination which showed higher efficiency than 60.5% by Na₂S₂O₂ treatment togather with shorting efficiency of reaction time. 3) When such sample as polyphenol which gives dark brown color was treated with ozone for 50 minutes after being made into acidic, neutral and alkaline solution, the transmittance increased from 30-40% to 70% and gave better result in alkaline solution.

다수의 냉동시스템에 의한 저온 저장고의 에너지 성능평가

김성만,윤종호,박영하,이의준,강동언,현명택 제주대학교 산업기술연구소 2000 尖端技術硏究所論文集 Vol.11 No.1

The cool storage system(CSS) is a specific building that is required only cooling load without heating during the whole year. CSS uses a electric energy which is very expensive and is required much amount of energy due to temperature differences between interior and ambient temperatures. The purpose of this study is to assess the energy performance of the multi-unit cooler operating control system. For the prediction of its performance, two types of test cell are installed at Korea Institute of Energy Research (KIER). First cell is equiped with one large unit cooler, and second cell consists of two small unit coolers. According to the results of experiments using these cells, the multi-unit cooler operating control system is found to be effective in energy saving and beneficial for storage due to much less deviation of temperature.