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        Cardioprotective Effect of Squalene on Lipid Profile in Isoprenaline-Induced Myocardial Infarction in Rats

        R. Anandan,K.H. Sabeena Farvin,S. Hari Senthil Kumar,K.S. Shiny,Suseela Mathew,T.V. Sankar,P.G. Viswanathan Nair 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.4

        We studied the cardioprotective effect of squalene on isoprenaline-induced myocardial infarction in male al-bino rats with respect to changes in the levels of lipid components in plasma and heart tissue. Prior administration of 2% squa-lene in feed for 45 days significantly reduced the isoprenaline-induced elevation in the levels of cholesterol, triglycerides, andfree fatty acids in plasma and heart tissue of rats following myocardial infarction. It exerted an anitlipidemic effect by re-ducing the level of low-density lipoprotein cholesterol with a parallel rise in the level of high-density lipoprotein cholesterolin plasma of experimental rats. A tendency to prevent the isoprenaline-induced depletion of phospholipids in the myocardiumof experimental rats was also observed. In the present study, the pretreatment with squalene significantly counteracted the iso-prenaline-induced lipid peroxidation and maintained the rats at near normal status. The results of the present study indicatethat the overall cardioprotective effect of squalene is probably related to an inhibition of lipid accumulation by its hypolipi-demic properties and/or its antioxidant properties.

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