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Vibration isolation system with a compact damping system for power recycling mirrors of KAGRA
Akiyama, Y,Akutsu, T,Ando, M,Arai, K,Arai, Y,Araki, S,Araya, A,Aritomi, N,Asada, H,Aso, Y,Bae, S,Baiotti, L,Barton, M A,Cannon, K,Capocasa, E,Chen, C-S,Chiu, T-W,Cho, K,Chu, Y-K,Craig, K,Dattilo, V,Do Institute of Physics 2019 Classical and quantum gravity Vol.36 No.9
<P>A vibration isolation system called the Type-Bp system used for power recycling mirrors has been developed for KAGRA, the interferometric gravitational-wave observatory in Japan. A suspension of the Type-Bp system passively isolates an optic from seismic vibration using three main pendulum stages equipped with two vertical vibration isolation systems. A compact reaction mass around each of the main stages allows for achieving sufficient damping performance with a simple feedback as well as vibration isolation ratio. Three Type-Bp systems were installed in KAGRA, and were proved to satisfy the requirements on the damping performance, and also on estimated residual displacement of the optics.</P>
Role of Rho-kinase in regulation of insulin action and glucose homeostasis
Furukawa, Noboru,Ongusaha, Pat,Jahng, Wan Jin,Araki, Kazushi,Choi, Cheol Soo,Kim, Hyo-Jeong,Lee, Yong Hee,Kaibuchi, Kozo,Kahn, Barbara B.,Masuzaki, Hiroaki,Kim, Jason K.,Lee, Sam W.,Kim, Young-Bum Elsevier 2005 Cell metabolism Vol.2 No.2
<P><B>Summary</B></P><P>Accumulating evidence indicates an important role for serine phosphorylation of IRS-1 in the regulation of insulin action. Recent studies suggest that Rho-kinase (ROK) is a mediator of insulin signaling, via interaction with IRS-1. Here we show that insulin stimulation of glucose transport is impaired when ROK is chemically or biologically inhibited in cultured adipocytes and myotubes and in isolated soleus muscle ex vivo. Inactivation of ROK also reduces insulin-stimulated IRS-1 tyrosine phosphorylation and PI3K activity. Moreover, inhibition of ROK activity in mice causes insulin resistance by reducing insulin-stimulated glucose uptake in skeletal muscle in vivo. Mass spectrometry analysis identifies IRS-1 Ser632/635 as substrates of ROK in vitro, and mutation of these sites inhibits insulin signaling. These results strongly suggest that ROK regulates insulin-stimulated glucose transport in vitro and in vivo. Thus, ROK is an important regulator of insulin signaling and glucose metabolism.</P>