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      • 고분화 화강암에서의 Eu 동위원소 분별작용

        이승구(Seung-Gu Lee),Tsuyoshi Tanaka 대한지질학회 2021 대한지질학회 학술대회 Vol.2021 No.10

        희토류원소중의 하나인 Eu은 자연계에서 2가, 3가와 같이 2개의 산화수를 갖고 있고, 아울러 두개의 동위원소(<SUP>151</SUP>Eu, <SUP>153</SUP>Eu)만을 갖고 있다. 그리고 운석으로 규격화한 암석내 희토류원소 분포도는 화성암의 진화사 즉 분화도를 이해하기위한 중요한 인자 중의 하나이다. 그리고 고분화 화강암 중 일부는 그 함량을 원시운석으로 규격화하였을 때 ‘희토류원소의 테트라드 효과’라 불리우는 독특한 희토류원소 분포도와 더불어 Eu의 부(-)의 이상이 매우 큰 지구화학적 특징을 보여준다. 최근 Lee and Tanaka (2019, 2021a)는 희토류원소 중의 하나인 Eu의 안정동위원소의 새로운 분석법의 개발과 더불어 토대로 분화된 화강암에서의 Eu 동위원소의 분별작용을 보고하였다(2021B). 이 발표에서는 고분화 화강암과 분화도가 크지 않은 화강암에서의 희토류원소 분포도의 특성과 Eu 동위원소비의 차이(즉 동위원소 분별작용)을 활용하여, 희토류원소 테트라드 효과의 발달정도-화강암질 마그마의 분화도-Eu의 이상의 크기 변화 그리고 Eu 동위원소 분별작용의 발생도를 비교함으로써 희토류원소의 테트라드 효과의 형성과정과 Eu의 부(-)의 이상의 형성과정의 선후관계에 대해 토의하고자 한다. Lee, S.-G. and Tanaka, T., 2019, Determination of Europium isotopic ratio by multi-collector inductively coupled plasma mass spectrometry using a Sm internal standard, Spectrochim. Acta Part B, 156, 42-50. Lee, S.-G. and Tanaka, T., 2021a, Gd matrix effects on Eu isotope fractionation using MC-ICP-MS: Optimizing Europium isotope ratio measurements in geological rock samples. Int. J. Mass. Spec., 116668. Lee, S.-G. and Tanaka, T., 2021b, Eu isotope fractionation in highly fractionated igneous rocks with large Eu negative anomaly Geochem. J., 55(4), e9-e17.

      • Selective substrate uptake: The role of ATP-binding cassette (ABC) importers in pathogenesis

        Tanaka, Kari J.,Song, Saemee,Mason, Kevin,Pinkett, Heather W. Elsevier 2018 Biochimica et biophysica acta, Biomembranes Vol.1860 No.4

        <P><B>Abstract</B></P> <P>The uptake of nutrients, including metals, amino acids and peptides are required for many biological processes. Pathogenic bacteria scavenge these essential nutrients from microenvironments to survive within the host. Pathogens must utilize a myriad of mechanisms to acquire these essential nutrients from the host while mediating the effects of toxicity. Bacteria utilize several transport proteins, including <U>A</U>TP-<U>b</U>inding <U>c</U>assette (ABC) transporters to import and expel substrates. ABC transporters, conserved across all organisms, are powered by the energy from ATP to move substrates across cellular membranes. In this review, we will focus on nutrient uptake, the role of ABC importers at the host–pathogen interface, and explore emerging therapies to combat pathogenesis. This article is part of a Special Issue entitled: Beyond the Structure-Function Horizon of Membrane Proteins edited by Ute Hellmich, Rupak Doshi and Benjamin McIlwain.</P>

      • SCIESCOPUSKCI등재

        Mechanism of Action of and Resistance to Aminoglycoside Antibiotics

        Tanaka, Nobuo The Pharmaceutical Society of Korea 1983 Archives of Pharmacal Research Vol.6 No.1

        Waksman's group discovered SM in 1944, and opened a new field of antibiotcs: i. e. AGs. A large group of antibiotics containing aminosugar and/or aminocyclitol is called the AGs. A majority of AGs are produced by actinomycetes. In the first period, AGs effective against tuberculosis were chiefly examined. Following the studies on NM and KM, AGs active against staphyllococci and gram-negative robs were investigated. The discovery of GM and synthesis of DKB and AMK led to the studies on the third generation AGs, which show a broad antimicrobial spectrum including Pseudomonas aeruginosa and drug-resistant bacteria. Since opportunistic infection caused by drug-resistant bacteria are increasing, the third generation AGs are extensively investigated at present.

      • Clinical Decision-Making for the Geriatric Dental Patient : Treatment Concept and Procedure

        Tanaka, Hisatoshi 경희대학교 2001 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.2001 No.1

        A major difficulty in Prosthetic treatment of the elderly is finding the right treatment for each patient. Excellent high-level prosthetic methods can be applied successfully in treatment of the elderly. It is a fact that most complete denture patients have significantly decreased chewing efficiency compared to dentate subject and patients with overdenture or implant-supported prosthesis. These patients had rated stability and their ability to chew with the implant-supported prosthesis as better than with the denture because of the better mechanical stability. However, each patient has his own criteria for selecting a particular type of prosthetic treatment, beyond what may be recommended by the dentist. Therefore, the principles of prosthetic treatment in geriatric patients should be based on simplicity and must take into account the individual patient's needs: his oral and general health status, socio-economical status and oral comfort. The conventional complete denture still remains an important option in meeting the needs of the elderly patient. Factors such as posterior tooth form, occlusal scheme, and tooth arrangement are important in proper denture construction. Yet the correctness of the occlusion depends primarily on outcome of the registration of the horizontal maxillo-mandibular relation. Frequently, occlusal errors are due to not having recognized the structural and functional alterations within the masticatory system, which prevent recording a physiologic maxillo-mandibular relationship. There could be a great risk that the closure path will change after denture insertion. If the dentist does not take into account a patient's trouble registering maxillo-mandibular relation, then the patient will probably have denture instability. Also, long-term denture wearers often undergo facial morphology changes as a result of not only occlusal wear of the dentures and residual ridge resorption but also masticatory dysfunction. We need to know whether or not we can create a method of mandibular re-positioning for a patient that will change the facial skeletal structure, and will therefore correct their mandibular dysfunction. There has been no references regarding of morphological change analysis in relation to functional masticatory muscle activity, which is fundamental to understanding maxillo-mandibular relation. Yet we recently performed a study concerning the relationship between morphological change and TMJ dysfunction. One hundred complete denture patients were randomly selected for evaluation of TMJ disorder and relationship between TMJ and clinical symptoms. Of this group, 68.6% had internal derangement and 55.7% had osteoarthrosis in the TMJ. Results showed that there was a higher frequency of short-cycle denture life among the patients who were suffering from internal derangement. Also, the degree of severity of TMJ disorder was related to abnormality of maxillo-mandibular relation. Therefore, the prevalence of temporo-mandibular joint disorder among complete denture wearers should be considered in relation to the abnormality of maxillo-mandibular relation in elderly patients, and will be discussed.

      • SCIESCOPUS

        A boundary element method based on time-stepping approximation for transient heat conduction in anisotropic solids

        Tanaka, Masa,Matsumoto, T.,Yang, Q.F. Techno-Press 1996 Structural Engineering and Mechanics, An Int'l Jou Vol.4 No.1

        The time-stepping boundary element method has been so far applied by the authors to transient heat conduction in isotropic solids as well as in orthotropic solids. In this paper, attempt is made to extend the method to 2-D transient heat conduction in arbitrarily anisotropic solids. The resulting boundary integral equation is discretized by means of the boundary element with quadratic interpolation. The final system of equations thus obtained is solved by advancing the time step from the given initial state to the final state. Through numerical compuation of a few examples the potential usefulness of the proposed method is demonstrated.

      • Embryological Consideration of Dural AVFs in Relation to the Neural Crest and the Mesoderm

        Tanaka Michihiro 대한신경중재치료의학회 2019 Neurointervention Vol.14 No.1

        Intracranial and spinal dural arteriovenous fistulas (DAVFs) are vascular pathologies of the dural membrane with arteriovenous shunts. They are abnormal communications between arteries and veins or dural venous sinuses that sit between the two sheets of the dura mater. The dura propria faces the surface of brain, and the osteal dura faces the bone. The location of the shunt points is not distributed homogeneously on the surface of the dural membrane, but there are certain areas susceptible to DAVFs. The dura mater of the olfactory groove, falx cerebri, inferior sagittal sinus, tentorium cerebelli, and falx cerebelli, and the dura mater at the level of the spinal cord are composed only of dura propria, and these areas are derived from neural crest cells. The dura mater of the cavernous sinus, transverse sinus, sigmoid sinus, and anterior condylar confluence surrounding the hypoglossal canal are composed of both dura propria and osteal dura; this group is derived from mesoderm. Although the cause of this heterogeneity has not yet been determined, there are some specific characteristics and tendencies in terms of the embryological features. The possible reasons for the segmental susceptibility to DAVFs are summarized based on the embryology of the dura mater.

      • Soil Respiration as an Environmental Indicator of Human Impacts

        TANAKA, Haruo,SAKAGAMI, Kan-ichi,HAMADA, Ryunosuke,SUZUKI, Kimitake,SATO, Miyoko 경희대학교 지구환경연구소 1998 국제세미나 Vol.1998 No.-

        Soil respiration represents as an environmental indicator of human impacts. Field soil respiration is considered a good indicator if conducted with several replications and for long term monitoring. Potential soil respiration acts as a unique environmental indicator of human impacts. Decrease of potential soil respiration reflects the decline of the organic matter by human impacts.

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