가토에서 CCNU 로 유발된 골수 저형성증의 혈액학적 소견과 골수스캔의 변화에 관한 연구

김승택,이명철,최두혁,고창순,김병국,이문호,박선양,최성재,김노경,최영희 대한내과학회 1986 대한내과학회지 Vol.30 No.1

To understand systematically the hematological changes including the bone marrow changes in chemotherapeutic agent-induced bone marrow hypoplasia and to define the relationship between hematological and bone marrow scan findings and prognosis of the hypoplasia, CCNU (lomustine) was given orally to 44 rabbits to induce hypoplasia of the bone marrow. And serial changes of peripheral blood and bone marrow findings and (111)In Cl(3)((111)In scan)/(99m)Tc tin colloid bone marrow scan((99m)Tc scan) were checked before and after induction of hypoplasia. With assessment of 28 evaluable rabbits, the following results were obtained: 1) Significant hypoplasia of the bone marrow developed around day 4 of CCNU administration and recovered around day 14(cellularity 51,4±13.5% and 24. 5±14.97o before and after CCNU respectively, p<005). Megakaryocyte count was significantly depressed from 95.67,26% to 36.7$gt;31.82%(P$lt;0.005). M: E ratio was decreased from 162±1.19 to 0, 0.5$lt;0. 43(p±0.005). Shift to left(475), maturation a(40%), naked nucleus and degenerated cells(20%), increase of lymphocytes(47%), monocytes and reticulum cells were also found. 2) The uptake ratio of the 99(m)Tc tin colloid bone marrow scan was markedly increased in contrast to the depression of the bone marrow(4.4±2.12 and 14.1±7.06 before and 4 days after CCNU, respectively, p40. 005). Tc scan uptake ratio was inversely related to the cellularity(r=-0.442, p$lt;0.05) and megakaryocyte number of the bone marrow(r= 0.89, p< 0.01) and peripheral blood granulocyte (r = 0. 54. Pg0.01) and platelet count(r=0.40, p$lt;0.05). There was not significant correlation between (111)In scan uptake ratio and hematologic parameters. 3) The amplitude of the change of the (99m)Tc scan uptake ratio was significantly related to the prognosis of the rabbits with experimentally induced hypoplasia of the bone marrow(dead 5.1±2,67, survivors 2,5±0.96, P<0.01). The change of the (111)In scan uptake ratio was not related to the prognosis of these rabbits. In experimentally induced rrow hypoplasia, morphologic changes in addition to the numerical changes of the bone marrow elements were observed. And serial (99)Tc scan of the bone marrow appears to be helpful assessing the severity and predicting the outcome of bone marrow hypoplasia.

급성 골수성 백혈병(M6)에 합병된 중추성 요붕증 1 예

김성연,조보연,이홍규,고창순,민헌기,김병국,김노경,신찬수,이명식,강덕현,조종태 대한내과학회 1989 대한내과학회지 Vol.37 No.2

Leukemia is known to be an extremely rare cause of diabetes insipidus. We report a case of diabetes insipidus as a complication of leukemia. An 18 year-old man was admitted because of polyuria polydipsia and fever. Bone marrow aspiration and biopsy revealed the diagnosis of acute erythroleukemia (AML, M6). On the water deprivation test, the diabetes insipidus was confirmed to be of the central type. He was managed with intranasal vasopressin for diabetes insipidus with good response. Induction chemotherapy was administered without response, and the patient died of septicemia and respiratory failure 2 months after initial diagnosis. A short review of the literature related to this subject is also presented.

시험관내에서 당화시킨 인슐린의 생체내 활성

김성완,김성연,조보연,이홍규,고창순,민헌기,이문규,김철희,민용기,장학철,정대원,배철민 대한당뇨병학회 1990 Diabetes and Metabolism Journal Vol.14 No.2

정상임부와 임신중독환자의 혈장 Renin 활성도 및 Aldosterone 농도에 미치는 이뇨의 효과

김한석,이현식,이장규,성호경,고주환,조석신 대한핵의학회 1973 핵의학 분자영상 Vol.7 No.1

The changes of plasma renin activity, aldosterone concentration, serum sodium, and potassium levels were studied before and after the water loading followed by diuretics injection. The materials were: 13 non-, 11 normal-, and 11 toxemic pregnancy cases. The plasma renin activity and aldosterone concentration of the cord and postpartum blood were also measured. Following were the results: 1. The plasma renin activity was elevated significantly in normal pregnancy, and slightly in toxemic pregaancy. The serum sodium levels were decreased in pregnancy. 2. The plasma aldosterone concentration was slightly decreased in normal pregnancy, and slightly increased in toxemic pregnancy, however, statistically insignificant. 3. The plasma renin activity of the cord and postpartum blood were lower than those of pregnancy cases. 4. The changes of plasma renin activity after the diuretic administration showed an initial increase, which recovered within 2 hours. These changes were the least in normal pregnancy, and the most in toxemic pregnancy. 5. The changes of plasma aldosterone concentration after the diuretic administration were similar to those of plasma renin activity, although the variations were not so wide.

전남대학교병원 응급실을 통한 급성중독 실태조사

이용복,주은희,서세민,고익배,김미숙,정영녀 전남대학교 약품개발연구소 1996 약품개발연구지 Vol.4 No.1

This study was aimed to take the available informations about the acute poisoning, its prevention and therapy. This survey was accomplished with acute intoxicated patients in the ER(emergency room) of Chonnam National University Hospital during 42 months from Jan.1986 to June 1989. The intoxicated patients occupied 5.8% of total ER patients (47007 cases). The average of intoxicated patients per day in ER was 2.13. On sex analysis, males occupied 49.3% and females 50.7%. On the motive of poisoning, intoxication by accident occupied 42.1%, by suicide attempt 39.4%, and by the others 18.5%. Poisoning substances included CO poisoning(23.9%), agricultural agents (22.8%), drugs(15.4%), chemicals(14.6), bites, rodenticides and food poisoning. The mortality of intoxicated patients was 8% (216 cases) and the major death-inducing substance was paraquat(39.8%). To decrease and prevent these acute poisonings, we suggest, first, that agricultural agents and psychotropic drugs must be carefully controlled by authorities, second, the informations on the acute poisoning continuously collected, third, poison control center established as soon as possible.

비주사법으로 측정한 정상 한국인 비장의 크기

고창순,이정상,신현정,김명재,이문호 대한핵의학회 1972 핵의학 분자영상 Vol.6 No.1

This is an attempt to evaluate normal spleen size in the Koreans. Spleen scans were obteined in 29 patients who were admitted to the Seoul National University Hospital because of trivial illnesses. All scans were performed by use of (51)^Cr-labelled, heat-treated erythrocyte. As a simple screening criteria for the presence of splenomegaly, vertical height of the sp]een was considered to be the best one. After statistical analysis it was concluded that the upper limit of normal spleen height is 13 cm in anterior view and 14 cm in lateral view.

비스테로이드성 소염진통제의 약물상호작용에 관한 연구

주은희,이령인,조행남,이용복,고익배 전남대학교 약품개발연구소 1997 약품개발연구지 Vol.6 No.1

According to the test increase of NSAID-uses, the possibility of the occurrence of drug interaction became increased. So we surveyed the drug interaction of NSAIDS in order to inhibit NSAID-related side defect. This study was accomplished for the NSAID-administered inpatients in Chonnam University Hospital at one day from Jan. to June in 1991. The NSAID-administered inpatients occupied 20.2% of total 3598 drug-administered inpatients On clinical department, orthopedic surgery occupied the highest value of 15.1% of NSAID-administered patient On the route of NSAID administration, injection occupied 32.7%, internal medicine 61.2%, external medicine 0.3% and the combination of injection & internal medicine 5.8%. On NSAID dosage form, injection occupied 38.5%. internal medicine 67% and external medicine 0.396. On the number of used NSAID, ale occupied 89.8%, two 9.2% arid three 1%. The average number of NSAID used by a patient was 1.1. The possible occurrence rate of drug interaction of NSAIDS was 33.1%. As the number of teed drug increased, the occurrence possibility of drug interaction of NSAIDS tended to increase. The possible occurrence rate of drug interaction of NSAIDS reached 100% in above 21 drug-used casts. The harmful interaction of NSAIDS could occur such as digitalis toxicity with digoxin in 3 cases, hypoglyocemia with antidiabetics in 8 cases, nephrotoxicity with diuretics in 57 cams, hemorrhage with anticoagulants or thrombolytics in 57 case, gastrointestinal hemorrhage with NSAIDS in 63 cases, the decease of antihypertensive effect with antihypertensives in 104 roses and the decrease of anti-inflammatory effect with antacids in 135 uses. So we should carefully monitor the drug interaction of NSAIDS and provide drug information to health team in order to prevent the harmful interaction of NSAIDS.

원산지가 다른 대두박의 육성돈 생체내 아미노산 이용률

김재황,유성오,송영민,박성진,고영두 한국영양사료학회 1999 韓國營養飼料學會誌 Vol.23 No.6

육성돈 단백질 사료로서 원산지가 다른 대두박 및 이들 원료에 어분을 3%씩 대체하여 배합한 한국산 대두박(KSBM), 중국산 대두박(CSBM), 인도산 대두박(ISBM), 한국산 대두박 + 어분(KSF), 중국산 대두박 + 어분(CSF) 및 인도간 대두박 + 어분(ISF)의 6처리구를 공시하여 생체내 아미노산 이용율을 루명하고자 (T-cannula가 장착된 6두의 돼지를 6 × 6 Latin 방각법으로 배치한 후) 대사 시험을 실시하였으며, 결과를 요약하면 다음과 같다. 1. 외관상 Fecal 아미노산 소화율은 모든 처리구 중에서 ISBM구가 다소 높았고 CSBM구가 낮았으나 거의 비슷한 경향이였으며, 대두박의 일정량을 어분으로 대체하므로서 다른 어분 대체구보다 중국산 대두박에 어분을 대체한 CSF구의 소화율이 상당히 증진되었다. 각 처리구의 필수아미노산중에서는 arginine, histidine 및 methionine의 소화율이 높았고 비필수아미노산 중에서는 glutamic acid의 소화율이 높았다. 2. 외관상 ileum 아미노산 소화율은 모든 처리구 중에서 KSBM구가 86.6%로서 가장 높았고 CSBM구가 80.1%로 낮았으나 대두박의 일정량을 어분으로 대체하므로서 다른 어분 대체구보다 중국산 대두박에 어분을 첨가한 CSF구의 소화율이 증진되었다. 각 처리구의 필수아미노산 중에서는 arginine, histidine 및 methionine의 소화율이 높았고 비필수아미노산 중에서는 glutamic acid의 소화율이 높았다. 3. Fecal 아미노산 소화율에서 ileum 아미노산 소화율을 뺀 차이로서 가장 큰 차이는 CSBM 및 KSF구에서 나타났으며, 각 처리구의 필수아미노산 중에서 가장 큰 차이는 KSBM, ISBM, KSF 및 CSF구에서는 threonine이였고, CSBM구에서는 valine이며, ISF구에서는 phenylalanine이였다. 비필수아미노산 중에서 가장 큰 차이는 KSBM, CSF 및 ISF구에서는 glycine이였고, CSBM, ISBM 및 KSF구에서는 proline이였다. This studies were performed to compare the effects of various prorein sources such as Korean soybean meal (KSBM), Chinese soybean meal (CSBM) and Indian soybean meal (ISBM), and Korean soybean meal + Fish meal (KSF), Chinese soybean meal + Fish meal (CSF) and Indian soybean meal + Fish meal (ISF) replaced 5 percent of their soybean meals by 3 percent of fish meal on the amino acid digestibility of growing pigs. Six pigs fitted with a simple T-cannula were assigned in 6 × 6 Latin Square Disign for digestion trial. The results obtained were as followed. 1. Apparent fecal amino acid digestibility of the ISBM was a little higher than any other treatments, and digestibility of the CSBM was the lowest of all the treatments, and the digestibility of the CSF treatments which replaced a fixed quantity of the CSBM by fish meal was grown much more than the others. The digestibility of Arginine, Histidine, and Methionine were higher on the essential amino acids of each treatments, and the digestibility of glutamic acid was higher on the non-essential amino acids. 2. Apparent Ileum amino acid digestibility of KSBM(86.6%) was the highest of all the treatments, but that of CSBM(80.1%) was the lowest, As replacing CSBM by a fish meal, the digestibility of CSF was improved. The digestibilities of Arginine, Histidine, and Methionine were higher on the essential amino acids, and the digestibility of Glutamic acid was higher on the non-essential amino acids. 3. When fecal amino acid digestibility was subtracted by Ileum amino acid digestibility, the highest difference appeared at CSBM and KSF. The highest difference on the essential amino acid of each treatment was that Threonine is KSBM, ISBM, KSF and CSF, Valine is CSBM, phenylalanine is ISF. The highest difference on the non-essential amino acid was that Glycine is KSBM, CSF and ISF, proline is CSBM, ISBM and KSF.

전남대학교병원 입원환자 약제 알러지에 관한 연구

주은희,서세민,이용복,고익배 전남대학교 약품개발연구소 1996 약품개발연구지 Vol.4 No.1

This study was accomplished to take the available informations about drug allergy, its prevention and therapy. Drug allergy was surveyed with the inpatients in Chonnam National University Hospital during 14 days from Oct, 5 to Oct. 18, 1989. The medical doctors of the ward of the clinical department wrote the drug allergy survey card and our team members reviewed the chart profiles to perform exactly. The drug allergic patients occupied 3.2% of total 657 inpatients. The longer the hospitalization period, the higher the ratio of the occurrence of drug allergy. On the allergy-induced drug, cephalosporins occupied 10 cases, penicillins 7 cases, NSAIDS 3 cases and the miscellaneous drugs 8 cases. On the route of drug administration in the case of drug allergy, parenteral route occupied 16 cases and oral route 5 cases. The symptom of drug allergy included skin eruption(16 cases), palpitaion(6 cases), drug fever(4 cases), itching sense(3 cases), flushing face(1 case) and syncope(1 case). The major test of drug allergy was skin test. On the onset time of drug allergy after starting drug therapy, 3 cases occurred immediately, 4 cases after 1 day-2 days, 5 cases during 2 days-1 week and 5 cases after 2 weeks.

만성신부전증에서 혈청 CEA치에 관한 연구

이정상,신영태,정순일,고창순,김성권,표희정,권인순 대한핵의학회 1980 핵의학 분자영상 Vol.14 No.2

저자들은 1979년 3월부터 1980년 10월까지 서울대학교병원내과에 입원하여 만성신부전증으로 진단받고 혈액투석요법을 받지 않은 환자 15예, 혈액투석요법을 시행중인 환자 39예 및 신장이식술을 받고 신장능이 호전된 환자 23예에서 혈청 CEA치를 방사면역측정법으로 측정하여 정상대조군과 비교하여 다음과 같은 결과를 얻었다. 1) 정상 성인 65명의 혈청 CEA치의 범위는 1.0∼4.3 ng/ml이었으며 평균은 1.6±0.66 ng이었다. 2) 혈액투석요법을 시행치 않은 만성신부전증 환자 15예의 혈청 CEA치는 0.3∼8.3 ng/ml이었고 평균은 3.6±2.10 ng/ml로써 정상대조군에 비하여 유의하게 증가되어 있었다(p$lt;0.001). 3) 혈액투석요법으로 치료중인 만성신부전증 환자 39예의 혈청 CEA치는 0.7∼6.7 ng/ml로 평균이 3.0±1.52 ng/ml이며, 정상대조군에 비하여 유의하게 상승되어 있으나(p$lt;0.001), 혈액투석을 받지 않은 환자군과는 유의한 차이가 없었다. 4) 신이식 환자 23예의 혈청 CEA치의 분포는 1.8∼10.8 ng/ml이고 평균은 3.8±1.96 ng/ml로 역시 정상대조군에 비하여 유의하게 증가되어 있으나(p$lt;0.001), 만성신부전증 환자군과는 유의한 차이가 없었다. 5) 이상의 혈청 CEA치가 정상범위 이상으로 상승된 49명��환자중 이학적 소견이나 검사소견상 악성종양은 발견되지 않았다. The serum CEA levels were measured by radioimmunoassay technique in 15 patients with chronic renal failure, who were not treated with hemodialysis, in 39 patients under hemodialysis and in 23 patients who received renal transplantation. The results were compared with those in 65 normal adults and the following results were obtained. 1) Serum CEA concentrations in 65 normal adults were in the range of 1.0 to 4.3 ng/ml with a mean value of 1.6±0.66 ng/ml. 2) Serum CEA concentrations in 15 chronic renal failure patients who were not treated with hemodialysis, were in the range of 0.3 to 8.3 ng/ml with a mean value of 3.6±2.10 ng/m1 which was significantly higher than those of normal controls(P$lt;0.001). 3) Serum CEA concentrations in 39 chronic renal failure patients under hemodialysis were also much higher than normal controls(p$lt;0.001), but not significantly different from those of the patients who were not under hemodialysis(P$gt;0.05). 4) In 23 patients who received renal transplantation, serum CEA levels were snificantly higher than normal controls(P$lt;0.001), but not significantly different from those of chronic renal failure patients.