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      • 세로토닌성 항우울제가 백서의 Schedule-Induced Polydipsia에 미치는 영향

        이기철,이정호,박중섭,최영민,전성일,정홍경,하준명,정재현 대한생물치료정신의학회 1999 생물치료정신의학 Vol.5 No.2

        Object : Schedule-induced polydipsia is considered as an animal model of obsessive-compulsive disorder inrats. The authors evaluated the chronic effects of fluoxetine and clomipramine as serotonergic antidepressants and haloperidol as dopaminergic antagonist on the schedule-induced polydipsia in rat.Methods : Spraque-Dawley rats weighing 200-250gm were individually housed, maintained and allowed free access to water for 1 week. And then the rats were placed on a restricted diet. To induce polydipsia, rats were placed in automatic cage where a pellet dispenser automatically dispensed 90mg pellets on a fixed-time 60 seconds(FT 60s) feeding schedule over 150-minute test session for a day. Water was available at all times during the feeding schedule in automatic cage. After 4 weeks of daily exposure to the FT 60s feeding schedule, experimental rats met a predetermined criterion for polydipsic behavior(greater than 3 times of water per session on average). 4 groups of rats were administered fluoxetine(5mg/kg/i.p.), clomipramine(5mg/kg/i.p.), haloperidol(0.1mg/kg/i.p.), vehicle(1cc/kg/i.p.) for 3 weeks. Rats were tested once a week to access schedule induced polydipsic behavior. The chronic effects of experimental drugs on schedule induced polydipsic behavior were analyzed with repeated analysis of variance and Scheffe test as a post-hoc comparison.In order to measure water consumption in non-polydipsic food-deprived rats, a separate group of rats(N=8) were individually housed and given a single bolus(14.5 gm) of food per day which maintained them at their average body weight.Results and Conclusion : The results were as follows ;1) After 4 weeks of daily feeding procedure with fixed time schedule for 60 seconds per day, the experimental group showed significant differences than the control in the amount of water consumption as compared with their baseline water intakes. At the same periods, there were no differences between the experimental group and the control in body weight. 2) The clomipramine treated group and the fluoxetine treated group showed significant decrease in the amount of water intake as compared with their baseline of polydipsic water intakes for 3 weeks of treatment. However, the haloperidol treated group and the vehicle control group showed no changes of amounts of water intake for 3 weeks of treatment as compared with their baseline of polydipsic water intakes. 3) At 2 weeks of drug treatment, clmipramine treated group(16.88±6.51ml) and the fluoxetine treated group(22.50±10.35ml) showed significantly lower amounts of water intake than the haloperidol treated group (41.25±7.06ml) or vehicle control group(37.50±12.54ml). And also the clomipramine treated group(13.75±5.18ml) and the fluoxetine treated group(18.75±3.54ml) showed significantly lower amounts of water intake than the haloperidol group(35.00±11.65ml) and the vehicle control(34.38±6.78ml) at 3 weeks of drug treatment. Above findings suggest that the fixed time feeding procedure for schedule-induced polydipsia as an animal model of obsessive compulsive disorder was effective to the evaluation of pharmacological challenge study. The author confirmed that schedule-induced polydipsia was successfully decreased for 3 weeks of administration of clomipramine and fluoxetine but there was no response to haloperidol.

      • KCI등재

        교잡종 찰옥수수에 대한 연구 : Ⅰ. 찰옥수수 "연농×재래" 교잡종의 생육 및 수량특성 Ⅰ. Growth and Yield Characteristics in Waxy Maize Hybrid Yeonnong × Jaerae

        이희봉,정재영,최현구,김기훈,김효기,주정일 충남대학교 농업과학연구소 2001 농업과학연구 Vol.28 No.2

        재래종 찰옥수수 F₁ 교잡종에 대한 생육 및 수량비교를 위해 충남대학교 농과대학 실험포장에서 육성한 이들 교잡종의 식물학적 특성에 대한 연구 결과는 다음과 같다. 1. 간장은 대조구에 비해 대학찰×재래찰, FR805/1K₃×고령찰이 가장 크게 나타났으나, FR805/1K₃×대학찰, 찰옥 1호에서 대조구와 비슷하게 나타내었다. 2. 착수수는 간장에서와 마찬가지로 대학찰×재래찰, FR805/1K₃×고령찰이 대조구보다 높게 나타났으나 대학찰×재래찰, 찰옥 1호는 비슷하였다. 3. 분얼수는 각 교잡종들간에 큰 차이가 없었다. 4. 이삭의 길이는 대조구에 비해 교잡종들이 거의 2배이상의 크기를 나타내었다. 5. 이삭직경은 FR805/1K₃× 고령찰의 교잡종을 제외하고 대조구와 비슷하게 나타났다. 6. 이삭열수는 Daehakchal×1K₁/LE만이 대조구와 유의성을 나타내고 기타 교잡종은 대조구와 비슷하였다. In order to evaluate the characteristics of growth and yield in F_(1) waxy hybrids using Korean local maize lines, six hybrids including check, Chalok # 1, were planted at the experinental field of e Chungnam National University. Stem and ear heights of Yeonnong × Jaerae and FR805/IK_(3) × Koryong hybrids were higher than the check hybrid. Number of fillers per plant in all hybrids were similar as 0.3 to 0.5 per plant Ear length of waxy hybrids was longer than 15㎝ of check hybrid and ear diameter was also thicker than check except FR805/IK_(3) × Koryong waxy hybrid. A final result, Yeonnong × Jaerae among hybrids was comparatively superior to other hybrids in the test.

      • KCI등재후보

        우리나라 일부 석면사업장의 석면폐 유병률

        백도명,백남원,최정근,손미아,임정기,이원진,문영한,박정선,최병순 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.1

        Asbestos industry has been in operation over 60 years in Korea. However, the prevalence of asbestosis has not been yet reported. With rapid turn-over of workers, previous cross-sectional studies of current workers on the job could not find cases with exposures long enough for the development of asbestosis. This study was done to evaluate asbestosis prevalence of those worksites with operation history of more than 20 years. In total, 139 workers from 5 worksites were examined. Asbestos industries covered in the study include 2 asbestos textile, 1 brake lining, and 2 ship repairing worksites. Chest x-ray was taken from all workers and read by two experts familiar with pneumoconiosis classification according to 1980 ILO guidelines. Those with findings compatible with asbestosis were further ckecked with high resolution computerized tomography (HRCT). Pulmonary function tests were done according to ATS guidelines, and occupational and previous medical history was taken through a standardized interview. Air-borne asbestos was measured according to NIOSH method 7400. The air-borne asbestos concentrations ranged from 0.2-1.3 f/cc for asbestos textile, from 0.7-1.0 f/cc for brake lining, and from 6.3-7.8 f/cc during asbestos removal at ship repairing worksite. Of the 139 workers 25 had abnormal chest radiographic findings, and 10 of them had findings compatible with pneumoconiosis. When work history and current asbestos measurements were accounted, 9 workers who had more than 10 years of asbestos exposure history showed chest radiographic findings of pneumoconiosis with Finally, 4 workers showed finding of pulmonary fibrosis and/or pleural thickening at HRCT, and 2 of them had restrictive lung function changes. The study results showed that, among 139 subjects, there were 4(3%) definite asbestosis cases confirmed with HRCT. The prevalence of probable asbestosis was 7% for 10-14 years of exposure, 13% for 15-19 years of exposure, and 23% for 20 or more years of exposure. The prevalence of compensable asbestosis with abnormal lung function was 4-6% for those with 15 or more years of exposure.

      • 적응관측기를 이용한 SPMSM의 속도 및 위치 센서리스 제어

        정택기,이정철,이홍균,정동화 국립7개대학공동논문집간행위원회 2003 공업기술연구 Vol.3 No.-

        This paper is proposed to position and speed control of a surface permanent magnet synchronous motor(SPMSM) drive without mechanical sensor. An adaptive state observer is used for the mechanical state estimation of the motor. The observer is developed based on a nonlinear model of the SPMSM, that employs a d-q rotating reference frame attached to the rotor. A adaptive observer is implemented to compute the speed and position feedback signal. The validity of the proposed sensorless scheme is confirmed by various response characteristics.

      • KCI등재

        황색포도상구균 신속 검출용 간이 진단키트

        김기영,박샛별,문지혜,이상대,이새롬,장윤정 충남대학교 농업과학연구소 2013 농업과학연구 Vol.40 No.2

        This study was performed to develop a rapid test kit for pathogenic Staphylococcus in various samples. The rapid detection kit has been fabricated based on nitrocellulose lateral-flow strip. Colloidal gold and Staphylococcus antibodies were used as a tag and a receptor, respectively. Manually spotted Staphylococcus antibody and anti-mouse antibody on the surface of nitrocellulose membrane were used as test and control lines, espectively. Feasibility of the rapid kit to detect Staphylococcus aureus in samples were evaluated. The intensity of the color of the tes line started to increase with the samples in which higher concentration of the cells were contained. The sensitivity of the sensor was 106 cfu/mL Staphylococcus spiked in PBS. Also, the rapid test kit could detect 105 cfu/mL of Staphylococcus in chicken meat extract.

      • 상호운용성 지원을 위한 이동 에이전트 시스템 설계

        정성옥,이정기,홍성표,송기범,이준 조선대학교 전자정보통신연구소 2002 電子情報通信硏究所論文誌 Vol.5 No.1

        A mobile agent is a computer program that acts autonomously on behalf of a person or organization and that has the unique ability to transport itself from one system in a network to another. An agent system is a platform that can create, interpret, execute, transfer and terminate agents. But, most current mobile agent systems adopted their own architectures, being implemented in various ways. Since those agent systems provide different interfaces, agens created in one mobile agent system could not move to other agent systems perform their task. To solve this problem, interoperability becomes one of the important issues on mobile agent systems. The OMG(Object management Group) proposed: the MAF(Mobile Agent Facility) specification for the interoperability among heterogeneous mobile agent systems. The MAF specification contains MAFAgentSystem and MAFFinder interfaces, and defines agent management, code mobility and naming rule. In this paper, we propose an execution model that can execute mobile agents within an agent system and migrate them to a remote agent system as conforming MAF, and design the structure and functions of its agent system. Our model uses Java and CORBA ORB in its the implementation and exploits their characteristics appropriately. Specifically its agents beside its clients can spawn child agents and control other agents.

      • KCI등재후보

        효율적인 일정계획에 의한 제조실행 제어

        정인성,이윤상,이상복,왕지남 대한설비관리학회 2004 대한설비관리학회지 Vol.9 No.4

        In this paper, we develop scheduling system under MTO (Make-To-Order) Production and implement it to real application. Generally, scheduling system is regarded as company specific problem such that the required business logic might be different within a same industry. The differences are caused by different constraints of each company requirements. Company specific algorithms are commonly employed using rule-base or heuristic procedure. Based on these characteristics, heuristic procedure are developed and implemented for developing MES (manufacturing execution system). The proposed approach are applied to real industry and proved as an efficient approach in terms of practical views.

      • KCI등재

        급속혼화조건에서 Al(Ⅲ) 가수분해종의 분포특성

        정철우,손정기,손인식,강임석 대한상하수도학회 2004 상하수도학회지 Vol.18 No.2

        The overall objective of this research was to find out the role of rapid mixing conditions in the species of hydrolyzed Al(Ⅲ) formed by different Al(Ⅲ) coagulants. When an Al(Ⅲ) salt is added to water, monomers, polymers, or solid precipitates may form. Different Al(Ⅲ) coagulants (alum and PACI) show to have different Al species distribution over a rapid mixing condition. During the rapid mixing period, for alum, formation of dissolved Al(Ⅲ) (monomer and polymer) increases, but for PACI, precipitates of Al(OH)_(3(s)) increases rapidly. Also, for alum, higher mixing speed favoured Al(Ⅲ) polymers formation over precipitates of Al(OH)_(3(s)) but for PACI, higher mixing speed formed more precipitates of Al(OH)_(3(s)). At A/D and sweep condition, both Al(OH)_(3(s)) and dissolved Al(Ⅲ) (monomer and polymer) exist, concurrent reactions by both mechanism appear to cause simultaneous precipitation.

      • 생후 0-15 개월 소아의 볼거리 항체가 측정

        정은경,나기찬 조선대학교 1993 The Medical Journal of Chosun University Vol.18 No.2

        To determine the proper age of the Mumps vaccination, we measured the degree of immunity of 55 children with the age from birth to 15 months to mumps antibody titer by indirect immunofluorescent antibody method. 1) 40.0% (22/55) of the children was positive for mumps Ig G antibody and 3.6%(2/5) was positive for mumps Ig M antibody. 2) By age group, 19 of 31 children with the age from birth to 4 months were positive mumps Ig G antibody, but all the children was negative between 4 month and 12 months. And, 3 of 7 children with the age between 13 months and 15 months were negative for mumps Ig G antibody. 3) One child was positive both Ig G and Ig M antibody. In conclusion, passive mumps antibody began to diappear after 4 months of age, and also began to develop inapparent infection of mumps before 15 months of age, therefore, it is considered that the early mumps vaccination will be required before 15 months of age.

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