천식에서 관련 유전자들 사이의 상호작용과 천식에대한 영향

이준혁,박성우,장안수,박춘식 순천향대학교 의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

..

고양이 위 평활근에서 KCI에 의한 근수축에 대한 Protein Kinase의 조절

심상수,김승록,심혜선,이덕주,한상준,윤신희,조양혁,김명석 大韓消化器病學會 1998 大韓消化器病學會誌 Vol.32 No.3

고양이 위 평활근 수축에 대한 Vanadate와 Pervanadate의 효과

심상수,최효봉,심혜선,이덕주,윤신희,한상준,김명석,조양혁 大韓消化器病學會 1999 大韓消化器病學會誌 Vol.33 No.1

우리 나라 해사중재의 현황과 개선 방안

성재모,김성준 한국해운물류학회 2003 해운물류:이론과실천 Vol.- No.5

해운, 무역, 보험과 관련한 분쟁은 법원보다는 중재에 회부되는 경우가 일반적이다. 그러나 국내 해운선사들이 해운 분쟁을 대한상사중재원에 회부하는 건수는 갈수록 줄어들고 있고, 대부분은 런던해사 중재에 회부되고 있다. 이번 연구에서는 해운선사의 해사중재현황을 5개 선사를 중심으로 조사하였다. 조사결과 용선분쟁의 90% 이상이 런던해사중재에 회부되고 있고, 대한상사중재원에 회부되는 중재는 2.2%에 불과했다. 이는 해사 분쟁의 당사자가 국내 선사와 제3국 기업이 주류를 차지하고 있는 것이 가장 큰 원인인 것으로 파악된다. 그밖에 해운과 관련한 영국의 판례가 용선계약서 해석의 원칙이 되고 있는 것이 해운업계의 오랜 관행으로 자리잡고 있는 것도 주요한 원인으로 작용하였다. 해운과 관련한 계약은 대부분 국제간에 이루어지기 때문에 해상법이 발달한 영국법에 기초한 런던중재조항이 분쟁 당사자들에게는 공평하게 느껴질 수 있다. 하지만, 국내 선사들간의 해사 분쟁 중 다수가 런던중재를 이용하고 있는 것으로 나타나고 있다. 따라서 현재 대한상사중재원에서 취급하고 해사중재제도가 갖고 있는 문제점을 파악하고, 그 개선방안을 모색해 보았다. It is quite general that a dispute concerned with shipping, trading and insurance is referred to the arbitration panel instead of court. But, the number of case referred to the Korea Commercial Arbitration Board in respect of shipping become fallen every year. Instead, most disputes are referred to the London Maritime Arbitrators Association. The focus of this research is to investigate the current situation of arbitration cases in Korean shipping companies in more details. In the result of the research, it shows that more than 90% of charterparty dispute is referred to the London Maritime Arbitrators Association and only 2.2% is referred to the Korea Commercial Arbitration Board. That is why many leading cases under English law has become a principle of interpretation of the shipping contracts and become a custom in the shipping area. The contributory cause of the above situation is that the Korea Commercial Arbitration Board has a systematic problem. As many contracts concerned with shipping is internationally made, many people in the shipping area might feel that the London Arbitration Clause based on English law would be fair and reasonable. Nevertheless, we should recognize the Korea Commercial Arbitration Board's systematic problem and grope for a method of improving the systematic problem.

보안위협 모니터링을 위한 AI 데이터셋 구성방안 연구

한상현, 조인준 배재대학교 공학연구소 2021 공학논문집 Vol.23 No.1

Cyber-attacks are evolving into a form of a long-term continuous attack by forming a dense group. However, there are cases of being defenseless against hacking attacks due to the lack of information on vulnerabilities exposed to security threats. In addition, organizations and companies with limited assets and response capabilities are often unable to take action due to the lack of measures to respond to such attacks. To solve this problem, we create a shared dataset by collecting various vulnerability information that has been disclosed, and after learning AI, we intend to present information on security vulnerabilities and effective detection and response methods for hacking attacks targeting vulnerabilities. 사이버 공격은 치밀하게 집단을 구성하여 장기간 지속적인 공격을 하는 형태로 진화하고 있다. 하지만 보안위협에 노출된 취약점들에 대한 정보 부재로 해킹공격에 무방비로 당하는 사례도 발생하고 있다. 또한 자산 및 대응역량이 제한된 기관 및 기업들은 이러한 공격에 대응할 수 있는 방안 부재로 조치를 할 수 없는 경우가 상당히 많다. 이러한 문제점을 해결하기 위해 공개되어있는 각종 취약점 정보들을 모아 공유 데이터셋을 만들어 AI 학습 후 보안취약점에 대한 정보와 취약점을 노린 해킹공격에 대한 효과적인 탐지와 대응하는 방안을 제시하고자 한다.

Characterization of Silver Inkjet Overlap-printing through Cohesion and Adhesion

Sang?Ho Lee,Young?June Cho 대한전기학회 2012 Journal of Electrical Engineering & Technology Vol.7 No.1

We introduce an understanding of silver (Ag) inkjet overlap-printing characteristics from the viewpoints of cohesion between ink droplets and adhesion between an ink droplet and a surface. The printing characteristics were closely monitored by changing the surface energy to elucidate the effect of adhesion and cohesion on printing instability, such as droplet merging and line bulging. The surface energy of the substrate was changed through the hydrophilization of a hydrophobic fluorocarbon-coated surface. The surface energy and ink wettability of the prepared surfaces were characterized using sessile drop contact angle analysis, and printing instability was observed using an optical microscope after drop-on-demand inkjet printing with a 50% overlap in diameter of deposited singlet patterns. We found that the surface energy is not an appropriate indicator based on the experimental results of Ag ink printing on a hydrofluoric-treated silicon surface. The analytical approach using adhesion and cohesion was helpful in understanding the instability of the inkjet overlap-printing, as adhesion and cohesion represent the direct interfacial relationship between the Ag inks used and the substrate.

편평세포폐암에서 p53 돌연변이의 발현과 TNM 병기와의 상관관계

이상숙,한승범,전영준 啓明大學校 醫科大學 1994 계명의대학술지 Vol.13 No.4

Primary lung cancer is now recognized as a major cause of cancer death in Korea as well as the whole world. Non-small-cell lung cancers(NSCLC) comprise about 75% of lung cancer and squamous cell carcinoma is the most common type in Korea. Mutations of p53 gene are common in variety of human cancers, including lung cancer. The p53 gene appears to inhibit the proliferation of cells from the G1 to the S phase of cell cycle and is able to suppress the transformations of cells by other oncogenes, to inhibit the growth of malignant cells in vitro and suppress the tumorigenic phenotype of transformed cells. Alteration or inactivation of p53 by mutation, or by its interactions with oncogene products of DNA tumor viruses, can lead to cancer. These mutations seems to be the most common genetic changes in human cancers. p53 gene mutation is known to be a poor prognostic marker in breast cancer and has significant association with lymph node involvement. But in human lung cancer the association of p53 mutations and TNM stages are controversial. Immunohistochemical staining can detect only mutant p53 protein bacause of markedly prolonged half life of mutant p53 protein. We performed the immunohistoschemical staining on 48 surgically resected and 10 bronchoscopically biopsized specimens of primary squamous cell carcinoma of the lung with monoclonal antibody(DO 7) and analyzed the relationship between the expression of p53 protein and clinical TNM stages. p53 protein was detected in 60.3% of total 58 cases. p53 protein was positive in 52.9% of stage I(17cases), 83.3% of stage Ⅱ(6 cases), 72.2% of ⅢA(18 cases), 42.9% of ⅢB(7 cases) and 50% of stage Ⅳ(10 cases) which revealed no significant correlation between p53 protein detection and stages. There was no significant correlation between p53 protien detection and No and N₁-₃as well Mo and M₁. In conclusion, we couldn't find any significant correlation between p53 protein detection and TNM stages which suggests p53 mutation is frequent in squamous cell carcinoma of the lung but play different role in progression of clinical stages.

불응성 자가면역질환에서의 자가조혈모세포이식

민도준,양동원,민창기,김완욱,이상헌,박성환,김동욱,이종욱,조철수,민우성,김범생,김호연,김춘추 대한조혈모세포이식학회 2001 대한조혈모세포이식학회지 Vol.6 No.1

배경: 기존의 치료에 불응하고 예후가 불량한 자가면역질환 환자들에게 최근 고용량 면역억제 및 조혈모 세포이식이 새로운 치료방법으로 대두되고 있다. 저자들은 다발성 경화증(multiple sclerosis, MS) 및 류마티스 관절염(rheumatoid arthritis, RA) 등 2명의 자가면역질환 환자들에서 자가조혈모세포 이식을 시행하였다. 방법: 말초혈액 조혈모세포 가동화를 위하여 cyclophosphamide (4 g/㎡) 및 granulocyte colony stimulating factor (10 g/kg/day)를 투여하였고, CD34+ 세포를 분리·채집 하였다, 이식 전처치로 MS 환자에서 BEAM 및 antihymocyte globulin (ATG) (3.75 mg/kg), RA 환자에서 fludarabine (180 mg/㎡), ATG (10 mg/kg)와 busulfan (8 mg/kg)을 투여하였다. 결과: 호중구 수가 500/㎕ 이상으로 회복되는 기간은 MS 환자에서 9일, RA 환자에서 15일이었다. 혈소판이 20.000/㎕ 이상으로 회복되는 가간은 RA 환자에서 9일 이었고, MS 환자에서는 혈소판 감소증이 발생하지 않았다. 비혈액학적 독성으로 MS 환자에서 WHO 1도의 오심 및 점막염이 관찰되었다. MS 환자는 이식 6개월 후까지 시력감소가 남아있었으나, 이식전에 관찰되던 감각이상 및 운동장애 등의 신경학적 이상 소견은 더 이상 관찰되지 않았다. RA 환자는 이식 1개월 후 관절 증상 및 검사소견의 호전을 보였다. 결론: 불응성 자가면역질환 환자에서 고용량 면역억제 및 조혈모세포이식은 적은 독성으로 높은 치료효과를 기대할수 있으며, 향후 이 시술의 임상적 의의를 규명하기 위하여 전향적이고 장기적인 연구가 필요할 것으로 사료된다. Background: High-dose immunosuppressive therapy followed by autologous hemathpoietic stem cell transplantation (HSCT) has been proposed as a new approach to treat severe, refractory autoimmune diseases. We describe two patients with refractory autoimmune diseases (one multiple sclerosis 〔MS〕and one rheumatoid arthritis〔RA〕) who underwent T-cell-depleted autologous peripheral bleed stem cell transplantation for the first time in Korea. Methods: We mobilized autologous stem cells with cyclophisphamide (4 g/㎡) and granulocyte colony-stimulating factor (10 ㎍/kg/day). Stem cells were enriched ex vivo using CD34-positive immunoselection and reinfused after high-dose chemotherapy with BEAM and antithymocyte globulin (ATG) (3.75 mg/kg) in MS, or fludarabine (180 mg/㎡), ATG (10 mg/kg) and busulfan (8 mg/kg) in RA. Results: The engraftment with an absolute nerutrophil count greater than 500㎕ occurred on day 9 in MS and 15 in RA, respectively. The time to nontransfused platelet count greater than 2.000/㎕ was 9 day in RA. MS patient did not show ant episode of thrombocytopenia. Regimen-related non-hematopoietic toxicity was minimal. For 6 months since HSCT, them patient with MS had been free from previously existed sensory and motor abnormalities except decreased visual acuity. Then patient with RA and only one tender joint and two mildly swollen joints with improvement in laboratory parameters at one month after HSCT. Conclusion: These results underscore the feasibility and potential efficacy of intensive immunosuppression followed by autologous HSCT for treatment of intractable autoimmune diseases. The durability of remission, however, remains to be clarified.

Roxithromycin 으로 치료 후 호전을 보인 미만성 범세기관지염 1예

어성준,박성우,이준혁,장안수,박춘식 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Diffuse panbronchiolitis is a clinical pathologic condition characterized by chronic inflammation of respiratory bronchioles, with clinical features that position it as a differential diagnosis among the sinopulmonary syndromes. We experienced 46-year-old male patient who complained of dyspnea and productive sputum for 2 years. Diagnosis was made by the clinical and radiological features and confirmed by transbronchial biopsy. The clinical findings included chronic sinusits, productive cough,dyspnea, rhonchi, and wheezes. High resolution computerized tomography showed a diffuse nodular pattern, airway ectasia, and airway wall thickening. The biopsy showed interstitial accumulation of foam cells and lymphoid cells in the walls of respiratory bronchioles. We treated low does of roxithromycin, After 8 months, the patient nearly improved symptoms and HRCT findings.

효율적인 서비스 품질 측정 방법에 관한 연구

박상준,조재립 慶熙大學校 레이저 工學硏究所 2003 레이저공학 Vol.14 No.-

As many organizations are searching for ways to compete more effectively in today′s market environment. Service quality is become the most important fact to improve their competition. The objectives of this paper are to provide an overview of service Quality and to discuss how to measure it more efficiently. This study develops a conceptual ″SERVPERF″ and ″SERVQUAL″ of service quality, which identifies only performance based measurement. And Fuzzy quality measuring (FQM) using Fuzzy rule based algorithm to adept survey to date sets is proposed. Furthermore, the study examines the applicability of Fuzzy rule based measurement.