관동맥질환에서 저밀도 지단백 입자 크기의 분포

임효영,김인숙,승기배,강동헌,전두수,장기육,박준철,이수영,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

Baculovirus Vector System에 의해 발현된 재조합 Pseudorabies Virus Major Capsid Protein의 면역원성

전무형,안동준,장경수,조용성,박종현,송재영,현방훈,안수환 충남대학교 생물공학연구소 1997 생물공학연구지 Vol.5 No.-

The recombinant pseudorabies virus major capsid protein (rMCP) was produced by expression of the MCP gene in Sf-9 cell using baculovirus transfer vector system. Following evaluation of the immunochemical properties of the rMCP, the immunogenicity of the recombinant subunit protiens were investigated in guinea pig and swine to obtain the preliminary guide line for the subunit vaccine using rMCP and gP50. It was proved that ultrasonication and 30% ammonium sulfate was most efficient to concentrate and purify the protein. The rMCP was safe in mice, guinea pigs and piglets. In guinea pigs, rMCP mixed with various adjuvants induced substantial degree of serum neutralizing antibody titers, but revealed incomplete protecivity against challenge. In swine, the combination of rMCP and gP50 showed the higher serum neutralizing antibody titers and cellular immune responses than rMCP alone. However, the protectivity was lower in comparison with the commercial gI-deleted inactivated vaccine. We expect these results to contribute to characterization of MCP gene of Korean isolate of PRV and to ultilize as preliminary information for prodution and evaluation of PRV recombinant subunit vaccines.

Electrosorption and Separation of Co²and Sr²Ions from Decontaminated Liquid Wasres

Jun0Soo Kim,Chong-Hun Jung,Won-Zin Oh,Seung-Kon Ryu 한국탄소학회 2002 Carbon Letters Vol.3 No.1

가상공간의 가공 공정과 상태 구현에 관한 연구

이수훈,김봉석,홍민성,김종민,JUN NI,박상호,송준엽,이창우,하태호 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

This paper presents virtual machining system in order to realize turning process in virtual space. A reliable virtual turning process simulation was developed based on the surface shaping system which is capable of considering geometric model, thermal error model, and vibration model. Accuracy of surface shape resulting from proposed machining simulator was verified experimentally. This paper also developed the watchdog agent that continuously assessed, diagnosed, and predicted performance of products and machines in machining. The Watchdog agent extracted feature signal using time-frequency analysis among various signals from multi-sensor and evaluated machining condition using performance confidence value.

Captopril과 Nifedipine 병합요법의 강압효과에 관한 임상적 연구

이영수,문언수,김준호,공수정,정시진,주용진,정상만 건국대학교 의과학연구소 1993 건국의과학학술지 Vol.3 No.-

Background: The hypotensive effect of captopril(angiotensin converting enzyme inhibitor) and nifedipine(calcium channel blocker) was studied. Method: Captopril(75mg) and nifedipine(30mg) were administered in 30 hypertensive adults during twelve weeks after a week observation for washout with stepwise increments of the dose according to the patient's blood pressure in every two weeks. Result: The supine blood pressure were decreased from 169.5±22.3/104.0±20.3 mmHg to 130.4±21.3/82.4±19.5mmHg at the end of twelve weeks during therapy.(p<0.05) The standing blood pressure were also decreased conferrably and to the some lower level. Hematologic examination and blood chemistry revealed no discernible abnormal findings before and after the treatment. During the period of the study a few probably drug-related symptom such as cough and headache, gastrointestinal disturbance developed but not troublesome enough to administering. Conclusion: Captopril and nifedipine regimen is well tolerated and effective in the treatment of hypertensive patients.

Pseudorabies Virus의 Major Capsid Protein 유전자의 클론닝과 Baculovirus Vector System에 의한 발현

안동준,전무형,송재영,박종현,현방훈,장경수,안수환 충남대학교 생물공학연구소 1997 생물공학연구지 Vol.5 No.-

Pseudorabies is caused by Pseudorabies virus (PRV: Aujeszky's disease virus) of Herpesviridae that is characterized by 100 to 150nm in size with a linear double-stranded DNA molecule with of approximately 90 × 10 exp (6)Da. This disease affects most of domestic animals such as swine, cattle, dog, sheep, cat, chicken, etc. causing high mortality and economic losses. In swine, young piglets show high mortality and pregnant sows, reproductive failures. However the adult swine reveals no clinical signs in general. But they become a carrier state and play an importnat role for propagation of the disease. In this study, the nucleotide sequence of major casid protein gene of PRV, Yangsan strain isolated from the diseased swine in Korea was analyzed, and the recombinant MCP was produced by expression of the MCP gene in Sf-9 cell using baculovirus transfer vector system. As result, in BamHI digestion, MCP gene locus of PRV YS strain showed different from that of Indiana S strain. The patterns of enzyme mapping were also found to be unidentical each other. The sequence of the MCP gene partially analyzed showed 98.09% identity to Indiana S strain. The expression of MCP in Sf-9 cell cotransfected by pVLMCP-44 baculovirus expression vector was characterized by Southern blot hybridization, immunofluoresent and immunocytochemical tests, SDS-PAGE and Western blotting. The rMCP with M.W. 142kDa was most effectively expressed in Sf-9 cells at the 3-4th days post inoculation of the recombinant baculovirus by 2 moi.

상고 중국어에 보이는 모음(母音) 교체(交替)(ablaut)를 통한 어휘 파생 현상에 대한 소고(小考)

김준수 ( Kim Jun-soo ) 한국중국언어학회 2017 중국언어연구 Vol.0 No.71

Since the last century, many scholars' efforts have contributed to revealing that Old Chinese was a language in which relatively abundant changes in the form of words took place on the contrary to Modern Chinese. This study discussed ablaut phenomenon, which has been relatively less studied compared with the prefix or suffix. In particular, among 16 groups of cognate words that were presented in the study of Pulleyblank (1973) as words formed by ablaut, this study examined two groups of ― wei 圍(^*G^wЩl)/ wei 衛(^*G^wads) and he 合(^*guːb)/ hui 會(^*goːbs) that can be verified using Chinese paleography data. In addition, the main vowel discrepancy between yi 抑(^*?ŋЩg) and yang 仰(^*ŋaŋ?) that was left as a future task in the study of Kim, Jun-soo 金俊秀 (2016b) was also explained as an example that reflects ablaut phenomenon.

中国延边旅游人力资源现状及开发对策

徐哲俊(Xu,Zhe-Jun),金红,英(Xu,Zhe-Jun),金春洙(Kim, Chun-Soo) 글로벌경영학회 2012 글로벌경영학회지 Vol.9 No.3

With the development of Yanbian tourism and entering from all directions of foreign enterprises, which will have a great impact on the development and management of tourism human resources in China. As Yanbian tourism develops rapidly in recent years, the demand for tourism human resources has a rapid expansion. However, the development and management of human resources is relatively backward, which has seriously limited the development of Yanbian tourism and needs to be solved as soon as possible. Therefore, this paper elaborates the human resources of Yanbian, analyses the problems about the development and management of human resources, and then finds that the total quantity of Yanbian human resources is insufficient, whose personnel training has a great gap compared with its market demand;its quality and level as a whole is somewhat low; professionals of tourism and hotel management are deficient;training work falls behind, which can not satisfy the tourism demand;incentive mechanism is on shortage, which leads to a frequent flow of personnel;employees have a weak sense of service. Then, it constructed a “Trinity” pattern of human resources development and management in Yanbian tourism. This paper puts forward practical countermeasure and measures from 6 aspects of establishing the correct concept of tourism talents, letting local governments and tourism administration departments play a leading role sufficiently, improving and strengthening the tourism human resources training, improving Yanbian tourism education system, building perfect talent and incentive mechanism, strengthening the occupation career management of tourism enterprise employee and so on, which provides theoretic and practical reference for the scientific development of human resources in Yanbian. 旅游业的持续快速发展以及国外旅游企业的全方位进入,将对中国旅游人力资源开发与管理 带来极大的冲击。近年来延边旅游业迅猛发展,旅游业对人力资源的需求急剧膨胀,但是,旅 游人力资源的开发与管理的相对滞后,严重制约着延边旅游业的发展,需要迅速加以解决。因 此,本文首先阐述了延边旅游人力资源的现状,分析了旅游人力资源开发与管理中存在的问 题,发现了延边旅游人力资源总量相对不足,人才培养滞后于市场需求;整体素质及层次偏 低;旅游及酒店管理专业人才匮乏;培训工作落后,不能满足旅游业的需求;缺乏有效的激励 机制,人员流动频繁;从业人员服务意识薄弱。然后,构建了延边旅游业“三位一体”人力资源开 发与管理模式。最后,提出了树立正确的旅游人才观念、充分发挥地方政府和旅游行政管理部 门的指导作用、完善和加强旅游人力资源培训、改善延边旅游教育体系、建立完善的人才使用 和激励机制、强化旅游企业员工职业生涯管理等6个方面提出了切实可行的对策和措施,为延边 旅游企业人力资源的科学发展提供理论与实践。鉴。

양전자방출단층촬영을 이용한 초점주의와 작동기억의 뇌 활성화 양상 비교

김재진,조상수,김명선,손정우,이재성,이동수,이명철,권준수 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.2

연구목적: 단순 초점주의 과제와 보다 고도의 집중을 요하는 작동기억 과제를 수행하는 동안의 뇌 활성화 양상을 비교하여, 두 인지기능 과정을 매개하는 정상적 신경회로의 특성과 차이를 알아보는 것을 목적으로 하였다. 방법: 정상인 14명을 대상으로 시각처리 대조 과제, 단순 초점주의 과제, 작동기억 과제 등 세 가지 인지과제를 주고, 과제 수행 동안 [□O]H₂O를 추적자로 한 양전자방출단층활영을 실시한 후 감산분석을 통해 초점주의와 작동기억의 신경회로 지도를 작성하여 비교분석하였다. 결과: 초점주의 동안 활성화되는 부위는 좌측으로 편측화되고 산발적으로 분포하는 양상이었고, 특히 전대상이랑과 운동영역을 포함한 전두엽, 일차 및 이차 시각피질 등의 활성화가 특징적이었다. 작동기억 동안의 뇌 활성화 역시 산발적 분포와 좌측 편측화 양상이 관찰되었으나, 시각피질보다는 전두엽의 활성화가 우세하였고, 특히 우측 전대상이랑의 현저한 활성화가 특징적이었다. 결론: 초점주의와 작동기억은 개념적으로 공통점과 차이점을 내포하고 있는 것처럼 매개 신경회로에서도 공통 혹은 특이한 영역을 각각 가지며, 전대상이랑의 역할이 두 기능에 공통적으로 중요하고, 이차 시각피질과 전전두피질이 두 기능 각각에 더 중요하게 작용하는 것 같다. Objectives:This study was undertaken to identify neural substrates for simple focused attention and more highly-focused working memory i normal people and investigate their characteristics and differences. Method: Fourteen normal subjects were studied with [□O]H₂O positron emission tomography during a visual processing baseline task, simple focused attention task and working memory task. Results were analyzed with the subtraction analysis to map the neural correlates of focused attention and working memory. Results: Activated areas during focused attention tended to be lateralized to the left and scattered over various regions including the anterior cingulate, motor area, and primary and secondary visual cortices. While the areas activated during working memory also show the left lateralization and scattered distribution, activation prevailed more in the frontal lobe than in the visual cortex, and was particularly remarkable in the right anterior cingulate. Conclusions: Focused attention and working memory do not have only conceptually commonalities and differences but also have common and specific areas in their neural substrates. The anterior cingulate may commonly play an important role in both cognitive functions, whereas secondary visual cortex and prefrontal cortex seem to be predominantly implicated in each function, respectively.

원위 경골 간부 골절에서 최소 침습적 경피적 금속판 고정술과 관혈적 금속판 고정술의 비교

유성호 ( Seong Ho Yoo ),안성준 ( Seong Jun Ahn ),송무호 ( Moo Ho Song ),김부환 ( Bu Hwan Kim ),이민수 ( Min Soo Lee ),박종하 ( Jong Ha Park ) 대한골절학회 2006 대한골절학회지 Vol.19 No.1

목적: 경골 원위부 골절의 치료에 있어 최소 침습적금속판 고정술과 관혈적 고정술에 대한 비교를 통한 효율성에 대한 연구고찰을 하고자 한다. 대상 및 방법: 2001년 6월부터 2004년 6월까지 경골 원위부 골절에 대하여 수술을 시행한 최소 1년 이상의 추시가 가능하였던 30예 중 최소 침습적 금속판 고정술을 시행한 15예를 A군, 관혈적 금속판 고정술을 시행한 15예를 B군으로 나누어 수술시간, 술 후 재활, 술 후 운동범위, 동통에 대하여 McLennan과 Ungersma의 기준을 이용한 임상평가, 술 후 염증반응에 대한 C-반응성 단백 및 술 후 합병증을 후향적으로 비교 분석하였다. 결과: A군과 B군의 수술시간은 각각 63분 (45∼105)/129분 (80∼120), 능동적 관절 운동가능시기는 8.3일 (6∼14)/15.8일 (13∼21), McLennan과 Ungersma의 기준에 의한 임상평가는 두 군 모두에서 대부분 양호 이상의 결과를 보였으나, B군에서는 보통 1예가 있었다. 술 후 3일, 7일째 각각 시행한 CRP는 A군에서는 4.0 mg% (범위: 0.9∼7.2)/0.5 mg% (0.1∼1.5), B군에서는 7.97 mg% (2.8∼14.6)/1.0 mg% (0.3∼1.6)로 A군에서 조직손상이 적고 회복이 빨랐다. 술 후 합병증으로는 A군에서는 표재성 감염 1예와 5도 이상의 족관절 외반변형 1예가 있었고, B군에서는 표재성 감염 1예, 감염성 불유합 1예와 10도 미만의 족관절 배굴장애를 보이는 경우가 2예 있었다. 결론: 경골 원위부 골절의 수술적 치료에서 최소 침습적 금속판 고정술이 관혈적 고정술에 비해 조직의 염증반응과 합병증이 적고 수술시간 및 술 후 재활 등에서 보다 효율적인 술식으로 사료된다. Purpose: To evaluate the efficacy of the surgical treatment through the comparison of MIPPO vs open plate fixation in the treatment of the distal tibia fracture retrospectively. Materials and Methods: 30 patients with distal tibia fracture from Jun. 2001 to Jun. 2004 were divided into two groups depending on the surgical method. Minimum follow up was 12 months. Group A consisted of 15 patients treated with MIPPO, Group B was 15 patients treated with open plate fixation. The clinical outcomes were evaluated retrospectively from operation time, rehabilitation, ROM, interval change of postoperative CRP to assess postoperative inflammatory reaction, postoperative complications and clinical result with the use of McLennan and Ungersma criteria. Results: There were no significant differences in clinical result by McLennan and Ungersma criteria in both groups. The postoperative 3 days and 7 days CRP were 4.0 mg% (0.9∼7.2)/0.5 mg% (0.1∼1.5) in group A and 7.97 mg% (2.8∼14.6)/1.0 mg% (0.3∼1.6) in group B, shows more minimal tissue injury and early recovery in group A. Operation time in group A was shorter than group B. Normal recovery of ROM was quicker in Group A. In complications, group A showed one superficial infection and one angular deformity and group B showed one superficial infection, one infected nonunion and two ankle stiffness. Conclusion: There were no significant differences in clinical result and bony union. MIPPO technique is superior to group B in view of the minimal tissue injury, complications, operation time and postoperative rehabilitation.