Heme oxygenase-1 (HO-1)/carbon monoxide (CO) axis suppresses RANKL-induced osteoclastic differentiation by inhibiting redox-sensitive NF-κB activation

( Sun-uk Bak ),( Suji Kim ),( Hae-jun Hwang ),( Jung-a Yun ),( Wan-sung Kim ),( Moo-ho Won ),( Ji-yoon Kim ),( Kwon-soo Ha ),( Young-guen Kwon ),( Young-myeong Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2017 BMB Reports Vol.50 No.2

Heme oxygenase (HO-1) catalyzes heme to carbon monoxide (CO), biliverdin/bilirubin, and iron and is known to prevent the pathogenesis of several human diseases. We assessed the beneficial effect of heme degradation products on osteoclastogenesis induced by receptor activator of NF-κB ligand (RANKL). Treatment of RAW264.7 cells with CORM-2 (a CO donor) and bilirubin, but not with iron, decreased RANKLinduced osteoclastogenesis, with CORM-2 having a more potent anti-osteogenic effect. CORM-2 also inhibited RANKLinduced osteoclastogenesis and osteoclastic resorption activity in marrow-derived macrophages. Treatment with hemin, a HO-1 inducer, strongly inhibited RANKL-induced osteoclastogenesis in wild-type macrophages, but was ineffective in HO-1^+/-cells. CORM-2 reduced RANKL-induced NFATc1 expression by inhibiting IKK-dependent NF-κB activation and reactive oxygen species production. These results suggest that CO potently inhibits RANKL-induced osteoclastogenesis by inhibiting redox-sensitive NF-κB-mediated NFATc1 expression. Our findings indicate that HO-1/CO can act as an antiresorption agent and reduce bone loss by blocking osteoclast differentiation. [BMB Reports 2017; 50(2): 103-108]

저용량의 클로자핀에 의해 경련이 유발된 정신분열증 환자 4례

윤준현,김정진,백인호 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.3

Clozapine은 추세외로 증상과 지연성 운동장애를 거의 일으키지 않는 비전형 항정신병 약물로서 치료 저항성 정신분열증 환자들의 치료에 우수한 효과가 있는 것으로 알려져 있다. 그러나 기존의 항정신병 약물로 치료를 받고 있는 환자들의 약 1%에서 경련이 발생하는 것과 비교해서 clozapine를 투여받는 환자들은 경련의 발생 비율이 보다 높은 것으로 알려져 있다. 또한 이러한 경련은 clozapine의 투여에 의해 점차적으로 경련의 역치가 낮아져 발생하게 되므로 clozapine의 용량이 증가함에 따라 경련의 발생 비율도 함께 증가하는 것으로 보고되어져 왔다. 저자들은 정신분열증 환자들에게 clozapine을 투여하던 중 이전의 보고들과는 달리 저용량에서 전신성 경련이 발생한 환자 4례를 경험하였다. 본 증례에서는 경련이 clozapine을 증량하여 투여한 직후에 발생하였기 때문에, 약물의 용량보다는 clozapine 투여 후에 혈중 clozapine 농도가 급격히 증가하는 것에 기인한 것으로 생각되었다. 본 증례를 통해 저자들은 치료 저항성 정신분열증 환자들에게 clozapine을 투여할 경우 고용량 투여, 급격한 증량에 주의한다면 경련을 최소화할 수 있다고 생각하였다. Clozapine is an atypical antipsychotics that has shown to be effective in treating patients with refractory schizophrenia and those with intolerance to currently available antipsychotics. It also appearer to be less likely to cause extrapyramidal symptoms and tardive dyskinesia. But clozapine has been associated with an unusual high incidence of seizures in patients with no previous history of ictal episodes. Seizures occur in approximately 1% of patients treated with antipsychotic drugs. But the prevalence is higher with clozapine. Clozapine-induced seizures are reported to occur in a dose-related manner by progressively lowering the seizure threshold on most all patients as the dose is increased. But seizure does not usually necessitate discontinuation of clozapine treatment. We experienced four cases of seizure induced by low doses of clozapine treatment in schizophrenic patients. Since most of the seizures have occured soon after increase of a clozapine dose, they may have related more to rapid increase in blood clozapine levels than to that of dose. It is also possible that dose did not accurately predict blood levels for these patients. The possibility of seizures should not pose a barrier a barrier to clozapine treatment for patients with refractory psychotic disorders. The risks and morbidity of seizures can be minimized through attention to clinical management.

갑상선 질환에서 혈청 Microsome 항체 측정의 의의

윤영옥,장순모,박호자,이준열,양기화,정인숙,강석진 대한임상병리사협회 1984 임상병리사회지 Vol.16 No.1

번호이동성제도 시행 이후의 소비자 행동에 관한 실증분석

윤충한,정준호 한국정보사회진흥원 2006 정보화정책 Vol.13 No.2

우리나라 이동전화시장의 공정한 경쟁을 위해 도입된 번호이동성 제도는 제도 시행이후 시장에 여러 가지 긍정적인 변화를 가져온 것으로 판단된다. 제도 시행이후 가입전환은 증가하였으며, 시장점유율의 차이는 줄어들고 허핀달지수는 지속적으로 내려가고 있는 등 시장구조에 상당한 변화가 일어나 이동전화시장이 더 경쟁적인 상태로 변화하고 있음을 보여 준다. 본 연구는 집계변수 측면에서 확인되는 이러한 이동전화시장의 변화가 번호이동성으로 소비자들의 선택이 더욱 용이해지고 가입전환에 드는 비용이 줄어들어서 발생하는 현상인지를 직접적으로 확인하기 위해 소비자선택모형을 이용하여 시장의 번호이동성제도의 효과를 실증적으로 분석하였다는 점에서 의의가 있다. 관측되는 가입전환의 증가 현상이 실제로 번호변경에 따르는 비용으로 오랫동안 가입전환을 하지 못했던 소비자들이 대거 번호이동하였기 때문에 나타났다는 본 연구의 실증분석 결과는 전환비용과 번호이동제의 효과 분석에 많은 시사점을 준다.

하악골 골절 환자에 있어 수술후 합병증으로 발생한 골수염의 치험례

윤규호,전인성,신용길,박준호,허남오,방석준 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.4

The term osteomyelitis literally means inflammation of bone marrow. It is described as an inflammatory condition of bone primarily engaging the medullary Following circulatory collapse and ischemia, the involved portions of the bone become necrotic. Cellulitis and osteomyelitis are the most frequent complications of fractures of the mandible and maxilla, because there is an abscessed tooth in the line of fracture. Since most fractures are compound fractures, infection may develop because of contact with oral secretions or outside air. The treatment of chronic osteomyelitis is still under debate. Some authors rely on antibiotics alone, while others advocate combination with surgery. But when infection occurs, establish proper drainage and administer antibiotics. Author treated a case of infected mandibular fracture with mandibular osteotomy, sequestrectomy, iliac bone graft and hyperbaric oxygen therapy, who had suffered suppurative osteomyelitis and mandibular nonunion following the open reduction of the mandibular fracture.

무세정 Wave Soldering 공정 기술에 관한 연구

윤준호,장인철,신영의 중앙대학교 기술과학연구소 1997 기술과학연구소 논문집 Vol.27 No.-

본 연구는 저잔사 무세정 플럭스를 사용한 솔더링 공정에 대한 실험을 수행하였다. 일반적으로 세정이 요구되는 플럭스와 같은 조건에서 실험할 후 비교하여 육안 검사와 인장 시험을 통해 저잔사 플럭스의 특성과 문제점 그에 따른 최적 조건을 검토하였다. 실험한 결과로부터 기존의 플럭스와 저잔사 무세정 플럭스의 결함 발생 조건을 검토하였고, 시편이 접합력 측정하여 품질을 평가하였다. 접합력에 있어서는 저잔사 무세정 플럭스가 기존 플럭스보다 약 10~20N 정도로 높게 나타났지만, 변동폭도 크게 나타나 접합의 재현성면에서 문제가 있는 것으로 생각되며, 솔더링 공정 상 (특히 예열온도, 예열 시간, 납조 접촉 시간)의 보다 세심한 주의를 요하는 것으로 사려된다. Wave soldering with low residue, non-cleaning flux has been studied from perspective initial solderability using visual inspection and mechanical tensile test. Soldering fillet including joining force with non-cleaning flux and cleaning flux were compared in wave soldering process. As a result of visual inspection, for low residue non-cleaning flux, optimal conveyor speed was 1.0~2.0 m/min and optimal preheat temperature was 50~125℃. For cleaning type flux, optimal conditions were 0.6~1.0 m/min, 110~125℃. As result of tensile test, initial tensile force of non-cleaning flux is lower than cleaning flux. It is recommenced to use non-cleaning flux for demanding higher strength and to use cleaning flux for demanding on repeatability. The influences of filling the holes on tensile force are also explored. To inspect that holes was filled with solder are more important than the lower- side fillet deformed well in PTH(PIH)devices.

축산물 소비행태의 70·80년대 비교분석 : A Compatison of the 1970's with the 1980's

尹錫元,朴俊浩 중앙대학교 경제연구소 1990 經濟論文集 Vol.- No.4

Per capita consumption of livestock product in Korea has increased remarkably during last two decades(the 1970's and the 1980's) mainly due to the increase of per capita real income. In this process, the consumption behavior of the livestock product has been changed during the two decades. The paper attempts to compare the consumption behavior of the major livestock products(beef, pork, chicken) for the 1970's with that for the 1980's by using Nerlovian Partial Adjustment Model and quarterly time series data from 1973 to 1978 and from 1983 to 1988. The major findings and implications are as follows. 1. As the price elasticities of beef for the two decades were estimated -0.06∼-0 10 and -2.0∼-0 28, respectively, the price elasticity for beef in the 1980's was more elastic than the 1970's, even the two price elasticities for the two decades were inelastic. This means that when the domestic beef market is opened, the consumption of beef will increase gradually. 2. Beef and pork were strong substitutes for each other in the 1970's. However, it has been changed to the least substitutes which is very inelastic in the 1980's. 3. Though pork and chicken were complements for each other in the 1970's, it has been changed to the substitutes in the 1980's 4. The incomes elasticities for beef and pork in the 1980's became more inelastic than that in the 1980's. However, the income elasticity for chicken in the 1980's became more elastic than that for chicken in the 1970's. This seems to be the results of recent prosperity of chicken processing industry.

黃芩 抽出物이 DNCB로 誘導된 생쥐의 Allergy性 接觸皮膚炎에 미치는 影響

全宰弘,姜允皓 동국대학교 한의학연구소 1998 東國韓醫學硏究所論文集 Vol.7 No.1

본 실험은 황금이 Allergy性 접촉피부염의 면역과민반응 및 염증반응에 미치는 영향을 조사하기 위해서 시행되었다. 실험을 위해 BALB/C계 생쥐를 DNCB 처리군과 DNCB 처리 후 황금추출액을 경구 투여한 황금추출물투여군(HGET군)으로 나누어 2,4-dinitrochlorobenzene(DNCB)를 도포하여 Allergy性 접촉피부염을 유발한 뒤, 시간의 경과에 따라 contact hypersensitivity assay, 피부의 일반적인 구조 혈관생성, 림프구를 비롯한 염증세포, sulfated acid mucosubstance, 비만세포, IL-2 R, ICAM-1 그리고 CD11b의 변화를 관찰하였다. Contact hypersensitivity assay에서 HEGT군은 DNCB처리군에 비해 有意性있는 ear swelling의 감소를 보였다. 피부표피의 변화에서 HEGT군에서 DNCB처리군에 비해 감소된 것으로 나타났다. 또한 혈관생성, 림프구의 침투 및 표피 기저층과 가시층 세포치 손상은 HEGT군에서 DNCB처리군에 비해 감소된 것으로 나타났다. 또한 혈관생성, 림프구를 비롯한 염증세포, sulfated acid mucosubstance와 비만세포, IL-2 R 양성반응세포, ICAM-1 양성반응세포 그리고 CD11b 양성반응은 Allergy性 접촉피부염의 면역과민반응억제와 항염증작용에 효과가 있는 것으로 사료된다. This study was performed to investigated the effects of an immunosuppression and a mitigation of inflammation of Scutellaria baicalensis GEORGI on Allergic contact dermatitis. In order to study, after oral administration of Scutellaria baicalensis GEORGI extract, contact hypersensitivity assay, general morphologic change of skin, suIfated acid mucosubstance, mast cell, lL-2R, ICAM-1 and CD11b were observed in BALB/C mouse induced allergic contact dermatitis by the contact sensitizing DNCB. Ear swelling in contact hypersensitivity assay was decreased in the Scutellaria baicalensis GEORGI extracts administered(HEGT) group, compared with DNCB painted group. In the general morphologic change of skin, hyperplasia of keratinocytes, increase of lymphocytes and inflammatory cell, increase of vasculogenesis and epidermal lymphocytes infiltration, increase of cell damage in epidermal basal layer and prickle layer were decreased in the HEGT group, compared with DNCB painted group. Increase of sulfated acid mucosubstance, mast cell, lL-2R positive cell, ICAM-1 positive cell, CD11b positive cell were decreased in the HEGT group, compared with DNCB painted group.

관상동맥 스텐트 내 재협착의 발생에 미치는 임상적 관동맥 조영술적 요인들

윤혁준,김기식,박형섭,이영수,현대우,한성욱,허승호,김윤년,김권배,박남희,원경숙 대한순환기학회 2003 Korean Circulation Journal Vol.33 No.12

국내 민간투자(SOC)사업의 효율화 방안에 대한 연구

이호경,김상철,윤준선,백준홍 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

The purpose of this study is to examine the theoretical concept and practical example of Social Overhead Capital(SOC) project based on development of nation the world. Also, the critical access is to find the way we can develop domestic SOC project underway in private and nationwide. Furthermore, anther access is to propose clearly how to utilize BOT, BTO in financial, technical, CM method focusing on more systematic and effective result.