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      • KCI등재

        Recovery Effects from Oxidative Cell Damage by So-Hap-Hyang-Won on Bovine Aortic Endothelial Cells (BAEC)

        Lee,,Mi-Hwa,Kim,,Ji-Young,Ju,,Hyun-Yang,Lee,,Ju-Young,Roh,,Sang-Keun,Gu,,Bon-Seong,Kim,,Min-Ho,Han,,Sang-Min,Kim,,Hong-Sik,Choi,,Won-Chul The Society of Korean Medicine 2003 대한한의학회지 Vol.24 No.4

        So-Hap-Hyang-Won, a traditional oriental medicine used in the treatment of stroke patients, was examined for its ability to reverse the cell damage caused by lipid peroxidation products and oxidative stress in bovine aortic endothelial cells (BAEC). The effects of herbal medicine on cell proliferation and recovery of oxidative damaged situation were studied in BAEC, which was considered an appropriate in vitro model for stroke resulting from various vascular diseases prevalent in advanced age. In a clinical study of stroke patients, So-Hap-Hyang-Won appeared to improve considerably arm and leg movements as well as consciousness disturbance condition, compared with other traditional medicines used for stroke. When BAEC were treated with extracts of the lyophilized herbal medicines, only that of So-Hap-Hyang-Won stimulated cell proliferation and showed no toxicity even at high concentrations. In studies of BAEC treated with extracts of the lyophilized material of the 14 components of So-Hap-Hyang-Won, only the extract of Foeniculi Fructus stimulated cell growth at all concentrations tested. Moreover, when cells were treated with Foeniculi Fructus (10 and 100 mg/ml) extract after prior exposure to t-BHP ($l0\mu\textrm{M}$) or HNE ($0.2\mu\textrm{M}$), lipid peroxidation products which are known to be involved in aging and vascular diseases, or after the exposure to SIN-l ($500\mu\textrm{M}$), which generates nitric oxide (NO) and other reactive oxygen species, there was substantial recovery from the oxidative damage, presumably due to the radical-scavenging effect of Foeniculi Fructus extract. Foeniculi Fructus not only showed stimulatory effects on cell growth and cell damage repair in BAEC, but also appeared to show the most anti-aging activity among all the herbal components of So-Hap-Hyang-Won.

      • SCOPUSKCI등재

        Structure-Activity Relationships of Polyhydroxyursane-type Triterpenoids on the Cytoprotective and Anti-inflammatory Effects

        Jung,,Hyun-Ju,Nam,,Jung-Hwan,Lee,,Kyung-Tae,Lee,,Yong-Sup,Choi,,Jong-Won,Kim,,Won-Bae,Chung,,Won-Yoon,Park,,Kwang-Kyun,Park,,Hee-Juhn The Korean Society of Pharmacognosy 2007 Natural Product Sciences Vol.13 No.1

        Eleven polyhydroxyursane triterpenoids (PHUTs) were tested to determine their cytoprotective, immunosuppressive and anti-inflammatory effects. To compare the bioactivities of $19{\alpha}$-hydroxyursane-type triterpenoids {23-hydroxytormentic acid (6), its methyl ester (7), tormentic acid (8), niga-ichigoside $F_1$ (9),euscaphic acid (10) and kaji-ichigoside $F_1$ (11)} of the Rosaceae crude drugs (Rubi Fructus and Rosa rugosae Radix) with PHUTs possessing no $19{\alpha}-hydroxyl$ of Centella asiatica (Umbelliferae), the four PHUTs, asiaticoside (1), madecassoside (2), asiatic acid (3), and madecassic acid (4) were isolated from C. asiatica and 23-hydroxyursolic acid (5) from Cussonia bancoensis. Cytoprotective effects were assessed by measuring cell viabilities against cisplatin-induced cytotoxocity in $LLC-PK_1$, cells (proximal tubule, pig kidney) to determine whether these agents have protective effects against nephrotoxicity caused by cisplatin. The inhibitory effect of 11 PHUTS on nitric oxide (NO) and prostaglandin $E_2\;(PGE_2)$ were evaluated by measuring nitrite accumulation in lipopolysaccharide (LPS)-induced macrophage RAW 264.7 cells, and their anti-inflammatory effects were tested in 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema model. Six MHUTs (compounds 1, 2, 4, 6, 10, and 11) exhibited higher cell viabilities during cisplatin-induced cytotoxicity testing even at a concentration of $200\;{\mu}g/ml$ than cisplatin only-treated group, suggesting that ese compounds have the potentcytoprotective efffcts. Compounds 1 and 3 of the C. asiatica and niga-ichigoside $F_1$ exhibited no inhibitory effect on NO and/or $PGE_2$ production whereas other PHUTs produced mild to significant NO and/or $PGE_2$ production.The four compounds (2, 5, 9, and 10) potently inhibited mouse ear edema induced by TPA whereas two compounds (1 and 3) had no activity in this test. These results suggest that many PHUTs are potentchemopreventives. Structure-activity relationship (SAR) was also discussed in each assay with regard to the significant role of OHs at the position of 2, 3, 6, 19, and 23 and to the glycoside linkage at the 28-carboxyl.

      • SCISCIESCOPUS
      • KCI등재

        연구보문 : 토양환경 ; 탑라이스 생산지역 논 토양 중 잔류중금속의 벼 흡수이행

        박상원 ( Sang Won Park ), 양주석 ( Ju Seok Yang ), 류승원 ( Seung Won Ryu ), 김대연 ( Dae Yeon Kim ), 신중두 ( Joung Du Shin ), 김원일 ( Won Il Kim ), 최주현 ( Ju Hyeon Choi ), 김선림 ( Sun Lim Kim ), Andrew Flynn Saint) 한국환경농학회 2009 한국환경농학회지 Vol.28 No.2

        비오염 지역인 `06년 "탑라이스(Top-rice)" 생산단지 논토양에서 채취한 토양, 볏짚, 정조, 왕겨, 현미, 쌀겨 및 백미를 분석한 결과 다음과 같다. 논토양 중 비소 1.235 mg/kg, 카드뮴 0.094 mg/kg, 구리 4.412 mg/kg, 납 4.728 mg/kg 및 수은 0.0279 mg/kg으로 우리나라 토양환경보전법상 중금속 오염 우려 및 대책기준을 초과하는 지역은 없었다. 백미 중 비소 0.051 mg/kg, 카드뮴 0.040 mg/kg, 구리 0.345 mg/kg, 납 0.065 mg/kg 및 수은 0.0015 mg/kg으로 잔류허용기준을 초과하는 시료는 없었다. 벼에 흡수·이행된 중금속은 대부분 볏짚에 높게 분포하였고 그 다음으로 쌀겨 부위가 약간 높게 분포 하였다. 그 밖에 정조, 왕겨, 현미 및 백미 중에는 비슷한 농도로 낮게 분포하는 것을 알 수 있었다. 토양 중 중금속과 백미 중 중금속간 흡수기울기는 카드뮴(Cd 0.431)>구리(Cu 0.054)≒수은(Hg 0.052)>비소(As 0.021) >> 납(Pb 0.008) 순으로 토양 중 카드뮴이 벼에 흡수되어 쌀로 쉽게 이행되어 축적될 가능성이 제일 컸다. 벼에 흡수된 구리와 수은도 흡수이행이 용이하였고, 비소와 납은 거의 쌀로 이행되지 않았다. 벼의 지상부로 흡수·이행된 중금속 중 63.3-93.4%는 볏짚에 존재하였으며, 정조에 6.6-36.7%, 왕겨에 0.6-5.7%, 현미에 3.2-31.3%, 쌀겨에 0.8-4.6% 그리고 백미에 1.1-26.7%가 분포하는 것으로 나타났다. 카드뮴의 경우 지상부로 흡수된 양의 26.7-31.3%가 백미 또는 현미에 분포하였다. Heavy metal residues in soil, rice straw, unhulled rice, rice hull, polished rice, and rice barn on the rice paddy in the "Top rice production complex which is non-contaminated area were evaluated. It was observed that the average concentrations of As, Cd, Cu, Pb, and Hg in the paddy soils were 1.235, 0.094, 4.412, 4.728 and 0.0279 mg/kg, respectively. There were no cultivation areas exceeded of the threshold for soil contamination designated by "The Soil Environment Conservation Law" in Korea. For the polished rice, there were no samples exceeded of a permissible level of heavy metal residues such as 0.051 mg/kg of As, 0.040 mg/kg of Cd, 0.345 mg/kg of Cu, 0.065 mg/kg of Pb and 0.0015 mg/kg of Hg. For the uptake and translocation of heavy metals to rice plant, a main part of heavy metal accumulation was rice straw, and then rice bran. Furthermore, it shown that accumulation of heavy metals in unhulled rice, rice hulls, brown rice, and polished rice was approximately similar as low. The slopes of translocation of heavy metals from soil to polished rice were following order as Cd, 0.4321>Cu, 0.054≒Hg, 0.052>As, 0.021>Pb, 0.008. It was observed that potential ability of Cd uptake in rice plant and then its translocation into polished rice was very high. Concentrations of copper and mercury absorbed in the rice plant were moderate for translocating into the polished rice, while the arsenic and lead in the plant were scarcely translocated into the polished rice. The distribution of heavy metals absorbed and translocated into aboveground parts of rice plant was appeared that there were remained at 63.3-93.4% in rice straw, 6.6-36.9% in unhulled rice, 0.6-5.7% in rice hulls, 3.2-31.3% in brown rice, 0.8-4.6% in rice bran and 1.1-26.7% in polished rice. The accumulation ratio of Cd in the aboveground parts of rice plant was remained at 26.7-31.3% in brown and polished rice.

      • KCI등재

        공주감영의 상징적 복원과 구도심활성화를 위한 연구

        김주원(Kim Ju-won) 역사문화학회 2008 지방사와 지방문화 Vol.11 No.2

        본 논문은 2008년 1월 공주시청과 홍익대 환경개발연구원이 맺은『공주고도 역사문화관광개발 마스터플랜 및 설계용역』 계약의 일환으로 진행된 충청감영지구의 보존 및 재개발 계획안의 이론적 근거와 설계 내용을 정리, 확립하고자 씌여졌다. 현재의 공주시 감영지구는 다른 감영도시들에 비하여 원형복원의 가능성이 요원하고 구도심 공동화의 전형적인 모습을 보여주는 듯하다. 하지만 이러한 외형적인 초라함 뒤에는 중세와 근대를 잇는 점진적인 변화의 모습이 보존되어 있으며 대규모 재개발을 피해 살아난 도시조직이 존재한다. 현재에 보존이 덜된 감영관련 유적들도 추정지의 발굴을 통해 얼마나 많이 새로 발견될지 모르기에 섣불리 보존의 한계성을 논하기도 어렵다. 계획 시 무엇보다 중요하게 다루어졌던 것은 현재 살아 작동하는 오래된 도시조직이었다. 연구에 있어서는 조선시대와 일제식민시대의 가로망을 따라 형성된 주거지와 이 안에 공원처럼 존재하는 유적지들의 지속가능성(Sustainability)있는 공존을 통해 역사도시를 구상하는데 초점을 두었다. The following thesis has been prepared to summarize and to clarify the theoretical basis and the contents of the restorational and regenerational proposal for Chung-cheong Gam-young District of Gong-ju Si. The proposal formed a part of 『The Masterplan and Outline Proposal of the Historic/ Cultural/Tourism Development for Gong-ju Si』 works done under the contract signed between the Environmental Development Research Laboratory of Hong-ik University and the City Hall of Gong-ju Si in January 2008. The current old town of Gong-ju Si seems to show the typical aspect of the old-town depression symptom and to have relatively little chance to execute the original restorational works compared to other Gam-young Sis. However, there exists the urban fabric which survived the largescale modern redevelopment and preserved the grain of the gradual change. Also, in fact, it is difficult to define the range of the restorational works yet as there still are many possibilities to excavate Gam-young related relics from any of the potential sites. It was the long-survived urban fabric which had been dealt most importantly within the proposal. The thesis focused on the balanced co-ordination between the residential area which has been formed along the street networks originating from the late Cho-sun and the Japanese colonial era and the archeological sites which were being used like small parks to propose the sustainable development of the historic city.

      • 구강균에 대한 각종 한약제의 증식 억제

        정영건,지원대,김성영,곽동주,서수교,백경연 한국위생과학회 1997 한국위생과학회지 Vol.3 No.1

        The effect of oriental medicines an the growth of oral bacteria(B. pumilus JU4, B. coagulans JU6, B. subtilis var globigii JU7 and B. subtilis var. globigii JU9) which were isolated from teeth, gums and tongues of patients was investigated. lt was shown that the water extracts of Glycyrrhiza glabra L. var. glandulifera Regel et Zucc., Schizandrae Fructus and Coptidis Rhizoma have the strong antimicrobial activity against every test organism. Especially, the water extract of Schizandrae Fructus has the most antimicrobial activity against all test bacteria of which MIC were the same as 0.25%. The growth of oral bacteria B. pumilus JU4 was inhibited by addition of the water extracts of Glycyrrhizae Radix, Schizandrae Fructus and Coptidis Rhizoma in the concentration of 0.9%, 0.2% and 0.1% respectively. It was tested that specific growth rates of B. pumilus JU4 in each concentration of the water extracts of Glycyrrhizae Radix, Schizandrae Fructus and Coptidis Rhizoma. From the results, the test showed that mean of specific growth rates of B. pumilus JU4 decreased 102%, 186% and 210% in 3% concentration of the water extracts of Glycyrrhizae Radix, Schizandrae Fructus and Coptidis Rhizoma more than those in control respectively.

      • SCISCIESCOPUS
      • SCOPUSKCI등재

        소아 중환자의 TISS 에 관한 고찰

        김동옥,김성덕,민성원,손주태 대한마취과학회 1989 Korean Journal of Anesthesiology Vol.22 No.2

        There are few reports analyzing the results of intensive care for children in Korea. A total of 40 critically ill pediatric patients were evaluated in terms of Therapeutic Intervention Scoring System (TISS), The group was composed of patients from 4 services: cardiothoracic surgery, pediatric surgery, pediatrics and other surgeries. We evaluated duration of stay and cost in pediatric intensive care unit (PICU), Seoul National University Hospital, and TISS related to departments. The patients with higher TISS showed longer duration of stay and higher cost in PICU than those with lower TISS. The duration of stay of the patients with high TISS more than 50 was 5.0 days, but it was 2.8 days in 40-49, 2.4 days in 30-39, 2.1 days in 20-29 and 1.9 days in 10-19 of TISS's, respectively. The postoperative first day cost of intensive care was approximately 2,210,000 Won in the patients with high TISS more than 50, but it was 1,060,000 Won in 40-49, 220,000 Won in 30-39, 460,000 Won in 20-29, 120,000 Won in 10-19 of TISS's, respectively. The patients in cardiothoracic surgery showed higher values in maximum, minimum and discharge TISS than other services. Maximum, minimum and discharge TISS of the patients in cardiothoracic surgery were 41, 28 and 23, respectively. TISS's of patients in pediatric surgery and neurosurgery were similar, but durations of stay in PICU were 3.5 days in pediatric surgery and 1.2 days in neurosurgery. In this study, we conclude that duration of stay in PICU and cost of intensive care might be proportional to TISS.

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