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급성 세균성 감염증에 대한 Cefotetan(Yamatetan^ⓡ)의 임상적 효과
김주옥,안원전,박종훈,노흥규,박종우 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.1
Total 20 cases of infectious diseases were treated with Cefotetan at the Dept. of internal medicine, Chung Nam National University Hospital, Dae Jeon, Korea, from January 1985 to April 1985. Among 20 cases, 6 were the patients with acute pyelonephritis, 7 were pneumonia, 2 were acute cholecystitis, 2 were chronic bronchitis, 2 were cellulitis and 1 was lung abscess. The response was good in 16 cases, and poor in 4 cases. The laboratory tests were normal except I which was reversible. (mild elevation of SGOT and SGPT) The side effects were noted in 2 cases, such as skin eruption and drug fever, which were improved with supportive care. Cefotetan was thought to be useful against acute bacterial infections of respiratory, urinary, biliary tracts and cutaneous tissue.
Systemic Lupus Erythematosus를 동반한 Multiple sclerosis
이지현,이기주,윤성호,부귀범,손현화,박유환,정춘해,김진호,정원영 조선대학교 부설 의학연구소 1998 The Medical Journal of Chosun University Vol.23 No.2
Multiple sclerosis and lupus erythematosus are chronic, potentially disabling diseases of unknown cause. It is a rare occasion that the finding of both diseases occurs in one patient. Because both diseases may affect the central nervous system, it may be difficult at times to differentiate symptoms of lupus erythematosus from those of multiple sclerosis. As far as we know, there was no case report of SLE in multilple sclerosis in Korea. We report a case of multiple sclerosis accompanied by SLE.
권희석,이승휘,권순욱,주원남,박은호 漢陽大學校 環境科學硏究所 1991 環境科學論文集 Vol.12 No.-
신도시 계획에 따른 환경파괴 및 변화가 예상되는 분당지구의 어족자원을 보호하기 위하여 신도시 건설이전의 어류분포상을 조사하였다. 분당지구에는 잉어과 8종, 기름종개과 4종, 메기과, 뱀장어과, 송사리과, 드렁허리과, 극락어과, 구굴무치과 및 둑중개과 각 1 종을 포함하여 9 개과 19종이 분포하고 있었다. 최근 환경오염으로 감소추세에 있는 송사리, 드렁허리 및 버들 붕어가 이 지역에 존재한다는 것은 주목할 만한 것으로 특히 늪말지역의 늪지대는 신도시 건설 후에도 현재의 환경을 보존하여 이 지역 초, 중, 고등학교의 어류생태학 교육장으로 활용함이 좋을 것이다. 따라서 이 지역의 각별한 보호와 분별있는 개발이 요망된다. The freshwater fish fauna of Bundang Region, Kyungki-do, Korea, where dramatic environmental changes will be expected due to new city project, was censused to establish base line data for natural conservation program. Nineteen species belonging to 9 families were collected in this region. They were mainly cyprinids and cobitids. The Oryzias latipes, Monopterus albus, and Macropodus chinensis which are rare fish in recent years were found in this region. A swamp region called Neupmal is of particular interest in ichthyology excursion site for primary, middle and high school boy. Therefore, careful organization of new city plan and preservation of ichthyological fauna are strongly recommended.
文濬典,崔達永,朴元煥,尹相柱 대한동의병리학회 1993 동의생리병리학회지 Vol.8 No.-
연구배경 : 최근 우리나라에 있어서도 생활 양식의 서구화로 말미암아 다발하고 있는 각종 현대병의 하나인 고지혈증을 한의학적으로 치료하기 위한 방법론의 개발을 연구목적으로 하여, 한의학의 전통적 병인 개념인 담음이론을 통해 고지혈증의 한의학적 개념을 설명하고, 〈의학입문〉처방인 소조중탕을 통해 치료 약재의 개발 가능성을 실험적으로 규명하고자 한다. 방법 : 실험동물에 cholesterol현탁액을 투여하여 고지혈증을 유발시키면서, 〈의학입문〉에 수재된 소조중탕을 투여하여 혈청지질에 포함되어 있는 total-cholesterol, H. D. L-cholesterol, triglyceride, phospholipid 등의 함량변화를 관찰한다. 결과 : 血淸中 total-cholesterol과 triglyceride含量에 미치는 影響은 對照群에 比하여 매우 顯著한 有意性있는 減少가 나타났으며, 血淸中 H.D.L.-cholesterol과 phospholipid含量에 미치는 影響은 對照群에 比하여 有意性있는 減少가 나타났으며, 血淸中 total cholesterol과 HDL cholesterol의 比率은 對照群에 比하여 有意性이 認定되지 않지만 total cholesterol과 phospholipid의 比率은 對照群에 比하여 有意性이 認定된다. 결론 : 祛痰之劑인 小調中湯은 高脂血症의 改善에 有意性있는 成績을 나타내므로 高脂血症과 痰飮은 相關性이 있으며 脂質代謝異常에 따른 動脈硬化症에도 活用될 수 있는 것으로 思慮된다. In order to study the effects of Xiaotiaozhongtang on hyperlipidemia, white rats were induced by lipid metabolism disorder by the oral-injection of cholesterol. The effects of Xiaotiaozhongtang on lipid in serum were measured by the quantity of total-cholesterol and of H.D.L-cholesterol and of triglyceride and of phospholipid, by the rate of total-cholesterol vs H.D.L-cholesterol and of total-cholesterol vs phospholipid in serum. As a result, we can conclude as follows: 1. Effects of Xiaotiaozhongtang on total-cholesterol and triglyceride levels in serum of cholesterol treated rats were very noticeable. 2. Effects of Xiaotiaozhongtang on H. D. L-cholesterol and phospholipid levels in serum of cholesterol treated rats were noticeable. 3. Effect of Xiaotiaozhogtang on the rate of total-cholesterol vs H. D. L-cholesterol in serum of cholesterol treated rats was unnoticed, but on the rate of total-cholesterol vs phospholipid was noticeable. Thus,as the above-mentioned, on hyperlipidemia, the effects of Xiaotiaozhongtang can be recognized. Secondly, both hyperlipidemia and "phlegm-retention" have correlation each other. In the last place,Xiaotiaozhongtang may be used to artherosclerosis induced by, lipid metabolism disorder, hyperlipidemia.
( Weon Ju Lee ),( Hyun Bo Sim ),( Sang Lim Kim ),( Yong Hyun Jang ),( Seok Jong Lee ),( Do Won Kim ),( Kyung Chan Kim ),( Soon Ho Yim ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: 5-aminolevulinic acid (5-ALA) stimulates murine hair growth in vivo study. Glycyl- Histidyl-Lysine (GHK) peptide increases hair follicle size and stimulates stem cell proliferation. Objectives: To investigate the efficacy of a combination of 5-ALA and GHK peptide (ALAVAX) on hair growth Methods: Cell culture of keratinocyte, melanocytes and fibroblast was performed for MTT assay. Seven-week old C57BL/6N mice were treated with 100 mg/ml ALA ± 5-minute red or blue LED or 100 mg/ml ALAVAX ± 5-minute red or blue LED once a day for 24 days for evaluation of hair growth. Cultured human hair organs were treated with 100 times-diluted ALAVAX ± 20-minute red LED for 7 days. Forty five patients with male pattern hair loss were treated with ALAVAX once a day for 6 months. Total hair count, hair diameter, hair length and patients’ assessment were evaluated at week 4, 12 and 24 after treatment. The penetration of ALAVAX into hair follicles was examined under the fluorescent microscopy. Results: Hair growth was most conspicuous in mice treated with ALAVAX + red LED. Hair growth of cultured hair organs was significantly increased after treatment with ALAVAX only. Total hair count, hairlength and patients’ assessment in humans was significantly improved in the group treated with ALAVAX. No adverse event was reported. The penetration of ALAVAX in human hair follicles was prominent. Conclusion: ALAVAX could be considered as one of the useful agents for the treatment of male pattern hair loss.
Effect of vitamin D in cultured sebocytes
( Weon Ju Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Vitamin D regulates growth and differentiation of keratinocytes and other cell types. Recently, sebocytes were identified as bioactive vitamin D-responsive target cells. Inflammatory cytokines play an important role in the pathophysiology of acne. Sebocytes synthesize inflammatory cytokines. We investigated changes in the expression of inflammatory biomarkers after the treatment of cultured sebocytes with vitamin D (10<sup>-10</sup> to 10<sup>-6</sup> M) or vitamin D (10<sup>-8</sup> to 10<sup>-6</sup> M) and Propionibacterium (P.) acnes (1010 CFU/μl) or vitamin D (10-8 to 10-6 M) and 40 mJ/cm2 ultraviolet B (UVB) or vitamin D (10-8 to 10-6 M) and 70 mJ/cm2 UVB. Real time-polymerase chain reaction and enzyme-linked immunosorbent assay were done to measure changes in the expression of inflammatory biomarkers including IL-1ß, IL-6, IL<sup>-8</sup> and TNF-α. Vitamin D (10-10 to 10<sup>-6</sup> M) decreased the expression of IL-1ß, IL-6, IL-8 and TNF-α in cultured sebocytes. In addition, the treatment with P. acnes (10<sup>10</sup> CFU/μl) and vitamin D (10<sup>-6</sup> M) decreased the expression of IL-1β, IL-6, and IL-8 in cultured sebocytes. Furthermore, the treatment with 40 mJ/cm<sup>2</sup> UVB and vitamin D (10<sup>-6</sup> M) decreased the expression of IL-1β, IL-6 and TNF-α in cultured sebocytes at day 1 compared with no treatment. In conclusion, vitamin D has a potential to decrease the expression of inflammatory biomarkers in cultured sebocytes even under stressful conditions and may be effective in the treatment of acne.