일개 대학병원에 내원한 원발성 폐암 환자의 인구학적 및 병리학적 특성

주혜원,강경필,김민근,박민석,임현민,이현경,이성순,이영민,김주인,염호기,최수전,이혁표 인제대학교 2006 仁濟醫學 Vol.27 No.-

Background : Recently, the lung cancer mortality rank first in Korea. The prognosis of lung cancer is not good enough with current treatments and multimodality treatments are required. So we are interested in the characteristics of lung cancer patients for better treatment. Methods : We searched lung cancer patients since 1994. Then we collected the data of primary lung cancer patients about the demographic features, histologic types and diagnotic methods. We divided the total period into 2 haves and specific analysis was tried. Results : 1) Total 850 patients were included. 633 (74.5%) were male and 217 (25.5%) were female. 2) The mean age was 65 ± 11 years old. and the peak age was 7th decades. 3) Squamous cell carcinoma(334/850, 39.3%) was slightly more prevalent than adenocarcinoma(302/850, 35.5%). Conclusion : From these results, we expected that older persons will be diagnosed to have lung cancer and adenocarcinoma will be more dominant histologic type with time.

과두과증식을 동반한 안면비대칭 환자에서 과두절제술의 적용과 효과

임경섭,차정열,황충주 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.6

과두과증식은 하악의 3차원적인 골격적인 비대가 일어나는 병적인 상태이다. 이러한 과두과증식의 원인은 호르몬의 작용, 외상, 감염, 유전, 태아기 때의 요인, hypervascularity 등의 요인으로 알려져 있다. 과두과증식의 진단 시 가장 중요한 것은 과두과증식 상태가 아직도 활성화 상태인지 판단하는 것이다. 이러한 과두과증식의 상태에 따라서 안면비대칭 환자의 치료는 이환측 과두의 성장 부위를 제거하는 과두절제술을 시행하는 방법, 성장이 완료될 때까지 기다렸다가 통상적인 악교정 수술만을 시행하거나 과두절제술을 병행하는 시술방법이 있다. 과두과증식의 활성화 상태를 판단하는 것은 치료 안정성에 매우 중요한 요인이며, bone scan이나 주기적인 3차원 컴퓨터 단층촬영이나 정모두부방사선사진 등을 통하여 확인할 수 있다. 본 보고에서는 과두과증식을 동반한 안면비대칭 환자를 과두절제술을 이용하여 개선한 증례를 소개하고자 한다. Condylar hyperplasia is a pathologic condition showing 3-dimensional skeletal hyperplasia of the mandible. The reason for condylar hyperplasia is not yet known, but the effects of hormone, trauma, infection, genetics, fetal condition, and hypervascularity are known as possible reasons. When we diagnose a patient as having condylar hyperplasia, it is important to decide if it is in progress or not. Treatment for facial asymmetry due to condylar hyperplasia are decided accordingly, including condylectomy, that is removal of growth site of the affected condyle, and conventional orthognathic surgery only or condylectomy with orthognathic surgery after the completion of growth. Therefore, it is important to determine the growth state of condylar hyperplasia in treatment stability. This is verified through bone scan and regular check-ups with 3D CT or PA cephalogram. This case report introduces an improved case of facial asymmetry with condylectomy together with orthognathic surgery.

치태에서 분리된 Streptococcus mutans에 대한 서양산 고추냉이(Armoracia rusticana) 뿌리 추출물의 향균효과

김혜경,박호원,신일식,이주현,서현우 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.2

천연항균제의 개발에 대한 관심이 날로 증가하는 가운데,다수의 연구들에서 Escherichia coli. Salmonella typhimurium, Pseudomonas aeruginosa, Vibrio parahaemolyticus, Staphylococcus aureus, Bacillus subtilis, Aspergillus parasiticus, Helicobacter pylori 등 다양한 세균들에 대한 서양산 고추냉이의 항균 효과가 밝혀 진 바 있다. 서양산 고추냉이가 치아우식증의 원인균인 Streptococcus mutans에 대해서도 항균성을 나타낸다는 보고가 있으나,아직까지 구강내에서 분리된 임상분리균주를 대상으로 한 연구는 미진한 실정이다. 본 연구에서는 사람의 구강내에서 분리 및 동정된 Streptococcus mutans에 대한 서양산 고추냉이 뿌리 추출물의 항균 효과를,대표적 항균제인 클로르헥사딘과 비교하여 알아보고,Streptococcus mutans 표준균주에 대한 서양산 고추냉이 뿌리 추출물의 효과와 비교하고자 하였다. 항균 효과를 평가하기 위해 최소억제농도와 최소살균농도를 측정하여 다음과 같은 결론을 얻었다. 1. 본 연구에서 Streptococcus mutans 임상 분리균주와 표준균주에 대한 서양산 고추냉이 뿌리 추출물의 최소억제 농도는 각각 평균 0.083∼0.25% (833.33∼2500 ppm), 평균 0.25%(2500 ppm)으로 나타나,두 종류의 균주에 대한 항균 효과에는 뚜렷한 차이가 없는 것으로 나타났다. 2. 서양산 고추냉이 뿌리 추출물은 0.083∼0.25%의 농도에서 콜로르헥사딘(0.0021∼0.0041%)과 대등한 항균 효과를 가지는 것으로 나타났다. Recently interesting in development of antimicrobial agent from natural origin has been increased in these days. Many studies have been reported antimicrobial effect of Horseradish(Armoracia rusticana) root extracts against various microorganisms such as Escherichia coli, Salmonella typhimurium, Pseudomonas aeruginosa, Vibrio parahaemolyticu, Staphylococcus aureus, Bacillus subtilis, Aspergillus parasiticus, Helicobacter pylori. The main component related to antimicrobial activity in horseradish is well known as allyl isothiocyanate(AIT). In this study, we investigated the antimicrobial effects of Horseradish(Armoracia rusticana) root extracts against Streptococcus mutans isolated from human dental plaque, Streptococcus mutans reference strain and compared with that of chlorhexidine. Horseradish root extracts and chlorhexidine were tested to determine their minimum inhibitory concentration(MIC) and minimum bactericidal concentration(MBC). The result of this study can be summerized as follows: 1. Horseradish root extracts showed antimicrobial effect against both S. mutans isolated strain and reference strain, their MIC were respectively 0.083∼0.25% (833.33∼2500 ppm), 0.25% (2500 ppm). Horseradish root extracts showed antimicrobial effect against S. mutans isolated strain at same or slightly lower concentration compared with MIC of reference strain. 2. 0 083∼0.25% horseradish root extracts showed similar antimicrobial effect with chlorhexidine (0.0021∼0.0041%).

주변성 법랑모세포종의 증례

송주섭,김경아,고광준 대한구강악안면방사선학회 2006 Imaging Science in Dentistry Vol.36 No.2

Peripheral ameloblastoma is an extremely rare odontogenic soft tissue tumor with histologic characteristics similar to those of the intraosseous ameloblastoma. It appears in the gingiva and oral mucosa. And it usually does not show any bone involvement on radiographs, except for saucer shaped erosion of underlying alveolar bone. Recurrence is considered uncommon. We report a case of peripheral ameloblastoma with bone involvement. Histologically it presented with follicles and nest of tumor cells with palisading pattern. And radiographs showed the typical saucer shaped alveolar bone erosion at the distal area of right mandibular third molar. At 6-month follow-up after operation, no local recurrence was noted.

인체 간 Microsome에서의 우슬 추출물의 Cytochrome P450 약물 대사효소에 대한 억제작용

김경아,이지숙,박히준,김진우,김창주,심인섭,한승무,임사비나 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective : Achyranthes bidentata radix (Usul) has been used as anti-arthritic, antiallergic, antidiuretic and so on Recently extracts of Achyranthes bidentata radix have shown anti-inflammatory and cancer preventive effects in vitro and in vivo. Methods : We therefore evaluated the inhibitory potential of ehtanol extracts of Achyranthes bidentata radix on cytochrome P450(CYP) isoforms-catalyzecd reactions, which relate to causes of cancer and inflammation, including CYP1A2, CYP2C9, CYP2C19, CYP2E1, CYP2D6, CYP2C8, and CYP3A4, using human liver microsomal preparations. Results : The extracts showed weak or negligible inhibitory effects on CYP2C9-catalyzed (S)-warfarin 7-hydroxylation, CYP2C19-catalyzed S-mephenytoin 4-hydroxylation, and CYP2D6-catalyzed dextromethorphan O-demethylation with each IC50 over 1750 g/㎖, respectively. However, it showed relatively significant inhibitory effect on CYP1A2-catalyzed phenacetin O-deethylation and CYP2E1-catalyzed chloizoxazone 6-hydroxylation with IC50s of 970.5 g/㎖ and 821.4 g/㎖, respectively. Conclusions : These results suggest that extracts of Achyranthes bidentata radix have inhibitory effects on CYP-catalyzed reactions, expeciallyCYP1A2 and CYP2E1, in human liver microsomes. These effects appear to relate to anti-inflammatory and cancer prevention following decrease of reactive oxygen species formed by CYP, especially CYP1A2 and CYP2E1, by Achyranthes bidentata radix. However, further evaluation is necessary to demonstrate and to confirm its effects in human.

정신분열병 환자의 신경인지기능 결함 유형

백주희,이호택,장호균,박병관,이상연,김은경 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.2

연구목적 : 정신분열증의 인지기능장애가 전반적인 결함인지 아니면 특정한 결함인지 논란이 지속되고 있다. 본 연구에서는 표준화된 신경심리검사 도구인 벤튼 신경심리검사(Benton Neuropsychological Assessment. 이하 BNA)를 사용하여 정신분열병 환자에서 특정한 신경인지기능 결함 유형이 관찰되는지 평가하고자 하였다. 대상 및 방법 : 정신장애 진단통계편람 제4판(DSM-Ⅳ) 진단기중에 따라 분류된 (1) 편집성 정신분열병 입원 환자 30명과 (2) 연령, 성별, 교육정도를 일치시킨 정상 대조군 30명을 연구 대상으로 하여 정신분열병 환자의 임상 증상을 양성 및 음성증상척도(Positive and Negative Syndrome Scale, 이하 PANSS)로 평가하여 인지 결함과 임상 증상간의 상관관계를 검증하였다. 결 과 : BNA 12개 검사(시간지남력 검사, 좌우지남력 검사, 연속숫자학습, 얼굴재인 검사, 직선지남력판단, 시각형태변별 검사, 판토마임재인, 촉각형태지각, 손가락위치판단, 음소변별, 3차원토막구성, 운동지속력 검사)중에서 정신분열병 환자는 정상 대조군에 비해 연속숫자학습(이하 유의수준 p〈0.05), 얼굴재인 검사, 촉각형태지각, 손가락위치판단에서 통계적으로 유의하게 저하된 수행을 보였다. 또한 정신분열병 환자는 정상 대조군에 비해 손가락위치판단 하위 요인 중 오른손, 왼손, 이점역에서 저조한 수행을 보였고, 시각형태변별 검사의 주변오류에서 유의하게 많은 오류를 나타냈다. 정신분열병 환자군에서 PANSS 총점, 양성 및 음성증상척도도 점수와 각 검사, 하위 요인, 오류 점수간에는 유의한 상관관계가 나타나지 않았다. 결 론 : 정신분열병 환자군에서 임상증상과 독립적인 언어성 작동기억, 학습, 주의력 및 안면지각기술과 촉각정보처리 등 시각과 촉각 양식의 지각 과제에서 복잡한 감각정보처리의 결함을 보이며, 이러한 신경인지기능 결함 유형은 선행 연구에서 제시된 특정한 결함 유형과 최소한 부분적으로 일치되는 소견이다. 한편 정신분열병 환자가 대상 위치검사에서는 상대적으로 정상적인 수행을 보인 반면 대상 인식검사에서는 결함을 나타냈으며, 언어성 작동기억이 결함을 보인 결과는. (1) 전전두엽과 두정엽 피질간의 상호연결이나 (2) 전전두엽과 해마간의 상호연결의 기능 이상을 시사할 가능성이 있으나 후속 연구에서 확증이 필요하다. Objectives : Schizophrenic patients have been reported to be associated with abnormal performance on a broad range of neuropsychological tests. But it has been a persistent controversy in the neuropsychology of schizophrenia whether this disorder is characterized by generalized deficits or specific deficits. The purpose of this study was to investigate, using standardized Benton Neuropsychological Assessment(BNA), whether the specific pattern of neurocognitive deficits is found in schizophrenics. Methods : The subjects were composed of (1) 30 schizophrenic inpatients who were diagnosed as paranoid subtype according to DSM-Ⅳ diagnostic criterior and (2) 30 normal subjects with matching demographic variables(i. e. age, sex, educational level). All tests of BNA were given schizophrenic patients and normal subjects, and the performances of schizophrenic patients and normal subjects were compared on all aspects of BNA. Schizophrenic symptoms were assessed via Positive and Negative Syndrome Scale(PANSS) to determine the relationship between clinical symptoms and schizophrenic cognitive deficits. Results : Of 12 tests of BNA, schizophrenic patients performance on Serial Digit Learning (SDL), Facial Recognition Test(FR), Tactile Form Perception(TFP), Finger Localization(FL) were significantly lower than those of normal subjects. In addition, schizophrenic patients showed significantly lower performances than those of normal subjects on Right Hand, Left Hand, Identification of two simultaneously touched fingers of FL, and more Peripheral Error on Visual Form Perception Test(VFPT). Finally, no significant correlation was found with respect to the relationships between total scores, positive symptoms scores, negative symptoms scores of PANSS, and all scores of BNA tests in schizophrenic patients. Conclusion : These results suggest that schizophrenic patients may have a specific pattern of neurocognitive deficits in verbal working memory, learning, attention, and complex sensory information processing in visual and haptic modality such as facial perception skills, tactile information processing, independent of psychotic symptoms. The pattern of deifcits is at least in partial, in agreement with many previous study results. On the tests of linguistic functions, visuospatial perception, and constructional abilities, schizophrenic patients' performance were not significantly different from those of normal subjects. The findings on visuospatial perception and constructional abilities imply that some posterior cortical zones may be relatively uncompromised in schizophrenia. Both poor performances on object recognition tests relative to normal performances on object location tests and verbal working memory dysfunction may be associated with the putative dysfunction of the reciprocal connections either (1) between the prefrontal and parietal cortex or (2) between the prefrontal cortex and hippocampal formation. This tentative explanation remains to be confirmed.

4종의 식품 부패 미생물에 대한 국내산 자생 식물 열매 추출물의 항균성 탐색

권민경,이해은,박주연,한영숙 동아시아식생활학회 2003 동아시아식생활학회지 Vol.13 No.5

To select new useful domestic plants with antimicrobial activities, thirty five samples of berry plant were distributed from Plant Diversity Research Center in Korea Research Institute of Bioscience and Biotechnolog. Their extracts with methanol were tested against Escherichia coli, Salmonella typhimurium, Staphylococcus aureus, Listeria monocytogenes by paper disc method. The methanol extracts from Viburnum dilatatum, Viburnum erosum, Aralia continentalis, Camellia japonica, Acer trumcatam, Arasaema takesimense and Rhysocarpus intermedius were effective against S. aureus and the results were as follows: Viburnum erosum 6.5 ㎜, Viburnum dilatatum and Aralia continentalis 7.0 ㎜, Rhysocarpus intermedius 8.0 ㎜, Acer to mcatum 9.0 ㎜, Camellia japonica and Arisaema takesimense 9.5 ㎜ And only the methanol extract from Camellia japonica was effective against L. monocytogenes, 7.0 ㎜. Antimicrobial activities of E. coli and S. typhymurium were not detected. The minimum inhibitory concentration(NIC) of berry of Camellia japonica was examined as 1,250 ㎍/mL against S. aureus and as 1,250 ~ 2,500 ㎍/mL against L. monocytogenes.

특수형 방사성 동위원소 운반캡슐의 안정성 평가

이주찬,서기석,구정회,방경식,한현수,박성원 대한방사선 방어학회 2001 방사선방어학회지 Vol.26 No.1

특수형 방사성물질 운반캡슐은 국내외의 수송관련 법규에 규정된 기술기준을 만족하도록 설계, 제작되어야 한다. 본 연구의 목적은 하나로에서 생산된 192Ir 특수형 동위원소 운반캡슐의 건전성을 평가하는데 있다. 법규에서 규정된 낙하시험, 타격시험, 굽힘시헝 및 가열시험조건에 대한 안전성 시험을 수행하였으며, 각각의 시험 전후에 누설시험을 수행하였다. 또한, 안전성시험과 더불어 컴퓨터코드를 이용한 전산해석을 수행하여 안전성시험 전에 시험결과에 대한 예측자료로 활용되었다. 낙하시험 및 가열시험 결과 캡슐 표면에서 약간의 흠집과 변형이 발생하였으나, 각각의 시험에서 평가기준이 되는 캡슐의 손상이나 용융 등은 발생하지 않았다. 또한 각 시험 후 수행한 누설시험 결과 누설이 발생하지 않았다. 따라서 특수형 방사성물질 운반캡슐은 법규에서 규정하는 기술기준을 만족하도록 설계, 제작되었음이 입증되었다. All of sealing capsules to transport a special form radioactive material should be designed and fabricated in accordance with the design criteria prescribed in IAEA standards and domestic regulations. The objective of this study is to demonstrate the safety of a shipping capsule for 192Ir special form radioisotope which produceed in the HANARO. The safety tests were carried out for the impact, percussion, bending and heat test conditions. And leakage tests were carried out before and after the each test. Also, the safety analyses were performed using computer codes in order to verify the test results. The capsule showed slight scratches and deformation, and maintained its structural and thermal integrities in all tests without any severe damage or melting. It also met the allowable limits of leakage rate after earth test. Therefore, it has been verified that the capsule was designed and fabricated to meet all requirements for the special form.

배송업무 아웃소싱 모델

송경주,임석철 한국경영과학회 2000 한국경영과학회 학술대회논문집 Vol.- No.1

최근 기업들은 자사의 핵심역량을 극대화하기 위하여 배송업무를 포함한 물류업무를 전문적인 제3자에게 위탁하는 아웃소싱이 확대되는 추세이다. 특히 제조업체는 제품 배송업무의 아웃소싱을 다양한 형태로 추진할 수 있기 때문에 아웃소싱 계획단계에서 최적의 업무프로세스 모델링이 매우 중요하며, 자사에 맞는 아웃소싱 모델을 선정하도록 의사결정을 지원할 체계적인 접근방법이 필요하다. 본 연구는 배송업무 아웃소싱 현황을 조망하고, 배송업무 아웃소싱을 위한 고려사항과 업무절차를 배송전문업체 선정단계와 운영단계, 그리고 성과평가단계로 구분하여 제시한다.

2003년 5월의 연무 관측시 에어로졸의 기상·물리·화학 특성

임주연,전영신,조경미,이상삼,신혜정 한국대기환경학회 2004 한국대기환경학회지 Vol.20 No.5

Severe haze, mist, and fog phenomena occurred in the central part of Korea during 15~25 May 2003 resulted in poor visibility and air quality. When these phenomena occurred, Korean peninsula was under the effects of anticyclone. The atmosphere was stable, and wind speed was so weak. Under this meteorological conditions, air quality was worse and worse. The characteristics of aerosol in Seoul, Incheon, and Gosan (Jeju) during this period are investigated from the PM_(10). TSP concentrations and aerosol number concentrations. Concentrations of PM_(10) and TSP measured at KMA increased upto 176 and 230㎍/㎥ on 22 May 2003, respectively. Aerosol number concentrations of size range from 0.82 to 6.06 ㎛ increased in Seoul on 17, 19, and 21~24 May 2003, and the concentrations of NO₂ and SO₂had maximum value of 0.165 ppm at Gwanak Mt. and 0.036 ppm at Guro-dong on 23 May 2003, respectively. Result from analysis on heavy metal elements showed high concentrations of Zn, Pb, Cr, Ni, Cu, and Cd during 20~24 May 2003. This event is examined by comprehensive analyses of synoptic weather conditions, satellite images, concentrations of suspended particles and air pollutants, and heavy metal elements.