Berberine의 항생제 내성 황색포도구균에 대한 항미생물 효과

김해경,차정단,유용욱,김강주,이동근 원광대학교 생체재료·매식연구소 2000 원광생체재료·매식 Vol.9 No.1

Antibiotic-resistant Staphylococcus aureus (S. aureus) emerged in many parts of the world and increased complex clinical problems. Therefore, new agents are needed to treat to antibiotic-resistant S. aureus. Some natural products are candidates of new antibotic substances. Previous reports showed that the extract of Coptidis Rhizoma and Phellodendri Cortex have antimicrobial effects. The main antibacterial substance of Coptidis Rhizoma and Phellodendri Cortex is berberine. In this study, we examined the antimicrobial activity of berberine to antibiotic-resistant S. aureus. We isolated the 13 strains of antibiotic-resistant S. aureus from the oral cavity of healthy children in a preschool, and investigated the antimicrobial activity of berberine. We examined the effects of berberine on the level of resistance to antibiotic-resistant S. aureus. We observed that the invasion of S. aureus into human gingival fibroblasts was blocked by berberine. Berberine inhibited the growth of antibiotic-resistant. S. aureus as a dose dependent maner. Minimum inhibition concentration (MIC) of berberine against antibiotic-resistant S. aureus was 50-100 ㎍/ml. The inhibition of S. aureus invasion was depended on the concentration of berberine in human gingival fibroblasts. The MIC of ampicillin against antibiotic-resistant S. aureus was 32 ㎍/ml. However, the MIC of ampicillin against antibiotic-resitant S. aureus in the presence of 50 ㎍/ml berberine was 1 ㎍/ml. These data indicate that the combination with berberine and β-lactam antibiotics resulted in the synergistic reaction. These results suggest that the berberine may have the antimicrobial activities to antibiotic-resistant. S. aureus, and the mechanism may be the inhibition of growth and intracellular invasion. and alteration of antibiotic-resistance level of antibiotic-resistant S. aureus.

The Effects of Functional Electrical Stimulation on Forced Vital Capacity and Phonation Capabilities in Children with Spastic Cerebral Palsy

Joung Youl Ju,Kwon Young Kang,Hee Joon Shin 국제물리치료학회 2011 Journal of International Academy of Physical Ther Vol.2 No.2

The purpose of this study is to see the effect of functional electrical stimulation on forced vital capacity and alternating motion rate in children with spastic cerebral palsy. This study divided 20 children with spastic cerebral palsy into two groups; functional electrical stimulation treatment group and control group. Functional electrical stimulation treatment group had 20min per day treatment three times a week for four weeks and the control group did not have any treatment. Before and after intervention, this study measured forced vital capacity and alternate motion rate(/peo/,/teo/) for all children. Forced vital capacity showed statistically significant increase for the group with functional electrical stimulation(p<.05) while the control group did not show any significant increase(p>.05). Alternate motion rate showed statistically significant increase for the group with functional electrical stimulation(p<.05) while the control group did not show any significant increase(p>.05). This result shows that functional electrical stimulation affected the ability of the children with spastic cerebral palsy who have decreased breathing and phonation capability.

슬링운동이 중간볼기근 안정화에 미치는 효과

주정열(Joung-Youl Ju),서병도(Byoung-Do Seo),박규현(Giu-Hyoun Park) 한국엔터테인먼트산업학회 2014 한국엔터테인먼트산업학회논문지 Vol.8 No.4

본 연구의 목적은 슬링운동이 중간볼기근 안정화에 미치는 영향에 대한 연구이다. 대학생 24명을 슬링운동군(n=12)과 대조군(n=12)으로 나누어 실시하였다. 슬링운동군은 슬링을 이용하여 중간볼기근 안정화 운동을 6주 동안 주 3회 50분간 실시한 후 균형근력과 근활성도, 혈류량을 평가하였다. 연구결과 집단내 운동군의 운동전·후의 균형능력과 근활성도는 유의하게 증가하였다(p<.05). 반면에 집단간 혈류혈류량은 유의한 변화가 없으나 슬링운동군에서 혈류량의 증가는 있었다. 이 연구에서 슬링운동을 통한 중간볼기근 훈련이 모든 대상자들에게 중간볼기근 근활성화와 신체 균형능력과 오금동맥의 혈류흐름을 향상시키는 것을 알았다. The purpose of this study was to evaluate muscle activity of gluteal medius muscle, blood frow of popliteal artery and body balance in 24 adults. 24 adults was randomized in twop groups, suspension sling exercise and control group. In the experimental groups, the gluteal medius muscle of suspension sling exercise for 20minutes duration three time per week for 6 weeks were respectively preformed, control group was not performed. Before and after experiments, EMG of gluteal medius muscle, blood frow of popliteal artery and body balance was measured in all adults. In comparison of difference before and after experiment, the body balance of the gluteal medius muscle of suspension sling exercise was significantly increased than the control group(p<.05, EMG of gluteal medius muscle of the gluteal medius muscle of suspension sling exercise was significantly increased more than the control group(p>.05) and blood frow of popliteal artery of the gluteal medius muscle of suspension sling exercise was not significantly increased more than the control group(p>.05) but blood frow increased. We found that the gluteal medius muscle of suspension sling exercise is useful to improve the EMG of gluteal medius muscle, body balance and blood frow of popliteal artery in all adults.

The Effects of Functional Electrical Stimulation on Forced Vital Capacity and Phonation Capabilities in Children with Spastic Cerebral Palsy

Ju, Joung-Youl,Kang, Kwon-Young,Shin, Hee-Joon International Academy of Physical Therapy Research 2011 Journal of International Academy of Physical Ther Vol.2 No.2

The purpose of this study is to see the effect of functional electrical stimulation on forced vital capacity and alternating motion rate in children with spastic cerebral palsy. This study divided 20 children with spastic cerebral palsy into two groups; functional electrical stimulation treatment group and control group. Functional electrical stimulation treatment group had 20min per day treatment three times a week for four weeks and the control group did not have any treatment. Before and after intervention, this study measured forced vital capacity and alternate motion rate(/peo/,/teo/) for all children. Forced vital capacity showed statistically significant increase for the group with functional electrical stimulation(p<.05) while the control group did not show any significant increase(p>.05). Alternate motion rate showed statistically significant increase for the group with functional electrical stimulation(p<.05) while the control group did not show any significant increase(p>.05). This result shows that functional electrical stimulation affected the ability of the children with spastic cerebral palsy who have decreased breathing and phonation capability.

배곧은근의 기능적 전기자극 적용이 경직형 뇌성마비아동에서 호흡능력 및 발성에 미치는 영향

주정열(Joung-Youl Ju),양승훈(Seung-Hoon Yang),서병도(Byeong-Do Seo) 한국엔터테인먼트산업학회 2013 한국엔터테인먼트산업학회논문지 Vol.7 No.3

본 연구의 목적은 기능적전기자극 적용이 경직형뇌성마비 아동의 호흡능력, 최대발성시간에 대한 영향을 평가 하고자한다. 20명의 경직형뇌성마비 아동을 기능적전기가극군과 대조군으로 나누었으며 기능적전기자극군은 주당 3회 30분씩 6주를 적용하였다. 실험전·후의 호흡능력(강제폐활량, 최대호기유속), 최대발성시간(아,우)을 평가 하였다. 연구 결과 호흡능력(강제폐활량, 최대호기유속), 최대발성시간(아, 우)에서 기능적전기자극군이 대조군보다 유의하게 향상되었다. 경직형뇌성마비 아동에게 6주 동안 기능적전기자극 적용 시킨 결과호흡능력(강제폐활량, 최대호기유속), 최대발성시간(아, 우)를 향상 시킨다고 사료된다. The aim of this study is to evaluate the influence of respiratory muscle capacity(forced vital capacity, peak expiratory flow), maximum phonation time by functional electrical stimulation in children with spastic cerebral palsy. 20 children with spasticity cerebral palsy was randomized in 2 groups, Functional electrical stimulation and control group. In the experimental groups, Functional electrical stimulation during 30 minutes for 3 time per week for 6weeks were respectively preformed, Control groups was not performed. Before and after experiments, respiratory muscle capacity(forced vital capacity, peak expiratory flow), maximum phonation(/a/, /u/) was measured in all children. These finding in comparison of difference before and after experiment, the respiratory capacity(forced vital capacity, peak expiratory flow), maximum phonation time(/a/, /u/) of functional electrical stimulation group was significantly increased than the control group(p<.05). We found that the functional electrical stimulation is useful to improve the respiratory muscle capacity(forced vital capacity, peak expiratory flow) and maximum phonation(/a/, /u/) in children with spasticity cerebral palsy.

발목, 발에 냉적용이 기능 수행에 미치는 효과

주정열 ( Joung Youl Ju ),이명희 ( Myung Hee Lee ),최용원 ( Yong Won Choi ) 대한물리의학회 2008 대한물리의학회지 Vol.3 No.1

청소년 프로그램 개발과 성과평가를 위한 Logic model 적용의 참여연구 - 참여연구 전개과정을 중심으로 -

김정율 ( Kim Joung-youl ) 한국청소년활동학회 2017 한국청소년활동연구 Vol.3 No.2

본 연구는 청소년 프로그램 개발에 있어서 성과중심 사고를 고취하기 위하여 실시된 참여연구에 대한 보고서로서 참여연구의 전개과정과 성과중심 프로그램개발 및 평가도구로서 최근 주목받고 있는 Logic Model 기법의 적용가능성을 탐색하였다. Logic Model 서로간의 논리적 인과관계를 중시하는 연결을 통하여 최종적인 성과를 염두에 두고 프로그램을 설계해 나가도록 하고 있다. 즉 하나의 프로그램에 대하여 투입(input)이 이루어지고 다양한 조직 내부적인 활동(activity)을 통해 산출(output)이 나오고 그것이 프로그램 참가자에게 장기적으로 어떠한 영향 또는 성과(outcome)로 나타나게 될지를 ‘일의 논리적 순서'에 따라 기술하는 방식으로 프로그램을 계획하고 평가하는 관리방법이다. 이를 청소년지도 현장에 적용한 본 연구에서는 첫째 로직모델의 적용은 프로그램 수행에 있어서 본연의 목적에 집중하고 명료화 할 수 있음을 확인하였다. 둘째 현장지도자들의 청소년지도 활동과 업무전문성확보에 용의하다. 셋째 성과를 구체적으로 확인 가능한 형태로 미리 계획하고 실행함으로서 이용청소년에게 무엇을 줄 수 있는 지를 명료화 하였다. 넷째 프로그램의 수행을 매개로한 조직내부적 소통을 증진할 뿐만 아니라 조직 외부의 관계자들에게 조직과 조직의 일의 효용성을 설득하기에 용의하였다. This study was researched for the applicable possibility of a Logic Model recently receiving attention as an evaluation tool, and the development process of Participatory Research and performance-based program development which is the first report on the Participatory Research conducted to encourage the performance-based thinking of field leaders and organizations in the youth field program development. The Logic Model is designed by keeping in mind a program with a final performance through a logical causal relationship between each other. In other words, input is achieved through one program and output is coming through a number of organization internal activities. It is a management method to plan and evaluate the program as a way of describing accordance with the logical order of the matter whether presented as the long-term impact or performance (outcome) of the target program. First, applying this study to the youth education field, the application of the Logic model has confirmed the concentration of the basic object and to clarify the way in performing the program. Second, it is willing to obtain the expertise and youth education activity for young people (who educate) (who are educated) in the field. Third, it ensures what we are able to give to the youth who use the facilities by performing in pre-planned and concreting and verifiable results. Fourth, it is easy to improve the internal communication of the organization as well as to convince the effectiveness of the work of the organizations to the external organization.

무절연 궤도회로의 ESJ설계에 대한 연구

김정열(Kim Joung-Youl),신석균(Shin Seok-kyun),정용운(Joung Youg-Woon),이기서(Lee Key-Seo),이길영(Lee Gil-Young) 한국철도학회 2000 한국철도학회 학술발표대회논문집 Vol.- No.-

In this paper propose the new method on desig ESJ(Electrical Separation Joint) of Jointless Track Circuit. ESJ has a capability to saparate track signal electrically but enable conected a track section physically. So It is more proper to high-speed line. Because that demand a critical traveling safety and convient taking a train. In spite of existing ESJ of Jointless Track Circuit, UM71, S-bond, According to new pole-zero placement and desgining tuining-unit, It is possible to prove a independence of track-section and track-signal in new ESJ design of this paper.

경주지역 가와사끼병의 임상적 고찰

정재열,Seo, Yu Kyong,김애숙,이선주,조성민,이동석,김두권,최성민 東國大學校醫學硏究所 2007 東國醫學 Vol.14 No.1

현재 한국에서 1990년 이후로 약 3년마다 전국적인 역학적 연구 결과를 발표하고 있으나, 경주 지역에서의 역학적 연구 결과는 현재까지 없는 실정이다. 이에 저자들은 최근 7년 동안 경주 지역 가와사끼병 환자에 대한 역학적인 고찰과 함께 임상적 특징을 알아보고자 본 연구를 시행하였다. 2000년 1월 1일부터 2006년 12월 31일까지 7년 동안 동국대학교 경주병원 소아과에 가와사끼병으로 입원한 환자 총 100명을 대상으로 하였다. 임상 증상, 검사 소견 및 심초음파 검사에 의한 관상동맥 합병증 등을 의무기록지를 통하여 후향적으로 분석하였다. 가와사끼병의 남녀 비는 1.7:1이었고,평균 나이는 약 32개월이었다. 각 계절별 차이는 크게 없었으며, 정형 가와사끼병은 83%, 비정형 가와사끼병은 17%였다. 양측성 결막 충혈 93%, 입술의 홍조 및 균열, 혀 , 구강 발적 등이 93%, 부정형 발진 91%,손발의 경성 부종과 홍조 80%,급성기의 비화농성 경부 림프절 비대가 52%의 빈도로 각각 발현하였다. 관상 동맥류는 7%에서 발생하였다. 관상 동맥류 발생을 예측할 수 있는 위험 인자를 보면, ALT(p=0.04), 알부민(p=0.008), CRP(p=0.027), IVIG 초회 치료에 반응이 없는 경우(p=0.001), 농뇨(p=0.046)가 통계적으로 유의하였다. 고용량의 IVIG의 초회 치료에 반응하지 않은 경우는 14%였다. IVIG 초회 치료에 반응하지 않는 군을 예측할 수 있는 위험 인자를 보면 AST (p=0.019), ALT(p=0.003), ESR(p=0.017), 농뇨(p=0.047)가 통계적으로 유의하였다. 경주 지역 가와사끼병의 임상 양상은 다른 연구 결과들과 크게 다르지 않았으며,가와사끼병에서 관상통맥류의 위험 인자도 다른 연구에서와 마찬가지로 유사한 것으로 생각된다. From 1990, nationwide epidemologic studies of Kawasaki disease have been conducted every 3 years in Korea, yet no study has been reported from Gyeongju. We investigated epidemiology and clinical characteristics of Kawasaki disease in Gyeongju for 7 years. We retrospectively analyzed the medical records of 100 Kawasaki disease patients, admitted to the Dongguk University Hospital Pediatrics from January 1st, 2000 to December 31st 2006, based on clinical symptoms, laboratory findings and coronary artery cumplications by echocardiography. Male tu female ratio was 1.7:1 and mean age was 32 months. There was no seasonal variation. Incidences of typical and atypical Kawasaki disease were 83% and 17%, respectively. Incidence of occurring symptoms were as follows: 93% of conjunctival injection; 93% of lip redness fissuring, tongue and oral erythema; 91% of amorphous skin rash; 80% of hand, foot erythema and edema; 52% of non-purulent cervical lymph node enlargement. For others, 46% of pyuha. 7% of coronary artery aneurysm was noted. Significant predictable risk factors for coronary artery aneurysm were ALT(p=0.04), albumin (0=0.008), CRP(D=0.027), nonresponsiveness to initial IVIG(intravenous immunoglobulin) treatment(p=0.001) and pyuria(p=0.046). 14% of patients were unresponsive to initial high dose IVIG treatment. Significant predictable risk factors for initial IVIG treatment failure were AST(p=0.019), ALT(p=0.003), ESR(p=0.017) and pyuria(p=0.047). The results of our study on epidemiologic and clinical characteristics of Kawasaki disease in Gyeongju were similar to other studies. Also, predictable risk factors of coronary artery aneurysm and initial high dose IVIG treatment failure were as similar as in other studies.

New Soluble Pentacene Precursors for the Application of Organic Thin-Film Transistors

Joung, Meyoung-Ju,Ahn, Jin-Hee,Kang, Seung-Youl,Baek, Kyu-Ha,Ahn, Seong-Deok,Do, Lee-Mi,Kim, Chul-Am,Kim, Gi-Heon,You, In-Kyu,Yoon, Sung-Min,Suh, Kyung-Soo Korean Chemical Society 2003 Bulletin of the Korean Chemical Society Vol.24 No.12