Integration of Chemical and Biofertilizers Improved the Availability of Nitrogen and Phosphorus in Soil but Did Not Influence the Growth of Young Natural Rubber Plants

Mercykutty Joseph,Kochuthresiamma Joseph,Jacob Mathew 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

Validation of aseptic processes for pharmaceuticals

Joseph, Lincy,George, Mathew,Jain, Saurabh Kumar Kyung Hee Oriental Medicine Research Center 2010 Oriental pharmacy and experimental medicine Vol.10 No.4

Sterile Products may be broadly classified into two main categories, according to the manner in which they are produced: those which are sterilized after the product has been filled and sealed in the final container(s) ("terminally sterilized" products) and those where the sterilization stage (or stages) takes place is it before or after the bulk product filled in to final container. In this latter instance, all subsequent processing (typically, the filling and sealing operations) must be conducted aseptically in order to prevent recontamination of the sterilized product. The two most common pharmaceutical applications of aseptic processing methods are (a) the filling of liquid products following sterilization by filtration and (b) the filling of previously sterilized bulk powder products. An aseptic processing operation should be tested using a microbiological growth medium (media fill) during lyophilized injection formulation, filling, loading, lyophilisation, stoppering, and unloading activities.

Definitive Closure of the Tracheoesophageal Puncture Site after Oncologic Laryngectomy: A Systematic Review and Meta-Analysis

Joseph M. Escandón,Arbab Mohammad,Saumya Mathews,Valeria P. Bustos,Eric Santamaría,Pedro Ciudad,Hung-Chi Chen,Howard N. Langstein,Oscar J. Manrique 대한성형외과학회 2022 Archives of Plastic Surgery Vol.49 No.5

Tracheoesophageal puncture (TEP) and voice prosthesis insertion following laryngectomy may fail to form an adequate seal. When spontaneous closure of the fistula tract does not occur after conservativemeasures, surgical closure is required. The purpose of this study was to summarize the available evidence on surgical methods for TEP site closure. A comprehensive search across PubMed, Web of Science, SCOPUS, and Cochrane was performed to identify studies describing surgical techniques, outcomes, and complications for TEP closure.We evaluated the rate of unsuccessful TEP closure after surgical management. A meta-analysis with a random-effect method was performed. Thirty-four studies reporting on 144 patients satisfied inclusion criteria. The overall incidence of an unsuccessful TEP surgical closure was 6% (95% confidence interval [CI] 1–13%). Subgroup analysis showed an unsuccessful TEP closure rate for silicone button of 8% (95% CI<1–43%), 7% (95% CI<1–34%) for dermal graft interposition,<1% (95%CI<1–37%) for radial forearm free flap,<1% (95% CI<1–52%) for ligation of the fistula, 17% (95% CI<1–64%) for interposition of a deltopectoral flap, 9% (95% CI<1– 28%) for primary closure, and 2% (95% CI<1–20%) for interposition of a sternocleidomastoid muscle flap. Critical assessment of the reconstructive modality should take into consideration previous history of surgery or radiotherapy. Nonirradiated fields and small defects may benefit fromfistula excision and tracheal and esophagealmultilayer closure. In cases of previous radiotherapy, local flaps or free tissue transfer yield high successful TEP closure rates. Depending on the defect size, sternocleidomastoid muscle flap or fasciocutaneous free flaps are optimal alternatives.

Amorphous iron phosphate: potential host for various charge carrier ions

Mathew, Vinod,Kim, Sungjin,Kang, Jungwon,Gim, Jihyeon,Song, Jinju,Baboo, Joseph Paul,Park, Wangeun,Ahn, Docheon,Han, Junhee,Gu, Lin,Wang, Yuesheng,Hu, Yong-Sheng,Sun, Yang-Kook,Kim, Jaekook Springer Science and Business Media LLC 2014 NPG Asia Materials Vol.6 No.-

Monoclinic-Orthorhombic Na_1.1Li_2.0V₂(PO₄)₃/C Composite Cathode for Na⁺/Li⁺ Hybrid-Ion Batteries

Baboo, Joseph Paul,Song, Jinju,Kim, Sungjin,Jo, Jeonggeun,Baek, Sora,Mathew, Vinod,Pham, Duong Tung,Alfaruqi, Muhammad Hilmy,Xiu, Zhiliang,Sun, Yang-Kook,Kim, Jaekook American Chemical Society 2017 Chemistry of materials Vol.29 No.16

<P>Monoclinic Li3V2(PO4)(3) (LVP) has been considered a promising cathode material for lithium-ion batteries for the past decade because of its high average potential (>4.0 V) and specific capacity (197 mAh g(-1)). In this paper, we report a new monoclinic-orthorhombic Na1.1Li2.0V2(PO4)(3)/C (NLVP/C) composite cathode synthesized from monoclinic LVP via a soft ion-exchange reaction for use in Na+/Li+ hybrid-ion batteries. High-resolution synchrotron X-ray diffraction (XRD), thermal studies, and electrochemical data confirm room temperature stabilization of the monoclinic-orthorhombic NLVP/C composite phase. Specifically, we report the application of a monoclinic-orthorhombic NLVP/C composite as cathode material in a Na half-cell. The cathode delivered initial discharge capacities of 115 and 145 mAh g(-1) at a current density of 7.14 mA g(-1) in the 2.5-4 and 2.5-4.6 V vs Na/Na+ potential windows, respectively. In the lower potential window (2.5-4 V), the composite electrode demonstrated a two-step voltage plateau during the insertion and extraction of Na+/Li+ ions. Corresponding in situ synchrotron XRD patterns recorded during initial electrochemical cycling clearly indicate a series of two-phase transitions and confirm the structural stability of the NLVP/C composite cathode during insertion and extraction of the hybrid ions. Under extended cycling, excessive storage of Na ions resulted in the gradual transformation to the orthorhombic NLVP/C symmetry due to the occupancy of Na ions in the available orthorhombic sites. Moreover, the estimated average working potential and energy density at the initial cycle for the monoclinic-orthorhombic NLVP/C composite cathode (3.47 V vs Na/Na+ and 102.5 Wh kg(-1), respectively) are higher than those of the pyro-synthesized rhombohedral Na3V2(PO4)(3) (3.36 V vs Na/Na+ and 88.5 Wh kg(-1)) cathode. Further, the cathode performance of the composite material was significantly higher than that observed with pure monoclinic LVP under the same electrochemical measurement conditions. The present study thus showcases the feasibility of using a soft ion-exchange reaction at 150 degrees C to facilitate the formation of composite phases suitable for rechargeable hybrid-ion battery applications.</P>

Facile Redox Synthesis of Layered LiNi_1/3Co_1/3Mn_1/3O₂ for Rechargeable Li-ion Batteries

Baboo, Joseph Paul,Park, Hyosun,Song, Jinju,Kim, Sungjin,Jo, Jeonggeun,Pham, Duong Tung,Mathew, Vinod,Xiu, Zhiliang,Kim, Jaekook Pergamon Press 2017 Electrochimica Acta Vol. No.

<P><B>Abstract</B></P> <P>The present work reports on the development of layered-type Li<I> <SUB>x</SUB> </I>(Ni<SUB>1/3</SUB>Co<SUB>1/3</SUB>Mn<SUB>1/3</SUB>)O<SUB>2</SUB> (<I>x</I> =1.05 and 1.1) cathodes by a simple ambient temperature redox synthesis followed by post-heat treatments with added lithium source. The intermediate precursor (Ni<SUB>1/3</SUB>Co<SUB>1/3</SUB>Mn<SUB>1/3</SUB>O<I> <SUB>y</SUB> </I>) was synthesized through redox reaction between KMnO<SUB>4</SUB>, CoCl<SUB>2</SUB> and NiCl<SUB>2</SUB> in aqueous KOH medium. Synchrotron XANES and ICP measurements were performed to confirm the changes in the oxidation states and successful control in stoichiometric ratio of ternary transition metal oxide (Ni<SUP>2+</SUP> <SUB>0.33</SUB>Co<SUP>3+</SUP> <SUB>0.35</SUB>Mn<SUP>4+</SUP> <SUB>0.32</SUB>O<I> <SUB>y</SUB> </I>) during the redox reaction. Synchrotron X-ray diffraction studies of post lithiation confirmed the formation of a well-developed layer-type hexagonal phase of α-NaFeO<SUB>2</SUB> with least cation mixing, as observed from the estimated lattice parameters (<I>a</I> =2.858Å and <I>c</I> =14.228Å), integrated intensity ratio (<I>I</I> <SUB>003</SUB>/<I>I</I> <SUB>104</SUB> =1.79), and <I>c</I>/3<I>a</I> ratio (∼1.659) values. FE-SEM images revealed loosely agglomerated particles with average diameters of 60nm in the intermediate product while the particle-size grows to a few hundred nanometers after lithiation at elevated temperatures. The electrochemical performances in the potential range of 3.0–4.3V vs. Li/Li<SUP>+</SUP> at 14 mAg<SUP>−1</SUP> indicated that reasonable specific capacities and cycle performances are registered for all the prepared cathodes. In particular, the Li<SUB>1.05</SUB>(Ni<SUB>1/3</SUB>Co<SUB>1/3</SUB>Mn<SUB>1/3</SUB>)O<SUB>2</SUB> composition demonstrated the highest capacity retention value (∼99%) after 50 cycles and better rate performances (104, 91, 76, and 67 mAhg<SUP>−1</SUP>) at high current densities (229, 457, 914, and 1429 mAg<SUP>−1</SUP> respectively).</P> <P><B>Highlights</B></P> <P> <UL> <LI> LiNi<SUB>1/3</SUB>Co<SUB>1/3</SUB>Mn<SUB>1/3</SUB>O<SUB>2</SUB> cathode synthesis via an ambient temperature redox reaction. </LI> <LI> The stoichiometric elemental composition is controlled by the redox synthesis. </LI> <LI> The cathode exhibits ordered layer-type structure with minimal cation mixing. </LI> <LI> The cathode exhibited reasonable electrochemical properties versus lithium. </LI> </UL> </P>

Threshold Voltage Control through Layer Doping of Double Gate MOSFETs

Saji Joseph,George James T,Vincent Mathew 대한전자공학회 2010 Journal of semiconductor technology and science Vol.10 No.3

Double Gate MOSFETs (DG MOSFETs) with doping in one or two thin layers of an o therwise intrinsic channel are simulated to obtain the transport characteristics, threshold voltage and leakage current. Two different device structures- one with doping on two layers near the top and bottom oxide layers and another with doping on a single layer at the centre- are simulated and the variation of device parameters with a change in doping concentration and doping layer thickness is studied. It is observed that an n-doped layer in the channel reduces the threshold voltage and increases the drive current, when compared with a device of undoped channel. The reduction in the threshold voltage and increase in the drain current are found to increase with the thickness and the level of doping of the layer. The leakage current is larger than that of an undoped channel, but less than that of a uniformly doped channel. For a channel with p-doped layer, the threshold voltage increases with the level of doping and the thickness of the layer, accompanied with a reduction in drain current. The devices with doped middle layers and doped gate layers show almost identical behavior, apart from the slight difference in the drive current. The doping level and the thickness of the layers can be used as a tool to adjust the threshold voltage of the device indicating the possibility of easy fabrication of ICs having FETs of different threshold voltages, and the rest of the channel, being intrinsic having high mobility, serves to maintain high drive current in comparison with a fully doped channel.

Validation of aseptic processes for pharmaceuticals

Lincy Joseph,Mathew George,Saurabh Kumar Jain 경희대학교 융합한의과학연구소 2010 Oriental Pharmacy and Experimental Medicine Vol.10 No.4

Sterile Products may be broadly classified into two main categories, according to the manner in which they are produced: those which are sterilized after the product has been filled and sealed in the final container(s) (“terminally sterilized” products) and those where the sterilization stage (or stages) takes place is it before or after the bulk product filled in to final container. In this latter instance, all subsequent processing (typically, the filling and sealing operations) must be conducted aseptically in order to prevent recontamination of the sterilized product. The two most common pharmaceutical applications of aseptic processing methods are (a) the filling of liquid products following sterilization by filtration and (b) the filling of previously sterilized bulk powder products. An aseptic processing operation should be tested using a microbiological growth medium (media fill) during lyophilized injection formulation, filling, loading, lyophilisation, stoppering, and unloading activities.

Effect of Extended Nickel Doping and Secondary Heat Treatment on the Electrochemical Properties of High Energy Spinel LiMn_1.3Ni_0.7O_y Cathode

Paul, Baboo Joseph,Do, Giang Xuan,Mathew, Vinod,Gim, Jihyeon,Song, Jinju,Kim, Sungjin,Tung, Duong Pham,Kim, Jaekook The Electrochemical Society 2014 Journal of the Electrochemical Society Vol.161 No.10

<P>The present study investigates on the effect of excessive Ni doping, secondary heat-treatment and their influence on the structural and electrochemical properties of LiMn<SUB>1.3</SUB>Ni<SUB>0.7</SUB>O<SUB>y</SUB> spinel samples prepared by a two-step solid state synthesis. X-ray diffraction (XRD), Fourier transform infra-red spectroscopy (FTIR), scanning electron microscopy (SEM), electrochemical studies and in-situ synchrotron XRD (SXRD) results acquired during electrochemical lithiation indicates that the concentration of Mn<SUP>3+</SUP> and the corresponding ordering of the spinel composition can be controlled by excessive nickel doping and secondary annealing (at 700°C). Moreover, the above characterizations also confirmed long-range cation ordering (<I>P</I>4<SUB>3</SUB>32) in addition to minor contributions from the Mn<SUP>3+</SUP> content in the secondary annealed spinel (LiMn<SUB>1.3</SUB>Ni<SUB>0.7</SUB>O<SUB>y</SUB>). More importantly, the combined effect of extended Ni-doping and secondary heat-treatment is clearly reflected as an enhancement in the rate performances of LiMn<SUB>1.3</SUB>Ni<SUB>0.7</SUB>O<SUB>y</SUB> spinel cathode at elevated current rates (discharge capacity of around 88 and 61 mAh/g at 0.457 and 0.914 A/g current densities).</P>

High Frequency Transient Vibration Analysis for the Detection and Diagnosis of Faults in Low Speed Rolling Element Bearings

Joshua Altmann,Joseph Mathew 대한기계학회 1997 Asia-Pacific Vibration Conference Vol.1 No.1