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Evaluation of the Biocompatibility of Cuttlebone in Mouse
원상철,이주명,정종태,박현정,서종필,Won, Sangcheol,Lee, Joo Myoung,Cheong, Jongtae,Park, Hyunjung,Seo, Jongpil The Korean Society of Veterinary Clinics 2015 한국임상수의학회지 Vol.7 No.2
골대체재는 지연유합이나 유합부전 그리고 골절술과 관절고정술 시 골편의 연속성 확립이 필요한 경우 골절의 주요 결손부위를 채우는데 주로 활용되고 있다. 자가골을 대체할 수 있는 천연 골이식재의 대표적인 것이 calcium carbonate (CC)이며, 갑오징어의 오적골(Cuttlebone, CB) 또한 천연 CC로 이루어져 있다. 본 연구에서는 오적골의 다양한 전처리 후 직경 5 mm 두께 2 mm의 형태로 가공하여 생체적합성을 평가하고자 하였다. 조직검사에서 결합조직 두께는 2, 4주차 모두 CBHA군에서 가장 유의성 있게 얇았다 (p < 0.05). 이상의 결과들은 CBHA가 생체 내에 적용하는 골대체재로서 생체적합성이 매우 높은 것으로 나타났다. 따라서 CBHA는 편평골에 있어 생체적합성이 뛰어난 골대체재로 그 가치가 있는 것으로 생각되며, 수의 임상에 있어서 활용성이 매우 높을 것으로 사료된다. Bone grafting is widely used to bridge major bone defects or to promote bone union. Natural calcium carbonate (CC) has been used as a bone substitute material and used to scaffold for bone morphogenetic protein (BMP). The aims of this study is to evaluate the biocompatibility of cuttlebone (CB) and hydroxyapatite from CB (CBHA). Each material was shaped into disks (5 mm in diameter and 2 mm in thickness). To test biocompatibility, the disks were implanted into the dorsal subcutaneous tissue in mice. Fibrous capsule thickness around each disk was evaluated histologically at 2 and 4 weeks after implantation. Concerning biocompatibility, fibrous capsule thickness of CBHA was significantly thinner than that of CB and CHA (p < 0.05) at 2 and 4 weeks after implantation. Based on the clinical and histological results, CBHA would be a safe material for use inside the body and has more effective osteoconduction than CB.
랫드에서 hyaluronic acid에 의한 유착 방지 효과에 관한 연구
이종훈,이주명,윤영민,강태영,우호춘,강윤호,김남중,김희석,이경갑,정종태,Lee, Jong hoon,Lee, Joo Myoung,Yun, Young min,Kang, Tae young,Woo, Ho choon,Kang, Yoon ho,Kim, Nam joong,Kim, Hee seok,Lee, Kyoung kap,Cheong, Jongtae 대한수의학회 2004 大韓獸醫學會誌 Vol.44 No.4
This study was conducted to investigate the effect of hyaluronic acid (HA) on prevention of abdominal adhesions depending on various concentrations thereof by inducing an abrasion experimentally in the cecum of rats. Each group was consisted of 10 rats, and 40 rats were divided into 4 groups comprising the saline treatment group, HA 0.4% treated group, 0.6% treated group, and 0.8% treated group. And abrasion was caused in the cecum by using dry gauze and thereby, adhesion was induced. On 7 days after the operation, adhesions of each region were evaluated into the range of 0-4. Significant difference was found in the adhesion score between the control group and each experimental group (P<0.05). Also, HA 0.4% treatment group showed the lowest adhesion score (P<0.05). In the light of the above results, HA 0.4% solution was more effective on prevention of adhesion than HA 0.6% and 0.8% solution.
Evaluation of the Bone Defect Regeneration after Implantation with Cuttlebone in Rabbit
원상철,이주명,박현정,서종필,정종태,Won, Sangcheol,Lee, Joo-Myoung,Park, Hyunjung,Seo, Jongpil,Cheong, Jongtae The Korean Society of Veterinary Clinics 2015 한국임상수의학회지 Vol.7 No.2
골대체제는 지연유합이나 유합부전 그리고 골절술과 관절고정술 시 골편의 연속성 확립이 필요한 경우 골절의 주요 결손부위를 채우는데 주로 활용되고 있다. 본 연구에서는 오적골의 다양한 전처리 후 직경 5 mm 두께 2 mm의 형태로 가공하여 rhBMP-2의 담체로써 골전도력과 골유도력을 평가하고자 하였다. 결합조직의 두께는 2, 4주차 모두 오적골유래 hydroxyapatite 적용군(CBHA)에서 가장 유의성 있게 얇았다(p < 0.05). Radiologic gray-level histogram의 측정에서는 4주차에서 CBHA군이 산호유래 hydroxyapatite 적용군(CHA)군보다 유의성 있게 높게 나타났으며(p < 0.05), 12주차에서는 CHA군의 변화율이 가장 적었다. 전체 12주 동안의 변화율에서는 CBHA가 가장 많은 변화를 보였다. 폐쇄율에 있어서는 4, 8, 12주차 모두 CHA군이 다른 군에 비해 유의성 있게 높게 나타났으며(p < 0.05), 8주차에서는 bmp를 적용한 오적골 적용군(CB1bmp)이 CBHA군보다 유의성 있게 높게 나타났다(p < 0.05). 이상의 결과들은 CBHA가 생체 내에 적용하는 골대체재로서 골유도능력이 우수한 것으로 나타났다. 따라서 CBHA는 편평골에 있어 생체적 합성이 뛰어난 골대체재로 그 가치가 있는 것으로 생각되며, 수의 임상에 있어서 활용성이 매우 높을 것으로 사료된다. Bone grafting is widely used to bridge major bone defects or to promote bone union. In the evaluation of bone defect regeneration, 5 mm-diameter defects were created in rabbit calvaria. Concerning biocompatibility, fibrous capsule thickness of CBHA (hydroxyapatite from cuttlebone) was significantly thinner than that of CB (cuttlebone) and CHA (hydroxyapatite from coral) (p < 0.05) at 2 and 4 weeks after implantation. Concerning 12-week total changes of radiologic gray-level histogram, CBHA was significantly higher than CHA (p < 0.05). In the evaluation of bone defect regeneration, bone formation of CHA was significantly higher than that of CB and CBHA (p < 0.05). Based on the clinical and histological results, CBHA would be a safe material for use inside the body and has more effective osteoconduction than CB. It is suggested that CBHA is a valuable bone graft material.
장광호,이주명,Jang, Kwang-ho,Lee, Joo-myoung 대한수의학회 1998 大韓獸醫學會誌 Vol.38 No.2
Photosensitization occurred in a 4-month old Holstein calf soon after going onto the pasture lush with green Japanese millet(Echinochloa crusgalli). Skin lesions were restricted to the unpigmented white area of skin. They were most pronounced on the dorsum of the body, diminishing in degree down the sides and were absent from the ventral part. The demarcation between lesions and normal skin was clearcut. There were edema, exudation and sloughing of affected skin on the left gluteal region, and erythema, edema and scab on right scapular region. Interception of the light, discontinuance of Japanese millet ingestion, and the administration of antihistamine and penicillin made the calf rapid recovery. This disease was considered photosensitization due to chlorphyll in ingested Japanese millet.
양재혁,정종태,이주명,황규계,임윤규,Yang, Jaehyuk,Cheong, Jongtae,Lee, Joo-Myoung,Hwang, Kyu-Kye,Lim, Yoon-Kyu 대한수의학회 2010 大韓獸醫學會誌 Vol.50 No.4
A 3-day-old Appaloosa colt was examined because of acute onset of ataxia, left-sided head tilt, fever and heart murmur. The foal continued to nurse but became increasingly depressed and mild colic. On plain radiological examination, the foal was normal. Uroperitoneum was diagnosed following abdominocentesis. Postmortem examination revealed bladder rupture. The lesion was in the dorsomedial part of the bladder wall. We suggested that the cause of bladder rupture was parturient trauma. Even though the rupture was associated with trauma, the margin of rupture of bladder was clearly smooth and regular.
윤희정,노재욱,오화균,홍기옥,이주명,윤영민,Youn, Hee-Jeong,Noh, Jae-wuk,Oh, Hwa-gyun,Hong, Ki-ok,Lee, Joo-myoung,Yoon, Young-min 대한수의학회 1998 大韓獸醫學會誌 Vol.38 No.1
To investigate the effect of acupuncture on bovine parasitosis, we first surveyed the prevalence of parasite by fecal sedimentation and floatation techniques, and Giemsa stain for blood parasites. Coccidia were the most frequent parasite(22.1%), which followed by Buxtonella sulcata. Others were very few. After acupuncture, infection rates of Coccidia and B sulcata started to decrease at 1 day after acupuncture(DAA) and reduced to 5.3% and 0% at 7 and 21 DAA, respectively. In comparison between treated and control groups, due to small sample number, statistical evaluation was impossible. But diarrhea of treated group was slightly decreased, while, haemoparasites infection rate is decreased in control group. To gain the confident result of acupuncture effect, the more investigation is needed.
김학회(Hak Hee Kim),이주명(Joo Myoung Lee),정명규(Myoun Kiu Chung) 한국공업화학회 2002 공업화학 Vol.13 No.2
활성탄은 톱밥, 야자각, coal, coke, 커피 폐기물, 고추씨 등과 같은 원료로부터 제조된다. 본 연구에서는 socrose을 원료로 하여 NaOH와 ZnCl_2를 사용하여 화학적 활성화법으로 활성탄을 제조하였다. 활성탄 제조 공정은 탄화, 활성화, 수세 및 건조의 순으로 진행하였다. 활성탄의 물리적 특성을 알아보기 위해 77 K에서의 질소 흡착, BET식과 BJH식으로 분석하였다. 비표면적, 세공용적 및 세공크기값은 각각 513~1198 ㎡/g, 0.33~0.91 ㎤/g, 15~19 Å로 계산되었다. 또한 제조한 활성탄의 세공 및 표면 구조를 알아보기 위해 SEM 분석을 실시하였다. Activated carbons can be prepared from several raw materials, such as wood, coconut shell, coal, coke, waste coffee, pepper~seed, etc. In this study, activated carbon was manufactured from sucrose by chemical activation with sodium hydroxide and zinc chloride. The preparation process for activated carbon was performed in the following sequence; carbonization, activation, washing and drying. The physical properties of activated carbon were characterized by the adsorption of nitrogen at 77 K, by using BET and BJH equation. The values of surface area, pore volume and pore size were calculated as 513~1198 ㎡/g, 0.33~0.91 ㎤/g, 15~19 Å, repectively. The porosity and surface of this activated carbon were observed by SEM photographs.
김소라,조창석,김민재,강태영,이주명,박현정,정종태,이경갑,윤영민,Kim, So-La,Cho, Chang-Seok,Kim, Min-Jae,Kang, Tae-Young,Lee, Joo-Myoung,Park, Hyun Jung,Cheong, Jongtae,Lee, Kyoung-kap,Yun, Young-min 대한수의학회 2007 大韓獸醫學會誌 Vol.47 No.4
A 4-year-old spayed female, Yorkshire terrier dog with a history of petechial and ecchymotic hemorrhages on the face, trunk and hind limb was referred to Veterinary Medical Teaching Hospital, Cheju National University. The complete blood count revealed a marked thrombocytopenia ($96{\times}10^3/{\mu}l$). The biochemical profile showed only slightly increased glucose. The coagulation profile such as prothrombin time and activated partial thromboplastin time, was within the reference range. In Giemsa staining, there were no endoparasites like as Babesia spp. on the RBC. This case was diagnosed as a idiopathic thrombocytopenia in a Yorkshire terrier dog. She was treated with prednisone (1 mg/kg BW, IM q 12 h) and cephalosporin (10 mg/kg BW, IM, q 12 h). When rechecked on day 6, the platelet was within reference range ($507{\times}10^3/{\mu}l$) and also petechial and ecchymotic hemorrhages on the body were gradually improved without any complications. The dose of prednisone was decreased to 0.5 mg/kg BW, q 24 h. On day 17, we finished treatment because all the clinical signs, blood and serum chemistry were reference range and platelet count was dramatically increased.