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RISS 인기검색어
- 검색키워드
- 저자 : Jonge-Levitan (검색결과 2 건)
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Dietary Herbal Supplements with Phenylephrine for Weight Loss
Frank Greenway,Lilian de Jonge-Levitan,Corby?artin,Andrew Roberts,Irene Grundy,Catherine Parker 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.4
This study was designed to evaluate the efficacy and safety of a dietary herbal supplement containing citrusaurantium and phenylephrine in the treatment of obesity. Two pilot studies enrolled healthy subjects with body mass indexes2540 kg/m2 to similar 8-week weight loss programs. Safety was assessed by physical examination and laboratory tests atscreening and 8 weeks. The first pilot study randomized eight subjects to citrus aurantium (herbal phenylephrine) or placebo.Body composition by DEXA scan, waist circumference, and resting metabolic rate (RMR) were measured at baseline and 8weeks. Food intake and appetite ratings were measured at baseline and week 2. The second pilot study randomized 20 sub-jects to two 2-hour RMR tests a week apart after phenylephrine (20 mg) or placebo followed by phenylephrine (20 mg) threetimes a day for 8 weeks. In the first pilot study, the citrus aurantium group gained 1.13. 0.27 (mean. SEM) kg comparedwith 0.09. 0.28 kg in the placebo group (P. .04). RMR at baseline rose more in the citrus aurantium group, 144.5. 15.7kcal/24 hours, than the placebo group, 23.8. 28.3 kcal/24 hours (P. .002), but not at 8 weeks. DEXA, waist circumfer-ence, food intake, and hunger ratings were not different. In the second pilot study, the phenylephrine group lost 0.8. 3.4 kgin 8 weeks (not significant), and RMR increased more in the phenylephrine group (111.5. 32.6 vs. 37.4. 22.7 kcal/24hours, P. .02). There were no significant safety issues in either study. Although no toxicity was seen, these pilot studiessuggest phenylephrine is not efficacious for weight loss.
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Globin Digest: No Evidence for a Weight Loss Mechanism
Frank Greenway,Andrew Roberts,Catherine Parker,Irene Grundy,Lilian de Jonge-Levitan,Marlene Most,James Ferguson 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.4
This study was designed to document the mechanism through which globin digest, a dietary herbal supple-ment, might cause weight loss by exploring possible fat malabsorption, calorie malabsorption, energy expenditure, and fat ox-idation. Six healthy subjects were placed on an outpatient diet for 14 days and given a meal containing 40.9 g of fat on days5 and 11, and stools were collected for 72 hours after each meal for analysis of fecal fat content. Four grams of globin digestwas given with one meal and placebo with the other. In another separate study, six subjects were placed on a 100-g fat, weight-maintaining diet for 14 days. All food was prepared by the Pennington Center (Baton Rouge, LA) metabolic kitchen. Globindigest (2 g) or placebo was given with each of three meals per day, and stool was collected for calorie determinations duringthe last 72 hours of each week. Subjects received globin digest during one of the 2 weeks and placebo during the other. Rest-ing metabolic rate and respiratory quotient were measured on the last day of each 1-week period. There was no increase in72-hour fecal fat or fecal calories by bomb calorimetry during either of the studies. There was no difference in the respira-tory quotient. Globin digest did result in an increase in resting metabolic rate. However, this increase was not statistically sig-nificant. Globin digest, if effective, does not cause weight loss or fat loss through fat malabsorption or a relative increase infat oxidation. Future studies are needed to document the efficacy of globin digest for weight loss in humans before furthermechanistic investigation is attempted.
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