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이종화,장봉기,박종안,박종영,김완종,우기민 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.3
Although numerous studies have shown that cadmium disturbs the normal biological processes in central nervous system the mechanism of toxicity is not well understood The present study has investigated the effect of cadmium on oxidative stress, Na+/K- ATPase activity and the aggregation of amyloid beta peptide(β-amylotd) in neuronal cell Ime, HT22 cell LC_(5) and LC_(50) of cadmium for HT22 cell resulted from MTT assay was 4 1 μM and 9 5 μM, respectively Cadmium(2 to 8 μM) dose-dependently increased the lipid peroxidation and decreased the content of glutathione Cadmium 4 μM showed a significant decrease in Na^(-)/K^(+) ATPase activity as compared with control group The aggregation of P-amyloid was accelerated in a dose-dependent manner by the treatment with 2 to 8 μM cadmium These results suggest that the neurotoxicity of cadmium can be mediated by the increase in oxidative stress and decrease in Na^(-)/K^(+) ATPase activity.
카드뮴이 마우스 뇌에서 아연의 항상성에 관여하는 유전자발현에 미치는 영향
박종안,여은영,남상훈,장봉기,이종화,김완종 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.4
Metallothionein (MT), a small protein molecule which can bind of release metal tons, is involved in the regulation of cellular metal homeostasis This study was investigated the accumulation of cadmium in blood, tissue (liver, kidney and brain), and the effect of cadmium on several key genes (MT-Ⅰ, MT-Ⅱ, ZnT-1) in zinc metabolism m the mouse Mouses weighing 20-25g were randomly assigned to control and cadmium treated group (Cd group) Cd group was intraperitoneally injected with cadmium 2, 4, 8 mg/kg and control group was administerd with saline Mouses of each group were sacrificed by decapitation 4 hours after the administration of cadmium Cadmium contents in blood, fiver, kidney and brain were increased by a dose-dependent manner Accumulation of cadmium was mainly occurred in liver and kidney Induction of MT-I and MT-11 protein was increased, but ZnT-1 expression was decreased to a dose-dependent manner by the treatment of 2~8mg/kg cadmium These results suggested that cadmium can be transported to brain and alter the expression of several key genes in zinc homeostasis.
내시경적 절제로 진단된 폴립 형태의 심재성 낭종성 위염 2예
허종현,조영화,성용완,유재훈,구동영,김갑식,노지훈,문원 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2
Gastritis cystica profunda (GCP) is a disease characterized by hyperplastic and significant extension of cystic dilatation of the gastric mucous glands, which results in a cystic lesion in gastric submucosa. It often occurs on the part of gastroenterostomy, but can be found in the stomach without any previous surgery. GCP has variable gross finding including solitary polyps, diffuse ones, submucosal tumors, and rare giant gastric mucosal fold. It is difficult to tell GCP from a cancerous lesion by gross finding that the disease demands a necessary tissue biopsy, though GCP is commonly showed as a benign in the progress. We report a case of GCP in polypoid types diagnosed by endoscopic polypectomy.
안종필,기완서,오영신 조선대학교 국토개발연구소 1997 국토개발연구 Vol.17 No.1
Recently, a rapid economical development and industrialization require large amount of land of industrial estate and expansion of citis. Therefore the construction of large and deep basements takes place in built up areas where the braced excavation for earth retaining structures causes many problems such as settlement and damages of nearby buildings and underground utilities. This study deals with the behavior of the retaining earth structures and the ground movement around it based on the measuring results which were obtained from the two ground sites. The results of elasto-plastic wall design program involving the effect of lateral flow pressure showed a good agreement with the output of finite difference computer program which covers the behavior of wall as the ground movement around it.
李鐘玩,梁点紅 釜山大學校 附設 體育科學硏究所 1992 體育科學硏究所 論文集 Vol.8 No.-
Recently the aging population is rapidly increasing, the lifetime of the Korean people has reached to 66.9 years for men, 75.0 years for women in 1990 and the population over age 65 takes 4.7%. Such an increase in aging people results in wide spread diseases of the aged, so we are urgent to find the way to cope with them. Osteoporosis is one of typical diseases of the aged, but proper treatment is not yet developed. Hence the prevention is the best way keeping from osteoporosis which gives the high rate of fracture in the aged and may reduce the quality of life. In particular, exercises in one's youth would give a better chance for one to increase bone mass and peak bone mass, and hence to take time on lose of bone mass in declining years. Osteoporosis results from physical aging of bones, it's occurance may depend on several factors, such as nutrition, hormone and exercises, hence it is desirable to study osteoporosis through joint works with nutritionist, physician, physiologist and athletic experts. Here our research works may be summerized as follows. (1) The lose of bone mass is not only the reason of fracture from osteoporosis. (2) The peak bone mass taken in one's youth is a proper measure of osteoporosis. (3) The exercise prescription may not give enough direct load to skeleton. (4) The long time loading exercises of skeleton may increase bone mass. (5) The resistance training is good for the increase of bone mass. (6) There is no training threshold for bone health. Therefore, based on preparatory study, physical experts are considered to study how much the lose of bone mass can be reduced, and restored from the exercise prescription and to find the best way of exercise prescription.