http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
현명수,서석권,윤능기,이종영,이승훈,이무식,Hyun, Myung-Soo,Suh, Suk-Kwon,Yoon, Nung-Ki,Lee, Jong-Young,Lee, Seoung-Hoon,Lee, Mu-Sik 대한예방의학회 1992 예방의학회지 Vol.25 No.2
현재까지도 완전히 규명되지 못한 간질환과 혈청 구리 및 아연농도와의 관련성을 밝히고, 이들의 진단적 가치를 알아보고자 1990년 10월에서 1991년 8월 사이에 대구시 소재 모 대학병원 내과와 건강진단센터에 내원한 사람들 중에서 무작위로 선정한 정상 63명, 간경변 60명 그리고 간암 33명을 대상으로 일반적 특성을 조사하였고, 체내 일일 변동을 고려하여 공복시 오전 9시에서 11시 사이에 혈액을 채취하여 간기능검사의 생화학적 표지자와 혈청 구리 및 아연농도의 분석에 사용하였다. 혈청 구리의 평균농도는 대조군 $91.97{\pm}4.76{\mu}g/dl$, 간경화군 $106.21{\pm}2.73{\mu}g/dl$ 그리고 간암군 $127.05{\pm}0.77{\mu}g/dl$이었고, 대조군과 간경화군 사이에 통계적으로 유의한 차이는 없었으나, 간경화군과 간암군사이에는 통계적으로 유의한 차이를 보였다(p<0.05). 아연에 있어서는 대조군 $110.82{\pm}7.24{\mu}g/dl$,간경화군 $68.10{\pm}5.43{\mu}g/dl$ 그리고 간암군 $63.78{\pm}2.20{\mu}g/dl$로 나타났고, 간경화군과 간암군 사이에 통계적으로 유의한 차이는 없었으나, 대조군과는 두 군 모두 통계적으로 유의한 차이를 보였다(P<0.05). Cu/Zn비는 세 군 사이에 모두 통계적으로 유의한 차이가 있었다(p<0.05). 간기능검사의 생화학적 표지자들 중에 총 단백, 알부민, ALP 그리고 총 빌리루빈은 세 군 간에 모두 통계적으로 유의한 차이가 있었으나(p<0.05), ALT와 AST의 간경화군과 간암군 간의 차이는 통계적으로 유의하지 않았고, 직접 빌리루빈은 대조군에 대해 간암군에서 통계적으로 유의한 차이가 없었다. 헐청 구리와 아연농도 그리고 Cu/Zn비와 통계적으로 유의한 상관관계를 보인 표지자는 세 군에서 다양하게 나타났다. 다중 로지스틱 회귀분석에서 간경화 및 간암에 대한 odds ratio는 혈청 아연농도만이 각각 0.951, 0.952로 통계적으로 유의하였고(p<0.05), 혈 청 구리 농도와 Cu/Zn비는 통계적인 유의성이 없었다. 세 군에 대한 판별분석에서 구분을 위한 주요변수로 선정된 것은 알부민, ALP, 혈청 아연농도, 나이 그리고 총 빌리루빈이었고, 이를 적용하여 판별한 결과 바른구분의 백분율은 대조군 95.4%, 간경변군 73.4%, 간암군 75.7%로 총 84.0% 였다. 본 연구는 아연이 간질환에 대해 독립적으로도 억제하는 효과가 있을 것이며, 혈청 아연농도의 측정은 간질환의 진단에 유용하게 이용될 수 있을 것임을 시사하고 있다고 생각된다. This study was done to identify the association between serum copper and zinc levels and the cirrhosis and hepatocellular carcinoma(HCC), and to evaluate its diagnostic value on liver diseases. Sixty-three healthy persons, 60 patients with cirrhosis and 33 patients with hepatocellular carcinoma were rendomly selected and investigated for their general characteristics from October 1990 to August 1991. For analysis of the biochemical markers in liver function test and the serum copper and zinc levels, their fasting venous blood were sampled at 9:00 to 11:00 in the morning and centrifuged to separate the serum within one hour. All the samples were immediately analysed for biochemical markers and stored at $-20^{\circ}C$ in polypropylene tubes further copper and zinc analysis. Mean of serum coppper levels was $91.97{\pm}4.76{\mu}g/dl$ in control, $106.21{\pm}2.73{\mu}g/dl$ in cirrhosis and $127.05{\pm}0.77{\mu}g/dl$ in HCC. The value of HCC was statistically significantly higher than that of the control and cirrhosis(p<0.05). Serum zinc levels were $110.82{\pm}7.24{\mu}g/dl$ in control, $68.10{\pm}5.43{\mu}g/dl$ in cirrhosis and $63.78{\pm}2.20{\mu}g/dl$ in HCC. The values of cirrhosis and HCC were statistically significantly lower than that of control(p<0.05). The Cu/Zn ratio was statiatically significantly different among three groups(p<0.05). Test total protein, albumin, ALP and total bilirubin of biochemical markers of liver function were statistically significantly different among three groups(p<0.05). Differences between cirrhosis and HCC for ALT and AST, and between the control and HCC for direct bilirubin were not statistically significant. Biochemical markers statistically significantly correlated with serum copper and zinc levels and Cu/Zn ratio(p<0.05), were variable in three groups. In multiple logistic regression, odds ratio of serum copper level and Cu/Zn ratio had no statistical significance on the cirrhosis and the HCC, but that of serum sinc was statistically significant as 0.951 and 0.952(p<0.05). Serum copper and zinc levels and Cu/Zn ratio were not statistically significantly different between the cirrhosis and HCC. H\Albumin, ALP, zinc, total bilirubin and age among all variables were selected as main variables for three-group discriminant analysis. Percentage of 'grouped' cases correctly classified by these five variables was 98.4 for control, 73.4 for cirrhosis, 75.7 for HCC and 84.0 for all subjects. This study suggests that zinc level is considered to play a role as diagnostic marker on the hepatic disorders and be more useful than serum copper level and Cu/Zn ratio in diagnosis of the liver diseases.
UHF RFID 태그 칩용 저전력, 저면적 비동기식 EEPROM 설계
백승면,이재형,송성영,김종희,박문훈,하판봉,김영희,Baek, Seung-Myun,Lee, Jae-Hyung,Song, Sung-Young,Kim, Jong-Hee,Park, Mu-Hun,Ha, Pan-Bong,Kim, Young-Hee 한국정보통신학회 2007 한국정보통신학회논문지 Vol.11 No.12
본 논문에서는 $0.18{\mu}m$의 EEPROM cell을 사용하여 수동형 UHF RFID 태그 칩에 사용되는 저전력, 저면적의 1Kbits 비동기식 EEPROM IP를 설계하였다. 저면적 회로 설계 기술로는 $0.18{\mu}m$ EEPROM 공정을 이용하여 비동기식 EEPROM IP를 설계하므로 command buffer와 address buffer를 제거하였고 separate I/O 방식을 사용하므로 tri-state 데이터 출력 버퍼(data output buffer)를 제거하였다. 그리고 저전압(low voltage)의 VDD에서 EEPROM cell이 필요로 하는 고전압(high voltage)인 VPP와 VPPL 전압을 안정적으로 공급하기 위해 기존의 PN 접합 다이오드 대신 Schottky 다이오드를 사용한 Dickson 전하펌프를 설계하므로 전하펌프의 펌핑단(pumping stage)의 수를 줄여 전하펌프가 차지하는 면적을 줄였다. 저전력 회로 설계 기술로 Dickson 전하 펌프(charge pump)를 이용하여 VPP generator를 만들고 Dickson 전하펌프의 임의의 노드 전압을 이용하여 프로그램과 지우기 모드에서 각각 필요로 하는 VPPL 전압을 선택하도록 하게 해주는 VPPL 전원 스위칭 회로를 제안하여 쓰기전류(write current)를 줄이므로 저전력 EEPROM IP를 구현하였다. $0.18{\mu}m$ 공정을 이용하여 설계된 비동기식 EEPROM용 테스트 칩은 제작 중에 있으며, 비동기식 1Kbits EEPROM의 레이아웃 면적은 $554.8{\times}306.9{\mu}m2$로 동기식 1Kbits EEPROM에 비해 레이아웃면적을 11% 정도 줄였다. In this paper, a low-power and small-area asynchronous 1 kilobit EEPROM for passive UHF RFID tag chips is designed with $0.18{\mu}m$ EEPROM cells. As small area solutions, command and address buffers are removed since we design asynchronous I/O interface and data output buffer is also removed by using separate I/O. To supply stably high voltages VPP and VPPL used in the cell array from low voltage VDD, Dickson charge pump is designed with schottky diodes instead of a PN junction diodes. On that account, we can decrease the number of stages of the charge pump, which can decrease layout area of charge pump. As a low-power solution, we can reduce write current by using the proposed VPPL power switching circuit which selects each needed voltage at either program or write mode. A test chip of asynchronous 1 kilobit EEPROM is fabricated, and its layout area is $554.8{\times}306.9{\mu}m2$., 11% smaller than its synchronous counterpart.
Beneficial Effects of Cynaroside on Cisplatin-Induced Kidney Injury In Vitro and In Vivo
Nho, Jong-Hyun,Jung, Ho-Kyung,Lee, Mu-Jin,Jang, Ji-Hun,Sim, Mi-Ok,Jeong, Da-Eun,Cho, Hyun-Woo,Kim, Jong-Choon Korean Society of ToxicologyKorea Environmental Mu 2018 Toxicological Research Vol.34 No.2
Anti-cancer drugs such as cisplatin and doxorubicin are effectively used more than radiotherapy. Cisplatin is a chemotherapeutic drug, used for treatment of various forms of cancer. However, it has side effects such as ototoxicity and nephrotoxicity. Cisplatin-induced nephrotoxicity increases tubular damage and renal dysfunction. Consequently, we investigated the beneficial effect of cynaroside on cisplatin-induced kidney injury using HK-2 cell (human proximal tubule cell line) and an animal model. Results indicated that $10{\mu}M$ cynaroside diminished cisplatin-induced apoptosis, mitochondrial dysfunction and caspase-3 activation, cisplatin-induced upregulation of caspase-3/MST-1 pathway decreased by treatment of cynaroside in HK-2 cells. To confirm the effect of cynaroside on cisplatin-induced kidney injury in vivo, we used cisplatin exposure animal model (20 mg/kg, balb/c mice, i.p., once a day for 3 days). Renal dysfunction, tubular damage and neutrophilia induced by cisplatin injection were decreased by cynaroside (10 mg/kg, i.p., once a day for 3 days). Results indicated that cynaroside decreased cisplatin-induced kidney injury in vitro and in vivo, and it could be used for improving cisplatin-induced side effects. However, further experiments are required regarding toxicity by high dose cynaroside and caspase-3/MST-1-linked signal transduction in the animal model.
인동덩굴로부터 분리된 Cynaroside이 Doxorubicin으로 유도된 인간 근위세뇨관 HK-2 세포의 괴사에 미치는 저해 효과
노종현,정호경,이무진,장지훈,심미옥,정자균,정다은,안병관,조현우,Nho, Jong Hyun,Jung, Ho Kyung,Lee, Mu Jin,Jang, Ji Hun,Sim, Mi Ok,Jung, Ja Kyun,Jung, Da Eun,An, Byeong Kwan,Cho, Hyun Woo 한국약용작물학회 2017 한국약용작물학회지 Vol.25 No.5
Background: Cynaroside is a flavone, a flavonoid-like compound, known by different names (luteoloside and cinaroside). It is commonly found in Lonicera japonica Thunb., Chrysanthemum moriflium, and Angelica keiskei. The process of cell death has been classified as necrosis and apoptosis. Necrosis refers to unregulated cell death induced by a chemotherapeutic agent. Doxorubicin is an anthracycline anti-cancer drug used to treat acute leukemia, cancer, and lymphoma. However, it induces nephrotoxicity including tubular damage. Therefore, we investigated the protective effect of cynaroside against doxorubicin-induced necrosis in HK-2 cells. Methods and Results: To confirm the beneficial effect of cynaroside on doxorubicin-induced necrosis, HK-2 cells, a human proximal tubule epithelial cell line were treated with $10{\mu}M$ doxorubicin and $80{\mu}M$ cynaroside. Doxorubicin treatment resulted in increased DNA fragmentation, caspase-3 activity and mitochondria hyperactivation during cell necrosis. However, pretreatment with $80{\mu}M$ cynaroside attenuated DNA fragmentation, caspase-3 activity and mitochondria hyperactivation induced by $10{\mu}M$ doxorubicin in HK-2 cells. Conclusions: These results indicated that pretreatment with cynaroside ameliorated doxorubicin-induced necrosis in HK-2 cells. Therefore, cynaroside be used as a therapeutic agent for improving doxorubicin-induced nephrotoxicity. However, further studies are required to evaluated the toxicity of cynaroside treatment in animals and to determine its protective effect against doxorubicin-induced nephrotoxicity in an animal model.
넓은 전압 범위와 개선된 파워-업 특성을 가지는 밴드갭 기준전압 발생기의 스타트-업 회로
성관영,김종희,김태호,카오투안부,이재형,임규호,박무훈,하판봉,김영희,Sung, Kwang-Young,Kim, Jong-Hee,Kim, Tae-Ho,Vu, Cao Tuan,Lee, Jae-Hyung,Lim, Gyu-Ho,Park, Mu-Hum,Ha, Pan-Bong,Kim, Young-Hee 한국정보통신학회 2007 한국정보통신학회논문지 Vol.11 No.8
본 논문에서는 넓은 동작전압 범위와 저소비 전력 그리고 개선된 파워-업 특성을 가지는 캐스코드 전류 거울형 CMOS 밴드갭 기준전압 발생기의 스타트-업 회로를 제안하였다. 새롭게 제안된 스타트-업 회로는 기존의 스타트-업 회로에 비해 안정적인 파워-업 특성을 가지며 공급전압(VDDA)이 높아지더라도 밴드갭 기준전압 발생기 회로의 동작에 영향을 미치지 않는 것을 모의실험을 통하여 확인하였고 $0.18{\mu}m$ tripple-well CMOS 공정을 이용하여 테스트 칩을 제작하고 측정하였다. 측정 된 기준전압 Vref는 평균값이 738mV이고 $3{\sigma}$는 29.88mV이다. A start-up circuit of the bandgap reference voltage generator of cascode current mirror type with wide operating voltage range and enhanced power-up characteristics is proposed in the paper. It is confirmed by simulation that the newly proposed start-up circuit does not affect the operation of the bandgap reference voltage generatory even though the supply voltage(VDDA) is higher and has more stable power-up characteristic than the conventional start-up circuit. Test chips are designed and fabricated with $0.18{\mu}m$ tripple well CMOS process and their test has been completed. The mean value of measured the reference voltage(Vref) is 738mV and The three sigma value($3{\sigma}$) is 29.88mV.
이태영,이재형,김종희,심외용,김태훈,박무훈,하판봉,김영희,Lee, Tae-Young,Lee, Jae-Hyung,Kim, Jong-Hee,Shim, Oe-Yong,Kim, Tae-Hoon,Park, Mu-Hun,Ha, Pan-Bong,Kim, Young-Hee 한국정보통신학회 2008 한국정보통신학회논문지 Vol.12 No.1
The band-gap reference voltage generator which can be operated by low voltage is proposed in this paper. The proposed BGR circuit can be realized in logic process by using parasitic NPN BJTs because a $Low-V_T$ transistors are not necessary. The proposed BGR circuit is designed and fabricated using $0.18{\mu}m$ triple-well process. The mean voltage of measured VREF is 0.72V and the three sigma$(3{\sigma})$ is 45.69mv. 본 논문에서는 $Low-V_T$ 트랜지스터가 필요 없는 로직공정으로 Parasitic NPN BJT를 이용하여 저 전압에서 동작 가능한 밴드갭 기준전압 발생기 회로를 제안하였다. $0.18{\mu}m$ triple-well 공정을 사용한 BGR회로를 측정 한 결과 VREF의 평균전압은 0.72V $3{\sigma}$는 45.69mV로 양호하게 측정되었다.
강유전성 BaTiO₃의 분극처리에 의한 유사체액 내에서 Calcium Phosphate 생성
송종은,김은주,황규석,임용무,박영준 대한치과기재학회 2000 대한치과재료학회지 Vol.27 No.4
Barium titanate (BaTiO3; BTO) has wide application in industry, particularly in the manufacturing of dynamic random access memory chips, electro-optical switches, optical modulators, shutters, optical mixers, and sensors, owing to its ferroelectric and piezoelectric properties after poling treatment. There has recently been considerable interest in the properties of its role in osseointegration. In this study, we investigated the possibility of treating BTO by poling to improve osseointegration by examining the calcium phosphate (Ca-P) crystal growth behavior on the poled and non-poled BTO surfaces in simulated body fluids (SBF). The BTO samples were sintered at 1350℃ for 2 h in air, producing an average grain size of 7 ㎛, which were confirmed by SEM observation. The sintered BTO samples were then polarized (Ep=5 kV/cm) from 160℃ to 25℃ in a Si oil bath for 2 h. The poled and non-poled BTO samples were immersed in 1.5 SBF for 15 days, or 30 days at 37℃. After the immersion period, the morphological and compositional changes of the surface of the immersed BTO specimens were investigated using a field emission scanning electron microscope (FE-SEM) and an energy dispersive X-ray spectrometer (EDX). Qualitative analysis was then performed using fourier transform infrared (FTIR) analysis. Weak and coarse Ca-P crystals had grown on the surface of the non poled BTO, while a marked difference in the Ca-P forming pattern was visible for the poled BTO, showing the negatively charged surface induces a Ca-P layer more easily. We assumed that rapidly adsorbed cations (Ca2+ ions) on the negatively charged surface at the initial stage acted as nuclei for the formation of Ca-P crystals, while no nuclei would be available on the positively charged surface, due to the fact that sodium chloride (NaCl) crystals were formed owing to anion adsorption (Cl ions). In summary, these results demonstrate that poling the ferroelectric BTO surface negatively the possibility of implant osseointegration.
0.18 μm CMOS 공정을 이용한 밀리미터파 대역 전력 증폭기 설계
허상무,이종욱 경희-다반 ASIC 설계교육센터 2006 경희-다반 ASIC센터 논문집 Vol.7 No.-
We investigated the design of 20 GHz-band power amplifier using 0.18 pm CMOS technology. Considering the output power requirement and number of gain stages, the size of device was chosen as 2X150 pm. Using electro-magnetic(EM) simulation, the insertion loss of the substrate-shielded microstrip line was compared with conventional transmission line structure. From the EM simulation, the dimensions of the microstrip line were determined given the characteristic impedance. By using cascode topology and substrate-shielded microstrip line, a 3-stage amplifier achieved a 19-dB small-signal gain and 14-dBm of output power at 20 GHz.
이종보,이광열,송무효 東義大學校産業技術開發硏究所 1998 産業技術硏究誌 Vol.12 No.-
Dredged soils used in coast reclamation are soft clay that have different characteristics, depending upon the sites. In this study, the consolidation behavior of the soft clay are analyzed by conducting consolidation tests. Also, results by the test are compared with those of numerical analysis of "LRSC" equation to assess predictions of the consolidation settlement. Dredged soils used in this study are the expendable clay with the coefficient of peameability in the range of 6.1×10-7∼5.0×10-5cm/s, and a long term consolidation settlement calculated by "LRSC" equation showed higher values than experimental results. From the column tests, it is found that the maximum excess pore pressure takes place at the lower part of the column and this unusual phenomenon is supposed to be affected by the self-consolidation process.