내경동맥 지배 영역의 급성 허혈성 뇌졸중 환자에서 초 선택적 국소적 Urokinase주입술

김인규,김명규,김재규,조기현,김세종 대한신경과학회 1998 대한신경과학회지 Vol.16 No.5

Synergistic effect of melamine in combination with cyanuric acid on urinary tract toxicity in rats

Jong-Choon Kim, In-Chul Lee, Sung-Hwan Kim, Hyung-Sun Baek, Sung-Soo Kang 충북대학교 동물의학연구소 2013 Journal of Biomedical and Translational Research Vol.14 No.3

The present study investigated the urinary tract toxicity of melamine alone or in combination with cyanuric acid in rats. Male rats were orally administered melamine alone (800 mg/kg) or melamine plus cyanuric acid (50 mg/kg each) for 3 consecutive days. Although melamine treatment did not show any significant difference in body weight, kidney or urinary bladder weight, serum blood urea nitrogen (BUN) or creatinine levels, it caused a decrease in urinary pH and mild histopathological alterations in the kidney and urinary bladder. In contrast, co-administration of melamine and cyanuric acid induced a decrease in body weight, an increase in kidneys and urinary bladder weights, and an elevation in serum BUN and creatinine levels, which were not observed in animals treated with melamine alone. Histopathological examination showed that the incidence and severity of histopathological lesions in the kidney and urinary bladder were much higher than those in the melamine group. Urinalysis revealed an increase in urine occult blood, leukocytes and protein and a decrease in urinary pH. These results indicate that concomitant administration of cyanuric acid synergistically potentiated the urinary tract toxicity induced by melamine in rats. In this study, we first demonstrated the synergistic toxic effects of melamine in combination with cyanuric acid on urinary bladder and urinalysis in rats.

In-hospital mortality in patients with STEMI admitted during off hours

( Sung-Soo Kim ),( Myung Ho Jeong ),( Jeong Gwan Cho ),( Young Keun Ahn ),( Jong Hyun Kim ),( Shung Chull Chae ),( Young Jo Kim ),( Seung Ho Hur ),( In Whan Seong ),( Taek Jong Hong ),( Dong-hoon Choi 대한내과학회 2013 대한내과학회 추계학술대회 Vol.2013 No.1

Conflicting results exist on the outcome of off hours PCI in ST elevation myocardial infarction (STEMI). However, there were only a few studies that have focused on the clinical characteristics and outcomes of off hours PCI in STEMI. So, we studied the clinical characteristics and hospital mortality in STEMI patients treated with primary PCI during regular hours (weekdays 9:00 AM to 6:00 PM) versus off hours Weekdays 6:01 PM to 8:59 AM, weekends, and holidays) in Korea Acute Myocardial Infarction Registry. We analyzed in hospital and one year mortality among 5,665 consecutive ST segment elevation myocardial infarction patients treated with primary PCI between November 2005 to January 2008. Total 2,848 (50.2%) patients were treated during off hours. Baseline finding were similar, although regular hours patients were older. Median symptom to balloon time (304 min, IQR 175 to 750 vs. 270 min, IQR 145 to 551, p=0.001) were longer for regular hours primary PCI. Median door to balloon time (71min, IQR: 48 to 132 vs. 59 min, IQR 39 to 110 min, p=0.001) were longer for off hours pPCI. Also, Cardiac enzyme such as Max CK-MB (212.1±299.3 vs 194.7±303.4, p=0.031) and max TnI (72.6±239.5 vs. 58.9±94.4, p=0.013) were increased in off hours pPCI. However, unadjusted in hospital (6.0% off hours vs. 6.0% regular hours, p=0.946) and one year cardiac mortality (11.3% off hours vs. 11.7% regular hours, p=0.661) were comparable. In multivariate analysis, off hours primary PCI did not predict an adverse outcome. In conclusion, when primary PCI was performed within an appropriate reperfusion strategy, the clinical effectiveness of either off hours or regular hours pPCI is comparable.

衛生昆蟲에 대한 無公害農藥(昆蟲發育沮害劑)의 殺蟲機作 및 應用技術開發硏究

金正和,李炯來,李仁煥,李容揆,崔鐘錫 충북대학교 농업과학기술연구소 1993 農業科學硏究 Vol.10 No.2

In recently, much pesticides were used for control of agricultural and medical insects. The result of using pesticides were social problem because of environmental pollutions with pesticides in urban and farm village. The environmental pollutions were very serious. This experiment was conducted to eluciated of reduce to environmental pollution bring about using pesticides (organophosphates, carbamates, pyrethroids, and insect growth regulators) for control of medical insects(house fly, Musca domestica L and mosquito, culex pipiens pallens copuillett) and carried out the method of pest control. And the result are summarized as follows. The Kyongbuk house fly strain treated with pyriproxyfen on third instar larvae were very high mortality and low emergence. When use it, at the same time, we can reduce degree of environ-mental pollution and house fly populations. Using of imidan was effective in Seoul and Chungnam house fly strains. In mosquito larvae, the efficacy of icon to chungbuk strain, propoxur to Chungnam and Chungbuk strain, imidan to Kyongbuk strain, fenthion to Chungnam strain were excellent. In result of spraying imidan and icon on adult mosquitoes, the efficacy of icon was excellent than imidan. In esterase electrophoresis, third instar larvae of Chungnam house fly strain fed on artificial diet mixed with pyriproxyfen LC50 were very high activity of -Est-αl in early stage(second day after third instar larvae fed on diet), and the activity of Est-αl was very strong in late stage(se-vents day after third instar larvae fed on diet). In Kyongbuk strain, -Est-αl and Est-αl were detected in early and late stage, and activities of and -Est-αl and Est-αl were detected almost equally in late stage. It was very characteristic in this experiment. Third instar larvae fed on diet mixed with pyriproxyfen LC95 were detected -Est-αl and Est-αl almost equally. It was believed moulting control in insects. In electrophoresis with head, thorax, abdomen of house fly adult, -Est-α2 -Est-αl, Est-αl, Est-α2, Est-α3 were detected in abdomen in susceptible strain and only -Est-αl, was net detected in thorax -Est-αl, was detected in head, thorax and abdomen of Chungbuk strain and -Est-αl was detected in head, -Est-α2 in thorax of same strain. Activities of chitinase in late instar larvae of house flies fed on artificial diet mixed with pyrip-roxyfen LC50 and LC95, in pyriproxyfen LC95, analysised low and high again with the lapse of time in Kyongbuk strain. This was believed that the activity of chitinase was became high just before emergence. The result of filter paper test with mosquitoes were very high index(265) of esterase activity in Chungnam strain among all mosquito strains. In this reason, we can suppose that used pyrip-roxyfen (IGR) in Chungnam area for control pest. In this reason, it was more reasonable made use of pyriproxyfen than other pesticide in Chungnam area.

Temporal trends and in-hospital outcomes of primary percutaneous coronary intervention in nonagenarians with ST-segment elevation myocardial infarction

( Joon Young Kim ),( Myung Ho Jeong ),( Yong Woo Choi ),( Yong Keun Ahn ),( Shung Chull Chae ),( Seung Ho Hur ),( Taek Jong Hong ),( Young Jo Kim ),( In Whan Seong ),( In Ho Chae ),( Myeong Chan Cho ) 대한내과학회 2015 The Korean Journal of Internal Medicine Vol.30 No.6

Background/Aims: Data regarding the outcomes of primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) in nonagenarians are very limited. The aim of the present study was to evaluate the temporal trends and in-hospital outcomes of primary PCI in nonagenarian STEMI patients. Methods: We retrospectively reviewed data from the Korea Acute Myocardial Infarction Registry (KAMIR) from November 2005 to January 2008, and from the Korea Working Group on Myocardial Infarction (KorMI) from February 2008 to May 2010. Results: During this period, the proportion of nonagenarians among STEMI patients more than doubled (0.59% in KAMIR vs. 1.35% in KorMI), and the rate of use of primary PCI also increased (from 62.5% in KAMIR to 81.0% in KorMI). We identified 84 eligible study patients for which the overall in-hospital mortality rate was 21.4% (25.0% in KAMIR vs. 20.3% in KorMI, p = 0.919). Multivariate analysis identified two independent predictors of in-hospital mortality, namely a final Thrombolysis in Myocardial Infarction (TIMI) flow < 3 (odds ratio [OR], 13.7; 95% confidence interval [CI], 3.2 to 59.0; p < 0.001) and cardiogenic shock during hospitalization (OR, 6.7; 95% CI, 1.5 to 30.3; p = 0.013). Conclusions: The number of nonagenarian STEMI patients who have undergone primary PCI has increased. Although a final TIMI flow < 3 and cardiogenic shock are independent predictors of in-hospital mortality, primary PCI can be performed with a high success rate and an acceptable in-hospital mortality rate.

대형 밀폐 챔버를 이용한 파프리카(Capsicum annumm L.) 개체의 이산화탄소 소비량 측정 및 정량화

신종화(Jong Hwa Shin),안태인(Tae In Ahn),손정익(Jung Eek Son) 한국원예학회 2011 원예과학기술지 Vol.29 No.3

파프리카의 상하위엽의 광합성 속도 차이를 측정하고, 광합성 측정용 챔버를 이용한 광합성량 측정치와의 차이를 비교하여 보다 정밀한 파프리카 생육시의 CO₂ 요구도를 알아보고자 본 연구를 수행하였다. 광합성측정장치(LI-6400)를 이용하여 위치 별 파프리카의 광합성속도를 측정하였다. 또한 파프리카 개체의 CO₂ 소모량의 정량화를 위하여 환경조절이 가능한 밀폐 챔버를 제작하고, 챔버 내부의 CO₂ 농도의 감소량을 측정하여 식물이 이용한 CO₂를 정량화하였다. 파프리카의 상위엽과 하위엽에서 광도증가에 따른 광합성 속도 상위엽에서 증가량이 상대적으로 크게 나타났다. 제작한 챔버 내부의 CO₂ 농도를 1,500μ㏖ · ㏖?¹ 수준으로 설정한 후, 일사량 변화에 따른 챔버 내부의 CO₂ 농도를 이용하여 식물체에 의해 소모된 양을 계산하였다. 엽면적이 7,533.4㎠ 인 파프리카의 경우, 적산광(x)에 따른 CO₂ 소모량은 다음과 같은 광합성량 추정 모델식으로 추정되었다: y = -0.06234 + 3.671<SUP>*</SUP>x/(2.589 + x) (R² = 0.9966<SUP>***</SUP>). 300μ㏖ · m?² · s?¹ 광도범위에서 챔버를 이용한 파프리카의 광합성속도는 3.4 μ㏖ CO₂ · m?² · s?¹ 이었고, 상위엽과 하위엽에서의 광합성 측정기에 의한 데이터와 비교하여 중간 값을 나타내었다. 따라서 실제 대규모 농가에서 단위엽의 광합성 측정에 의하여 CO₂ 시비량을 계산하면 실제 필요량과 공급량 간에 큰 차이가 발생할 수 있다. 따라서 엽 광합성속도 이외에도 본 연구에서와 같이 챔버를 이용하여 파프리카 식물체 개체가 소비하는 CO₂량을 정량화한다면 상업용 온실에 필요한 CO₂ 시비량을 정확하게 추정할 수 있다. This study was carried out to clarify precise CO₂ demands of paprika plants (Capsicum annumm L.) by measuring photosynthesis rates of the leaves in high, low positions, and the CO₂ consumption of a whole plant in a large sealed chamber. A photosynthesis measuring system (LI-6400) was used to measure the photosynthetic rates of the leaves located in different positions. A large sealed chamber that can control inside environmental factors was developed for measuring CO₂ consumption by a whole paprika plant. With increase of radiation, photosynthetic rates of the leaves in higher position became larger than those in lower position. The CO₂ consumption by the plant was estimated by using decrement of CO₂ concentration from initial level of 1500 μ㏖ · ㏖-1 in the chamber with increase of integrated radiation. A regression model for estimating CO₂ consumption by the plant (leaf area = 7,533.4 ㎠) was expressed with integrated radiation (x) and was suggested as y = - 0.06234 + 3.671<SUP>*</SUP> x / (2.589 + x) (R² = 0.9966<SUP>***</SUP>). The photosynthetic rate of the whole plant measured in the chamber was 3.4 μ㏖ CO₂ · m?² · s?¹ under 300 μ㏖ · m?² · s?¹ light intensity, which is in-between photosynthetic rates of the leaves in high and low positions. For this reason, some differences between required and supplied CO₂ amounts in greenhouses might occur when depending too much on photosynthetic rates of leaves. Therefore, we can estimate more accurately CO₂ amount required in commercial greenhouses by using CO₂ consumption model of a whole plant obtained in this study in addition to leaf photosynthetic rate.

본교 대학원 발전방안에 관한 연구

김종달,전도웅,전인철,조병권,박영규,오준석,나영일 龍仁大學校 1998 용인대학교 논문집 Vol.15 No.-

The purpose of this study was to suggest the developmental ideas for graduate school in Yougin University. For the methods of this study, the researches in administration of graduate students, personal researches in socialization of graduate school, and evaluation materials for graduate school were utilized. Additionally, the questionnaire survey about graduate students leas administered and analyzed and the ideas constructed from staff meeting for the development of graduate school were applied in preparing developmental plan. The results of this study are summarized as follow: 1. 1-2 years preparation - offers annual credits upto 30 - jop marketing upto 70% - advisor and student ratio 1 : 7 - professors' doctoral degree possession upto 90% - graduate school professors' research achievement upto 2 articles annually - research space per student upto 10m/2 3-4 years preparation - offers annual credits unto 33 - advisor and student ratio 1:4 - professors' doctoral degree possession upto 95% - graduate school professors' research achievement upto 2.5 articles annually 2. The educational goals of graduate school should be recognized among graduate students and the professionality of faculty members should be emphasized to teach graduate students in their relative major areas. The evaluation procedures for graduate class lecture and class administration in graduate school. 3. To reach unto lecture system, field study should be expanded and inter-credit system between Yongin universities and foreign university should be contracted. 4. Expanding of graduate school facilities should be cranked in to provine the optimal environment for the student education and schoolship should be widely offered to the students. 5. To promote the administrational development, the staff system should be changed from reverse hierarchy system to hierarchy system. Therfore, the number in lower administrational staffs should be larger than upper positions. And, the classification of authorities into department could be suggested for the efficacy of administration and management of graduate shool. 6. The specialization in each major should be emphasized. In the calc of graduate stool of physical education, the administration live should be unified in one body system. In the case of graduate school of business, one department of administration could be classified into management of sightseeing and tourism, management of distribution, tax accounting, then the specialty of the department can be forced. In the case of graduate school of art, the specialty can be forced by teaching highly performed skills and needed to switch from special graduate school to professional graduate school. The graduate school of health and school of environmental science are recommended to be built after all. Therefore, the connection between undergraduate and graduate curiculum can be established and open 2-3 more majors in the graduate school.

중년 여성의 에어로빅댄스와 헬스운동 참여에 따른 신체조성, 골밀도, 비특이적 운동효과에 대한 비교분석

전종귀,박인순 충남대학교 체육과학연구소 2006 體育科學硏究誌 Vol.23 No.1

This study performed to compare the body composition, bone mineral density and non specificity exercise effect following to the types of exercise program. Exercise program were divided to three types as aerobic-dance, health exercise, and general women. The subjects recruited for this study were 45 middle-aged women composed of 15 aerobics-dancers and 15 health exercisers who participated in regular exercise more than 1~2 years, and 15 non-exercisers. The subjects were methods in some variables influencing body composition and femoral bone mineral density by DTX-200. Non specificity exercise effect a survey instrument modified by the researcher and based on the Psychological Well-being index. The statistical methods utilized in this study were one way ANOVA and Sheffe test was used. The .05 level was in established in significance. The findings of this study were as follow; 1. In the characteristics of body compositions, health group was significantly lower than non-exercise group in body weight, total body fat, % fat and body mass index and lower than aerobic-dance group. Not significantly different among three groups in lean body mass. 2. In the femoral bone density, aerobic-dance and health groups were not significantly different among three groups in non-exercise group, and not different at all regions in non-exercise group between dominant and non-dominant formula. 3. In the characteristics of non specificity exercise effect, aerobic-dance group was significantly higher than health group and non-exercise group in the body, mind, nerves.

임신성 당뇨와 임신성 내당능장애에 관한 연구

윤인숙,이종국 대구보건대학 2005 대구보건대학 論文集 Vol.25 No.-

Some of the most common metabolic disorders that are complicated by pregnancy are gestational diabetes mellitus (GDM) and gestational impaired gluscose tolerance (GIGT). Many studies on GDM and GIGT have been conducted actively in or outside of Korea recently. This study was conducted to compare maternal characteristics and pregnancy outcomes in groups of GDM or GIGT with normal pregnant women, and on 759 pregnant women delivered at the one of general hospitals in Daegu city during the period of July 1, 2001, through June 31, 2003. We performed 50gm oral glucose tolerance test (50gm GTT) to screen GIGT and GDM in 759 pregnant women at 24~28 weeks of gestation. Among 181 women with plasma glucose level over 140mg/dl in 50gm GTT, 179 women underwent 100gm oral glucose tolerance test (100gm GTT) and National Diabetes Data Group thresholds were used to diagnose GIGT and GDM. We also examined and analysed some maternal characteristics and pregnancy outcomes retrospectively in groups of GDM, GIGT, and normal pregnant women. T-test was used to determine the statistical significance. The prevalence of GIGT and GDM was 19.1% and 4.5%, respectively. The prevalence of GDM in pregnant women with over than 150mg/dl was 4 times higher than in pregnant women with 140~149mg/dl in 50gm GTT. The average age of GIGT women and GDM women was significantly higher than that of normal pregnant women(P<0.05). The prevalence of GIGT and GDM in pregnant women aged over 30 was 67.6%, 72.7%, respectively. The prevalence of GDM in pregnant women with parity over 3 in GDM group was significantly higher than that in normal pregnant women(P<0.05). In relationship between GDM prevalence and blood types of pregnant women, the pregnant women with A blood type showed the highest prevalence in GDM(66.7%). The frequency of overweight newborn in the GDM group was two times higher than that in the GIGT or normal group. One of the most common metabolic disorders that is complicated by pregnancy is GDM and pregnancy complicated with GDM showed poor maternal and neonatal outcomes. Therefore 50gm GTT must be taken in all Korean pregnant women at 24~28 weeks of gestation as well as in all foreign pregnant women.

편두통 환자의 임상 양상 및 생체전기 자율반응과의 상관성 고찰

이현종,정인태,김수영,이두익,김건식,이재동,이윤호,최도영 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2004 東西醫學硏究所 論文集 Vol.2004 No.-

Objective : We had a clinical report in headache but didn't in migraine. We have planned this study in order to get the basic data of migraine in oriental medicine. Methods : The patient of 36 in migraine checked sec, age, onset, family history, severity of pain, influences of life, induced cause, clinical pain characteristics, associated symptom, treatment style, and paescription, frequency, using period of analgesics by a questionnaire and differentiated syndromes in migraine and evaluated autonomic bioelectric response recorder(ABR-2000). Results : There are 23.4% in prevalence rate of migraine. The ratio of sex is M: F=1:17. The age of an attack is the highest in thirties. The patient are the most in forties. The mean duration of illness is 12.0±9.9 years. 83.4% had a family history. 61.1% had a moderate grade in severity of pain. 77.8% selected fatigue in induced cause of migraine. 69.4% had tingling sense, nausea and vomiting in the associated symptoms. 91.7% used analgesics for treatment and 51.5% of them used analgesics voluntarily. 61.9% of them take analgesics less than once in a week. 33.6% had the phlegm syncope headache in differentiation of syndrome. In ABR-2000 results, item of graph showed low tendency mostly. Conclusions : We expected that this re port of clinical progress, differentiation of syndromes and ABR-2000 results in migraine would be used basic data by oriental medicine to treat migraine.