도료 제조공장 근로자의 유기 용제 노출에 관한 연구

강상완,조영민,오종민 경희대학교 환경연구소 1999 環境硏究 論文集 Vol.9 No.-

The exposure level to various organic solvents for 330 workers in 7 domestic paint factories was evaluated by using a gas chromatograph. As a result of the investigation, twenty-five types of organic solvent were detected in the working environment. The most common organic solvent was toluene(97.0%), and followed by m-Xylene(68.2%), MIBK(59.7%), p-Xylene(52.15%), MEK(48.8%) and o-Xylene(46.1%). The mean concentration was the highest in methanol(18.236 ppm) and methyl ethyl ketone(10.565 ppm), 1.1.1-trichloroethane(8.952 ppm) and ethyl acetate(8.179 ppm). The concentration of toluene was 6.540 ppm.

Analyzing the correlation of Spam Recall and Thesaurus

Kang,Sin-Jae,Kim,Jong-Wan 한국정보기술응용학회 2005 한국정보기술응용학회학술대회 Vol.2005 No.1

미세혈관문합때 염산 Ticlopidine의 항혈전 효과

강진성,전종완,한기환,정재홍,김선영 大韓成形外科學會 1987 Archives of Plastic Surgery Vol.14 No.1

Recent progress in microvascular surgery has opened new clinical possibilities in tissue transplantation and replantation by direct anastomoses of vessels less than one mm in external diameter. However, a large obstacle still remains in microsurgery, that is, occlusion of the anastomosis site by thrombosis which is mainly composed of platelets. Many anticoagulants and topical vasodilatic agents such as heparin, aspirin, persantin, coumarin and magnesium sulfate have been used to solve this problem. Heparin inhibits the conversion of prothrombin to thrombin and Factos Ⅴ,Ⅸ,--, Aspirin inhibits collagen-induced platelet aggregation whereas the primary action of persantin is to inhibit ADP-induced platelet aggregation and the release reaction of platelets. Currently, ticlopidine-HCI which is known to inhibit the platelet aggregation to ADP, collagen and epinephrine, is widely in use as an effective anticoagulant for the patients of atherosclerosis, hemodialysis, and subarachoid hemorrhage. Animal study was carried out for the ticlopidine-HCI to investigate the possibility of this agent to be used as a choice of anticoagulant in microvascular surgery. One hundred and twenty rats were divided into 3 groups. Group A was the control group. Aspirin and persantin were given orally in group B. Ticlopidine-HCI was given orally in group C. A femoral artery in one inguinal region and one femoral vein in the other side were severed and then were anastomosed with 10-0 nylon. The wounds were closed with 4-0 black silk. The patency was confirmed grossly and microscopically at 20 minutes, 3 days, and 3 weeks after anastomoses. The patency rates were as follows: 1. At 20 minutes after anstomoses, patency rates of arteries and veins were 100% in all groups. 2. At 3 days after anastomoses, in the control group the patency rates of arteries and veins were 95% and 85% respectively. Group B (aspirin-persantin)were 100% and 90% each. Compared with these, the patency rates of group C (ticlopidine) were better, all of the arteries and veins were patent. 3. At 3 weeks after anastomoses, the patency rates of arteries were 90% and veins were 80% in the control group. Arteries were 95% and veins were 90% in group B, whereas arteries were 100% and veins were 95% in group. C. Therefore, it is concluded that the ticlopidine can be used in microvasular surgery as an anticoagulant of choice.

제주지역의 akabane virus에 대한 역학조사 및 원인체 분리동정

강완철,김은주,현관종,전창익,김희석,이두식 濟州大學校 農科大學 動物科學硏究所 2000 動物科學論叢 Vol.15 No.1

미세혈관문합때 염산 ticlopidine의 항혈전 효과

전종완,강진성 啓明大學校 醫科大學 1998 계명의대학술지 Vol.7 No.1

Recent progress in microvascular surgery has opened new clinical possibilities in tissue transplantation and replantation by direct anastomoses of vessels less than one mm in external diameter. However, a large obstacle still remains in microsurgery, that is, occlusion of the anastomosis site by thormbosis which is mainly composed of platelets. Many anticoagulants and topical vasodilatic agents such as heparin, aspirin, persantin, coumarin, magnesium sulfate have been used to solve this problem. Heparin inhibits the conversion of prothrombin to thrombin and Factors V, IX, XI. Aspirin inhibits collagen-induced platelet aggregation wheras the primary action of persantin is to inhibit ADP-induced platelet aggregation and release reaction of platelets, Currently, ticlopidine-HCl which is known to inhibit the platelet aggregation to ADP, collagen and epinephrine, is widely in use as and effective anticoagulant for the patients of atherosclerosis, hemodialysis and subarachnoid hemorrhage. Animal study was carried out for the tichlopidine-HCl to investigate the possibility of this agent to be used as a choice of anticoagulant in microvascular surgery. One hundred and twenty rats were divided into 3 groups Group A was the control groups. Aspirn and persantin were given orally in group B. Ticlopidine-HCl was given orally in group C. A femoral artery in one inguinal region and one femoral vein in the other side were severed and then were anastomosed with 10-0 nylon. The wounds were closed with 4 ㅡ0 black silk. The patency was confirmed grossly and microscopically at 20 minutes, 3 days and 3 weeks after anastomoses. The patency rates were as follows: At 20 minutes after anastomoses, patency rates of arteries and veins were 100% in all groups. At 3 days after anastomoses, in the control group the patency rates of arteries and veins 95% and 85% respectively. Group B (aspirin-prersantin) were 100% and 90% each. Compared with these, the patency rates of group C (ticlopidine) were better, all of the arteries and veins were patent. At 3 weeks after anastomoses, the patency rates of arteries were 90% and veins were 80% in the control group. Arteries were 95% and veins were 90% in group B, whereas arteries were100% and veins were 95% in group C. Therefore, it is concluded that the ticlopidine can be used in microvasular surgery as and anticoagulant of choice.

칼라 영상의 분할을 위한 Mean Field Annealing EM 알고리즘

박종현,박순영,강성준,조완현 국립7개대학공동논문집간행위원회 2001 공업기술연구 Vol.1 No.-

In this paper we present a statistical model-based approach to the color image segmentation. A novel deterministic annealing EM and mean field theory are used to estimate the posterior probability of each pixel and the parameters of the Gaussian mixture model which represents the multi-colored objects statistically. Image segmentation is carried out by clustering each pixel into the most probable component Gaussian. The experimental results show that the mean field annealing EM provides a global optimal solution for the ML parameter estimation and the real images are segmented efficiently using the estimates computed by the maximum entropy principle and mean field theory.

RAW264.7 세포에서 interferon-r 및 LPS에 의해 유도되는 NO생성에 미치는 TALT-35의 영향

박종일,박경석,김종석,박지훈,윤은진,송경섭,서강식,김훈,윤완희,박승길,임규,황병두 충남대학교 생물공학연구소 2006 생물공학연구지 Vol.12 No.-

TALP-35 purified from human term placenta is known to increase microtubule polymerization and stabilize the polymerized microtubule. To examine the effect of TALP-35 on immune system this study was performed. MTT assay was performed to investigate the effect of TALP-35 on the proliferation of RAW264.7 cells. TALP-35 dose dependently suppress the proliferation of RAW264.7 cells at high concentration (above 1 μM) in unstimulated cells, in case of 10 μM TALP-35 treated cells the suppression was 25% but in stimulated cells it was only 15%. Cosedimentation assay was carried out to investigate whether TALP-35 can bind to tubulin of RAW264.7, monocyte/macrophage lineage of mouse, and polymerize it. TALP-35 polymerize the tubulin of RAW264.7 cells and sedimented in dose-dependent manner. To investigate the effect of TALP-35 on the expression of iNOS protein western blotting was performed. The expression level of iNOS was decreased dose dependently in high concentration of TALP-35 treatment. To examine the activity of iNOS, secreted NO was determined by method based on Griess reaction. Interferon-γ and LPS-stimulated production of NO from RAW264.7 cells was decreased dose dependently above 0.1 μM concentration of TALP-35 and 50% is decreased at 10μM of it. This study shows TALP-35 can control cytokine induced-iNOS expression therefore it might control inflammatory diseases.

관해유도 항암요법을 받는 백혈병 환자에서 진균 감염증의 예방 : 무작위 배정법과 이중 눈가림법에 의한 Fluconazole과 Nystain의 효과에 관한 다기관 공동연구 A Randomized, Double-blind, Multicenter Trial to Compare Fluconazole with Nystatin

최강원,오명돈,배현주,백경란,박선양,김병국,신완식,강문원,진종률,박종원,김춘추,김동집,한지숙,민유홍,이선주,고윤웅 대한화학요법학회 1993 대한화학요법학회지 Vol.11 No.2

Fluconazole의 진균 감염증 예방 효과와 안전성에 관하여 3개 대학병원에서 관해유도화학요법을 받는 급성 백혈병환자를 대상으로 무작위 배정법과 너도나도 누가림법에 의하여 연구하였다. 모두 62명의 환자에게 fluconazole(100㎎ bid) 또는 nystatin(1,000,000IU/day)을 무작위로 투여하였다. 투약은 관해유도화학요법과 같은 날짜에 시작하여 호중구수가 1,000㎣이상으로 회복되거나 진균 감염증이 확인되거나 의심되어 Amphotericin-B를 시작하거나, 약과 관련된 부작용이 나타날 때까지 계속하였다. 진균 colonization은 fluconazole군에서 감소하였으나 nystqatin군에서는 증가하였다, 표재성 진균감염증으로 nystatin군에서 C. albicans 진균혈증 1례와 C.parasilosis 진균혈중 1례가 발생하였다. 경험적 항진균요법으로 Amphotericin-B를 투여한 경우는 fluconazolerns 34명중 7례(21%), nystatinrns 28명중 10례(36%)였다(p<0.05). Fluconazole군과 nystatin군 사이에 부작용이나 사망률에 차이는 없었다. 결론적으로, fluconazole은 관해유도화학요법을 받는 급성 백혈병환자에서 진균의 colonization을 줄이는데 효과적이고 안전한 항진균제이다. We made a randomized, double-blind, multicenter trial to compare the efficacy and safety of fluconazole with nystatin for prevention of fungal infections in patients with acute leukemia. Sixty-two adult undergoing remission induction chemotherapy for cute leukemia were enrolled. Patients were randomly assigned to receive either fluconazole (100㎎ bid) or nystatin(1,000,000IU×6/day) with corresponding placebo. The study drug was started in initiation of chemotherapy and continued until recovery of neutrophil counts(>1,000/㎣), development of proven or suspected invasive fungal infection, or the occurrence of drug-related toxicity. Fungal colonization decreased in fluconazole(F) group, however increased in nystain(n) group. Superficial fungal infection occurred in 1 of 34 F group, whereas invasive fungal infection developed in 3 of 28 N group. Empirical amphotericin-B therapy was given in 7 of 34(21%) F group and 10 of 28(36%) N group(p>0.05). The incidence of drug-related side effects and overall moratlity were similar in both study groups.

동종 골수이식 후 만성 이식편대숙주반응 환자에서 발생한 폐렴구균에 의한 수막뇌염 1예

신완식,김병욱,유진홍,김동집,김춘추,박종원,이종욱,김동욱,강문원,김양리 대한감염학회 1993 감염 Vol.25 No.3

Graft-versus-host disease (GVHD) is a frequent complication after bone marrow transplantation. Infectious complications are common in GVHD patients due to defect in cell-mediated immunity. A rare case of S. pneumoniae meningoencephalitis occured in a patient with extensive form of chronic GVHD after allogeneic bone marrow transplantation. He was immediately treated with full dosage of ceftriaxone and ampicillin. He suffered from various complications such as sepsis, acute renal failure, atelectasis, and seizure. Despite of aggressive treatment, he died probably due to renal shutdown and massive subacute cerebral infarction of left cerebral hemisphere. This report showed two unusual and rare features. First, the infection site was CNS rather than respiratory system. Second, the causative organism was S. pneumoniae, which is rare cause of CNS infection in immunocompromised patients.

초등학교 어린이의 선수 활동을 통한 사회성 변화 연구

이완섭,배종진,강진구 춘천교육대학교 초등교육연구소 2003 敎育硏究 Vol.20 No.-