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교통동맥분절의 내측벽에서 기원한 내경동맥류 치험 2례 - 증례보고 -
이종원,석종식,권정택,민병국,Lee, Jong-Won,Suk, Jong-Sik,Kwon, Jung-Taek,Min, Byung-Kook 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.10
Aneurysms of the medial wall of the internal carotid artery(ICA) constitute a rare group of ICA aneurysms arising at locations other than at arterial division. Because these aneurysms usually have thin walls and wide necks associated with arteriosclerosis, neck clipping should be taken into special consideration. The authors report two cases of the aneurysm presented with subarachnoid hemorrhage, in which neck clippings ware performed with impunity.
본 히펠 린다우병에서 발생한 신장암의 뇌전이 - 증례보고 -
양승민,박상우,석종식,박종혁,권정택,민병국,Yang, Seung Min,Park, Sang Woo,Suk, Jong Sik,Park, Jong Hyuk,Kwon, Jeong Taik,Min, Byung Kook 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.8
Although brain metastasis of renal cell carcinoma is a major cause of death in Von Hippel-Lindau disease(VHL), it is not easy to distinguish local recurrence of hemangioblastoma from distant metastasis. In addition, hemangioblastoma has several characteristics suitable for recipient of "tumor-to-tumor metastasis". Authors report a case of Von Hippel-Lindau disease that had metastases of renal cell carcinomas.
이정훈 ( Jung Hoon Lee ),홍현종 ( Hyun Jong Hong ),권정택 ( Jeong Taik Kwon ),김영백 ( Young Baeg Kim ),석종식 ( Jong Sik Suk ) 대한뇌종양학회·대한신경종양학회·대한소아뇌종양학회 2007 대한뇌종양학회지 Vol.6 No.1
Meningiomas constitute about 15 to 18% of all intracranial tumors and are usally located in the subdural compartment. Intradural meningiomas may secondarily involve the overlying calvarial bone and provoke osteoblastic or, less commonly, an osteolytic reaction. Meningiomas developing outside the dura mater, without an intradural counterpart, are rare and have been reported in only 1 to 2% of all intracranial meningiomas. We present a rare case of coexisted subdural and extradural meningioma.
후방경유 요추 융합수술시 척추후관절낭 손상의 운동역학적 영향
박승원,김영백,황성남,최덕영,권정택,민병국,석종식,Park, Seung Won,Kim, Young Baeg,Hwang, Sung Nam,Choi, Duck Young,Kwon, Jeong Taik,Min, Byung Kook,Suk, Jong Sik 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.3
Objectives : Although posterior lumbar fusion operations had been reported to accelerate spinal degeneration, there have been only a few studies for their biomechanical effects. We have studied the change of motion range at the vertebral joint one level above the fusion(UVJ) in pedicle screw fixation group(PSF)(n=13) where facet capsule was destroyed and in posterior lumbar interbody fusion group(PLIF)(n=8) where it was spared. Patients and Methods : The patients were divided into early(3 to 6 months) and late(over 12 months) according to postoperative follow-up period. The flexion, extension and flexion-extension angles(FA, EA, FEA) were measured at the UVJ with pre-operative, early and late post-operative films. Results : Mean age and male to female ratio were $52.7{\pm}9.3$ and 1 : 3.2. Mean follow-up periods were $144.1{\pm}30.0$ and $528.8{\pm}160.3$ days in early and late groups, respectively. The FEA and FA in the late PSF($11.8{\pm}3.1$, $8.5{\pm}2.9$) were significantly greater than pre-operative angles($7.8{\pm}3.9$, $5.1{\pm}3.7$)(p<0.01, p<0.05). All angles in the PLIF showed no significant changes with time. The FEA and FA in the late PSF($11.8{\pm}3.1$, $8.5{\pm}2.9$) were significantly greater than those of the late PLIF($7.6{\pm}2.3$, $3.4{\pm}2.0$)(p<0.01, p<0.001). All angles at early follow-up period were similar between PSF and PLIF. The EA showed no significant change in relation with follow-up period or fusion method. Conclusion : As a result, the facet capsule injury in pedicle screw fixation seems to be related with increased flexion angle or degeneration of the adjacent joint above the fused vertebra in the late phase.
여상준,박승원,김영백,황성남,최덕영,석종식,정동규,민병국,Yeo, Sang-Jun,Park, Seung-Won,Kim, Young-Baeg,Hwang, Sung-Nam,Choi, Duck-Young,Suk, Jong-Sik,Chung, Dong-Kue,Min, Byung-Kook 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.11
Objectives : Transpedicular screw fixation has become an important method for internal fixation in variety of disorders. However, acceleration of degeneration at the adjacent segment in any follow. The goal of this study is to review the change of motion ranges of vertebral joints adjacent to fused level in lumbar spine. Methods : This study consists of 22 patients with degenerative spinal instability. Treatment of spinal instability includes posterior fusion with transpedicular screw fixation or transpedicular screw fixation with posterior lumbar interbody fusion. The flexion-extension angle(FEA) was measured from dynamic views of lumbar spine taken both at preoperative and post operative period. Results : The FEA of upper vertebral joint adjacent(FEA-u) to a fused L4-5 level was increased(p=0.010). The FEA-u was increased in case of L5-S1 fusion(p=0.025). The change of FEA-u in case of L5-S1 fusion was greater than that in L4-5 fusion(p=0.013). Conclusion : After L4-5 fusion, there seems to be more meaningful increase in FEA of L3-4 than that of L5-S1. The reason may be due to the damage of L3-4 facet joints during the operation, the other possible explanation may be the anatomical stability of L5-S1 vertebral joint. The change of FEA-u of L5-S1 fusion is increased more than that of L4-5 fusion. Because there are compensations in the adjacent vertebrae both above and below the fused L4-5, the compensatory motion in FEA-u of L5-S1 fusion was greater than that of the L4-5 fusion.
교모세포종 U-251MG, U-373MG세포주의 Cytokines처리에 의한 세포내 ICAM-1 발현
이종원,권정택,민병국,박승원,김영백,황성남,석종식,최덕영,Lee, Jong-Won,Kwon, Jung-Taek,Min, Byung-Kook,Park, Seung-Won,Kim, Young-Baeg,Hwang, Sung-Nam,Suk, Jong-Sik,Choi, Duck-Young 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.4
Objective : Despite advances in the understanding of tumor biology and the tumor immunology, there has been no effective treatment. The Intercellular adhesion molecule-1(ICAM-1) has been shown to be important in interaction involving cells of the immune system and to be upregulated in a number of cell culture systems by cytokines, including immune interferon($IFN-{\gamma}$) and tumor necrosis $factor-{\alpha}$($TNF-{\alpha}$). ICAM-1 has been identified as one of the ligands for lymphocyte function-associated antigen-1(LFA-1). The effectiveness of various cytokines to ICAM-1 induction on cultured human glioblastoma cell lines and potential efficacy of immunotherapy were studied. Method : Human glioblastoma cell lines, U-251 MG, U-373 MG were trypsinized and suspended at $1{\times}10^5cells/ml$ and grown on 8 well chamber slide, the cells were incubated in 0.3ml medium alone or medium containing $IFN-{\gamma}$(1000U/ml) or $TNF-{\alpha}$(250U/ml) or $IFN-{\gamma}$ plus $TNF-{\alpha}$ for 6, 12, 24, 48 and 72 hours. The coverslip were then removed and stained with a 1/30 dilution of anti-ICAM-1 antibody. Result : Surface antigen expression of ICAM-1 was increased by incubating glioblastoma cell lines with $IFN-{\gamma}$ and $TNF-{\alpha}$. Combined effect of $IFN-{\gamma}$ and $TNF-{\alpha}$ has induced more ICAM-1 expression on glioblastoma cell lines. Upregulation of ICAM-1 expression in an established glioblastoma cell line was of greater magnitude and more rapid following incubation with $IFN-{\gamma}$ plus $TNF-{\alpha}$. Surface antigen expression of ICAM-1 was increased for up to 48 hours after cytokine treatment on both cell lines(p<0.05). There was no difference on both cell lines(p>0.05). Conclusion : The results of the present study indicate that ICAM-1 expression in glioblastoma cell lines, U-251 MG and U-373 MG, are induced and enhanced after treatment with $IFN-{\gamma}$ and $TNF-{\alpha}$. Combined effect of $IFN-{\alpha}$ and $TNF-{\gamma}$ is stronger and more rapid than $IFN-{\gamma}$ or $TNF-{\alpha}$ alone.
지용철 ( Yong Cheol Ji ),권정택 ( Jeong Taik Kwon ),김영백 ( Young Baeg Kim ),석종식 ( Jong Sik Suk ) 대한뇌종양학회 2004 대한뇌종양학회지 Vol.3 No.1
Dumbell shaped schwannomas of hypoglossal nerve extending intra-and extracranially are very rare. The one case reports on a 54-year-old patient who presented with hoarseness and un a ware tongue atrophy. MRI showed inhomogeneous con-trast agent enhancement in a tumor in the cerebellomedullary cistern. The tumor extended midine and severely compressed brainstem. And it extended extracranially thorough the hypoglossal canal. The tumor was nearly total removed via suboc-cipital approach and the patient was discharged with improved hoarseness and no additional neurologic deficit.