개맥문동의 발아 생리에 관한 연구

이지니(Lee Jiny),이창희(Lee Chang Hee),김기선(Kim Ki Sun) 한국원예학회 1998 원예과학기술지 Vol.16 No.3

Changes of Phenolic Compounds and Abscisic Acid in Liriope spicata Seeds according to Cold Stratification and Seed Harvesting Date and Their Relationships to Germination

Chang Hee Lee,Jiny Lee,Ki Sun Kim 한국원예학회 2006 Horticulture, Environment, and Biotechnology Vol.47 No.1

This study was conducted to investigate the changes in total phenolic compounds and abscisic acid (ABA) according to cold stratification and seed harvesting date, and to examine the relationship between germination and the two probable inhibitors in Liriope spicata (creeping lily-turf) seeds. Germination percentage increased in a stratification duration-dependent manner and further stratification beyond 30 days did not show significant difference. Although total phenolic compounds and ABA contents of stratified seeds ranged from 30 to 60 days after cold stratification were slightly reduced, those of the seeds ranged from 0 to 30 days after cold stratification markedly decreased in a duration-dependent manner. Especially, total phenolic compounds and ABA within the seeds greatly decreased during the first 30 days of cold stratification. Depulped L. spicata seeds collected on October 12 did not germinate at all until 40 days after sowing, while those on following harvesting dates ranged from October 22 to December 21 showed various germination percentages ranged from 11.5 to 93.2%. Maximum germination percentage (93%) was obtained from seeds harvested from November 22 and December 1. The lowest content of phenolic compounds within seeds were found on November 22, following December 1, December 11, November 12, sequentially. The increase and decrease pattern of ABA during seed development was very similar to those of phenolic compounds within seeds. In conclusion, enhancing germination by depulping and cold stratification could be attributed to the removal of phenolic compounds and ABA within the pulps and the seeds of L. spicata. In addition, reduction of phenolic compounds contents and ABA within seeds during seed development seemed to be positively correlated with their germination percentage according to seed harvesting dates.

한국어교육에서의 양태 표현 연구 : '추측'과 '의지'를 중심으로

이윤진,노지니 국제한국어교육학회 2003 한국어 교육 Vol.14 No.1

This paper aims to study on Korean [Speculation] and [Intention] modal expressions, ‘-겠-, -(으)ㄹ 것이다, -것 같다, -모양이다, -(으)ㄹ게, -(으)ㄹ래, -(으)ㄹ 걸, -나 보다’, in order to construct the Korean pedagogical grammar. These expressions seem to be problematic for both Korean language learners and teachers because they have distinctive but slippery semantic differences. Therefore, it is difficult not only for learners to distinguish those expressions, but also for teachers to explain them in a clear way. After careful discussion of critical characteristics and differences of those expressions, this paper could obtain the meaningful results for teaching Korean [Speculation] and [Intention] modal expressions. The implications discussed in this paper can be summarized as follows. First, it is necessary to use interactive conversational situations for teaching modal expressions. Second, the characteristics and differences of those expressions should be presented by either definitions or example sentences. Third, [Politeness] is an important Korean language modal category closely related with [Speculation] and [Intention]. We need to mention the modal expressions realizing [Politeness] in the Korean language textbooks.

Evidence of potential interaction of chemokine genes in susceptibility to systemic sclerosis

Lee, Eun Bong,Zhao, Jinying,Kim, Jeong Yeon,Xiong, Momiao,Song, Yeong Wook Wiley Subscription Services, Inc., A Wiley Company 2007 Vol.56 No.7

<B>Objective</B><P>To examine genetic polymorphisms in the chemokine pathway, and to assess their interactions in relation to susceptibility to systemic sclerosis (SSc).</P><B>Methods</B><P>To identify the risk of SSc conferred by genetic polymorphisms in the chemokine pathway, 10 single-nucleotide polymorphisms (SNPs) from 8 candidate genes were studied in 99 patients with SSc and 198 age- and sex-matched controls in a Korean population. SNPs were genotyped by polymerase chain reaction–restriction fragment length polymorphism or sequence-specific primer methods. Genetic associations between each SNP and SSc risk, calculated as odds ratios with 95% confidence intervals, were estimated using chi-square tests. Haplotypes for the 2 polymorphisms in the gene CCL5 (RANTES) were constructed, and their associations with SSc were tested. Gene–gene interactions were investigated using a recently described novel method, and the results were confirmed by conditional logistic regression. Adjustment for multiple testing was based on Bonferroni correction.</P><B>Results</B><P>There was significant evidence of gene–gene interaction between polymorphisms in the genes CXCL8 (interleukin-8) and CCL5, and both of these were associated with an increased risk of SSc. This SNP–SNP interaction was confirmed by 2 independent statistical methods. The associations remained significant after Bonferroni adjustment for multiple testing. No significant association between each individual SNP or haplotype and the risk of SSc was found.</P><B>Conclusion</B><P>Crosstalk between the 2 chemokines CXCL8 and CCL5 may contribute to the susceptibility to SSc.</P>

miR-4463 regulates aromatase expression and activity for 17β-estradiol synthesis in response to follicle-stimulating hormone

Lee, Su-Yeon,Kang, Youn-Jung,Kwon, Jinie,Nishi, Yoshihiro,Yanase, Toshihiko,Lee, Kyung-Ah,Koong, Mi Kyoung The Korean Society for Reproductive Medicine 2020 Clinical and Experimental Reproductive Medicine Vol.47 No.3

Objective: The aim of this study was to investigate microRNAs (miRNAs) related to follicle-stimulating hormone (FSH) responsiveness using miRNA microarrays and to identify their target genes to determine the molecular regulatory pathways involved in FSH signaling in KGN cells. Methods: To change the cellular responsiveness to FSH, KGN cells were treated with FSH receptor (FSHR)-specific small interfering RNA (siRNA) followed by FSH. miRNA expression profiles were determined through miRNA microarray analysis. Potential target genes of selected miRNAs were predicted using bioinformatics tools, and their regulatory function was confirmed in KGN cells. Results: We found that six miRNAs (miR-1261, miR-130a-3p, miR-329-3p, miR-185-5p, miR-144-5p and miR-4463) were differentially expressed after FSHR siRNA treatment in KGN cells. Through a bioinformatics analysis, we showed that these miRNAs were predicted to regulate a large number of genes, which we narrowed down to cytochrome P450 family 19 subfamily A member 1 (CYP19A1) and estrogen receptor alpha (ESR1) as the main targets for miR-4463. Functional analysis revealed that miR-4463 is a regulatory factor for aromatase expression and function in KGN cells. Conclusion: In this study, we identified differentially expressed miRNAs related to FSH responsiveness. In particular, upregulation of miR-4463 expression by FSHR deficiency in human granulosa cells impaired 17β-estradiol synthesis by targeting CYP19A1 and ESR1. Therefore, our data might provide novel candidates for molecular biomarkers for use in research into poor responders.

Antenatal Corticosteroids and Clinical Outcomes of Preterm Singleton Neonates with Intrauterine Growth Restriction

Yoo Jinie Kim,Sung Hwan Choi,Sohee Oh,Jin A Sohn,Younghwa Jung,Seung Han Shin,Chang Won Choi,Ee Kyung Kim,Han Suk Kim,김병일,Jin A Lee 대한신생아학회 2018 Neonatal medicine Vol.25 No.4

Purpose: We assessed the influence of antenatal corticosteroid (ACS) on the inhospital outcomes of intrauterine growth restriction (IUGR) infants. Methods: A retrospective study was conducted with singletons born at 23+0 to 33+6 weeks of gestation at Seoul National University Hospital from 2007 to 2014. We compared clinical outcomes between infants who received ACS 2 to 7 days before birth (complete ACS), at <2 or >7 days (incomplete ACS), and those who did not receive ACS in IUGR and AGA infants. Multivariate logistic regression using Firth’s penalized likelihood was performed. Results: 304 neonates with 91 IUGR neonates were eligible. Among AGA neonates, mortality (adjusted odds ratio [aOR], 0.13; 95% confidence interval [CI], 0.02 to 0.78), hypotension within 7 postnatal days (aOR, 0.20; 95% CI, 0.06 to 0.64), and severe bronchopulmonary dysplasia (BPD) or death (aOR, 0.24; 95% CI, 0.07 to 0.77) were lower in complete ACS group after adjusting for pregnancy induced hypertension and uncontrolled preterm labor. Mortality (aOR, 0.18; 95% CI, 0.04 to 0.78), hypotension (aOR, 0.26; 95% CI, 0.09 to 0.70), and severe BPD or death (aOR, 0.33; 95% CI, 0.12 to 0.92) were also lower in the incomplete ACS group. Among IUGR infants, after adjusting for birth weight and 5-minute Apgar score, inhaled nitric oxide use within 14 postnatal days was lower in both complete ACS (aOR, 0.07; 95% CI, 0.01 to 0.67) and incomplete ACS (aOR, 0.04; 95% CI, 0.01 to 0.37) groups. Conclusion: ACS was not effective in reducing morbidities in IUGR preterm infants.

복합한약제제의 수면에 대한 연구

방금엽(Jinye Pang),이미경(Mi Kyung Lee),서승용(Seung Young Seo),전훈(Hoon Jeon),김대근(Dae Keun Kim),오기완(Ki Wan Oh),조형권(Hyoung Kwon Cho),은재순(Jae Soon Eun) 한의병리학회 2011 동의생리병리학회지 Vol.25 No.6

한국어 시각 단어재인과정에서 음운정보와 표기정보의 역할

태진이(Jini Tae),이창환(ChangHwan Lee),이윤형(Yoonhyoung Lee) 한국인지과학회 2015 인지과학 Vol.26 No.1

웹기반 실험을 통해 살펴본 연령에 따른 긍정정서 편향과 자기연령 효과의 차이

태진이(Jini Tae),최원일(Wonil Choi),이윤형(Yoonhyoung Lee) 한국자료분석학회 2023 Journal of the Korean Data Analysis Society Vol.25 No.3

얼굴 표정으로 전달되는 정서 정보는 사람들의 주의를 끄는데 특히 부정정서는 주의를 강하게 끈다. 하지만 노화에 진행됨에 따라 사람들은 부정 정서보다는 긍정 정서에 빠르게 주의를 기울이게 된다. 본 연구는 서구권의 이러한 연구 결과가 한국인들에게서도 나타나는지를 살펴보기 위하여 20세부터 69세까지의 지역사회 성인들을 대상으로 웹기반 탐침 탐사과제를 실시하고, 이를 통해 연령에 따른 자동적 정서 편향 효과를 차이를 비교하였다. 또한, 본 연구에서는 두 개의 연령 집단(젊은 배우 혹은 나이 든 배우)의 사진을 이용하여 참가자의 연령과 유사한 연령으로 보이는 자극에 주의를 기울이는 자기 연령 효과가 나타나는지를 확인하고자 하였다. 연구 결과, 모든 연령대의 참가자들은 부정 정서보다는 긍정 정서에 주의를 더 기울이는 특성을 보였고, 30대 참가자들의 경우에는 자신과 비슷한 나이대로 보이는 긍정 및 부정 얼굴 표정에 더 주의를 기울였다. 이러한 결과는 한국인의 경우 연령에 관계없이 긍정적인 얼굴 표정에 주의를 기울이며 주의 편향이 자극의 특성에 따라 달라진다는 것을 보여준다. Emotional information conveyed through facial expressions captures people's attention. While negative emotions closely related to general human survival tend to attract attention, as aging progresses, people tend to shift their attention more quickly to positive emotions than negative ones. This study utilized the dot-probe task to examine whether positive emotion bias varies with age among adults aged 20 to 69. Additionally, this study aimed to investigate whether the own-age effect occurs using photos of two age groups (i.e., a young actor and an elderly actor). The results of the study showed that participants of all age groups tended to focus more on positive emotions. The results also showed the own-age effect such that 30’s age group payed more attention to positive and negative facial expressions of the young actors. These results suggest that positive emotions are recognized as important social information for all age groups, and attention bias differs according to the nature of the stimuli.

Isolation and Characteristics of a GDP-mannose-3’, 5’-epimerase Gene From Panax ginseng C. A. Meyer

Piao Jinying,Jung-Hye Lee,Yu-Jin Kim,Deok-Chun Yang 고려인삼학회 2008 고려인삼학회 학술대회 Vol.2008 No.12