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- 저자 : Jinsook Kim (검색결과 160 건)
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Kim, Suhyeon,Kim, Songhee H.,Ahn, Jinsook,Jo, Inseong,Lee, Zee-Won,Choi, Sang Ho,Ha, Nam-Chul Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.12
The Gram-negative opportunistic pathogen, Pseudomonas aeruginosa, has multiple multidrug efflux pumps. MexT, a LysR-type transcriptional regulator, functions as a transcriptional activator of the MexEF-OprN efflux system. MexT consists of an N-terminal DNA-binding domain and a C-terminal regulatory domain (RD). Little is known regarding MexT ligands and its mechanism of activation. We elucidated the crystal structure of the MexT RD at 2.0 Å resolution. The structure comprised two protomer chains in a dimeric arrangement. MexT possessed an arginine-rich region and a hydrophobic patch lined by a variable loop, both of which are putative ligand-binding sites. The three-dimensional structure of MexT provided clues to the interacting ligand structure. A DNase I footprinting assay of full-length MexT identified two MexT-binding sequence in the mexEF-oprN promoter. Our findings enhance the understanding of the regulation of MexT-dependent activation of efflux pumps.
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Crystal structure of GSK3β in complex with the flavonoid, morin
Kim, Kuglae,Cha, Jeong Seok,Kim, Jin-Sik,Ahn, Jinsook,Ha, Nam-Chul,Cho, Hyun-Soo Elsevier 2018 Biochemical and biophysical research communication Vol.504 No.2
<P><B>Abstract</B></P> <P>GSK3β is a key kinase that plays a role in cellular signaling pathways. In Alzheimer's disease (AD), GSK3β has been implicated in hyperphosphorylation of tau proteins in the neuron, which is a hallmark of AD. Morin, a flavonoid that is abundant in nature, was found as an inhibitor of GSK3β that can reduce tau pathology <I>in vivo</I> and <I>in vitro</I>. In this study, we determined the crystal structure of GSK3β in complex with morin. The structure revealed that morin inhibits GSK3β by binding to the ATP binding pocket. Our findings augment the potential of morin as a functional food to help prevent AD, as well as to provide structural information to develop new therapeutics based on the morin skeleton.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Jinsook Kim,Kieun Lee,Eunsung Lee 한국청각언어재활학회 2020 Audiology and Speech Research Vol.16 No.4
Purpose: This study was to determine the effects of response tasks, such as button pressing and mental counting, and handedness on N100, N200, and P300 auditory event-related potential (AERP). Methods: A total of 50 normal-hearing young adults with the average age of 21.6 (±1.5) years participated in this study. Among them, 15 men and 15 women were right-handed and 10 men and 10 women were left-handed. An oddball paradigm was used to deliver 30 stimuli of 2 kHz target tone bursts and 120 stimuli of 1 kHz nontarget tone bursts. The stimuli were presented at 70 dB sound pressure level with the rate of 1/s. Results: The button pressing task elicited significantly smaller N100 and larger P300 amplitudes than the mental counting task. N200 latency was significantly lower and P300 amplitude was higher in left-handed participants than those who are right-handed. Appearance percentages of right-/left-handed participants for N100, N200, and P300 were 80/95%, 85/85%, and 75/75% for the button pressing task and 80/90%, 80/80%, and 70/70% for mental counting task, respectively. Conclusion: The significant difference in appearance percentage between response tasks supported that P300 was a strong endogenous potential. N100 and N200 were thought to have both endogenous and exogenous characteristics. A more sensitive approach in selecting the task of response for the target stimuli and careful consideration for the handedness is necessary for AERP recordings.
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Jinsook Kim 한국응용언어학회 2019 응용 언어학 Vol.35 No.4
The present study aims to investigate whether Korean EFL high school students engage in phonological coding when learning English vocabulary and whether phonological accessibility affects their vocabulary learning. Ninety-nine EFL Korean high school students participated in an experiment based on a 2x2 factorial design. The independent variables were learning condition (control versus articulatory suppression) and stimulus word type (phonologically regular versus irregular) and the dependent variable was short-term recall task scores. The findings showed a statistically significant main effect of learning condition and word type on the recall scores, and an interaction effect of the two independent variables on the recall scores. These results suggest that Korean EFL high school students do in fact engage in phonological coding when learning English vocabulary, that phonological accessibility is positively related to English vocabulary learning, and that interference with phonological coding is a more significant factor when learning phonologically irregular as opposed to regular words.
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Kim, Jinsook,Song, Insil,Jo, Ara,Shin, Joo-Ho,Cho, Hana,Eoff, Robert L.,Guengerich, F. Peter,Choi, Jeong-Yun American Chemical Society 2014 Chemical research in toxicology Vol.27 No.10
<P/><P>DNA polymerase (pol) ι is the most error-prone among the Y-family polymerases that participate in translesion synthesis (TLS). Pol ι can bypass various DNA lesions, e.g., <I>N</I><SUP>2</SUP>-ethyl(Et)G, <I>O</I><SUP>6</SUP>-methyl(Me)G, 8-oxo-7,8-dihydroguanine (8-oxoG), and an abasic site, though frequently with low fidelity. We assessed the biochemical effects of six reported genetic variations of human pol ι on its TLS properties, using the recombinant pol ι (residues 1–445) proteins and DNA templates containing a G, <I>N</I><SUP>2</SUP>-EtG, <I>O</I><SUP>6</SUP>-MeG, 8-oxoG, or abasic site. The Δ1–25 variant, which is the <I>N</I>-terminal truncation of 25 residues resulting from an initiation codon variant (c.3G > A) and also is the formerly misassigned wild-type, exhibited considerably higher polymerase activity than wild-type with Mg<SUP>2+</SUP> (but not with Mn<SUP>2+</SUP>), coinciding with its steady-state kinetic data showing a ∼10-fold increase in <I>k</I><SUB>cat</SUB>/<I>K</I><SUB>m</SUB> for nucleotide incorporation opposite templates (only with Mg<SUP>2+</SUP>). The R96G variant, which lacks a R96 residue known to interact with the incoming nucleotide, lost much of its polymerase activity, consistent with the kinetic data displaying 5- to 72-fold decreases in <I>k</I><SUB>cat</SUB>/<I>K</I><SUB>m</SUB> for nucleotide incorporation opposite templates either with Mg<SUP>2+</SUP> or Mn<SUP>2+</SUP>, except for that opposite <I>N</I><SUP>2</SUP>-EtG with Mn<SUP>2+</SUP> (showing a 9-fold increase for dCTP incorporation). The Δ1–25 variant bound DNA 20- to 29-fold more tightly than wild-type (with Mg<SUP>2+</SUP>), but the R96G variant bound DNA 2-fold less tightly than wild-type. The DNA-binding affinity of wild-type, but not of the Δ1–25 variant, was ∼7-fold stronger with 0.15 mM Mn<SUP>2+</SUP> than with Mg<SUP>2+</SUP>. The results indicate that the R96G variation severely impairs most of the Mg<SUP>2+</SUP>- and Mn<SUP>2+</SUP>-dependent TLS abilities of pol ι, whereas the Δ1–25 variation selectively and substantially enhances the Mg<SUP>2+</SUP>-dependent TLS capability of pol ι, emphasizing the potential translational importance of these pol ι genetic variations, e.g., individual differences in TLS, mutation, and cancer susceptibility to genotoxic carcinogens.</P>
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Verbal Routines in a Blind Korean Child’s Language Acquisition
Jinsook Kim 한국언어학회 2013 언어 Vol.38 No.3
This study investigates the strategies that a blind child uses to learn language in the absence of visual input. For the last several decades, numerous studies on blind children’s language learning have reported that many blind children use formulaic expressions and verbal routines in their speech; these expressions are composed of several unanalyzed chunks and are used as whole utterances. In this study, the data were collected from one visually impaired Korean child between 24 and 30 months. The child was audio- and video-recorded, and all data were transcribed. The Korean blind child used many verbal routines and formulaic expressions. The results support the ‘use first, analyze later’ strategy (Peters, 1987) in that the child used verbal routines creatively in different conversational contexts and became aware of meaning and the usage of formulaic expressions. This study shows that blind children can be actively involved in their own language learning and that through verbal routines, they learn not only linguistic structures but also social interactions.
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Korean L2 Learners Comprehension of VP-Ellipsis and One-Substitution in English
Kim, Jinsook 언어과학회 2015 언어과학연구 Vol.0 No.75
This study investigates the properties of VP-ellipsis(e.g., Anne made a cake. Lisa did too.) and one-substitution (e.g., Anne made a cake. Lisa made one too.) through the comprehension of these constructions by two groups of speakers: Korean-speaking L2 learners of English and native English speakers. According to Hankamer and Sag`s(1976) categorization, VP-ellipsis, as surface anaphora, is syntactically controlled, and one-substitution, as deep anaphora, is pragmatically controlled. Based on their dichotomous categorization, this study explores the characteristics of two types of anaphoric expression through empirical data gathered from the two participant group. The results reveal that comprehenders from both groups interpreted VP-ellipsis by reconstructing the verb phrase in the antecedent clause at the elided site with the help of syntactic parallelism. With regard to one-substitution, while most participants from both groups considered the anaphoric pronoun one as a higher N` In the antecedent clause, some Korean L2 learners understood one as referring to a lower N`. Although some Korean participants showed different interpretations of one-substitution, most of them comprehended VP-ellipsis and one –substitution as native English speakers did. The findings of this study contribute to bridging the gap between theory and practice through exploring comprehenders` interpretation of anaphoric expressions.
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