Conceptual Study for Tissue-Regenerative Biodegradable Magnesium Implant Integrated with Nitric Oxide-Releasing Nanofi bers

Jin‑Kyung Jeon,Hyunseon Seo,Jimin Park,Soo Ji Son,Yeong Rim Kim,Eun Shil Kim,Jong Woong Park,Woong‑Gyo Jung,Hojeong Jeon,Yu‑Chan Kim,Hyun‑Kwang Seok,Jae Ho Shin,Myoung‑Ryul Ok 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.4

The excessive initial corrosion rate of Mg is a critical limitation in the clinical application of biodegradable Mg implantsbecause the device loses its fi xation strength before the fractured bone heals. This study suggests a new approach to overcomethis hurdle by accelerating tissue regeneration instead of delaying the implant biodegradation. As angiogenesis is anessential process in early bone regeneration, a Mg implant coated with electrospun nanofi bers containing nitric oxide (NO),which physiologically promotes angiogenesis, is designed. The integrated device enables adjustable amounts of NO to bestored on the NO donor-conjugated nanofi ber coating, stably delivered, and released to the fractured bone tissue near theimplanted sites. An in vitro corrosion test reveals no adverse eff ect of the released NO on the corrosion behavior of the Mgimplant. Simultaneously, the optimal concentration level of NO released from the implant signifi cantly enhances tube networkformation of human umbilical vein endothelial cells without any cytotoxicity problem. This indicates that angiogenesis canbe accelerated by combining NO-releasing nanofi bers with a Mg implant. With its proven feasibility, the proposed approachcould be a novel solution for the initial stability problem of biodegradable Mg implants, leading to successful bone fi xation.

Differential Manifestation of Ocular Phenotypes in TALEN-mediated p19arf Knockout FVB/N and C57BL/6J mouse lines

Jin‑Sung Park,Joo‑Il Kim,Hyun‑Jin Lim,Soo‑Kyung Ryu,Euna Kwon,Kang‑Min Han,Ki‑Taek Nam,Han‑Woong Lee,Byeong‑Cheol Kang 한국유전학회 2020 Genes & Genomics Vol.42 No.9

Background p19arf, primarily known as a tumor suppressor, has also been reported to play an essential role in normal development of mouse eyes. Consistently, lack of p19arf has been associated with ocular defects, but the mixed background of the knockout (KO) mouse strain used raised a concern on the accuracy of the phenotypes observed in association with the targeted gene due to genetic heterogeneity. Object We carried out a study to investigate into the efect of genetic background on the manifestation of p19arf KO associated phenotypes. Methods We characterized the phenotypes of novel p19arf KO mouse lines generated in FVB/N and C57BL/6J using a transcription activator-like efector nuclease (TALEN) system in comparison to the reported phenotypes of three other p19arf-defcient mouse lines generated using homologous recombination. Results Ninety-fve percent of FVB/N-p19arf KO mice showed ocular opacity from week 4 after birth which worsened rapidly until week 6, while such abnormality was absent in C57BL/6J-p19arf KO mice up to the age of 26 weeks. Histopathological analysis revealed retrolental masses and dysplasia in the retinal layer in FVB/N-p19arf KO mice from week 4. Besides these, both strains developed normally from birth to week 26 without increased tumorigenesis except for a subcutaneous tumor found in a C57BL/6J-p19arf KO mouse. Conclusion Our fndings demonstrated surprisingly variable manifestation of p19arf-linked phenotypes between FVB/N and C57BL/6J mice, and furthermore between our mouse lines and the established lines, indicating a critical impact of genetic background on functional study of genes using gene targeting strategies in mice.

2차병원에서의 소아과 환자의 응급실 및 외래 이용에 관한 연구

김진희,배진호,전진호,문정웅 인제대학교 2006 仁濟醫學 Vol.27 No.-

Objectives : To analyze the characteristics of the pediatric patients who visited the emergency room and outpatient department of secondary hospital in order to properly guide pediatric patients to use emergency room and raise the efficiency Methods : The authors investigated and analyzed sex, age, visit day, visit time, length of stay, hospitalization and diagnostic entities of the pediatric patients who visited the emergency room and outpatient department of Wallace Memorial Baptist Hospital from January 2003 to December 2005 in a retroactive approach with their medical records. Results : For the three years, the number of total patients who visited the emergency room was 56,051 and among them, the number of pediatric patients was 7,490 (13.4%). The age group of 1 to 2 years was the largest with 2,488 (33.2%). The male to female ratio was 1.34:1. Sunday was the day of the week that the largest number of patienst visited with 2,375 (31.7%) and nearly half (48.4%) of the patients visited the emergency room during the weekend. The time when the most patient visited the emergency room was between 8 pm to 12 am. Regarding the length of stay, the highest number of patients (65.0%) stayed in the emergency room for on hour or less, and the average length of visit was 1.5 hours, which was rather short. Most patients (68.8%) left the hospital after taking simple physical examination and procedure(prescription). The most frequent diagnoses for the pediatric patients who visited the emergency room were acute pharyngitis (26.0%), acute gastroenteritis (20.7%), fever (6.6%). During the same period, the total number of pediatric patients who visited the outpatient department was 125,513. The age group of 3 to 5 was the largest with 36,041 (28.7%). The male to female ratio was 1.34:1. 6.0% of total outpatients required treatment in a hospital. Most frequent diagnoses of the outpatients were asthma (24.4%), pneumonia (12.0%), vaccination (8.7%), febrile convulsion (8.4%), acute pharyngitis (6.6%), acute gastroenteritis (5.8%). Conclusion : It is considered that a large number of pediatric patients still have used emergency room for treatment of simple and mild diseases instead of visiting outpatient department and/or primary hospital. Thus further efforts are required to properly guide pediatric patients to use emergency room and to raise the efficiency of their use.

사람, 집박쥐 및 마우스 파네트세포의 Lysozyme 면역반응성

정진웅,차정호,오수자,전정수 대한해부학회 1991 Anatomy & Cell Biology Vol.24 No.2

레이저 照射後 臼齒用 복합레진의 結合力에 關한 硏究

최웅진 全北大學校 齒醫學硏究所 1991 전북치대논문집 Vol.9 No.1

The purpose of this sutdy was investigating the bond strength between composite resin and enamel surface of the tooth. The enamels of sound primary molars and permanent premolars were used for experiment. They were extracted for orthodontic therapy or at physiologic exfoliation. They were classified into 10 groups at random ; 1 control group, 4 experimental groups were contained in self-curing resin and light-curing resin each. Laser impacts on each experimental groups were made at energy density of Q-switched Nd : YAG laser with 3.6J/m^2 and 10.8J/cm^2, Giant pulsed Nd : YAG laser 40J/cm^2 and Normal pulsed Nd : YAG laser with 40J/cm^2. Then the decalcified patterns of enamel by 36% phosphoric acid were investigated with scanning electron microscope add adhesive shear strength was measured on the each decalcified enamel surface after adhesion of light-curing and self-curing resin. All the decalcified enamel surfaces were classified into 3 groups and the hardness change after laser irradiation was examined. The obtained results were as follows. 1. There were not significant difference statistically between the light-curing resin groups in adhesive shear strength of primary molar(P>0.05), but significant increase in bonding force of self-curing resin groups as significant level α=0.05 in Q-switched Nd : YAG laser with 3.6J/cm^2, significant level α=0.01 in Normal pulsed Nd : YAG laser with 40J/cm^2. 2. There were not significant difference statistically between the light-curing resin groups in adhesive shear strength of permanent premolar, but significant increase in bonding force of self-curing resin groups as significant level α=0.05 in Q-switched Nd : YAG laser with 10.8J/cm^2 and Normal pulsed Nd : YAG laser with 40J/cm^2. 3. There were significant increase in bonding force of self-curing resin groups(α=0.01) in contrast to light curing resin groups when adhesive shear strength was examined with primary molar and permanent premolar. 4. In the hardness change after laser irradiation. primary molar was decreased significantly only in irradiation of Normal pulsed Nd : YAG laser as significant level α=0.01(P<0.01). In case of permanent premolar, significant decrease was seen statistically as significant level α=0.05 in Giant pulsed Nd : YAG laser irradiation and significant level α=0.01 in normal pulsed Nd : YAG laser irradiation(P<0.01).

백학산(경북 상주)의 식물상

이웅빈,임수진 Yong-In University 2005 自然科學硏究所論文誌 Vol.10 No.1

The flora of Mt. Baekhaksan(615m) was surveyed in this study from the middle of May till the middle of October, 1999. The vascular plants collected from this mountain are as following: Totally 178 taxa those are 4 forms, 28 varieties, 146 species, 106 genera, 60 families, 28 orders, and 4 phyla.. There are 1 taxa in this mountain known distributed only in northern parts, and no taxa known distributed only in southern parts. And there are 7 taxa of special protected plants which was designated from Ministry Environment of Korea, those are 2 taxa of 4th grade, 1 taxon of 3rd grade, 4 taxa of 1st grade. There are 2 taxa needed more ecological study with detail that are Larix gmelini var. prinsipisruprechtii Pilger and Sorbus amurensis Koehne.

독해에서 Linguistic Connectives의 역할에 대한 연구

윤웅진 부산대학교 사범대학 1992 교사교육연구 Vol.24 No.-

The aim of this paper is to survey the role and importance of linguistic connectives in reading comprehension. They may be defined as a syntactic structure siganlling underlying logico-semantic relations. The ability of a reader to detect the underlying organization of discourse is important for the comprehension and memory of what is read. In this sense, linguistic connectives might facilitate comprehension and memory for discourse by making logical, semantic relationships more explicit.

유리협점막이식술의 임상적 연구

김웅비,김 호,박형국,권혁진,김용각 大韓顎顔面成形再建外科學會 1995 Maxillofacial Plastic Reconstructive Surgery Vol.17 No.3

Free grafting of oral mucosa for minor oral reconstruction was first described by Propper in ridge extension surgery. Situation calling for mucosal grafting procedures may relate to periodontal surgery, minor and major preprosthetic surgery, implant surgery, reconstruction in deformity cases after trauma, congenital cleft, gross atrophy and ablative tumor surgery. In the cases of 9 patients with mucosal defect of intraoral or orbital cavity after wide excision of tumor, preprosthetic surgery, and orbitoplasty, full-thickness mucosal graft were used to close a large defect. Four patients received buccal mucosal graft for preprosthetic surgery or orbitoplasty, one patient had benign tumor and the others had malignant tumors located on the palate or upper alveolus. Buccal mucosal graft donor site morbidity and trismus were minimal and healing of surgical defect was satisfactory. So we present the case with review of literatures.

저점도 실리콘유의 유전특성에 관한 연구

홍진웅 光云大學校 1995 論文集 Vol.24 No.-

Silicone oils used insulating substances exhibits both the organic and inorganic properties, and it has many superior characteristics, such as the high thermal resistance and low thermal oxidation level when compared to other dielectric liquids. In order to investigate the dielectric characteristics, silicone oils of viscosity 1, 2, 5[cSt] had been chosen as the specimen and experiment has been performed in the temperature range of -70[℃] - 65[℃] and frequency range of 30 - 1 ×10? [Hz]. As a result, the linear decrease of loss at low frequency region in high temperature was due to the influence of applying frequency, whereas the increase of loss sat high frequency region was contributed by electrode's resistance. And increasing visosity, the activation energy increased from 3.77[㎉/mole] to 7.21[㎉/mole]. The dipole moment of specimen was become clear 1.48 - 2.26[debye] at high temperature region and 1.054 - 1.80 [debye] at low temperature region respectively.

EFL 독자의 대명사 해석책략

윤웅진 부산대학교 언어연구교육원 1997 언어연구 Vol.15 No.1

This paper examined 1) the relationship between EFL reader's overall comprehension and their comprehension of coreferential pronouns. 2) effects of pronoun identification processes on overall comprehension. and 3) their various strategies for different structures of coreferential ties. Subjects were 74 high-level EFL students from a girls' high school in Pusan. Overall comprehension was measured by a immediate recall protocols, and coreferent comprehension was measured by coreferent-identification task corelationship was found between overall comprehension and the comprehension of coreferential pronouns. Surprisingly. no effects of pronoun identification processes on overall comprehension were evidenced. Finally, subjects were found to use various strategies for different structures of coreferential ties. Results suggest that the EFL reader should use various strategies to identify the referent of pronoun used in different context.