주의력결핍 과잉행동장애 아동의 지적수준에 따른 정신병리와 실행기능의 차이

천은진,서완석,이종범,김진성,구본훈,송창진,성형모,배준용,배대석 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.4

To investigate psychopathoIogy and executive functions of attention deficit hyperactivity disorder (ADHD) children according to intelligence level, this study included 197 ADHD children who visited the outpatient department of neuropsychiatry of YeungNam University Medical Center, from July 2000 to June 2002. The children were divided into groups based on their intelligence levels. They were compared by the Personality Inventory for Children (PIC), Conncers' Continuous Performence Test (CPT), and Wisconsin Card Sorting Test (WCST). There were significant differences in PIC, on the subscales of verbal development, socialization and autism. In the CPT, there was no significant difference. In the WCST, there were significant differences in the total number of errors, the number of perseverative errors, the number of completed categories and the number of trials needed to complete the first category. Considering these results, the intelligence level of ADHD children is related to their disabilities and behavioral symptoms.Executive functions such as abstract thinking, categorization, working memory and flexibility had significant relationship to the intelligence levels of ADHD children. Therefore, the intelligence level of children with ADHD influences the higher executive functions of regulating attention and information processing rather than attentional functions and capacity alone.

쇼핑센터의 전력부문 온실가스 저감에 관한 연구

정진도(Jin-Do Chung),김장우(Jang Woo Kim),임헌천(Heon Cheon Lim),임수영(Soo Young Lim) 한국열환경공학회 2009 한국열환경공학회 학술대회지 Vol.2009 No.추계

안정화제를 사용한 회수수의 고형분량 및 방치시간에 따른 시멘트 모르터의 특성

金光華,김기정,이문환,이세현,한천구 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)

This study is intended to investigate the fundamental properties of cement mortar with solid content and leaving time of recycled water that stabilizing agent is added. According to the results, fluidity and air content does not make a big difference with variation of solid content. As the leaving time of recycled water is long, fluidity and air content increases. Setting time is shortened due to fine particle with an increase of solid content and leaving time. Compressive strength and flexural strength increase with an increase of solid content, and they increase at the leaving time of 1 day, but decrease after 2days. Length change by drying shrinkage is smaller than that of plain concrete, and is almost same with variation of solid content. And it is reduced at the leaving time of 1 day, but increases after that. Therefore, it analyzed that the effect of stabilizing agent is best under condition of adding ratio of 0.15%, solid content of 3% and leaving time of 1day, and it also works upto solid content of 5% and leaving time of 2days.

한국인 알코올 의존 자녀들과 도파민 D2, D4 수용체, GABAΑ 수용체 β Subunit 및 세로토닌 운반체 유전자 다형성 사이의 연관성에 대한 예비적 연구

천근아,김재원,전진용,이준영,남궁기 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.1

Objectives : The studies on the genetic risk factors of the children of alcoholics (COAs) are still in an early stage. The A 1 allele of the dopamine receptor 2 gene (DRD2) may be associated with the negative affect and positive alcohol expectancy of the COAs. In addition, several researchers reported that COAs might be associated with the GABA_(A) receptor β subunit gene (GABRB3) and serotonin transporter gene (5-HTTLPR). In this study, we investigated the association of polymorphism of the DRD2, Dopamine D4 receptor gene (DRD4), GABRB3, 5-HTTLPR with COAs to examine the genetic risk factors of COAs. Methods : Twenty-two COAs and 23 control children (children of non-Alcoholics ; Non-COAs) were included for the genetic study. All COAs aged 6 to 18 were recruited and selected from families of alcoholic patients in alcohol clinics of three university and mental hospital. Alcoholism of parents was classified as type I (non-antisocial, late onset) and type II (antisocial, early onset) by Cloninger's classification. The genotyping of the DRD2, DRD4, GABRB3, 5-HTTLPR was carried out. Chi-square method was used for evaluating the associations between genetic polymorphism and the COAs Results : The frequency of A1 + allele of DRD2 in COAs were significantly higher than Non-COAs (χ²=4.45, df= 1, p=0.035). Significant association between the genotype of DRD4 and COAs was found (χ²=8.32, df= 1, p=0.004). Gl- alleles of GABRB3 in COAs were significantly higher than in Non-COAs (χ²=6.622, df= 1, p=0.022). We found no association of the polymorphic alleles of 5-HTTLPR with the COAs (χ²=0.021, df= 1, p=0.884). There were significant associations between the type of parental alcoholism and depression of COAs. Conclusion : We found that the children of alcoholics had significantly increased genetic risk of alcohol drinking expectancy. This study provides some preliminary information on the risk and protective factors associated with the COAs, which can be usedas a foundation for prevention and intervention of future psychopathology.

신경정신장애의 분자 유전학적 접근

전진숙 고신대학교 의학부 1993 高神大學校 醫學部 論文集 Vol.9 No.1

The molecular genetic techniques including recombinant DNA technology play an important role in modem neuropsychiatric research and practice. The basic concepts of molecular genetics and the clinical applications were reviewed in degenerative disorders including Alzheimer's disease, schizophrenia, mood disorders, and other neurological disorders. The molecular genetic methods seem to have potential value in the following applications ; 1. The complete mapping of human genomes 2. The localization and cloning of genes for the hereditary disorders 3. The diagnosis and predictability of risks for the single-gene controlled disorders 4. The identification of gene products, and biochemical and physiological basis for the genetic diseases 5. The development of preventive methods and therapeutic drugs 6. In the future, availability of gene-replacement therapy for the same disorders

반복치료로 호전된 호산구성 폐렴 유사 폐흡충증 1예

박세진,김희규,김봉준,이천우,옥철호,정만홍 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

우리나라에서 인기 있는 게장등의 섭취로2) 성인뿐만 아니라 소아에서도 지속적으로 보고되고 있는 폐흡충증은 다양한 임상양상을 보일 수 있다. 저자들은 방사선 소견상 만성 호산구성 폐렴과 유사하였고, 반복적인 치료로 호전된 폐흡충증 1예를 경험하였기에 보고하는 바이다. Paragonimiasis mostly occurs by ingestion of raw or undercooked freshwater crabs or crayfish. Recently, re-emergence of paragonimiasis is reported because of ingestion of raw food such as freshwater fish and Gejang (marinated raw crabs). As the radiological features as well as the laboratory findings are similar to those of chronic eosinophilic pneumonia, the diagnosis of pulmonary paragonimiasis is often difficult and delayed. A 43 year-old female was visited our hospital for migrating and new developing consolidative lung lesions and peripheral blood eosinophilia. The eosinophil profile of leukocyte was 32% (absolute count 2,690 /mm3). Histologic finding was organizing pneumonia pattern with severe infiltration of eosinophils. Parasite specific antibody IgG forParagonimus westermani was positive (titer:0.61, normal range<0.20). After treatment with praziquantel (75mg/Kg once a day for 2days), the chest x-ray was clearly resolved. Follow-up study showed right pleural effusion, newly developed focal infiltration, and several nodules. After retreatment, we couldn't find any recurrent evidence.

45歲 以後에 初發한 偏執症候群의 特徵

田珍淑,張煥一,李成柱 大韓神經精神醫學會 1985 신경정신의학 Vol.24 No.1

The 25 patients, in whom paranoid symptoms had occurred after age 45, and who had been admitted to Kyung Hee University Hospital from May 1979 to June 1984, were compared with 40 paranoid schizophrenics who had fitted to the DSM-Ⅲ diagnostic criteria, to clarify whether such syndrome should be classified to schizophrenia or a separate entity. The results were as following; 1. The male to female ratio was 0.92:1 in late paraphrenics, in contrast with 2.33:1 in control (p>0.05). 2. The age at onset was 53.6±8.0 year in late paraphrenics, in contrast with 28.1±7.6 year in control (p<0.001). 3. Majority of late paraphrenics had been ill for 2 weeks to below 6 months (48.0%), while for above 2 years in control (60.0%) (p<0.0005). 4. The late paraphrenics had been in hospital for 32.1±18.6 days on the average, in contrast with 53.4±31.3 days (p<0.01). 5. At time of admission, majority of late paraphrenics had married (68.0%) (p<0.005), in contrast with being single in control (62.5%) (p<0.0005). But divorced, separated or deceased were more in late paraphrenics (32.0%) than control (p<0.05). 6. The numbers of children of late paraphrenics were 3.8±2.0, and of control 0.8±1.4 (p<0.001). 7. Upon socioesonomic classes, majority of both patients belonged to middle class (p>0.5), and control (42.5%) belonged to lower class more than late paraphrenics (20.0%) (p>0.05). 8. The control had been admitted more frequently (2.9±2.1 times) than late paraphrenics (1.4±0.9 times) (p<0.01). 9. Both patients had schizophrenic family members most of all (each other 12.0% and 7.5%) (p>0.5), the late paraphrenics had somewhat more paranoid disorder (8.0%) than control (2.5%) (p>0.3). 10. Majority of late paraphrenics had paranoid personality trait (80.0%) (p<0.0005), in contrast with schizoid one in control (55.0%) (p<0.025). 11. Precipitating factors were present in 92.0% of late paraphrenics and 60.0% of control (p<0.01). Among the contents, family problem was most predominant (56.0%) (p<0.0005) in late paraphrenics and marital and financial problems (each other 28.0%) (p<0.05) in next order, while work (30.0%) and interpersonal problem (17.5%) were more prominent in control (p>0.5). 12. Among the contents of delusions, majority of both patients had persecutory ones (80.0%) (p>0.5) and idea of reference (each other 40.0% and 62.5%) (p>0.05). Otherwise, late paraphrenics had infidelity (36.0%) and hypochondriacal (32.0%) ones (p>0.05), while delusion of being controlled (55.0%) (p<0.01) and other Schneiderian ones (30.0%) were more common in control (p<0.05). In addition, affective symptoms (72.0%) (p<0.05) and cognitive difecit (40.0%) (p<0.0005) were more common in late paraphrenics, while hallucination (60.0%) (p>0.3) and loosening of association (67.5%) (p>0.05) in control. 13. The responses to physical treatment mainly composed of antipsychotics were fair (each other 92.0% and 100.0%) (p>0.05). Otherwise, late paraphrenics administered antidepressants (24.0%) more than the control (p<0.01), while electroconvulsive therapy was used more in control (20.0%) (p>0.1). 14. Most of the clinical diagnoses at discharge were established as paranoid disorder (56.0%) and in next order, paranoid schizophrenia (20.0%). Based on the above results, we concluded that late paraphrenia should be classified to paranoid disorder rather than atypical psychosis in addition to the agreement with the validity of separating this syndrome from schizophrenia in DSM-Ⅲ.

酒精中毒의 生化學的 側面 : 酒精이 中樞神經系에 미치는 生化學的 影響

田珍淑 서울대학교 의과대학 정신과학교실 1987 서울醫大 精神醫學 Vol.12 No.3

Borrmann 4형으로 진단된 진행성 위암환자의 임상적 검토

천영국,김영태,홍수진,김진오,조주영,이문성,심찬섭 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Background/Aim: It is difficult to dignosis of Borrmann type 4 gastric cancer at the early stage, because of its special morphology. Most of the cases have been detected at the advanced stage with poor survival rate. We reviewed patients with advanced gastric cancer, to define clinicopathologic characteristics of Borrmann type 4 gastric cancer comparing other types of gastric cancer. Methods: 1033 patients with advanced gastric cancer were divided into two groups, consisting of 50 patients with Borrmann type 4 gastric cancer, and the remaining 983 patients with all other types of gastric cancer, which were then compared clinicopatologically. Results: The proportion of Borrmann type 4 gastric cancer to advanced gastric cancer was 4.48%(50/1,033). The patients with Borrmann type 4 gastric cancer to advanced gastric cancer was 4.48%(50/1,033). The patients with Borrmann type 4 gastric cancer were composed 20 males and 30 males and revealed the highest frequency 3rd decade (24.0%) in age (range 26-78). In giant folds group (n=27), the number of poorly differentiated cell type, lymph node metastasis, peritoneal seeding were 20 (74.1%), 17 (63,0%), 12 (44.4%). In non-giant folds group (n=23), the number of poorly differentiated type, lymph node metastasis, peritoneal seeding were 17 (73.9%), 15 (65.2%), 6 (26.1%). Rate of tumor invasion in serosa and beyound serosa was 88.9% in giant fold group, 63.0% in non-giant fold group. Surgery was performed in only 32% as a modality of treatment (vs. 82.5%). Characteristics findings of Borrmann type 4 gastric cancer in EUS showed a thickening of the third (submucosa) and fourth (muscularis propria) layers in 72% of 50 patients, and a well preserved five-layered gastric wall structure in 33 patients. Conclusions: We concluded that Borrmann type 4 gastric cancer was diagnosed more in females, as a more advanced disease, early detection was needed. And endoscopic ultrasonography is useful for diagnosis of Borrmann type 4 gastric cancer in the cases of suspicious results of gastroscopy.

綜合病院에서 精神科 諮問 調停活動 (Ⅰ) : 入院患者에 對한 精神科 諮問의 經驗 An Experience of Psychiatric Consultation for the Medical and Surgical Inpatients

田珍淑 고신대학교 의학부 1987 高神大學校 醫學部 論文集 Vol.3 No.1

The author assessed the results of psychiatric consultation based on semi-structured interview for 118 inpatients who were referred from June 1, 1986 to November 30, 1986. The results were as follows: 1. Contents related to the consulted patients; 1) The consultation was mostly performed in forties, and females were more consulted. 2) Most of all complained of gastrointestinal problems, and diagnoses of cardiovascular system were significantly prevalent among the above 45 yrs old. 3) 16.9% of the consulted patients had the previous history of psychiatric treatment. 2. Contents related to the consultee; 1) Psychiatric consultation was most frequently requested from Department of Internal Medicine. The consultation rate to total admission was 2.07%, and was highest in the Department of Neurosurgery. 2) Most frequent reason for consultation was physical symptoms without evidence. The reason as psychiatric complication was significantly common among the above 45 yrs old. 3) The consultation was mostly requested by doctors(92.4%). 4) 21.2% of patients was accounted for psychiatric consultation before it was performed. 5) The consultation was mostly requested within a week after admission. The medical parts tended to consult within a week, while the surgical parts did significantly over 3 weeks after admission. 3. Contents related to the consultant; 1) Among psychiatric diagnoses, neuroses were most predominant. In constrast to neuroses prevalent among the below 45 yrs old, organic mental disorder was predominant among the above 45 yrs old. 2) Of all recommendations, study and follow-up consults were most frequently advised. Follow-up as outpatients was significantly recommended among the below 45 yrs old. 3) Consultant felt that only 39.8% of all consulted were suited to the referral.