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- 저자 : Jia Hui Gan (검색결과 4 건)
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Acupuncture in Post-Stroke Shoulder Pain Syndrome with Multiple Sclerosis: A Case Study
Jia Hui Gan,Lorenzo A. Santorelli 사단법인약침학회 2021 Journal of Acupuncture & Meridian Studies Vol.14 No.1
The present case study illustrates the case of a 47-year-old female (Ms X) with primary progressive Multiple Sclerosis (MS) who presented with central post-stroke pain (CPSP) over her left shoulder and underwent acupuncture treatment (AT) since she appeared irresponsive to conventional treatment. The aim of this case study is to explore the effectiveness of acupuncture as a complimentary treatment in improving central neurogenic pain in MS patients affected by CPSP. AT lasted six weeks, some modification of the conventional AT points was required to ensure continuity and safety of the treatment plan. In fact, Ms X suffered from gingivitis that led to hypersensitivity of her left upper limb (UL) to acupuncture needling; moreover, she experienced sensation loss in her legs as a result of post-stroke complications. The outcome showed that the subject’s shoulder range of motion (ROM), Disabilities of the Arm, Shoulder and Hand (DASH) score and pain improved remarkably, enabling Ms X to resume post-stroke rehabilitation and reduce her analgesic intake.
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Wei Wang,Dong‑hui Fang,Jia Gan,Yi Shi,Hui Tang,Huai Wang,Mao‑zhong Fu,Jun Yi 한국유전학회 2019 Genes & Genomics Vol.41 No.7
Background In eukaryotic organisms, it has been well acknowledged that 3′ untranslated regions (3′ UTRs) of mRNA are actively involved in post-transcriptional regulations of gene expression. Although both shortening and lengthening of 3′ UTRs of specific candidate genes were explicitly documented to have functional consequences, landscape of 3′ UTR lengths in relation to evolutionary dynamics and biological meanings remains to be elucidated when large-scale data become available. Objectives The primary objective of this study was to revealed different inter- and intra-species patterns on length distribution of 3′ UTRs in comparison with 5′ UTRs and coding regions. Methods In the present study, we investigated 3′ UTR lengths in a highly curated set of 57,135 mRNA sequences among four well-studied and taxonomically diverse metazoan species (fruit fly, zebrafish, mouse and human). Results The average length ratio of 3′–5′ UTRs considerably increased from fruit fly (twofold) to human (fivefold). Moreover, genes can be characterized by the obviously different patterns of evolutionary change on 3′ UTR lengths. By utilizing the Gene Ontology annotations, genes with differential lengths of 3′ UTRs were suggested to have the divergent functional implications. In human, we further revealed that ubiquitously transcribed genes had higher median lengths of 3′ UTRs than the genes of tissue-restricted expressions. Conclusion We conducted a comprehensive analysis and provided an overview regarding 3′ UTRs biology of mRNAs in animals, whereas the mechanistic explanations of 3′ UTRs length variation in correlation to regulation of gene expression still remain to be further studied.
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Genetic structure of six cattle populations revealed by transcriptomewide SNPs and gene expression
Wei Wang,Huai Wang,Hui Tang,Jia Gan,Changgeng Shi,Qing Lu,Donghui Fang,Jun Yi,Maozhong Fu 한국유전학회 2018 Genes & Genomics Vol.40 No.7
There are abundant cattle breeds/populations in China, and the systematic discovery of genomic variants is essential for performing the marker assisted selection and conservation of genetic resources. In the present study, we employed whole transcriptome sequencing (RNA-Seq) technology for revealing genetic structure among six Chinese cattle populations according to transcriptome-wide SNPs and gene expression. A total of 68,094 variants consisting of 61,754 SNPs and 6340 InDels were detected and widely distributed among all chromosomes, by which the clear patterns of population structures were revealed. We also found the significantly differential density of variant distribution among genes. Additionally, we totally assembled 15,992 genes and detected obvious differences on the expression profiles among populations. In contrast to genomic variants, the measure of gene expression levels failed to support the expected population structure. Here, we provided a global landscape on the differential expression genes among these cattle populations.
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Modelling of Acoustic Waves Propagating in Nesting Fibonacci Super-Lattice Phononic Crystal
Min Zhao,Hai-Feng Qi,Jia-Hui Xu,Ya-Zhuo Xie,Xing-Gan Zhang,Jian Gao 대한금속·재료학회 2014 METALS AND MATERIALS International Vol.20 No.4
Herein, we report construction of one kind of nesting-Fibonacci-super-lattice phononic crystal, in whichthe super-lattice cell is a well-defined Fibonacci generation sequence. We present a comparative study onband-gap structures of acoustic waves propagating in one-dimensional, nesting Fibonacci-periodic structureand simple-periodic structure. We find that there are more band gaps in nesting Fibonacci super-latticemodels, and that they present behavior different from the split-up of band gaps with different generationnumbers. With the increase of generation number, more band gaps split and occur. Additionally, whengeneration number becomes larger, Bragg scattering becomes more significant: the characteristic curvesbecome flatter and band gaps become wider. Furthermore, we study the effect of various parameters suchas density, thickness and defects on band-gap structures. Our work is significant both for understandingthe intrinsic physical properties of nesting Fibonacci sequences and for providing flexible choices to meetreal engineering requirements.
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