The Safety and Efficacy of Daclatasvir and Asunaprevir with Chronic HCV Genotype 1 Infection and Hemodialysis

( Myeong Jun Song ),( Jung Hyun Kwon ),( Soon Woo Nam ),( Tae Hee Lee ),( Young Woo Kang ),( Ji Woong Jang ),( Seok Hyun Kim ),( Byung Seok Lee5 ),( Sea Hwan Lee ),( Hong Soo Kim ),( Ji Hoon Kim ),( S 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: We aimed to evaluate the efficacy and safety of Daclatasvir (DAV) and Asunaprevir (ASV) in patients with chronic hepatitis C virus (HCV) and chronic renal failure (CRF). Methods: 22 chronic hemodialysis patients with HCV infection at 12 medical centers have prospectively enrolled from Feb, 2016 to Feb, 2017 (NCT02580474). Of those, 9 patients who were followed 12 weeks after treatment ended were included. We evaluated the virological responses at each week 4, 12, 24 and the 12-week sustained virologic response (SVR12). The tolerability and safety of patients were also evaluated. Results: Of these 20 patients, there had no resistance-associated variant of NS5A (NS5A RAVs) and 2 patients showed indeterminate NS5A RAVs. 12 patients (54.5%) completed the 24 weeks treatment of DAV and ASV. 6 patients (27.2%) have continued, but 4 patients discontinued study prior to 12 weeks. Overall, all patients (n=9) achieved SVR12. Virologic response at week 4, 12 and 24 showed 94.4% (17/18), 93.3% (14/15), and 100% (12/12) respectively. DCV and ASV were well tolerated among the majority of patients and discontinuation of the treatment due to adverse events (hypertension, bradycardia, leukemia) was occurred in 3 patients. In two patients with indeterminate NS5A RAVs, one achieved SVR12 but the other showed viral breakthrough and discontinued treatment. Conclusions: In this study, DAV and ASV combination therapy for chronic hemodialysis patients with HCV infection achieved high sustained virological response with few adverse events. Close monitoring of safety and tolerability may be necessary when treating chronic hepatitis C patients with CRF receiving DCV and ASV.

딜티아젬 함유 코아 펠렛으로부터 약물의 용출에 미치는 폴록사머 함량의 영향

이승우,감성훈,홍지웅,최기송,박은석,지상철 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.4

In order to evaluate the effect of poloxamer 407 content on the dissolution profiles of pellets, diltiazem HCl (DTL) core pellets were prepared with poloxamer 407 (50∼90% w/w, with lactose as filler) using an extruder and a spheronizer. Any possible interaction between the drug and excipients was evaluated using DSC, IR and TLC. Dissolution tests were performed using USP basket method. In addition, scanning electron micrograph was performed to examine the surface roughness and cross sections. The release of DTL from the core pellets was decreased with increasing poloxamer 407 content. Cracks appeared on the surface of the core pellets with increasing the poloxamer 407 content, which may play a role on the retardation of the release of DTL from core pellets. There was no any significant interaction between the drug and excipients employed to prepare the core pellets.

남녀별 음주율 현황과 음주와 관련된 요인분석

이지전,이상욱,송재석,박웅섭 關東大學校 醫科大學 醫科學硏究所 2003 關東醫大學術誌 Vol.7 No.1

In this study, drinking prevalence and the factors associated with drinking by gender were investigated. A cross-sectional study was conducted from 22 April to 3 May in 2002. 1000 subjects(301 females and 699 males) aged 13 to 59 were personally interviewed by trained interviewers. Data on socio-demographic characteristics, drinking related behaviors and health behaviors of subjects were collected. Among females, 191(63.5%) subjects were drinkers and preferred beverage was beer. Drinkers were likely to be 30-39 year-old, employed, religionless, smokers and metropolitan city residents. Among males, 579(82.8%) subjects were drinkers and preferred beverage was Soju. Drinkers were likely to be 19-29 year-old, religionless, jobless, smokers and county residents. After adjusting for various confounders, age, religion and smoking were statistically significantly related to drinking. Smoker(Odds ratio=2.68 females, 2.77 males) and catholic-buddhist(OR=1.51 female, 3.83 males) had higher drinking risk than non-smoker and protestant. County residents had borderline significantly lower drinking risks(OR=0.50) than metropolitan city residents among females.

호르몬 불응성 전립선암 환자에서 mitoxantrone과 prednisone의 병합화학요법 후 통증완화 및 삶의 질 측정

이홍우,이지열,김세웅,이충범,강성학,조용현,황태곤,박용현,윤문수 대한화학요법학회 2000 대한화학요법학회지 Vol.18 No.3

목적 : 호르몬 불응성 전립선암 환자의 생명을 연장시키는 치료법은 현재로는 없으며, 현 시점에서의 치료목표는 증상의 경감 및 소실에 따른 삶의 질 향상에 두고 있다. 호르몬 불응성 전립선암의 고식적인 치료에 일차적인 치료법으로 간주되는 mitoxantrone과 prednisone의 화학요법이 호르몬 불응성 전립선암 환자의 통증완화 및 삶의 질에 어떠한 영향을 미치는지 알아보았다. 방법 : 1998년 7월부터 1999년 12월까지 증상이 있는 18명의 호르몬 불응성 전립선암 환자를 대상으로 하였으며, 일차적인 치료의 목표는 환자 본인이 기록하는 McGill-Melzack 6단계 통증척도에서 진통제의 증량 없이 2점이 감소(또는 첫 점수가 1점일 경우 통증의 완전소실)하는 것으로 하였다. 이러한 기준은 최소 3주 간격으로 시행한 자가 기록조사에서 연속적으로 2번 이상 유지될 때 유효한 것으로 간주하였다. 건강과 관련된 삶의 질 측정은 전신적 치료의 임상적 응용을 위한 실제적인 측정방법으로 개발되어 환자가 직접 작성하는 전립선암 특이성 삶의 질 측정기구(Prostate Cancer-Specific Quality-of-Life Instrument : PROSQOLI)의 비례연속형의 자가측정 척도(linear analogue self-assessment scale : LASA)를 이용하였으며, ECOG performance status를 사용하여 전신상태의 변화도 측정하였다. 결과 : 통증의 경감으로 나타나는 고식적인 치료의 반응은 66.7%(12/18)에서 나타났으며, 반응의 지속기간은 2개월에서 10개월까지로 평균 4.2±3.6개월이었다. PROSQOLI로 측정한 삶의 질은 통증에 대한 고식적인 치료반응을 보인 12명(66.7%) 모두가 삶의 질이 개선되었으며 특히 통증, 변비, 소변보기, 전반적인 복지상태에서의 유의한(p<0.05) 증가를 보였다. 치료 후 혈장 PSA 수치는 고식적인 반응의 유무에 관계없이 별 다른 변화를 보이지 않았으며, 골주사 또는 전산화 단층촬영으로 측정한 방사선학적 병변은 고식적인 반응을 보인 2명을 제외하고 치료 전과 비교하여 차이를 보이지 않았다. 병합 화학요법과 관련된 특별한 부작용은 관찰되지 않았다. 결론 : 통증을 동반한 호르몬 불응성 전립선암에서 mitoxantrone과 prednisone의 병합화학요법은 66.7%의 환자에서 통증의 감소 및 삶의 질이 향상되었다. 현재는 혈장 PSA 수치, 병소의 크기나 개수등이 치료의 지침이나 치료결과의 판정을 위한 객관적인 기준으로 사용되는 경향이 있지만, 앞으로는 환자를 중심으로 통증을 포함한 삶의 질 측정이 고식적 치료 후 치료결과 판정에 있어 객관적이고 적절한 방법이 될 것이다. Background : There is no evidence that therapeutic modalities prolong the survival of patients with hormone-refractory prostate cancer nowadays. The main goal of treatment is therefore improvement in quality-of-life including palliation of symptoms. We performed this study to investigate the benefit of mitoxantrone and prednisone chemotherapy in patients with symptomatic hormone-refractory prostate cancer using relevant end points of palliation regarding to pain and quality-of-life. Methods : From July 1998 to December 1999, we assessed the 18 patients with symptomatic hormone-refractory prostate cancer receiving mitoxantrone and low dose prednisone. The treatment end point was a palliative response defined as a 2-point decrease in pain assessed by a 6-point pain scale complemented by patients (or complete loss of pain if initially 1+) without an increase in analgesic medication and maintained for two consecutive evaluations at least 3 weeks apart. Health-related quality-of-life was evaluated with a series of linear analogue self-assessment(LASA) scale of the Prostate Cancer-Specific Quality-of-Life Instrument (PROSQOLI) and performance status was also measured. Results : Palliative responses were observed in 12(66.7%) of 18 patients. The duration of palliative responses were 4.2±3.6 months(range: 2 to 10 months). Treatment was well tolerated without specific side effects. There were no differences in prostate-specific antigen (PSA) level following treatment and no significant changes of radiologic findings evaluated by bone scan and/or CT were noted except 2 cases after chemotherapy. All the responding patients had an improvement in quality-of-life scales and performance status, however serum PSA levels were not changed. Conclusions : Chemotherapy with mitoxantrone and prednisone provides palliation and an improvement in quality-of-life for more than half (66.7%) of the patients with symptomatic hormone-refractory prostate cancer.

신경모세포종의 화학 및 방사선요법이 치아우식활성도에 미치는 영향

이지현,박기태,성기웅,김지연 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.3

소아암 환자의 치료 방법으로 주로 사용되는 항암화학요법이나 방사선요법이 구강 건강에 미치는 영향은 매우 크다. 구강 점막염, 타액 분비율의 변화, 구강내 감염을 야기할 수 있고, 부분무치증, 왜소치, 치근 발육이상, 저석회화증이 나타날 수 있다. 본 연구는 신경모세포종으로 치료 받은 환아들에 있어 항암치료가 치아우식증 발생 위험도에 어떠한 영향을 미치는지 알아보기 위해 실시되었다. 삼성서울병원 소아청소년과에 신경모세포종으로 내원하여 화학 및 방사선치료요법을 받은 환아들을 대상으로 Dentocult.. SM, Dentobuff.. Strip을 이용하여 항암치료 후의 타액 분비율, 타액 완충능, 타액 내의 Streptococcus mutans 수를 알아보고 정상 어린이들의 결과와 비교하였으며, 신경모세포종 환아에서 처음 치료를 시작한 나이, 치료 종결 후 경과 시간에 따라 치아우식활성도가 어떻게 달라지는지에 대해서도 알아보았다. 그 결과 타액 분비율은 환아가 대조군에 비해 유의성 있게 낮은 결과를 보인 반면(p<0.05), 타액 완충능과 Streptococcus mutans 수는 환아와 대조군 간에 유의성 있는 차이를 보이지 않았다. 환아에서 치료를 시작한 나이나 치료 종결 후 경과 시간에 따른 치아우식활성도에서도 통계적 유의차는 없었다. Chemotherapy or radiotherapy used for the treatment of pediatric cancer may have many adverse effects on the oral cavity. Oral mucositis, reduced salivary flow, oral infection, hypodontia, microdontia, arrested root development, and enamel hypoplasia are common oral complications. The aim of this study is to evaluate the effects of cancer therapy on dental caries activities. The children who had been treated for neuroblastoma in the department of pediatrics, Samsung Medical Center, were included and healthy children served as controls. The salivary flow rate, salivary buffering capacity, and Streptococcus mutans counts of both groups were evaluated using Dentocult SM and Dentobuff Strip. The dental caries activity related to the age at the start of treatment and the time elapsed since treatment completion were also evaluated. As a result, neuroblastoma patients had significantly lower salivary flow rate than the controls, while there were no significant differences between two groups as for salivary buffering capacity and Streptococcus mutans counts. The dental caries activities related to the age at the start of treatment and the time elapsed since treatment completion were not significantly different.

位相差 檢出方式을 利用한 토크미터에 대한 實驗的 考察

이종원,오세훈,김지웅,이준환 중앙대학교 생산공학연구소 1999 생산공학연구소 논문집 Vol.8 No.2

본 연구에서는 기존의 토크미터의 기계적 특성을 높이기 위하여 STS 304와 복합재료를 회전축에 사용한 위상차 검출방식의 토크미터를 개발하였다. 실험결과, 동시접합방식을 이용하여 제작된 토크미터 회전축의 기계적 특성이 다른 방식으로 제작된 것보다 우수한 것으로 나타났다. 유리강화복합재료의 적충각이 30˚, 동시 접합방식으로 접합된 토크미터 회전축의 고유진동수와 반경방향 강성은 STS304재질만을 이용하여 제작된 회전축보다 각각 64%, 137% 증가되어지는 것을 실험을 통해 증명하였다. In this study the angular twist type torque-meter was designed and manu factured with STS 304 and fiber-feinforced composite materials to improve the dynamic properties of the existing torque-meter. From the experimental and analytical results, it was found that the dynamic characteristics of co-cured bonded torque-meter rotating shaft were better than those of the adhesively and unreinforced torque-meter rotating shaft. For the torque-meter rotating shaft manufactured by co-cured bonded with kthe glass fiber-epoxy composite and with a stacking sequence of [±30˚/STS304]??, the natural frequency and the radial stiffness were increased by 64% and 137% compared to those of the unreinforced torque-meter rotating shaft.

Y-TZP의 물성에 미치는 Al₂O₃의 첨가방법의 영향

이홍림,문지웅 연세대학교 산업기술연구소 1993 논문집 Vol.25 No.1

To fabricate (Y-TZP)-Al₂O₃composite, two different mixing methods, conventional mechanical mixing and coprecipitation were studied. Mechanically mixed powder was properly densified by pressureless sintering, but its microstructural homogeneity and resistance against low temperature degradation were poor. Due to its umique powder structure, which was consisted of ZrO₂embeded by transition Al₂O₃, coprecipitated powder could not be fully densified by pressureless sintering, so exhibits poorer flexural strength than mechanically mixed powder, but its resistance against low temperature degradation was improved. By hot-pressing at 1550℃ for 1 h, coprecipitated powder could be fully densified, so the flexural strength decrease was not occurred. Al₂O₃size and its distribution of coprecipitated powder composite were smaller and more homogeneous, respectively, than mechanically mixed powder.

축약형 월경전기평가서 표준화 연구 및 인터넷상에서 적용 가능성

이만홍,김지웅,이정현,김덕만 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.1

연구의 목적 : 연구의 목적은 축약형 월경 전기 평가서(Shortened Premenstrual Assessment Form: SPAF)의 신뢰도 및 타당도를 알아보고, 인터넷상에서의 적용 가능성을 알아보기 위하여 시행되었다. 방 법 : 월경전 불쾌장애 환자 28명과 월경 전 불쾌장애에 해당하지 않는 가임 연령의 여자 연구 대상자 27명을 대상으로 세브란스 여성 정신 건강 특수 클리닉 홈페이지를 통하여 축약형 월경전기평가를 시행하게끔 하였다. 월경전 불쾌장애의 진단은 2개월간의 전향적인 평가를 통해 내려졌다. 결 과 : 축약형 월경전기 평가서는 정동요인, 통증 요인, 수분 저류 요인으로 구성되어 있으며, 검사-재검사 신뢰도는 0.80으로 우수하였다. 내적 일치도(Cronbach alpha) 또한 0.91로 우수하였으며, 월경전기평가서 점수와 축약형 월경전기 평가서의 상관계수는 0.92로 나타났다. 월경 전 불쾌장애 환자군과 월경전 불쾌장애에 해당하지 않는 연구 대상군 사이의 축약형 월경정기평가서 점수도 유의한 차이가 있었고(t=5.57, p<0.001), 판별 분석상에서 축약형 월경전기 평가서 점수가 두 집단을 잘 판별할 수 있는 것으로 나타났다(eigenvalue : 0.60, canonical correlation coefficiency : 0.61, Wilk's lamnda : 0.63). 두 집단을 구분하는 최적 절단점은 27점으로 추정되었고, 이때의 민감도(75%)와 특이도 76.9%)는 비교적 우수한 것으로 나타났다. 결 론 : 이상의 결과들을 종합할 때, 축약형 월경전기 평가서는 신뢰도 및 타당도가 우수한 월경전기증상 평가 도구로서 인터넷상에서도 유용하게 사용될 수 있는 도구임이 시사된다. Objectives : The purposes of this study are to investigate the reliability and validity of shortened premenstrual assessment form and the applicability to internet interface. Method : The total of 55 subjects were included in this study. Among them, 28 subjects had premenstrual dysphoric disorder, and the other 27 subjects did not. All subjects performed the shortened premenstrual assessment form through internet interface in the homepage of Severance Woman Clinic. The diagnosis of premenstrual dysphoric disorder was determined by prospective assessment for 2 months. Results : The shortened premenstrual assessment form consists of 3 factors : affect, pain and water retention. The test-retest reliability of this scale was 0.80, and internal consistency(Cronbach alpha) was 0.91. The correlation coeffeciecy between scores of the premenstrual assessment form and the shortened premenstrual assessment form was 0.92. The difference of the scores of the shortened premenstrual assessment form between the group of premenstrual dysphoric disorder and the group of non-premenstrual dysphoric disorder was significant(t=5.57, p<0.001). Discriminant analysis also revealed that the shortened premenstrual assessment form was useful to differentiate between premenstrual dysphoric disorder and non-premenstrual dysphoric disorder(eigenvalue : 0.60, canonical correlation coefficiency : 0.61, Wilk's lambda : 0.63). The cut-off point to differentiate between two groups was 27, and sensitivity(75.0%) and specificity(76.9%) of this scale for premenstrual dysphoric disorder was acceptable. Conclusion : In summary, the shortened premenstrual assessment form appeared to be reliable and valid for the assesment of premenstrual dysphoric disorder. And the results of this study also suggest that the shortened premenstrual assessment form is a useful tool for internet interface application.

900 MHz 대역 CMOS 가변이득 증폭기 설계

이지호,채규성,윤상웅,김창우 慶熙大學校 레이저 工學硏究所 2007 레이저공학 Vol.18 No.-

A vairable gain amplifier(VGA) has been designed for 900 MHz-band applications. The VGA consist of three blocks; a control voltage feeding block, variable gain block, and constant gain block. The VGA has been simulated using the TSMC CMOS libraries. At 900 MHz, the maximum gain is 34.6 dB with an 1 - dB gain compression output power of 3 dBm. The gain control range is 30 dB from 3.8 dB to 34.6 dB by the control voltage from 0.9 to 3.0 V. The gain control sensitivity of the VGA is 70 mV/dB, which is larger than a thermal voltage (26 mV/dB at the room temperature) in order to be insensitive to temperature variation.

심인성 색전 요인이 없는 뇌경색 환자에서 경식도 심초음파와 Acoustic Quantification을 이용한 대동맥 탄성의 평가

이종민,윤호중,임효영,박지원,김휘열,전희경,문건웅,정욱성,채장성,김재형,최규보,홍순조 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8