소뇌 출혈을 동반한 침입성 부비동 아스페르길루스증 1예

양현덕,박성욱,손일홍,이지용,석승한,조광호,이성수 圓光大學校 醫科學硏究所 2003 圓光醫科學 Vol.18 No.2

정신과 외래에서 향정신성약물을 복용 중인 환자에서의 하지불편증후군

지구덕,한승희,양명성,양창국 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.4

Objectives : The purpose ofthis study was to investigate the clinical characteristics and incidence of restless legs syndrome (RLS) in outpatients with psychiatric iltness. Methods : 146 adult patients (male 52, female 94) wcre selected from those who visited a psychiatric outpatient clinic. RLS was evaluated through an interview method using diagnostic criteria and a severity rating scale for RLS developed by the Intemational RLS Study Group (IRLSSG). The authors also applied Beck's Depression Inventory (BDI), Beck's Anxiety Inventory (BAI), the Pittsburgh SleeP Quality Index, Bames Akathisia Rating Scale and neurological examination. Rcsults : Thirty-four (23.3%) among 146 subjects were diagnosed as having RLS. Fifteen (44.1%) among those 34 RLS patients reported to have developed their RLS after starting their psychotropic agents and only 4 patients (11.7%) had Cu-rrently been receiving treatment for their RLS. The RLS group showed higher BDI and BAI scores (p<0.01) and lower sleep quality (p<0.01) compared to those of non-RLS. The RLS group also showed a significantly higher co-morbidity of Pa-rasomnias (χ²=8.5, P<0.01) and peripheral neuropathy (χ²=5.2, P<0.05). Conclusion : The results from this study suggest that a substantial proportion of outpatients with psychiatric illness are suffering RLS. Our data suggest that clinicians should pay attention to the possible presence of RLS among their patients who are taking psychotropic agents.

VRSA에 대한 항생물질을 생산하는 방선균의 분리

이지연,양시용,고은지,이승구,김시관,조왕식,송민동 建國大學校 自然科學硏究所 2002 建國自然科學硏究誌 Vol.13 No.2

본 연구가 VRSA에 대한 신규 항생물질 생산 균주를 얻기 위하여 실시하였다. 국내외에 채취한 토양시료에서 분리한 방선균 중, 임상분리 VRSA와 돌연변이 유발 VRSA에 대해 항균성을 나타내는 JY-24를 선별하였다. 선발 균주는 원통형의 포자 모양을 갖고 있으며, Bennett's 배지에 배양시 aerial mycelium color는 흰색을 나타냈으며, reverse side color는 대체로 노란색을 나타내었다. 항균물질 생산을 위한 탄소원으로는 fructose, mannose, 질소원으로는 yeast extract가 가장 우수하였으며 glucose의 첨가로 항균 물질 생산성이 증가하는 것으로 나타났다. 최적 초기 pH는 pH 7로 나타났으며, 28 ℃, 37℃, 45 ℃의 온도에서 균이 성장하는 것으로 나타났다. 또한 배양기간에 따라 항균물질 생산성을 조사한 결과, 임상분리 균주에 대해 5일 배양 시 가장 높았으나, 3일 배양과 7일 배양 시 동일한 생산성을 나타내 생산속도가 빠르며, 안정한 물질인 것이 파악되었다. 향후 균주동정 및 항균물질 정제에 관한 연구를 수행하고자 한다. An antibiotic substance producing strain JY-24, effective to the VRSA (Vancomycin-resistant Staphylococcus aureus), was isolated from soil. The spore chain of JY-24 was cylindrical, and its sulface was smooth. The aerial mass color of the strain was white, and its reverse side color was yellow. The strain did not produce soluble pigment. For the production antibiotics, fructose, mannose and yeast extract were favorable as carbon and nitrogen sources. Optimal initial pH for the production of the antibiotic was pH 7. Accumulation of the antibiotic in the culture broth reached at maximal level after 5 days cultivation in Bennett's medium.

카이토산을 이용한 방사성스트론튬 오염의 치료

김지열,송호천,양광희,최근희,채기문,범희승,김광윤 대한방사선 방어학회 1994 방사선방어학회지 Vol.19 No.3

본 연구에서는 마우스에 이미 오염된 방사성스트론튬(Sr-85)을 제거하는데 수용성카이토산이 어느정도 효과가 있는지 알아보고자 하였다. Sr-85를 정맥주사한 경우 주사후 1일째의 체내 잔류량은 72.9 ±5.7%, 5일째는 57.7 ±1.9%, 7일째는 54.2 ±1.4%로 서서히 감소하였으며, Sr-85를 복강내 주사한 경우는 주사후 5일째 54.4 ±1.2%, 15일째 50.6 ±0.8%로 정맥주사에 비해 낮은 잔류량을 보였다(5일째 잔류량의 비교, P<0.05), 0.3% 수용성카이토산을 1회 정맥주사해준 제21군 및 10% 수용성카이토산을 식이중에 섞어 먹인 제5군은 각각의 대조군에 비해 체내 잔류방사능의 차이가 없었으나 (P>0.05), 0.3% 수용성카이토산을 3일간 정맥주사한 제3군과 3% 수용성카이토산을 이틀 간격으로 15일간 복강내 주사한 제6군에서는 각각의 대조군에 비해 낮은 잔류방사능을 보였다. (P<0.01). 결론적으로 수용성카이토산을 연속적으로 정맥투여하거나 복강내 투여하는 경우에는 스트론튬의 골대사촉진 또는 골중의 스트론튬과의 반응등을 통해 그 배출을 촉진시킬 것으로 사료되었다. The aim of the present study was to elucidate the effect of the water soluble chitosans on the removal of contaminated radiostrontium(Sr-85) from the bone of mice. The remaining radioactivities in intravenously injected controls(group 1) were higher than in intraperitoneally injected controls (group 4, P<0.01). The % retention at day 5 were 57.7 ±1.9%, 54.4 ±1.2%, respectively. Single intravenous injection of 0.3% water soluble chitosan and continuous oral ingestion of 10% water soluble chitosan for 15 days were ineffective on the removal of contaminated radiostrontiums. Multiple intravenous or intraperitoneal injections of water soluble chitosan effectively removed contaminated radiostrontiums (P<0.01 vs controls). In conclusion, water soluble chitosan might remove once incorporated radiostrontium from bones of mice. further studies were needed to elucidate the mechanism of the removal.

광주전남지역 정상신생아의 상부 구순 계측치와 형태에 대한 연구

조안영,양정열,이승찬,천지선 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1

Background and objectives : The face is the one of the most variable parts of the body and characterized not only by separated part but also by interrelation of the parts. Especially, in the case of bilateral cleft lip and palate, compared with unilateral case, it is necessary to establish the facial anthropometry in newborns, because of current trend of early intervention, such as fetal surgery, lip adhesion, and nasoalveolar molding device. Millard presented the concept of rotation advancement for unilateral cleft lip repair, and, thesedays, this method of cleft lip closure is acknowledged as the most optimal principle. However, it can produce a scar that crosses the upper one third of the philtrum obliquely. The purpose of this study is to determine the configuration of the vermillion tubercle, the Cupid's bow, and the philtrum, and to suppose that which anthropometric data and proportional index could be significant to determine the configulation of the philtrum in case of bilateral cleft lip and other deformity, which can't identify the philtral shape. Materials and Methods : 74 newborn infants, who were full-term normal infant In Gwangju-Jeonnam area were examined from April to June 2003. Mean gestational ages were 39 weeks. Mean birth weight was 3.3 Kg. Five anthropometric data, which were base of columella to tubercle, nasal base to Cupid's bow peak, Cupid's bow to commissure, philtrum, peak to peak, and mouth width were measured. And the proportional indexes of each data were evaluated. Morphologic parameter, which were the shape of vermillion tubercle, the Cupid's bow, the philtrum, were analized. Results : Mean values of five anthropometric data were 14.1±2.2, 10.5±2.7, 16.5±2.5, 6.9±1.8, and 26.7±4.9 each. And the one of these, Philtral width, peak to peak, and 7 proportional indexes which were ①/④, ②/④, ③/④, ⑤/④, ④/③, ④/②, ④/① have a significance according to 3 types of the philtral shape. The most common shape of vermillion tubercle is protrusion type (89.2%), and that of Cupid's bow is normal type (52.7) and that of philtrum is parallel from nostril base to vermilion border (70.7%). Conclusion : My study supplies the plastic surgeon and others with specialized interests in the craniofacial surgical area with fundamental normative population data that will help them decide what IS abnormal. And corrective surgery of the face and cranium is becoming so precise that the techniques and data detailed in this paper are essential to its further development.

광주전남지역 정상 신생아의 코의 형태와 계측치에 대한 연구

이유진,양정열,이승찬,천지선,박상기 朝鮮大學校 附設 醫學硏究所 2003 The Medical Journal of Chosun University Vol.28 No.2

Background and Objectives: Cleft lip and palate are common defects in congenital deformity. They are the most frequent deformity in the face. Nose deformity is most common among various facial deformity at the center of face. So we must operate to correct the deformity at the earliest stage to give a patient and parent spiritual relief from anxiety, and it is the trend of the treatment recently. We must know the facial anthropometry in newborn to try at the early stage, but there is a lack of literature and research on newborns. So we carried out this research to form base data for operations. Materials and Methods : The noses of 90 newborns in Gwangju-Cheonnam area were analyzed quantitatively, based on 10 nasal measuring points and 13 anthropometric values taken directly from the face of newborns. The relationship between the nasal measurements were studied in 11 proportion indices. Results : Following are our mean values in newborn. Width of the nasal root was 13. 9mm. Width of the nose was 22. lrnm, Width of the columella was 4. 5mm. Height of the nose was 22.6mm. Length of the nasal bridge was 20.1mm. Nasal tip protrusion was 8.9mm. Width of the nostril floor was 6.4mm. Thickness of the nasal ala and length of the nasal ala were 4.0mm, 15.4mm. Length of the columella was 3.9mm. The most common nostril shape was Type II (0-45 degrees in inclination of the nostril axis from the horizontal). Nasal index was 97.8. Columella-nasal tip protrusion length index was 43.9. Conclusion : The development of the columella was relatively incomplete in the case of newborn and was the result to appear. The normal indicies could be used clinically in identifying the it's normality as well as morphologic characteristics of the craniofacial structures. They also could be used in differential diagnosis between the morphologically similar congenital craniofacial anomalies. In preoperative design, in setting the criteria of the postoperative results, and assessing the effect of the operation, Finally, they supply the plastic surgeon and the other specialists in the craniofacial surgery with basic normal population data.

시설노인의 자아존중감과 우울

박금자,이지현,배경의,강양희,송후승 노인간호학회 2007 노인간호학회지 Vol.9 No.1

Purpose: The purpose of this study was to identify levels of self-esteem and depression in the elders who are residents in welfare facilities and to provide basic data for developing nursing intervention programs for these people. Methods: The participants in this study were 192 older people who scored 24 or higher on the K-MMSE (Korean-Mini Mental State Examination), and have lived for three months or more in one of 4 institutions located in B Metropolitan City. The data were collected by structured questionnaire from August 1 to 20 2006 and frequency, percentage, mean and standard deviation, and Pearson correlation coefficient were used to analyze the data with the SPSS/12.0 program. Results: 1. The score for self-esteem of the participants was 33.70± 7.20 (tool range: 10-50), and for depression, 6.57±3.98 (tool range: 0-15). 2. There was a slightly negative correlation between self-esteem and depression (r=-.388, p=.000). 3. There were significant differences in self-esteem according to education level (F=4.486, p= .012), and level of intention to be admitted to facility (F=7.504, p=-.000). 4. There was significant difference in depression according to education level (F=3.832, p=.023), type of religion (F=3.837, p= .005), level of intention to be admitted to facility (F=7.987, p=.000). Conclusion: This study might help in developing nursing intervention programs to improve self-esteem and reduce depression these elders.

제4경추의 형태와 초경을 통한 성숙지표에 관한 연구

이규홍,황용인,김윤지,박양호,백승학,차경석 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.1

본 연구는 측모 두부 규격 방사선사진을 이용하여 성장 중인 아동의 제4경추 형태를 경추 몸체부 하연의 만곡 정도에 따라 분류하고 초경의 시기와 수완부 골 성숙 단계를 평가하여, 성장 중인 아동의 골격적 부정교합의 진단 및 악정형 치료를 위한 성장 시기 평가에 제4경추의 형태 변화가 진단의 참고자료로 활용될 수 있는지를 연구하였다. 11-14세 여자 환자 중, 같은 날짜에 촬영된 측모 두부 규격 방사선사진과 수완부 방사선사진이 모두 있는 81명을 대상으로 환자의 측모 두부 규격 방사선사진상 제4경추 몸체부 하연의 만곡 정도에 따라 세 그룹으로 분류하였다. (Group A - 제4경추 몸체부 하연의 만곡 정도가 1.05 mm 이하, Group B -제4경추 몸체부 하연의 만곡 정도가 1.05- 2.07 mm 사이, Group C -제4경추 몸체부 하연의 만곡 정도가 2.07 mm 이상)세 그룹에서 각각 제4경추 몸체부의 수직 길이, 수평 길이, 수직/수평 비율, 초경의 시기, 수완부 골 성숙 단계를 측정한 결과 다음과 같은 결론을 얻었다. 평균 수완부 골 성숙 단계는 Group A가 SMI 5.67 ± 2.57단계, Group B는 SMI 8,73 ± 2.41 단계, Group C는 SMI 10.00 ± 1.47단계로 나타났다. GroupA에서 Group B, Group C로 갈수록 제4경추의 수직 길이, 수평 길이, 수직/수평 비율, 수완부 골 성숙 단계에 있어서 각각 유의하게 더 큰 값을 보였다. 본 연구대상 아동의 평균 초경 시기는 11.64 ± 0.92세를 보였다. 제4경추 몸체부 하연의 만곡 정도, 수직 길이, 수평 길이, 수직/수평 비율은 수완부 골 성숙 단계와 각각 서로 유의한 양의 상관관계를 나타냈다. 초경을 경험한 그룹이 초경을 경험하지 않은 그룹에 비해 제4경추의 수직 길이, 수평 길이, 수직/수평 비율, 수완부 골 성숙 단계에 있어서 유의하게 큰 값을 보였다. 연구 결과 측모 두부 규격 방사선사진상 제4경추 하연의 만곡 깊이가 2.07 mm 이상인 경우 성장의 완료 단계에 가까운 시기로 나타나 이 시기의 악정형적 치료는 큰 효과를 얻을 수 없을 것으로 사료된다. Objective: This study analyzed the morphologic changes of the fourth cervical vertebra body to determine the skeletal age of orthodontic patients during growth. Methods: Eighty-one female patients aged from 11 to 14 who had cephalograms taken on the same day were examined. The subjects were divided into three groups depending on the depth of the concavity of the lower border of the fourth cervical vertebra (Group A: less than 1.05 mm, Group B: 1.05 - 2.07 mm, Group C: greater than 2.07 mm). Menarcheal timing, SMI stage, length, width and ratio of length and width of the fourth cervical vertebra body were analyzed and the following results were obtained. Results: The average SMI stage of group A,B and C were 5.67 ± 2.57, 8.73 ± 2.41, and 10.00 ± 1.47, respectively. Length, width, ratio of length and width, and SMI stage were greater in group B than group A and in group C than group B. Mean menarcheal timing was 11.64 ± 0.92 years. Concavity depth, length, width, ratio of length and width showed a significant positive correlation with SMI stage, especially with the concavity depth. Conclusion: The results of this study propose a simple method for determining the timing of orthopedic treatment by measuring the concavity depth of the fourth cervical vertebra on the cephalogram.

광주광역시 치매의 유병률과 위험인자의 도시-농촌 지역 비교

신일선,김재민,윤진상,김석재,양수진,김웅장,이승현,강순아,곽지영,이형영 大韓神經精神醫學會 2002 신경정신의학 Vol.41 No.6

연구목적 : 본 연구의 목적은 광주광역시의 도시 및 농촌 지역에 거주하는 노인에서 치매의 유병률과 위험인자를 조사하고자 하였다. 부가적으로 이 두 지역간에 치매의 유병률과 위험인자를 비교하고자 하였다. 방 법 : 광주광역시의 전형적인 도시와 농촌지역의 65세 이상의 노인(N=1,598)을 대상으로, 2단계의 역학연구를 수행하였다. 1차 선별 단계에서는 38명의 훈련된 연구보조원이 대상노인을 면담하여, 사회인구학적 특징을 조사하고 한국판 간이정신상태검사(Korean version of Mini-Mental State Examination ; MMSE-K)로 평가하였다. 2차 임상 진단 단계에서는 1차 단계에서 MMSE-K 점수가 24점 이하인 노인(N=431)을 대상으로, 전문연구팀의 임상적 평가를 통해 치매를 진단하고 원인질환별로 알쯔하이머병(Alzheimer's disease ; AD), 혈관성 치매(vascular dementia ; VaD) 및 기타 치매로 분류하였다. 대상노인에서 치매의 유병률을 측정한 후, 광주광역시 전체 노인의 연령보정 유병률을 산출하였다. 전체 대상에서 AD의 위험인자를 조사한 후, 도시와 농촌군으로 나누어 분석을 다시 시행하였다. 결 과 : 1차 및 2차 단계의 참가율은 각각 71.0%(N=1,134) 및 83.2%(N=410) 였다. 연구 참여 노인(N=1,134)에서 전체 치매, AD 및 VaD의 유병률은 최소 각각 9.7%, 5.2%, 1.8%였다. 광주광역시 전체 노인의 연령 보정 유병률은 각각 10.7%, 5.7%, 1.9%인 것으로 산출되었다. AD의 독립 위험인자는 고령, 여성, 무학이었다. 도시와 농촌에 따른 유병률의 차이는 파악되지 않았다. 그러나 AD의 위험인자는 지역에 따라 차이가 있었다. 도시 노인에게는 무학만이, 농촌 노인에게는 고령과 여성인 경우가 독립 위험인자였다. 결 론 : 광주광역시 노인에서 치매의 유병률은 높았고, 이는 국내 다른 지역에서 수행된 선행연구 결과와 유사하였다. 알쯔하이머형 치매의 위험인자는 도시와 농촌에 따라 다른 결과를 보였다. 본 연구 결과는 한국에서의 치매의 실태를 반영하며, 치매의 적절한 관리와 예방을 위해서는 지역성 특성이 고려되어야 함을 시사한다. Objectives : The purpose of this study was to investigate the prevalence rate and risk factors of dementia in an urban and a rural sample of older persons in the metropolitan Kwangju area, Republic of Korea. In addition, the prevalence rate and risk factors of dementia between the two samples were compared. Methods : A two-phase epidemiological study of residents aged 65 or over(N=1,598) was conducted in a highly developed, urban and a non-contiguous, poorly developed, rural area of metropolitan Kwangju. In the first(screening) phase, 38 trained research assistants collectively peformed in-home interviews for all participants. Detailed sociodemographic characteristics were gathered and the Korean version of Mini-Mental State Examination (MMSE-K) was administered. In the second (diagnosing) phase, diagnosis of dementia was established for those scoring 24 or less on the MMSE-K in the screening phase(N=431), and etiological types of dementia were classified to Alzheimer's disease(AD), vascular dementia(VaD) or miscellanous type by two teams of experts. Prevalence rate of dementia was determined in the participants, and age-standardized prevalence rate adjusted by age distribution in metropolitan Kwangju was estimated. For AD, the risk factors were investigated in all participants, and analyses were repeated for the urban and rural samples separately. Results : The participating rates in the first and second phases were 71.0%(N=1,134) and 83.2%(N=410), respectively. In the participants, the prevalence rates of dementia(all types), AD and VaD were 9.7%, 5.2% and 1.8%, respectively. The age-standardized prevalence rates were 10.7%, 5.7% and 1.9%, respectively. Aging, female gender and no education(complete lack of formal education) were identified as independent risk factors for AD. No difference between the urban and rural samples was observed in the prevalence rates of dementia(all types), AD and YaD. However, risk factors for AD differed between these areas. In the urban sample, no education was the only significant factor ; whereas, aging and female gender were identified as risk factors in the rural sample. Conclusion : A high prevalence rate of dementia was observed among old persons in metropolitan Kwangju, consistent with previous studies conducted in other Korean areas. The risk factor profi1es for AD differed between urban and rural settings. The results of this study reflect the current status of dementia in Korea and suggests that appropriate management and prevention strategies for dementia should be tailored toward the geographic settings.

The Structure of BC3N Tubular Nanofiber Synthesized by Using PECVD

Ji Hoon Yang,박종윤,양철웅,Cheong Hwan Yang,Chulsu Jo,Jae-Il Lee,Ji-Beom Yoo,Jong-Min Kim,Kyuwook Ihm,Min Hyung Yum,Myeung Hoi Kwon,Nam-Kyu Park,Seung Youb Lee,Tai-Hee Kang,Yong Sook Shin,Yong-Wan Jin,장영록 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.51 No.I

Boron carbonitride (B$_x$C$_y$N$_z$) nanotubes were synthesized with a gas mixture of C$_2$H$_2$, NH$_3$, N$_2$ and B$_2$H$_6$ by using dc plasma-enhanced chemical vapor deposition. The compartmented B$_x$C$_y$N$_z$ nanofibers were vertically aligned on the substrate with a diameter of $\sim$70 nm and a length of $\sim$3 $\mu$m. The transmission electron microscope images showed the B$_x$C$_y$N$_z$ nanofibers to be nanotubes with a well-aligned wall structure. The images of an elemental mapping taken by using a transmission electron microscope equipped with an electron energy loss spectroscope showed that the carbon, nitrogen, and boron atoms in the compartmented B$_x$C$_y$N$_z$ tubular nanofiber were uniformly distributed. The atomic composition ratio of the B$_x$C$_y$N$_z$ tubular nanofibers was investigated by using X-ray photoelectron spectroscopy. The estimated ratio of each chemical component of the compartmented B$_x$C$_y$N$_z$ tubular nanofibers was $x$ = 0.37 (boron) : $y$ = 1.0 (carbon) : $z$ = 0.36 (nitrogen), which is very similar with that of BC$_3$N. Based on the experimental data, we suggest a chemical structure of the BC$_3$N nanotube that is consistent with the structure obtained from a theoretical calculation. Boron carbonitride (B$_x$C$_y$N$_z$) nanotubes were synthesized with a gas mixture of C$_2$H$_2$, NH$_3$, N$_2$ and B$_2$H$_6$ by using dc plasma-enhanced chemical vapor deposition. The compartmented B$_x$C$_y$N$_z$ nanofibers were vertically aligned on the substrate with a diameter of $\sim$70 nm and a length of $\sim$3 $\mu$m. The transmission electron microscope images showed the B$_x$C$_y$N$_z$ nanofibers to be nanotubes with a well-aligned wall structure. The images of an elemental mapping taken by using a transmission electron microscope equipped with an electron energy loss spectroscope showed that the carbon, nitrogen, and boron atoms in the compartmented B$_x$C$_y$N$_z$ tubular nanofiber were uniformly distributed. The atomic composition ratio of the B$_x$C$_y$N$_z$ tubular nanofibers was investigated by using X-ray photoelectron spectroscopy. The estimated ratio of each chemical component of the compartmented B$_x$C$_y$N$_z$ tubular nanofibers was $x$ = 0.37 (boron) : $y$ = 1.0 (carbon) : $z$ = 0.36 (nitrogen), which is very similar with that of BC$_3$N. Based on the experimental data, we suggest a chemical structure of the BC$_3$N nanotube that is consistent with the structure obtained from a theoretical calculation.