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( Hye Ji Jeon ),( Yong Soo Jang ),( Seon Gyeong Kim ),( Hui Gyeong Seo ),( Deok Gyeong Kim ),( Ji Won Min ),( Yun Sook Kim ) 대한산부인과학회 2019 대한산부인과학회 학술대회 Vol.105 No.-
Unicornuate uterus is caused by a failure of one Mullerian duct to develop.It is linked to an increase in obstetrical complications such as early miscarriages, ectopic pregnancy and preterm labor. Despite the association of ectopic ovaries and unicornuate uterus, ectopic ovaries are reported only sporadically. We introduce first case of ectopic pregnancy arising at a distal, fimbriated end of the fallopian tube, which was developed adjacent to the undescended ectopic ovary in unicornuate uterus. PI: A 32- year-old woman admitted emergency room of our clinic due to severe lower abdominal pain. Her last menstrual period was 9 weeks ago. Four weeks ago, she was performed dilatation and curettage at local clinic due to no G-sac in uterus and slowly increasing ß-human chorionic gonadotropin (ß-hCG). After dilatation and curettage, her ß-hCG was continuously increased from 2,400 mIU/mL to 2,800 mIU/mL. So, she was injected methotrexate (MTX) 50mg IM. One week after MTX injection, her ß-hCG was decreased to 1,700 mIU/mL. Her vital sign was stable. Her ß-hCG was 386 mIU/mL. Ultrasonogram: Fluid collection of anterior cul-de sac (CDS) was 70 X 50mm, posterior CDS was 30 X 26mm. The endometrial thickness was 5mm, and no G-sac. Laparoscopic Findings: Unicornuate uterus, about 500ml hemoperitoneum, left side salpinx and ovary was intact. Right side salpinx was seen, but no right side fimbriae and ovary. No ectopic mass in pelvic cavity. High up in the right abdomen, just below the liver, an ectopic mass could be visualized with a arising at a distal, fimbriated end of the fallopian tube, which was developed adjacent to the undescended right ectopic ovary. We removed ectopic mass. One day after operation, her ß-hCG decreased to 91 mIU/mL. She discharged. Hysterosalpingography: Unicornuate uterus, preserved patency of left salpinx and some right salpinx. MRI: Unicornuate uterus, Right ovary was seen at right inferior hepatic portion, bilateral normal kidney, double IVC.
Lignans from Silkworm Droppings and Their Promotional Activities on Heme Oxygenase-1 (HO-1)
Ji-Hae Park,Seung-Woo Yeon,Jin-Gyeong Cho,이대영,Yong-Soon Kim,백남인 한국응용생명화학회 2010 Applied Biological Chemistry (Appl Biol Chem) Vol.53 No.6
Six lignans, (+)-pinoresinol (1), (+)-lariciresinol (2), (+)-syringaresinol (3), syringaresinol-4-O-β-Dglucopyranoside (4), (+)-lariciresinol-4-O-β-D-glucopyranoside (5), and dehydrodiconiferylalcohol-9'-O-β-D-glucopyranoside (6), were isolated from silkworm droppings. The structures of six compounds were elucidated on the basis of 1D- and 2D-NMR spectroscopic analyses and optical rotational characteristics. The isolated compounds were evaluated for their effects on HO-1 activity. Compounds 2, 3, and 6 increased the expression of heme oxygenase-1 (HO-1) in HepG2cells. HO-1 is an antioxidant enzyme that catabolizes heme to carbon monoxide, free iron, and biliverdin, all of which are involved in the suppression of inflammatory mediators.