Intakes of Vitamin A, C, and E, and &bgr;-Carotene Are Associated With Risk of Cervical Cancer: A Case-Control Study in Korea

Kim, Jeongseon,Kim, Mi Kyung,Lee, Jae Kwan,Kim, Jae-Hoon,Son, Sung Kyong,Song, Eun-Seop,Lee, Kwang Beom,Lee, Jung Pil,Lee, Jong Min,Yun, Young Mi Routledge 2010 Nutrition and cancer Vol.62 No.2

<P> Cervical cancer is one of the most common gynecological malignancies in Korea, although the incidence has been declining in recent years. This study explored whether antioxidant vitamin intakes influenced the risk of cervical cancer. The association between antioxidant vitamin intakes and cervical cancer risk was calculated for 144 cervical cancer cases and 288 age-matched, hospital-based controls using unconditional logistic regression models. Cases reported statistically lower mean dietary intakes of vitamin A, &bgr; -carotene, and vitamin C than did controls. Total intakes of vitamins A and E, which included both dietary and supplement intake, were also lower in cases. Those patients in the highest quartiles of dietary vitamin A, &bgr; -carotene, and vitamin C intakes had statistically significantly lower cervical cancer risks than those in the lowest quartiles for vitamin A, &bgr; -carotene, and vitamin C: odds ratio (OR) = 0.36 [95% confidence interval (CI) = 0.19-0.69), OR = 0.48 (CI = 0.26-0.88), and OR = 0.36 (CI = 0.18-0.69), respectively. Total intakes of vitamins A, C, and E were strongly inversely associated with cervical cancer risk: OR = 0.35 (CI = 0.19-0.65), OR = 0.35 (CI = 0.19-0.66), and OR = 0.53 (CI = 0.28-0.99), respectively. The findings support a role for increased antioxidant vitamin intake in decreasing the risk of cervical cancer. These associations need to be assessed in large prospective studies with long-term follow-up.</P>

Anti-apoptosis and Enhancement of Glycosylation in Mammalian Cell Systems Using 30Kc19-30Kc6 Fusion Protein

Jeongseon CHOI,Hee Ho PARK,Hong Jai LEE,Jina RYU,Jongmin LEE,Won Jong RHEE,Tai Hyun PARK 한국생물공학회 2013 한국생물공학회 학술대회 Vol.2013 No.10

에너지 절약 및 이산화탄소 포집을 위한 축열식 순산소 연소로 개발

오정석(Jeongseon Oh),노동순(Dongsoon Noh),이대근(Daegeun Lee),홍성국(Sungkook Hong),양제복(Jebok Yang),고창복(Changbok Ko),이은경(Eunkyung Lee) 한국연소학회 2013 KOSCOSYMPOSIUM논문집 Vol.- No.46

의사의 환자 지향적 커뮤니케이션과 만성질환자의 삶의 질과의 관계: 건강행태의 매개효과를 중심으로

이정선 ( Lee Jeongseon ),최만규 ( Choi Mankyu ) 한국보건사회연구원 2018 保健社會硏究 Vol.38 No.3

의사의 환자 지향적 커뮤니케이션은 진료에 대한 환자의 만족도, 의사에 대한 신뢰도를 증가시킬 수 있고, 이를 통해 환자의 건강상태와 건강관련 행동을 변화시킬 수 있으며, 나아가 환자의 삶의 질에도 긍정적인 영향을 미칠 수 있다고 보고되고 있다. 이와 관련하여 국외에서는 활발히 연구되고 있으나, 국내에서는 관련 연구가 부족한 실정이다. 이에 본 연구는 의사의 환자 지향적 커뮤니케이션이 만성질환자의 삶의 질에 미치는 영향을 파악하고, 이 과정에서 음주, 흡연, 신체활동 등 건강행태의 매개효과를 확인하고자 하였다. 이를 위해 국민건강영양조사(2015)에서 고혈압, 당뇨, 비만, 고콜레스테롤 혈증 중 한 가지 이상의 질환을 가진 1,680명의 성인을 대상으로 매개회귀분석을 실시하였다. 연구 결과, 환자 지향적 커뮤니케이션은 만성질환자들에게 건강지향적인 행동을 유도하는 효과가 있었으며, 건강증진 행위는 그들의 삶의 질에 긍정적인 영향을 미치는 매개요인으로 작용하였다. 본 연구는 만성질환자들의 삶의 질 향상을 위해 질병을 관리하고 치료하는데 있어서 의료인의 환자 지향적 커뮤니케이션의 중요성을 확인하였다는 점에서 의의가 있다고 하겠다. It is reported that physicians’ patient-centered communication improves patients’ satisfaction and trust in their physicians, which can affect their health-related behaviors and, in turn, their quality of life. However, patient-centered communication has not been actively researched in Korea. The purpose of this study was to investigate the effects of patient-centered communication on the quality of life of chronically ill patients and to verify the mediating role of health-related behaviors such as drinking, smoking, and physical activity. To that end, we conducted a mediated regression analysis for 1,680 patients who were identified in the 2015 Korea National Health and Nutrition Examination Survey as having hypertension, diabetes, obesity, and/or hypercholesterolemia. According to the results, patient-centered communication contributed to inducing health-oriented behaviors in chronically ill patients, and health-promoting behaviors played the role of mediators that positively influenced their quality of life. This study confirmed the importance of patient-centered communication in managing and treating chronic diseases and in improving the quality of life of the patients.

Systematic structure control of ammonium iodide salts as feasible UCST-type forward osmosis draw solutes for the treatment of wastewater

Park, Jeongseon,Joo, Heeyoung,Noh, Minwoo,Namkoong, Yon,Lee, Seonju,Jung, Kyung Hwa,Ahn, Hye Ryun,Kim, Seulah,Lee, Jong-Chan,Yoon, Jae Hoon,Lee, Yan The Royal Society of Chemistry 2018 Journal of materials chemistry. A, Materials for e Vol.6 No.3

<P>A variety of UCST-type thermoresponsive ammonium iodide salts is systematically designed and synthesised with desired aqueous solubility, phase-transition temperature, osmolality change, phase-transition concentration range, stability, and toxicity by controlling the ionic interactions, hydrophobicity, and symmetry of the salt structure. Suitable draw solutes can be selected based on the characteristics of the ammonium iodide salts as well as the feed solutions for feasible forward osmosis (FO)-based water purification. In this research, highly concentrated wastewater from a flue gas desulfuriser (FGD), with osmotic pressure three times higher than seawater, is targeted for purification by FO using the draw solutes. Two ammonium iodide salts (HM8I and HM10I) show a remarkable water flux from the wastewater samples and significantly lower salt leakage compared to conventional draw solutes. The osmolality of the phase-separated draw solution drops to less than one tenth of that of the initial feed solution, and reverse osmosis or nanofiltration can be applied to the solution with much lower external pressure for the final purification to produce fresh water. This systematic approach to the design and selection of suitable draw solutes can be an effective strategy for future practical FO-based wastewater treatment and seawater desalination.</P>

Dietary intake of folate and alcohol, MTHFR C677T polymorphism, and colorectal cancer risk in Korea

Kim, Jeongseon,Cho, Young Ae,Kim, Dong-Hyun,Lee, Bong-Hwa,Hwang, Dae-Yong,Jeong, Jinyoung,Lee, Hun-Jae,Matsuo, Keitaro,Tajima, Kazuo,Ahn, Yoon-Ok Oxford University Press 2012 The American journal of clinical nutrition Vol.95 No.2

<P>The incidence of colorectal cancer (CRC) is increasing sharply in Korea, and evidence has suggested the role of dietary methyl supply and related polymorphisms on colorectal carcinogenesis.</P>

인공지능이 의사결정에 미치는 영향에 관한 연구: 인간과 인공지능의 협업 및 의사결정자의 성격 특성을 중심으로

이정선(JeongSeon Lee),서보밀(Bomil Suh),권영옥(YoungOk Kwon) 한국지능정보시스템학회 2021 지능정보연구 Vol.27 No.3

인공지능(Artificial Intelligence)은 미래를 가장 크게 변화시킬 핵심 동력으로 산업 전반과 개인의 일상생활에 다양한 형태로 영향을 미치고 있다. 무엇보다 활용 가능한 데이터가 증가함에 따라 더욱더 많은 기업과 개인들이 인공지능 기술을 이용하여 데이터로부터 유용한 정보를 추출하고 이를 의사결정에 활용하고 있다. 인공지능에 관한 기존 연구는 모방 가능한 업무의 자동화에 초점을 두고 있으나, 인간을 배제한 자동화는 장점 못지않게 알고리즘 편향(Algorithms bias)으로 발생되는 오류나 자율성(Autonomy)의 한계점, 그리고 일자리 대체 등 사회적 부작용을 보여주고 있다. 최근 들어, 인간지능의 강화를 위한 증강 지능 (Augmented intelligence)으로서 인간과 인공지능의 협업에 관한 연구가 주목을 받고 있으며 기업도 관심을 가지기 시작하였다. 본 연구는 의사결정을 위해 조언(Advice)을 제공하는 조언자의 유형을 인간, 인공지능, 그리고 인간과 인공지능 협업의 세 가지로 나누고, 조언자의 유형과 의사결정자의 성격 특성이 의사결정에 미치는 영향을 살펴보았다. 311명의 실험자를 대상으로 사진 속 얼굴을 보고 나이를 예측하는 업무를 진행하였으며, 연구 결과 의사결정자가 조언활용을 하려면 먼저 조언의 유용성을 높게 인지하여하는 것으로 나타났다. 또한 의사결정자의 성격 특성이 조언자 유형별로 조언의 유용성을 인지하고 조언을 활용하는 데에 미치는 영향을 살펴본 결과, 인간과 인공지능의 협업 형태인 경우 의사결정자의 성격 특성에 무관하게 조언의 유용성을 더 높게 인지하고 적극적으로 조언을 활용하는 것으로 나타났다. 인공지능 단독으로 활용될 경우에는 성격 특성 중 성실성과 외향성이 강하고 신경증이 낮은 의사결정자가 조언의 유용성을 더 높게 인지하고 조언을 활용하는 것으로 나타났다. 본 연구는 인공지능의 역할을 의사결정과 판단(Decision Making and Judgment) 연구 분야의 조언자의 역할로 보고 관련 연구를 확장하였다는데 학문적 의의가 있으며, 기업이 인공지능 활용 역량을 제고하기 위해 고려해야 할 점들을 제시하였다는데 실무적 의의가 있다. Artificial intelligence (AI) is a key technology that will change the future the most. It affects the industry as a whole and daily life in various ways. As data availability increases, artificial intelligence finds an optimal solution and infers/predicts through self-learning. Research and investment related to automation that discovers and solves problems on its own are ongoing continuously. Automation of artificial intelligence has benefits such as cost reduction, minimization of human intervention and the difference of human capability. However, there are side effects, such as limiting the artificial intelligence’s autonomy and erroneous results due to algorithmic bias. In the labor market, it raises the fear of job replacement. Prior studies on the utilization of artificial intelligence have shown that individuals do not necessarily use the information (or advice) it provides. Algorithm error is more sensitive than human error; so, people avoid algorithms after seeing errors, which is called “algorithm aversion.” Recently, artificial intelligence has begun to be understood from the perspective of the augmentation of human intelligence. We have started to be interested in Human-AI collaboration rather than AI alone without human. A study of 1500 companies in various industries found that human-AI collaboration outperformed AI alone. In the medicine area, pathologist-deep learning collaboration dropped the pathologist cancer diagnosis error rate by 85%. Leading AI companies, such as IBM and Microsoft, are starting to adopt the direction of AI as augmented intelligence. Human-AI collaboration is emphasized in the decision-making process, because artificial intelligence is superior in analysis ability based on information. Intuition is a unique human capability so that human-AI collaboration can make optimal decisions. In an environment where change is getting faster and uncertainty increases, the need for artificial intelligence in decision-making will increase. In addition, active discussions are expected on approaches that utilize artificial intelligence for rational decision-making. This study investigates the impact of artificial intelligence on decision-making focuses on human-AI collaboration and the interaction between the decision maker personal traits and advisor type. The advisors were classified into three types: human, artificial intelligence, and human-AI collaboration. We investigated perceived usefulness of advice and the utilization of advice in decision making and whether the decision-maker’s personal traits are influencing factors. Three hundred and eleven adult male and female experimenters conducted a task that predicts the age of faces in photos and the results showed that the advisor type does not directly affect the utilization of advice. The decision-maker utilizes it only when they believed advice can improve prediction performance. In the case of human-AI collaboration, decision-makers higher evaluated the perceived usefulness of advice, regardless of the decision maker"s personal traits and the advice was more actively utilized. If the type of advisor was artificial intelligence alone, decision-makers who scored high in conscientiousness, high in extroversion, or low in neuroticism, high evaluated the perceived usefulness of the advice so they utilized advice actively. This study has academic significance in that it focuses on human-AI collaboration that the recent growing interest in artificial intelligence roles. It has expanded the relevant research area by considering the role of artificial intelligence as an advisor of decision-making and judgment research, and in aspects of practical significance, suggested views that companies should consider in order to enhance AI capability. To improve the effectiveness of AI-based systems, companies not only must introduce high-performance systems, but also need employees who properly understand digital information presented by AI, and can add non-digital

Fabrication and modeling of submicron InGaP/GaAs HBTs using a structure-based hybrid-π small signal model

Jaewoo Lee,Jong-In Song,Jeong Hoon Kim,Jeongseon Lee 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.43 No.51

Fabrication and structure-based hybrid- small signal modeling of a submicron InGaP/GaAs heterojunction bipolar transistor (HBT) are discussed. The submicron InGaP/GaAs HBTs were fabricated using electron-beam lithography. The emitter mesa was realized by using H3PO4-based and NH4OH-based wet etching solutions. The fabricated submicron InGaP/GaAs HBTs had an emitter area of 0.5 2 m2 and emitter-base spacings of 0.25 m, 0.85 m, 2 m, and 4 m. The extracted maximum oscillation frequencies (fmax) of the submicron InGaP/GaAs HBTs having emitter-base spacings of 0.25 m, 0.85 m, 2 m, and 4 m were 222.5 GHz, 167.5 GHz, 69.3 GHz, and 41 GHz, respectively, at Ic = 1 mA and Vce = 2 V.

근대 한국의 `여성` 주체 ― 기표의 각축을 통해 본 일제시기 여성 개념 ―

이정선 ( Jeongseon Lee ) 한림과학원 2017 개념과 소통 Vol.0 No.19

본 논문은 일제시기 <여성> 기표의 사용 양상을 통해 근대 한국의 여성 개념을 분석했다. 이를 위해 단어의 출현빈도 및 그 단어와 함께 출현하는 공기어(共起語)를 분석하는 어휘통계학의 방법을 사용했고, 한림대 한림과학원에서 구축한 19종 잡지 코퍼스를 활용했다. 일제시기에 여성 일반을 지칭하는 데 사용된 <여성> 기표로는 전통적 어휘인 `여자`, `부인`, `부녀`와 `woman`의 번역어였던 신조어 `여성` 등이 있었다. 그런데 이 어휘들은 한자어에 내포된 고유한 의미에 제한되면서도 사용 당시의 사회적 기대를 담아 새로운 의미를 획득하기도 했다. 특히 각종 사회운동이 활발하던 1920~1933년까지는 모두 운동의 주체로 조명되었다. 주로 `여자`는 교육의 대상 또는 민족주의적 주체, `여성`과 `부인`은 사회주의적 주체였고, 구도덕적 색채가 비교적 강했던 `부녀`는 어휘 사용 비중이 감소했다. 그러나 1920년대 후반에서 1930년대 초반에는 신여성에 대한 비난이 거세지면서, 어린 여성이자 착실한 여학생이어야 할 `여자`가 주로 남성들의 성적 관심과 단속의 대상이 되면서 운동색을 상실해 갔다. 또한 식민 당국의 탄압으로 사회주의운동이 지하화되는 가운데, 1930년대에는 `여성`과 `부인`의 운동색도 옅어졌다. 이어서 전시체제기에는 민족주의적 색채가 강하던 `여자` 대신 `부인`과 `여성`이 일본의 전쟁 수행을 위한 동원의 주체로 다시 부각되었다. 이들은 가정의 주인인 `부인`과 동양적 덕을 갖춘`여성`으로 자리매김되었고, 그와 함께 `여성`에 부착되어 있던 성적 자유의 측면은 제거되었다. 이처럼 일제시기 <여성> 기표들은 현재와 미래에 대한 서로 다른 전망을 담고 있었다. 따라서 기표의 사용 양상을 분석하는 것은 한국의 근대적 여성 개념의 형성·변용 및 여성 주체의 구성 과정을 살펴보는 작업이 된다. This paper examines the concept of `women` in early modern Korea through the usage patterns of female signifiers during the Japanese colonial period. For this purpose, lexical statistics on the frequency of words and their co-occurrences were used. The traditional female signifiers `yeo-ja ` (女子), `bu-in ` (婦人), `bu-nyeo ` (婦女) were considered, and also a new word `yeo-seong ` (女性), which is a translation of `woman.` These signifiers had been restricted to the specific meanings implied by their Chinese characters, but they gained new meanings corresponding to the social expectations current at the time of use. In particular, from 1920 to 1933, when various social movements were active, they all became the subjects of such movements. Thus, `yeo-ja` was a mostly an educational or nationalist subject, whereas `yeo-seong` and `bu-in` were used as socialist subjects, and `bu-nyeo,` which retained its traditional moral image, decreased in frequency. Starting somewhat later, in the mid to late 1920s, and continuing into the early 1930s, `yeo-ja,` which implied a young girl, also became a primary target of sexual interest and criticism. As the colonial authorities repressed the socialist movement, during the 1930s, the use of `yeo-seong` and `bu-in` in this context tailed off. During the wartime period, `bu-in` and `yeo-seong` again became prominent, now as the subject of Japanese mobilization efforts, whereas `yeo-ja` was deployed as a Korean nationalist subject. The usage of `bu-in` emphasized the role of a woman as hostess for her family, and `yeo-seong` was positioned to describe women considered to possess traditional oriental virtues, from which the aspect of sexuality had been removed. In sum, these female signifiers expressed different visions of the present and of the future, so that the analysis of their usage patterns is a convenient way to examine the formation and transform- ation of the modern concept of `women,` and also the formation process for female subjects in colonial Korea.

The Korea Cohort Consortium: The Future of Pooling Cohort Studies

Sang-Jun Lee,Kwang-Pil Ko,Jung Eun Lee,Inah Kim,Sun Ha Jee,Aesun Shin,Sun-Seog Kweon,Min-Ho Shin,Sangmin Park,Seungho Ryu,Sun Young Yang,Seung Ho Choi,Jeongseon Kim,Sang-Wook Yi,Daehee Kang,Keun-Young 대한예방의학회 2022 예방의학회지 Vol.55 No.5

Objectives: We introduced the cohort studies included in the Korean Cohort Consortium (KCC), focusing on large-scale cohort studies established in Korea with a prolonged follow-up period. Moreover, we also provided projections of the follow-up and estimates of the sample size that would be necessary for big-data analyses based on pooling established cohort studies, including population-based genomic studies. Methods: We mainly focused on the characteristics of individual cohort studies from the KCC. We developed “PROFAN”, a Shiny application for projecting the follow-up period to achieve a certain number of cases when pooling established cohort studies. As examples, we projected the follow-up periods for 5000 cases of gastric cancer, 2500 cases of prostate and breast cancer, and 500 cases of non-Hodgkin lymphoma. The sample sizes for sequencing-based analyses based on a 1:1 case-control study were also calculated. Results: The KCC consisted of 8 individual cohort studies, of which 3 were community-based and 5 were health screening-based cohorts. The population-based cohort studies were mainly organized by Korean government agencies and research institutes. The projected follow-up period was at least 10 years to achieve 5000 cases based on a cohort of 0.5 million participants. The mean of the minimum to maximum sample sizes for performing sequencing analyses was 5917-72 102. Conclusions: We propose an approach to establish a large-scale consortium based on the standardization and harmonization of existing cohort studies to obtain adequate statistical power with a sufficient sample size to analyze high-risk groups or rare cancer subtypes.