정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

Effect of Mechanical Alloying on the Microstructural Evolution of Al60Cr30Si10 Alloys Processed by Spark Plasma Sintering

Jeong‑Han Lee,Ik‑Hyun Oh,Jun‑Ho Jang,Ju‑Hun Kim,Sung‑Kil Hong,Hyun‑Kuk Park 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.5

In this study, Al, Cr and Si fine powders were alloyed by planetary ball milling to investigate their microstructural evolution,following their mechanical alloying behavior. The formation of Al(Cr) supersaturated solid solution by the Cr grainsembedded in Al-matrix, which contributed substitutional structure is discussed in relation to their structural evolution inaccordance with the distortion of a crystal lattice. The compacts of Al–Cr–Si alloys were prepared by rapid sintering withina short time by dense consolidation above the density of 99.9% as the formation of intermetallics, except in the case of thedistribution of single-phases induced by the Al-melting. The formation behavior of intermetallics was dominated by dependenceon the structures of the milled-powder and subsequent sintering temperature. To estimate the consolidated behaviorsof compacts, various approaches derived from TEM and XRD analysis were taken to obtain microstructural evidences ofthe inter-diffusion, following the presence of thermally stable intermetallics.

Rapid Consolidation of WC‑ZrSiO4 Hard Materials by Spark Plasma Sintering: Microstructure, Densification, and Mechanical Properties

Jeong‑Han Lee,Ik‑Hyun Oh,Ju‑Hun Kim,Sung‑Kil Hong,Hyun‑Kuk Park 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.9

Densely consolidated WC-based hard materials with 5–20 vol% ZrSiO4was fabricated by spark plasma sintering at 1400 ℃ ata constant heating rate of 70 ℃/min−1. To achieve mechanical alloying of WC-ZrSiO4, planetary ball milling was carried outfor 12 h, during which the brittle-brittle components (WC-ZrSiO4) became fragmented and their particles became refined. Itwas observed that certain, specific, non-isothermal sintering kinetics, such as apparent activation energy, sintering exponents,and densification strain, affected the densification behavior. The evolution of phase structure from powder to compact wasfound to be related the lattice distortion and micro-strain in the basal planes of WC. By examining the mechanical propertiesof the samples, it was that the added zircon content leads to enhanced fracture toughness (12.9 MPa m1/2) owing to thepresence of WC-ZrSiO4 in the cemented carbide. In fact, the microcrack propagation of the fracture passed through zirconfrom a transgranular to a ductile component (fcc) where the crack tips could be absorbed.

Influence of Phase Composition in TiAlSiN Hard Coatings on the Evolution of Structure and Mechanical Properties

Jeong‑Han Lee,Ik‑Hyun Oh,Jun‑Ho Jang,Ju‑Hun Kim,Sung‑Kil Hong,Hyun‑Kuk Park 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.3

The aim of this study is to investigate the structural evolution and mechanical properties of TiAlSiN coatings when processedby the arc ion plating method. To form a hard coating, Ti, Al, and Si powders were mechanically alloyed by planetary ballmilling; the powders were then densely compacted during a rapid sintering process into a ternary system coating, i.e. TiAlSi. The evolution of the structural phase from a powder to a compact material is dominated considerably by phase states suchas a supersaturated solid solution or intermetallic compounds. In the case of coating layers, the factors that determine thestructural evolution are associated with the phase stability of the nano-crystalline structure that in turn is associated withthe Ti/Al composition ratio. Motivated by this, we performed experiments to investigate the distribution of microstructures;the material’s binding energy, quantitative properties, transformation of crystal structure, and distribution of amorphous/crystalline were all recorded. In particular, the relationship between the physical and chemical properties during the coatingprocess is considered to be the dominant factor controlling the orientation and morphology of that zone (1, T, and 2). TheTiAlSiN coating layer was found to have hardness above 45 GPa and an adhesion above 100 N. In other words, understandingthe evolution and structure of TiAlSin helped us to produce a material with excellent properties that can be used as a hardcoating. Specifically, these properties were induced by a grain refinement of the nano-crystalline structure that correspondsto an increase in the silicon nitride contents.

工業敎育大學 敎育改善에 관한 硏究(Ⅲ)

宋周鎬,李昌岬,洪元杓,孟琦錫,任洪彬,李廷玟,李載元,李來烈,權五憲,金振淳,李文洙 충남대학교 공업교육연구소 1982 論文集 Vol.5 No.1

This paper aims at providing a concrete plan to improve technical and vocational teacher education in the College of Industrial Education of Chungnam National University. It is intended to propose a practical four-year regular and short-term course. Also, the estimated required facilities is included in this study as well as their management. The main conclusions and recommendations are summarized as follows; 1) The numbers of students enrollment should be reduced to 220 students which is the approximate number of future demand. 2) In order to offer to the students a broader education and to cope with the increase/decrease in demand of technical and vocational teacher within a specific field, the 8 department existing at the present (Department of Architecture Engineering Education, Civil Eng. Educ., Metallurgical Eng. Educ., Mechanical Eng. .Educ., Electrical Eng. Educ., Electronic Eng. Educ., Industrial Chemistry Educ. and Industrial Technology Educ.) would be combined into 5 (Department of Construction Engineering Education, Mechanical Eng. Educ., Electrical Eng. Educ., Industrial Chemistry Educ. and Industrial Technology Educ.). 3) The short-term course program is recommened to provide additional training and education to those candidates who already have experience in technical fields to meet an occasional demand. 4) It is necessary to add the Teaching Profession Section in the administrative organization of the College.

복강경하 대장절제술을 시행 받는 환자에서 라모세트론과 온단세트론외 술 후 오심 및 구토 예방 효과 비교

김효중;어전영;어근무;어정한;엄세훈;조광래;김명훈 인제대학교 2011 仁濟醫學 Vol.32 No.-

Objectives : We evaluated the efficacy of ramosetron and ondansetron for preventing postoperative nausea and vomiting (PONV) in laparoscopic colectomy. Methods and Materials : Eighty patients who received laparoscopic colectomy were randomly divided into two groups: R group (ramosetron 0.1mg PO) and O group (ondansetron 4mg twice IV). Injection or oral medication was administered before the induction of anesthesia in each group. Injection was administered at the end of surgery in O group. General anesthesia was induced using propofol and rocuronium, and maintained with sevoflurane, remifentanil and air (FiO2 0.5), We investigated the incidences of PONV in each group by the Rhodes index of nausea, vomiting and retching (RINVR) at postoperative 6 and 24 hours. Results : The incidence of PONV was not different between group at each time points after surgery (at postoperative 6 hours: 20% in group R, 17.5% in group 0, at postoperative 24 hours; 12.5% in group R, 7.5% in group 0). There was no difference in the severity of PONV, satisfaction, rescue drug usage. Conclusion : Prophylactic therapy with ramosetron is as effective as conventional prophylactic therapy with ondansetron for preventing PONV in general anesthesia for laparoscopic colectomy.

Plant regeneration from callus of Iris odaesanensis Y. N. Lee native to Korea via organogenesis

Bae, Kee-Hwa,Yoo, Kyoung-Hwa,Lee, Mi-Hyun,Jeong, Jae-Hun,Choi, Yong-Eui,Yoon, Eui-Soo The Korean Society of Plant Biotechnology 2013 식물생명공학회지 Vol.40 No.3

Iris odaesanensis Y. N. Lee. is an important endangered and native plant belonging to the family Iridaceae in Korea. This study describes a method for rapid micropropagation of this species via from leaf, rhizome and root explants derived calli. Leaf, rhizome and root explants were cultured on Murashige and Skoog (MS) medium supplemented with 2,4-dichlorophenoxy acetic acid (2,4-D) for callus induction. Rhizome explants yielded calli at a frequency of 72% when cultured at 1.0 mg/l 2,4-D. Calli were maintained at 1.0 mg/l 2,4-D. These calli were transferred to MS medium supplemented with 0, 0.5, 1.0, and 2.0 mg/l 2,4-D in combination with 0, 0.5, 1.0, and 3.0 mg/l BA for adventitious shoot induction. The highest number of adventitious shoot (228.9 per petri-dish) were formed at 1.0 mg/l 2,4-D and 1.0 mg/l BA. WPM medium was the best to convert calli into plantlets, where up to 98.2% of calli were regenerated into plantlets. This in vitro propagation protocol should be useful for conservation of this endangered plant.

서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)

김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1

In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.

고빌리루빈혈증을 동반한 자가면역성 간염 1례

서영범,김성욱,장재식,강혁주,이중현,윤병구,김욱년,이광헌,이구,유석동,양창헌,이정호,이영현,이창우,서정일 동국대학교 의학연구소 2000 東國醫學 Vol.7 No.-

자가면역성 간염은 대개 만성 경과를 가지며, 혈중 자가면역항체와 혈청 글로불린치의 상승, 그리고 조직학적으로 괴사 염증성 변화를 특징으로 하는 질환으로 아직 정확한 병인이 밝혀져 있지 않은 상태이다. 발병연령은 대개 젊은 영자(15-25세)에서 호발한다. 이 질환은 급성 간염의 임상경과를 보일 수 있으나, 심한 급성 간염이나 전격성 간염으로도 나타날 수 있는데, 이 경우 아주 나쁜 예후를 보인다고 한다. 치료는 자가면역성 간염 임상 경과의 다양성이나 병인, 병리기전의 불확실성에도 불구하고 대개 steroid 치료에 반응하는 것으로 알려져 있으며 대개 80%의 관해율을 나타내며 궁극적으로 간경변으로의 진행을 막을 수 있는 것으로 보인다. 저자들은 58세 남자에서 발생한 급성의 경과를 가지고 심한 황달을 동반한 자가면역성 간염을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Autoimmune hepatitis (AIH) is a chronic necroinflammatory liver disorder of unknown cause associated with circulating autoantibodies and a high serum globulin level. The age of onset of AIH show a peak between the age of 15 and 25 years. AIH can develop and be manifested as acute hepatitis, but severe form of acute hepatitis or fulminant hepatic failure has a poor prognosis. Although AIH is likely to progress from chronic active hepatitis to cirrhosis, steroid therapy can control the disease activity, prolong survival, improve the quality of life , and defer liver transplantation. In the present report we describe a 58-year-old man who admitted because of progressive jaundice and fatigue. He was diagnosed with AIH from laboratory test result showing positivity for antinuclear antibodies, anti-smooth muscle antibodies, and negativity for hepatitis viral markers and from liver biopsy. Steroid therapy, oral administration of prednisolone, was effective in improving the liver function test. Following liver biopsy 6 months after onset shows markedly improved necroinflammatory activity.

국제행사 시 경호안전 대책방안

이상철,권정훈 龍仁大學校 武道硏究所 2004 武道硏究所誌 Vol.14 No.2

One of the most important things for holding the international event successfully is that the safe of attendants at the event and the public. It is the measure for stabilizing national life and establishing public order. In the entrance of the 21st century the world is becoming globalized and many countries enter the alliance with others. A lot of problems awaiting solution are left and much effort for getting stabilization is made around the world. Such international events as summit and athletic meeting are increasing more and more and thus security needed for the successful events is a must. By this time the study for the successful events doesn't almost have carried out. The purpose of this thesis is to present some effective ways to hold the successful events. With an examination of the concept and meaning of the international event, some security activities that has been made in the international events are analyzed and further effective counterplans for successful security activities in the international events are suggested. In the chapter I, the necessity, objective, method and restriction of this thesis as well as the definition of the term frequently used are presented. In the chapter Ⅱ, the concept and meaning of the international event, the meaning of security activity and terrorism in the international society are presented. In the chapter Ⅲ, both native and foreign summit and athletic meeting which has been held are surveyed. In the chapter Ⅳ, some problems in security activities are introduced and countermeasures for this are suggested. Some problems are pointed as follows: the number of the guard and the equipment needed for events, event place, accommodations, traffic regulation, ceremony and communication facilities. And the couterplans which are the core of this study are presented by dividing them into three categories: facilities, application, and measure. In the facilities part, the number of the guard and the equipment needed for events, event place, accommodations, communication facilities are considered. In the application part, smoothy traffic regulation, reasonable drive of ceremony activity, unification with safe control organization and specialization, reexamination for the number of security guards needed for events, the improvement in the uniform of guards in the event place, the selection of the best quality of volunteers are considered. In the measure part, preparation for systemic devices, the harmony of international cooperation, the control of an assembly demonstration of NGO, national support and forming of people's sympathy are needed. International event is the largest event related with politics, economy, culture and thus such large-scale event must be a comprehensive counterplan in the light of safety check for the location of event, elimination of a hazard and safety check of facilities in and out, attendance on athlete and visitor and escort of VIP. Therefore the above counterplans for successful international event must be prepared as soon as possible.